Acetaminophen: adverse event reports in all combinations

Name: Acetaminophen, all combinations: adverse event reports that FDA received, by year and species
Creator: Pet Drug Reports
License: https://creativecommons.org/publicdomain/zero/1.0/

Active ingredient, alone and in combinations

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

FDA reports received through 26 Jun 2026. Counts include this ingredient alone and in combinations. Why brand names have no separate count.

From November 2011 to June 2026, FDA received 111 adverse event reports that name a drug with acetaminophen, alone or in a combination. 2 sets of active ingredients with acetaminophen have a drug page.

Of the 111 reports, 90 (81.1%) are about dogs. 14 reports are about people who were exposed to the drug (12.6%). In January to March 2026, FDA received 10 reports that name acetaminophen, alone or in a combination. The signs that appear in the largest number of the 111 reports are "Lethargy", "Death by euthanasia" and "Abnormal radiograph finding". A report is not proof that a drug caused a sign.

Fewer than 20 reports named this ingredient in the 12 months before June 2026, so this page gives no change. Reports about dogs are 81.1% of the reports that name this ingredient, and 72.6% of all reports.

Search engines list an ingredient page with 500 reports or more in all years. The page also needs 30 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.

Reports in the latest closed quarter

Reports that name acetaminophen, by the quarter in which FDA received them
Species	Jan to Mar 2026	Oct to Dec 2025	Jan to Mar 2025
All species	10	1	6
Dog	5	1	6
Cat	0	0	0
Horse	4	0	0
Other or not given	1	0	0

January to March 2026 is the latest closed quarter in the data.

All updates Feed of updates (RSS)

Drug pages with acetaminophen

A report names a drug by its set of active ingredients. Each set with acetaminophen that has a drug page is in the table, in order of name. The table has 2 sets.

Drug pages with acetaminophen, in order of name, with the reports of each page
Active ingredients	Reports, all years	Reports, latest 12 months
Acetaminophen	87	24
Acetaminophen + Codeine	20	4

A report can name more than one set, so the counts of the sets can add to more than the count of the page.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 111 reports that list the sign. One report can list more than one sign and more than one drug.

The sign that is in the largest number of the reports comes first.

Lethargy[unusually tired or inactive]23.4%26 reports
Death by euthanasia[the animal was euthanized]17.1%19 reports
Abnormal radiograph finding15.3%17 reports
Diarrhoea[diarrhea]13.5%15 reports
Lack of efficacy - NOS[the product did not have the expected effect]11.7%13 reports
Other abnormal test result NOS[abnormal laboratory result, type not specified]10.8%12 reports
Vomiting10.8%12 reports
Ataxia[unsteady, uncoordinated movement]8.1%9 reports
Decreased appetite8.1%9 reports
Inappetence[reduced appetite]8.1%9 reports
Weakness8.1%9 reports
Accidental exposure[exposure that was not intended]7.2%8 reports
Anorexia[not eating]7.2%8 reports
Death7.2%8 reports

Show the next 16 signs

Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]7.2%8 reports
Elevated serum alkaline phosphatase (ALP)[a liver and bone enzyme above the normal range]7.2%8 reports
Neutrophilia[high neutrophil count]7.2%8 reports
Elevated blood urea nitrogen (BUN)[a kidney value above the normal range]6.3%7 reports
Hypochloraemia[low blood chloride]6.3%7 reports
Monocytosis[high monocyte count]6.3%7 reports
Nausea6.3%7 reports
Thrombocytopenia[low platelet count]6.3%7 reports
Weight loss6.3%7 reports
Abnormal ultrasound finding5.4%6 reports
Anaemia NOS[low red blood cell count]5.4%6 reports
Dehydration5.4%6 reports
Elevated creatinine[a kidney value above the normal range]5.4%6 reports
Eosinopenia5.4%6 reports
Hyponatremia[low blood sodium]5.4%6 reports
Neutropenia[low neutrophil count]5.4%6 reports

Download all signs (CSV)

Reports by species

Dog81.1%90
Human exposure12.6%14
Horse5.4%6
Cat0.9%1

Reports for each month, Jul 2021 to Jun 2026

Dog53 reports

No chart: no month has 5 or more reports.

Cat1 report

No chart: no month has 5 or more reports.

Horse6 reports

No chart: no month has 5 or more reports.

Other or not given6 reports

No chart: no month has 5 or more reports.

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

Dog
Cat
Horse
Other or not given

Reports that name acetaminophen, by the year in which FDA received them and by species
Year	Dog	Cat	Horse	Other or not given	All species
2026	14	0	6	1	21
2025	15	0	0	0	15
2024	14	1	0	1	16
2023	2	0	0	1	3
2022	6	0	0	0	6
2021	6	0	0	5	11
2020	1	0	0	0	1
2019	3	0	0	1	4
2018	5	0	0	1	6
2017	5	0	0	1	6
2016	2	0	0	0	2
2015	1	0	0	0	1
2014	8	0	0	1	9
2013	4	0	0	1	5
2012	3	0	0	1	4
2011	1	0	0	0	1

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

Recovered/Normal20.7%23
Recovered with Sequela[recovered, with a lasting effect]0.9%1
Ongoing27%30
Died7.2%8
Euthanized17.1%19
Outcome Unknown27%30

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 111 reports that name acetaminophen.

Kind of report

Safety issue86.5%96
Lack of expected effectiveness1.8%2
Both safety and lack of expected effectiveness8.1%9
Manufacturing or product defect2.7%3
Other0.9%1

Age of the animal

Under 1 year4.5%5
1 to 3 years16.2%18
4 to 7 years18%20
8 to 11 years27%30
12 years and over32.4%36
Age not given1.8%2

Each share of kind and age is of the 111 reports that name acetaminophen.

Approved animal drugs with this active ingredient (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

The Green Book lists no approved animal drug with this active ingredient. FDA also receives reports for human drugs and compounded drugs that veterinarians prescribe.

FDA pages for this ingredient

How to Report Animal Drug and Device Side Effects and Product ProblemsThe FDA page that tells an owner or a veterinarian how to send a report.
Animal Drugs @ FDAThe search page of the Green Book, the FDA list of approved animal drugs.

The site checked these addresses on 2 Oct 2026. The links open in a new tab.

Cite this page

Pet Drug Reports. Acetaminophen, all combinations: adverse event reports that FDA received. https://petdrugreports.com/ingredient/acetaminophen/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. Ingredient names follow the Green Book, with salts and forms as FDA lists them.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?: The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book lists no approved animal drug with this active ingredient.
Do the reports show that the ingredient caused the signs?: No. A report can name more than one drug, and a drug can have more than one active ingredient. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices
How many reports did FDA receive in the latest 12 months?: FDA received 28 reports in the 12 months to June 2026. It received 17 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
What kinds of report are in the count?: Of the 111 reports received from November 2011 to June 2026, 86.5% are about a safety issue only. 9.9% are about a lack of expected effectiveness, alone or with a safety issue. 2.7% are about a defect of the product or its package.