Pet Drug Reports

Elevated blood urea nitrogen (BUN): in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: a kidney value above the normal range.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From January 1987 to June 2026, FDA received 17,743 adverse event reports for animal drugs that list this sign. That is 1.3% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 815 reports that list this sign.

Of the 17,743 reports, 78% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 32 of 1,149 clinical signs with a page. Reports that list this sign fell by 8.3% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cats are 21% of the reports that list this sign, and 11% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 132 drug pages.

Show the 132 drug pages
Drug pages with 20 or more reports that list this sign, in order of name
Active ingredientsReports that list the sign
(S) - methoprene33
Acepromazine Maleate83
Afoxolaner340
Afoxolaner + Moxidectin + Pyrantel Pamoate36
Alfaxalone24
Amlodipine67
Amoxicillin237
Amoxicillin + Clavulanate Potassium84
Amoxicillin Trihydrate + Clavulanate Potassium106
Ampicillin Sodium49
Atipamezole Hydrochloride71
Atropine51
Bedinvetmab487
Benazepril46
Bexagliflozin275
Bupivacaine21
Buprenorphine229
Butorphanol Tartrate177
Capromorelin109
Carprofen3,593
Cefovecin sodium548
Cefpodoxime proxetil161
Cephalexin70
Clindamycin66
Clodronate78
Clomipramine Hydrochloride33
Cyclosporine326
Deracoxib1,693
Desoxycorticosterone Pivalate80
Dexamethasone143
Dexamethasone Sodium Phosphate50
Dexmedetomidine63
Dexmedetomidine hydrochloride86
Dextrose45
Diazepam59
Diphenhydramine131
Dirlotapide44
Doxycycline131
Emodepside + Praziquantel42
Enalapril Maleate138
Enrofloxacin197
Eprinomectin + Esafoxolaner + Praziquantel32
Estriol50
Etodolac52
Famotidine242
Febantel + Praziquantel + Pyrantel Pamoate25
Fentanyl29
Firocoxib1,097
Florfenicol + Mometasone furoate + Terbinafine31
Flunixin Meglumine35
Fluoxetine hydrochloride31
Fluralaner580
Fluralaner + Moxidectin24
Frunevetmab181
Furosemide156
Gabapentin471
Grapiprant352
Hydromorphone61
Ilunocitinib35
Imidacloprid31
Imidacloprid + Moxidectin81
Insulin251
Isoflurane151
Ivermectin137
Ivermectin + Pyrantel Pamoate305
Ketamine Hydrochloride116
Ketoconazole26
Ketoprofen52
Lactulose21
Levothyroxine sodium90
Lidocaine26
Lotilaner79
Lufenuron41
Lufenuron + Milbemycin Oxime94
Marbofloxacin86
Maropitant870
Medetomidine50
Melarsomine Dihydrochloride291
Meloxicam1,917
Methimazole54
Methocarbamol34
Methylprednisolone Acetate89
Metoclopramide44
Metronidazole176
Midazolam79
Milbemycin Oxime133
Milbemycin Oxime + Praziquantel102
Milbemycin Oxime + Spinosad399
Mirtazapine119
Molidustat57
Moxidectin465
Nitenpyram57
Oclacitinib468
Omeprazole74
Ondansetron81
Orbifloxacin25
Ormetoprim + Sulfadimethoxine31
Oxibendazole38
Phenobarbital27
Pimobendan221
Polysulfated Glycosaminoglycan149
Pradofloxacin25
Prednisolone66
Prednisolone + Trimeprazine Tartrate54
Prednisone296
Propofol125
Pyrantel Pamoate51
Pyrantel Pamoate + Sarolaner104
Rabacfosadine31
Robenacoxib170
Sarolaner83
Sarolaner + Selamectin30
Selamectin298
Selegiline Hydrochloride114
Sevoflurane37
Sodium Chloride31
Spinosad308
Spironolactone26
Sucralfate124
Sulfadimethoxine25
Telmisartan37
Tepoxalin40
Tigilanol tiglate21
Tiletamine Hydrochloride + Zolazepam Hydrochloride32
Toceranib Phosphate47
Tramadol243
Trazodone44
Trilostane1,142
Ursodiol61
Velagliflozin280
Verdinexor20
Vitamin E51

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 135 ingredients.

Show the 135 ingredients

Reports by species

The share is of the 17,743 reports that list this sign. The sign is in 1.4% of all reports about the species dog. The sign is in 2.5% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Elevated blood urea nitrogen (BUN), by the year in which FDA received them
YearReports
2026403
2025818
2024922
2023529
2022383
2021369
2020414
2019514
2018584
2017644
2016680
2015672
2014631
2013590
2012723
2011750
2010763
2009837
2008810
2007871
2006890
2005766
2004823
2003543
2002315
2001266
2000410
1999322
1998300
199777
199613
199512
19949
19938
19925
19917
199012
198920
198823
198715

What these reports record

Outcome at the time of the report

  • Reports with this sign
  • All reports
  • Recovered/Normal3.8%670, All reports: 20.7%
  • Recovered with Sequela[recovered, with a lasting effect]1.2%221, All reports: 2.3%
  • Ongoing16.9%3,003, All reports: 17.4%
  • Died21.9%3,888, All reports: 4.9%
  • Euthanized9.7%1,715, All reports: 1.5%
  • Outcome Unknown13.7%2,428, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 17,743 reports that list this sign.

Age of the animal

  • Reports with this sign
  • All reports
  • Under 1 year5.4%963, All reports: 9.5%
  • 1 to 3 years11.1%1,963, All reports: 23.9%
  • 4 to 7 years19.3%3,416, All reports: 20.2%
  • 8 to 11 years29.4%5,222, All reports: 15.4%
  • 12 years and over33.1%5,874, All reports: 10.7%
  • Age not given1.7%305, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

All clinical signs

Cite this page

Pet Drug Reports. Elevated blood urea nitrogen (BUN): adverse event reports for animal drugs. https://petdrugreports.com/reaction/elevated-blood-urea-nitrogen-bun/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?

In plain words: a kidney value above the normal range. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.

How does the count of the latest 12 months compare with the 12 months before?

FDA received 815 reports in the 12 months to June 2026. It received 889 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

How many of these reports have a serious flag?

Of the 8,589 reports that say if the event was serious, 73.6% have the serious flag. The person who sends a report sets the flag.

Does a drug in the table cause this sign?

The reports do not show that. A report can name more than one drug. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices