Dog: adverse event reports for animal drugs
Species
Read this first. FDA says this about the data:
An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .
This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.
Contacting a veterinarianHow to report to FDAFrom January 1987 to June 2026, FDA received 1,001,350 adverse event reports about dogs for animal drugs. That is 72.6% of the 1,378,761 reports that FDA received from January 1987 to June 2026.
In the 12 months to June 2026, FDA received 53,340 reports about dogs. The signs that appear in the largest number of the 1,001,350 reports are "Vomiting", "Lethargy" and "Diarrhoea". A report is not proof that a drug caused a sign.
Since the last update of the FDA data
The site recorded an update of the FDA data on . 95 drug pages with reports about dogs have a different count. Open the update
Drug pages with reports about dogs
The table has every drug page with 20 or more reports about dogs, in order of name. No count decides which drug is in the table. The table has 307 drug pages.
Show the 307 drug pages
The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.
An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
Commonly used products may have a higher number of reported adverse events due to the higher total number of animals being given the product.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices
Signs that the reports list
A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 1,001,350 reports about dogs that list the sign.
The sign that is in the largest number of the reports comes first.
- Vomiting19.6%196,271 reports
- Lethargy[unusually tired or inactive]7.9%79,372 reports
- Diarrhoea[diarrhea]7.3%73,286 reports
- Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]6.9%68,980 reports
- Emesis[vomiting]6.4%63,696 reports
- Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]5.4%54,086 reports
- Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]5.4%53,948 reports
- Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]5.1%50,709 reports
- Anorexia[not eating]4.6%46,169 reports
- Lack of efficacy - NOS[the product did not have the expected effect]4.4%44,452 reports
- Depression[dull, quiet or withdrawn]3.4%34,449 reports
- Seizure NOS[seizure, type not specified]3.1%31,456 reports
- Death2.9%28,783 reports
- Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]2.5%25,001 reports
Show the next 16 signs
- Ataxia[unsteady, uncoordinated movement]2.4%23,941 reports
- Death by euthanasia[the animal was euthanized]2.3%22,996 reports
- Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]2.2%21,577 reports
- Digestive tract disorder NOS[digestive problem, type not specified]2%20,099 reports
- Behavioural disorder NOS[behaviour change, type not specified]1.9%19,143 reports
- Pruritus[itching]1.9%18,980 reports
- Ineffective, ascarids NOS[legacy FDA term: the product did not have the expected effect (ascarids nos)]1.8%18,226 reports
- Other abnormal test result NOS[abnormal laboratory result, type not specified]1.8%17,825 reports
- Emesis (multiple)[vomiting more than once]1.7%17,453 reports
- Lack of efficacy (ectoparasite) - tick NOS[the product did not have the expected effect: ticks]1.7%17,066 reports
- Weight loss1.7%16,886 reports
- Not eating1.7%16,605 reports
- Accidental exposure[exposure that was not intended]1.5%15,399 reports
- Decreased appetite1.4%14,318 reports
- Elevated blood urea nitrogen (BUN)[a kidney value above the normal range]1.4%13,838 reports
- Bloody diarrhoea[diarrhea with blood]1.4%13,694 reports
Reports by month and by year
FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
| Year | Reports |
|---|---|
| 2026 | 26,143 |
| 2025 | 54,118 |
| 2024 | 56,786 |
| 2023 | 45,680 |
| 2022 | 43,902 |
| 2021 | 47,423 |
| 2020 | 50,767 |
| 2019 | 52,735 |
| 2018 | 52,771 |
| 2017 | 58,310 |
| 2016 | 56,915 |
| 2015 | 55,141 |
| 2014 | 52,091 |
| 2013 | 52,635 |
| 2012 | 50,634 |
| 2011 | 37,625 |
| 2010 | 31,166 |
| 2009 | 28,069 |
| 2008 | 25,691 |
| 2007 | 19,733 |
| 2006 | 15,470 |
| 2005 | 13,674 |
| 2004 | 13,870 |
| 2003 | 8,545 |
| 2002 | 8,365 |
| 2001 | 8,998 |
| 2000 | 11,296 |
| 1999 | 7,415 |
| 1998 | 6,000 |
| 1997 | 2,894 |
| 1996 | 1,554 |
| 1995 | 911 |
| 1994 | 671 |
| 1993 | 512 |
| 1992 | 394 |
| 1991 | 430 |
| 1990 | 372 |
| 1989 | 549 |
| 1988 | 484 |
| 1987 | 611 |
What the reports record
Age of the animal
- Under 1 year10.3%102,804
- 1 to 3 years29.2%292,314
- 4 to 7 years24.5%245,390
- 8 to 11 years18.4%184,256
- 12 years and over10.1%100,721
- Age not given7.6%75,865
Weight of the animal
- Under 5 kg (11 lb)11.6%116,468
- 5 to 9.9 kg (11 to 22 lb)18.7%187,393
- 10 to 24.9 kg (22 to 55 lb)27.5%275,587
- 25 to 44.9 kg (55 to 99 lb)30.4%304,237
- 45 kg and over (99 lb and over)3.9%38,997
- Weight not given7.9%78,668
Outcome at the time of the report
- Reports about dogs
- All reports
- Recovered/Normal24.4%244,490, All reports: 20.7%
- Recovered with Sequela[recovered, with a lasting effect]3.1%30,991, All reports: 2.3%
- Ongoing20%199,998, All reports: 17.4%
- Died3.9%39,230, All reports: 4.9%
- Euthanized1.5%15,253, All reports: 1.5%
- Outcome Unknown25.7%257,057, All reports: 22.7%
An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 1,001,350 reports about dogs.
Kind of report
- Reports about dogs
- All reports
- Safety issue69.6%697,231, All reports: 64.5%
- Lack of expected effectiveness23.8%238,469, All reports: 18.9%
- Both safety and lack of expected effectiveness5%50,056, All reports: 4.3%
- Manufacturing or product defect1.5%15,041, All reports: 12.2%
- Other0.1%553, All reports: 0.1%
Each share of age, weight and kind is of the 1,001,350 reports about dogs. The thin bar is the same share in all 1,378,761 reports.
Ingredients, all combinations
The list has every active ingredient with 20 or more reports about dogs, in order of name. It has 254 ingredients.
Show the 254 ingredients
- (S) - methoprene
- Acepromazine Maleate
- Acetaminophen
- Acetylsalicylic Acid
- Afoxolaner
- Albendazole
- Alfaxalone
- Alprazolam
- Amantadine
- Amitraz
- Amlodipine
- Amoxicillin
- Amoxicillin Trihydrate
- Ampicillin Sodium
- Ampicillin Trihydrate
- Apomorphine
- Aspirin
- Atenolol
- Atinvicitinib
- Atipamezole Hydrochloride
- Atropine
- Attapulgite
- Azathioprine
- Azithromycin
- Bacitracin
- Bacitracin Zinc
- Bedinvetmab
- Benazepril
- Benazepril hydrochloride
- Betamethasone Acetate
- Betamethasone Valerate
- Bexagliflozin
- Bismuth Subsalicylate
- Budesonide
- Bupivacaine
- Buprenorphine
- Butorphanol Tartrate
- Capromorelin
- Carprofen
- Cefadroxil
- Cefovecin sodium
- Cefpodoxime proxetil
- Ceftiofur Sodium
- Cephalexin
- Cetirizine
- Chlorambucil
- Chloramphenicol
- Ciprofloxacin
- Cisapride
- Clavulanate Potassium
- Clindamycin
- Clindamycin Hydrochloride
- Clomipramine Hydrochloride
- Clonidine
- Clorsulon
- Clotrimazole
- Codeine
- Cyclophosphamide
- Cyclosporine
- Deracoxib
- Desoxycorticosterone Pivalate
- Detomidine Hydrochloride
- Dexamethasone
- Dexamethasone Sodium Phosphate
- Dexmedetomidine
- Dexmedetomidine hydrochloride
- Dextrose
- Diazepam
- Dichlorophene
- Diethylcarbamazine Citrate
- Difloxacin Hydrochloride
- Diltiazem
- Dimethyl Sulfoxide
- Diphenhydramine
- Dirlotapide
- Doramectin
- Doxorubicin
- Doxycycline
- Doxycycline Hyclate
- Emodepside
- Enalapril Maleate
- Enrofloxacin
- Eprinomectin
- Epsiprantel
- Erythromycin
- Estradiol
- Estriol
- Etodolac
- Famotidine
- Febantel
- Fenbendazole
- Fentanyl
- Fenthion
- Firocoxib
- Florfenicol
- Fluconazole
- Flunixin Meglumine
- Fluocinolone Acetonide
- Fluoxetine hydrochloride
- Fluralaner
- Furosemide
- Gabapentin
- Gentamicin
- Gentamicin Sulfate
- Glycopyrrolate
- Grapiprant
- Guaifenesin
- Hyaluronate Sodium
- Hydrocodone
- Hydrocortisone
- Hydrocortisone aceponate
- Hydrogen Peroxide
- Hydromorphone
- Hydroxyzine
- Ilunocitinib
- Imepitoin
- Imidacloprid
- Imidocarb Dipropionate
- Insulin
- Isoflupredone Acetate
- Isoflurane
- Itraconazole
- Ivermectin
- Ketamine Hydrochloride
- Ketoconazole
- Ketoprofen
- Lactic Acid
- Lactulose
- Levetiracetam
- Levothyroxine sodium
- Lidocaine
- Lincomycin Hydrochloride
- Loperamide
- Lotilaner
- Lufenuron
- Marbofloxacin
- Maropitant
- Mebendazole
- Meclofenamic Acid
- Medetomidine
- Medetomidine hydrochloride
- Melarsomine Dihydrochloride
- Melatonin
- Meloxicam
- Methadone
- Methocarbamol
- Methylprednisolone
- Methylprednisolone Acetate
- Metoclopramide
- Metronidazole
- Miconazole Nitrate
- Midazolam
- Milbemycin Oxime
- Minocycline
- Mirtazapine
- Misoprostol
- Mometasone furoate
- Mometasone Furoate Monohydrate
- Monensin
- Moxidectin
- Mupirocin
- Mycophenolate
- Neomycin Sulfate
- Nitenpyram
- Nystatin
- Oclacitinib
- Omeprazole
- Ondansetron
- Orbifloxacin
- Ormetoprim
- Oxibendazole
- Oxytetracycline
- Oxytetracycline Dihydrate
- Penicillin G Benzathine
- Penicillin G Procaine
- Pentobarbital
- Pentobarbital Sodium
- Pentoxifylline
- Pergolide mesylate
- Phenobarbital
- Phenylpropanolamine hydrochloride
- Phenytoin Sodium
- Pimobendan
- Piperazine
- Piperonyl Butoxide
- Polymyxin B Sulfate
- Polysulfated Glycosaminoglycan
- Ponazuril
- Posaconazole
- Potassium bromide
- Potassium Citrate
- Praziquantel
- Prednisolone
- Prednisolone Acetate
- Prednisolone Sodium Succinate
- Prednisone
- Pregabalin
- Primidone
- Propofol
- Pyrantel Pamoate
- Pyrantel Tartrate
- Pyrethrins
- Rabacfosadine
- Robenacoxib
- Ropinirole
- Salicylic Acid
- Sarolaner
- Selamectin
- Selegiline Hydrochloride
- Sevoflurane
- Sildenafil
- Silver sulfadiazine
- Sodium Chloride
- Sotalol
- Spinosad
- Spironolactone
- Stanozolol
- Sucralfate
- Sulfadiazine
- Sulfadimethoxine
- Telmisartan
- Tepoxalin
- Terbinafine
- Tetracaine
- Tetracaine Hydrochloride
- Tetracycline
- Theophylline
- Thiabendazole
- Thiostrepton
- Tigilanol tiglate
- Tiletamine Hydrochloride
- Toceranib Phosphate
- Toluene
- Tramadol
- Trazodone
- Triamcinolone
- Triamcinolone Acetonide
- Trilostane
- Trimeprazine Tartrate
- Trimethoprim
- Tylosin
- Tylosin Phosphate
- Tylosin Tartrate
- Ursodiol
- Vatinoxan hydrochloride
- Velagliflozin
- Verdinexor
- Vincristine
- Vitamin A
- Vitamin D
- Vitamin E
- Xylazine
- Zolazepam Hydrochloride
- Zonisamide
Breeds with a page
- Afghan Hound
- Airedale Terrier
- Akita
- Alaskan Malamute
- American Bulldog
- American Cocker Spaniel
- American Eskimo Dog Spitz
- American Foxhound
- American Pit Bull Terrier
- American Pit Bull Terrier
- American Staffordshire Terrier
- Anatolian Shepherd Dog
- Australian Cattle Dog (blue heeler, red heeler, Queensland cattledog)
- Australian Kelpie
- Australian Shepherd Dog
- Australian Terrier
- Basenji
- Basset Hound
- Beagle
- Bearded Collie
- Beauce Sheepdog (Beauceron)
- Belgian Malinois Shepherd Dog
- Belgian Shepherd Dog
- Belgian Tervueren Shepherd Dog
- Bernese Mountain Dog
- Bichon Frise
- Black and Tan Coonhound
- Black Mouth Cur
- Bloodhound
- Bluetick Coonhound
- Border Collie
- Border Terrier
- Borzoi
- Boston Terrier
- Boxer
- Boykin Spaniel
- Briard
- Brittany
- Brussels Griffon
- Bull Terrier
- Bulldog
- Bullmastiff
- Cairn Terrier
- Catahoula Leopard Dog
- Cavalier King Charles Spaniel
- Chesapeake Bay Retriever
- Chihuahua
- Chinese Crested Dog
- Chow Chow
- Clumber Spaniel
- Collie
- Coonhound
- Corgi
- Corso Dog
- Coton de Tuléar
- Dachshund
- Dalmatian
- Doberman Pinscher
- Dogue de Bordeaux
- Dutch Shepherd Dog
- Dutch Spitz (Keeshond)
- English Bulldog
- English Cocker Spaniel
- English Pointer Pointer
- English Setter
- Flanders Cattle Dog (Bouvier)
- Flat-coated Retriever
- Fox Terrier
- Fox Wire Terrier
- Foxhound
- French Bulldog
- French Wire-haired Pointing Griffon
- German Shepherd Dog
- German Short-haired Pointing Dog
- German Wire-haired Pointing Dog
- Giant Schnauzer
- Golden Retriever
- Gordon Setter
- Great Dane
- Great Pyrenees
- Greater Swiss Mountain Dog
- Greyhound
- Havanese
- Hound
- Hungarian Short-haired Pointing Dog (Vizsla)
- Irish Red Setter
- Irish Soft-coated Wheaten Terrier
- Irish Terrier
- Irish Wolfhound
- Italian Greyhound
- Jack Russell Terrier
- Japanese Chin (Spaniel)
- King Charles Spaniel
- Labrador Retriever
- Lakeland Terrier
- Leonberger
- Lhasa Apso
- Maltese
- Manchester Terrier
- Mastiff
- Mastiff
- Miniature Dachshund
- Miniature Pinscher
- Miniature Poodle
- Miniature Schnauzer
- Mountain Cur
- Newfoundland
- Norfolk Terrier
- Norwegian Black Elkhound
- Norwich Terrier
- Nova Scotia Duck Tolling Retriever
- Old English Sheepdog
- Old English Sheepdog (Bobtail)
- Pekingese
- Pit Bull
- Plott
- Pointer
- Pomeranian
- Poodle
- Portuguese Water Dog
- Pug
- Rat Terrier
- Redbone Coonhound
- Retriever
- Rhodesian Ridgeback
- Rottweiler
- Rough-haired Collie
- Saint Bernard Dog
- Samoyed
- Schipperke
- Schnauzer
- Scottish Terrier
- Setter
- Shar Pei
- Sheepdog
- Shepherd
- Shepherd Dog
- Shetland Sheepdog
- Shiba Inu
- Shih Tzu
- Siberian Husky
- Silky Terrier
- Smooth-haired Collie
- Spaniel
- Spitz
- Springer English Spaniel
- Springer Spaniel
- Springer Welsh Spaniel
- Staffordshire Bull Terrier
- Standard Long-haired Dachshund
- Standard Poodle
- Standard Smooth-haired Dachshund
- Standard Wire-haired Dachshund
- Terrier
- Tibetan Spaniel
- Tibetan Terrier
- Toy Fox Terrier
- Toy Poodle
- Treeing Feist
- Treeing Walker Coonhound
- Weimaraner
- Welsh Cardigan Corgi
- Welsh Pembroke Corgi
- Welsh Terrier
- West Highland White Terrier
- Whippet
- Yorkshire Terrier
A breed has a page when 100 or more reports give that one breed. Reports about crossbred animals are in the species count only.
Cite this page
Pet Drug Reports. Dog: adverse event reports for animal drugs. https://petdrugreports.com/species/dog/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .
Where the data come from
The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026.
The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.
Questions about these reports
- What ages are the dogs in the reports?
The figures are shares of the 1,001,350 reports about dogs received from January 1987 to June 2026. 29.2% give an age of 1 to 3 years. 24.5% give an age of 4 to 7 years. 7.6% give no age.
- How does the count of the latest 12 months compare with the 12 months before?
FDA received 53,340 reports in the 12 months to June 2026. It received 54,592 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
- What kinds of report are in the count?
Of the 1,001,350 reports received from January 1987 to June 2026, 69.6% are about a safety issue only. 28.8% are about a lack of expected effectiveness, alone or with a safety issue. 1.5% are about a defect of the product or its package.
- Do more reports for dogs show a higher risk for dogs?
No. FDA states this about the data.
An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
Commonly used products may have a higher number of reported adverse events due to the higher total number of animals being given the product.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices