Species
Dog: adverse event reports
985,675 reports, 72.6% of FDA's animal drug adverse event database
985,675 adverse event reports in FDA's database concern dogs: 72.6% of all reports received from January 1987 to March 2026. 53,292 arrived in the 12 months to March 2026, close to the 55,186 of the 12 months before. That is 70.9% of all reports received in those 12 months and about 25,116 reports a year over the whole record.
By active ingredient, the drugs named most often are ivermectin + pyrantel pamoate (14.9% of dog reports), milbemycin oxime + spinosad (13.1% of dog reports), fluralaner (6.7% of dog reports) and spinosad (5.8% of dog reports). Drugs given to the most animals lead the list for that reason; brands are masked in the public data.
The terms listed most often are vomiting (19.7%), lethargy (7.9%) and diarrhoea (7.3%). 38.3% of reports stating seriousness were classed as serious (38.6% across all species), and 5.5% record a death or euthanasia (6.4% overall).
FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases.
Drugs named most often, by active ingredient
| Active ingredients recorded for the drug | Reports | Share of dog reports | Share of the drug's reports that concern dogs |
|---|---|---|---|
| Ivermectin + Pyrantel Pamoate | 146,758 | 14.9% | 90.8% |
| Milbemycin Oxime + Spinosad | 129,605 | 13.1% | 92.1% |
| Fluralaner | 65,701 | 6.7% | 77.5% |
| Spinosad | 57,106 | 5.8% | 78.4% |
| Afoxolaner | 56,309 | 5.7% | 92.9% |
| Pyrantel Pamoate + Sarolaner | 50,479 | 5.1% | 97% |
| Moxidectin | 49,444 | 5% | 86.2% |
| Carprofen | 46,857 | 4.8% | 90.1% |
| Milbemycin Oxime + Praziquantel | 30,985 | 3.1% | 93.6% |
| Milbemycin Oxime | 29,905 | 3% | 91.9% |
| Selamectin | 29,371 | 3% | 47.3% |
| Oclacitinib | 28,319 | 2.9% | 94.5% |
| Lufenuron + Milbemycin Oxime | 26,199 | 2.7% | 95.2% |
| Melarsomine Dihydrochloride | 22,545 | 2.3% | 95% |
| Bedinvetmab | 18,661 | 1.9% | 98.6% |
| Sarolaner | 16,419 | 1.7% | 94.7% |
| Cyclosporine | 15,012 | 1.5% | 69.6% |
| Imidacloprid + Moxidectin | 13,021 | 1.3% | 56.1% |
| Ivermectin | 12,936 | 1.3% | 64.4% |
| Trilostane | 11,720 | 1.2% | 97.7% |
| Maropitant | 11,525 | 1.2% | 70.8% |
| Deracoxib | 10,992 | 1.1% | 91.9% |
| Nitenpyram | 10,646 | 1.1% | 49.9% |
| Lotilaner | 9,648 | 1% | 85.1% |
| Prednisone | 8,620 | 0.9% | 91.8% |
| Gabapentin | 8,569 | 0.9% | 82.1% |
| Ivermectin + Praziquantel + Pyrantel Pamoate | 8,512 | 0.9% | 94.6% |
| Meloxicam | 8,013 | 0.8% | 46.6% |
| Afoxolaner + Moxidectin + Pyrantel Pamoate | 8,010 | 0.8% | 91.3% |
| Firocoxib | 7,985 | 0.8% | 83.7% |
Ordered by report count, which follows how widely a drug is used. FDA states that these data "cannot be used to estimate the risk associated with the product or compare one drug or device product with another". openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand.
Signs listed in reports
share of dog reports listing the termall species
- Vomiting19.7%194,262
- Lethargy[unusually tired or inactive]7.9%78,049
- Diarrhoea[diarrhea]7.3%72,215
- Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]7%68,979
- Emesis[vomiting]6.5%63,623
- Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]5.4%52,788
- Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]5.3%52,053
- Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]5%49,593
- Anorexia[not eating]4.7%45,960
- Lack of efficacy - NOS[the product did not have the expected effect]4.4%43,644
- Depression[dull, quiet or withdrawn]3.5%34,408
- Seizure NOS[seizure, type not specified]3.1%30,727
- Death2.9%28,448
- Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]2.5%24,741
- Ataxia[unsteady, uncoordinated movement]2.4%23,651
- Death by euthanasia[the animal was euthanized]2.3%22,670
- Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]2.2%21,575
- Digestive tract disorder NOS[digestive problem, type not specified]2%20,066
- Pruritus[itching]1.9%18,904
- Behavioural disorder NOS[behaviour change, type not specified]1.9%18,804
- Ineffective, ascarids NOS[legacy FDA term: the product did not have the expected effect (ascarids nos)]1.8%18,226
- Other abnormal test result NOS[abnormal laboratory result, type not specified]1.8%17,584
- Emesis (multiple)[vomiting more than once]1.7%16,850
- Weight loss1.7%16,663
- Lack of efficacy (ectoparasite) - tick NOS[the product did not have the expected effect: ticks]1.7%16,264
- Not eating1.6%16,142
- Accidental exposure[exposure that was not intended]1.6%15,314
- Decreased appetite1.4%13,995
- Elevated blood urea nitrogen (BUN)[a kidney value above the normal range]1.4%13,714
- Bloody diarrhoea[diarrhea with blood]1.4%13,529
Single ingredients, pooled across combinations
- Pyrantel Pamoate229,690 reports · 23.3%
- Milbemycin Oxime219,337 reports · 22.3%
- Spinosad185,564 reports · 18.8%
- Ivermectin167,895 reports · 17%
- Moxidectin73,340 reports · 7.4%
- Sarolaner67,740 reports · 6.9%
- Fluralaner65,707 reports · 6.7%
- Afoxolaner63,981 reports · 6.5%
- Praziquantel61,904 reports · 6.3%
- Carprofen46,858 reports · 4.8%
- Lufenuron36,594 reports · 3.7%
- Selamectin29,419 reports · 3%
- Oclacitinib28,319 reports · 2.9%
- Melarsomine Dihydrochloride22,545 reports · 2.3%
- Bedinvetmab18,661 reports · 1.9%
- Imidacloprid17,629 reports · 1.8%
Age and weight
Age of the animal
Weight of the animal
Outcomes and report types
Outcome recorded in the report
What kind of report it was
Coloured bar: dog reports. Grey bar: all 1,357,245 reports. Outcomes are as stated by the reporter.
Trend
Reports by month FDA received them. The newest months are incomplete because FDA posts reports with a delay of three to six months.
| Measure | Dog | All reports |
|---|---|---|
| Reports | 985,675 | 1,357,245 |
| Classed serious, of reports stating it | 38.3% | 38.6% |
| Death or euthanasia recorded, per 1,000 reports | 54.5 | 63.8 |
| Filed as lack of expected effectiveness (wholly or partly) | 28.5% | 23% |
Breeds with their own page
- Labrador Retriever89,760 reports · 9.1% of dog reports
- Golden Retriever32,727 reports · 3.3% of dog reports
- German Shepherd Dog32,587 reports · 3.3% of dog reports
- Chihuahua25,766 reports · 2.6% of dog reports
- Yorkshire Terrier24,199 reports · 2.5% of dog reports
- Shih Tzu22,997 reports · 2.3% of dog reports
- Boxer18,925 reports · 1.9% of dog reports
- Beagle16,322 reports · 1.7% of dog reports
- Dachshund15,166 reports · 1.5% of dog reports
- Pit Bull14,236 reports · 1.4% of dog reports
- Australian Shepherd Dog14,176 reports · 1.4% of dog reports
- Jack Russell Terrier10,504 reports · 1.1% of dog reports
- Maltese10,060 reports · 1% of dog reports
- Pug9,166 reports · 0.9% of dog reports
- American Cocker Spaniel9,107 reports · 0.9% of dog reports
- Pomeranian9,097 reports · 0.9% of dog reports
- Rottweiler8,825 reports · 0.9% of dog reports
- Siberian Husky8,761 reports · 0.9% of dog reports
- Poodle8,723 reports · 0.9% of dog reports
- Boston Terrier8,505 reports · 0.9% of dog reports
- Border Collie8,154 reports · 0.8% of dog reports
- Bulldog7,807 reports · 0.8% of dog reports
- Bichon Frise7,263 reports · 0.7% of dog reports
- French Bulldog7,255 reports · 0.7% of dog reports
- Schnauzer7,063 reports · 0.7% of dog reports
- Miniature Schnauzer7,020 reports · 0.7% of dog reports
- Australian Cattle Dog (blue heeler, red heeler, Queensland cattledog)6,537 reports · 0.7% of dog reports
- Shetland Sheepdog6,234 reports · 0.6% of dog reports
- American Pit Bull Terrier5,818 reports · 0.6% of dog reports
- Terrier5,784 reports · 0.6% of dog reports
- Doberman Pinscher5,742 reports · 0.6% of dog reports
- West Highland White Terrier5,606 reports · 0.6% of dog reports
- Cavalier King Charles Spaniel5,047 reports · 0.5% of dog reports
- Great Dane4,863 reports · 0.5% of dog reports
- Basset Hound4,507 reports · 0.5% of dog reports
- German Short-haired Pointing Dog4,462 reports · 0.5% of dog reports
- Greyhound4,376 reports · 0.4% of dog reports
- Miniature Pinscher4,371 reports · 0.4% of dog reports
- Miniature Poodle4,365 reports · 0.4% of dog reports
- Miniature Dachshund4,076 reports · 0.4% of dog reports
- Standard Poodle3,930 reports · 0.4% of dog reports
- Toy Poodle3,914 reports · 0.4% of dog reports
- Lhasa Apso3,893 reports · 0.4% of dog reports
- Great Pyrenees3,623 reports · 0.4% of dog reports
- Havanese3,621 reports · 0.4% of dog reports
- Collie3,442 reports · 0.3% of dog reports
- Weimaraner3,318 reports · 0.3% of dog reports
- Rat Terrier3,152 reports · 0.3% of dog reports
- Mastiff3,093 reports · 0.3% of dog reports
- Corgi2,957 reports · 0.3% of dog reports
- Pekingese2,517 reports · 0.3% of dog reports
- Staffordshire Bull Terrier2,459 reports · 0.2% of dog reports
- Brittany2,376 reports · 0.2% of dog reports
- Cairn Terrier2,314 reports · 0.2% of dog reports
- Dalmatian2,249 reports · 0.2% of dog reports
- American Bulldog2,245 reports · 0.2% of dog reports
- Springer Spaniel2,243 reports · 0.2% of dog reports
- Springer English Spaniel2,178 reports · 0.2% of dog reports
- Retriever2,138 reports · 0.2% of dog reports
- Chow Chow2,133 reports · 0.2% of dog reports
- Bernese Mountain Dog2,005 reports · 0.2% of dog reports
- Scottish Terrier1,960 reports · 0.2% of dog reports
- Spaniel1,931 reports · 0.2% of dog reports
- Belgian Malinois Shepherd Dog1,768 reports · 0.2% of dog reports
- Irish Soft-coated Wheaten Terrier1,754 reports · 0.2% of dog reports
- Hound1,734 reports · 0.2% of dog reports
- Catahoula Leopard Dog1,696 reports · 0.2% of dog reports
- Shiba Inu1,675 reports · 0.2% of dog reports
- Hungarian Short-haired Pointing Dog (Vizsla)1,623 reports · 0.2% of dog reports
- English Setter1,558 reports · 0.2% of dog reports
- Welsh Pembroke Corgi1,516 reports · 0.2% of dog reports
- Chesapeake Bay Retriever1,476 reports · 0.1% of dog reports
- Newfoundland1,465 reports · 0.1% of dog reports
- Saint Bernard Dog1,456 reports · 0.1% of dog reports
- Akita1,387 reports · 0.1% of dog reports
- Shar Pei1,368 reports · 0.1% of dog reports
- American Eskimo Dog Spitz1,318 reports · 0.1% of dog reports
- Rhodesian Ridgeback1,311 reports · 0.1% of dog reports
- Airedale Terrier1,310 reports · 0.1% of dog reports
- Pointer1,266 reports · 0.1% of dog reports
- Fox Terrier1,220 reports · 0.1% of dog reports
- Coonhound1,153 reports · 0.1% of dog reports
- Bull Terrier1,112 reports · 0.1% of dog reports
- Bloodhound1,090 reports · 0.1% of dog reports
- Alaskan Malamute1,087 reports · 0.1% of dog reports
- English Cocker Spaniel1,084 reports · 0.1% of dog reports
- Standard Long-haired Dachshund1,059 reports · 0.1% of dog reports
- Welsh Cardigan Corgi1,021 reports · 0.1% of dog reports
- Samoyed999 reports · 0.1% of dog reports
- American Pit Bull Terrier992 reports · 0.1% of dog reports
- Italian Greyhound980 reports · 0.1% of dog reports
- English Bulldog932 reports · 0.1% of dog reports
- Silky Terrier851 reports · 0.1% of dog reports
- Shepherd842 reports · 0.1% of dog reports
- Irish Red Setter841 reports · 0.1% of dog reports
- Portuguese Water Dog838 reports · 0.1% of dog reports
- Coton de Tuléar814 reports · 0.1% of dog reports
- Boykin Spaniel803 reports · 0.1% of dog reports
- Old English Sheepdog753 reports · 0.1% of dog reports
- Whippet719 reports · 0.1% of dog reports
- Brussels Griffon636 reports · 0.1% of dog reports
- Dutch Spitz (Keeshond)635 reports · 0.1% of dog reports
- Bullmastiff619 reports · 0.1% of dog reports
- Standard Smooth-haired Dachshund578 reports · 0.1% of dog reports
- Corso Dog559 reports · 0.1% of dog reports
- German Wire-haired Pointing Dog532 reports · 0.1% of dog reports
- Tibetan Terrier528 reports · 0.1% of dog reports
- Chinese Crested Dog522 reports · 0.1% of dog reports
- Black and Tan Coonhound518 reports · 0.1% of dog reports
- Schipperke482 reports · 0% of dog reports
- King Charles Spaniel470 reports · 0% of dog reports
- Black Mouth Cur456 reports · 0% of dog reports
- Flanders Cattle Dog (Bouvier)443 reports · 0% of dog reports
- Welsh Terrier435 reports · 0% of dog reports
- Mastiff433 reports · 0% of dog reports
- Flat-coated Retriever426 reports · 0% of dog reports
- Treeing Walker Coonhound407 reports · 0% of dog reports
- Shepherd Dog404 reports · 0% of dog reports
- Japanese Chin (Spaniel)400 reports · 0% of dog reports
- Mountain Cur399 reports · 0% of dog reports
- Fox Wire Terrier394 reports · 0% of dog reports
- Anatolian Shepherd Dog390 reports · 0% of dog reports
- Basenji381 reports · 0% of dog reports
- Border Terrier369 reports · 0% of dog reports
- Spitz353 reports · 0% of dog reports
- Rough-haired Collie348 reports · 0% of dog reports
- Giant Schnauzer325 reports · 0% of dog reports
- Irish Wolfhound309 reports · 0% of dog reports
- Gordon Setter304 reports · 0% of dog reports
- Bluetick Coonhound282 reports · 0% of dog reports
- Norwich Terrier267 reports · 0% of dog reports
- Nova Scotia Duck Tolling Retriever262 reports · 0% of dog reports
- American Foxhound260 reports · 0% of dog reports
- Norwegian Black Elkhound250 reports · 0% of dog reports
- Bearded Collie249 reports · 0% of dog reports
- Tibetan Spaniel245 reports · 0% of dog reports
- Dutch Shepherd Dog243 reports · 0% of dog reports
- French Wire-haired Pointing Griffon238 reports · 0% of dog reports
- Plott211 reports · 0% of dog reports
- Australian Terrier200 reports · 0% of dog reports
- Irish Terrier199 reports · 0% of dog reports
- Greater Swiss Mountain Dog198 reports · 0% of dog reports
- Afghan Hound181 reports · 0% of dog reports
- Treeing Feist180 reports · 0% of dog reports
- Belgian Tervueren Shepherd Dog178 reports · 0% of dog reports
- Sheepdog176 reports · 0% of dog reports
- Redbone Coonhound176 reports · 0% of dog reports
- Manchester Terrier169 reports · 0% of dog reports
- American Staffordshire Terrier165 reports · 0% of dog reports
- English Pointer Pointer163 reports · 0% of dog reports
- Foxhound158 reports · 0% of dog reports
- Springer Welsh Spaniel157 reports · 0% of dog reports
- Belgian Shepherd Dog155 reports · 0% of dog reports
- Norfolk Terrier151 reports · 0% of dog reports
- Standard Wire-haired Dachshund146 reports · 0% of dog reports
- Dogue de Bordeaux140 reports · 0% of dog reports
- Borzoi136 reports · 0% of dog reports
- Beauce Sheepdog (Beauceron)132 reports · 0% of dog reports
- Setter128 reports · 0% of dog reports
- Smooth-haired Collie126 reports · 0% of dog reports
- Toy Fox Terrier120 reports · 0% of dog reports
- Leonberger119 reports · 0% of dog reports
- Lakeland Terrier115 reports · 0% of dog reports
- Australian Kelpie109 reports · 0% of dog reports
- Old English Sheepdog (Bobtail)106 reports · 0% of dog reports
- Clumber Spaniel104 reports · 0% of dog reports
- Briard104 reports · 0% of dog reports
Single-breed labels with at least 100 reports. Crossbred animals count in the species total only.
Questions about dog reports
How many adverse event reports involve dogs?
985,675 reports through March 2026, 72.6% of the database; 53,292 in the latest 12 months.
Which drugs are reported most often for dogs?
By active ingredient: ivermectin + pyrantel pamoate (146,758), milbemycin oxime + spinosad (129,605), fluralaner (65,701), spinosad (57,106) and afoxolaner (56,309). The order tracks how widely each is used; brands are masked in the public data.
What signs are reported most in dogs?
vomiting (19.7%), lethargy (7.9%), diarrhoea (7.3%), ineffective, heartworm larvae (7%) and emesis (6.5%).
What ages are the dogs in these reports?
1 to 3 years (29.2%), 4 to 7 years (24.4%) and 8 to 11 years (18.4%); age is not given in 7.6% of reports.
Do more reports mean more risk for this species?
No. Counts follow how many animals are treated and how readily their owners and veterinarians report. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources."
How do I report a problem?
Call the drug company using the number on the label, or send Form FDA 1932a to FDA. See the guide on how to report.
Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 30 Sep 2026. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.