Pet Drug Reports

Tiletamine Hydrochlorideadverse event reports that FDA received

Active ingredient

The Green Book lists no brand name for exactly this active ingredient.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From April 2012 to June 2026, FDA received 891 adverse event reports that name a drug with tiletamine hydrochloride as its active ingredient. Of the 891 reports, 422 (47.4%) are about dogs. 362 reports are about cats (40.6%).

In January to March 2026, FDA received 5 reports that name this drug. The signs that appear in the largest number of the 891 reports are "Lack of efficacy - NOS", "Death" and "Ineffective, anesthesia". A report is not proof that a drug caused a sign.

Reports that name this drug rose by 19.4% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cats are 40.6% of the reports that name this drug, and 11% of all reports.

Since the last update of the FDA data

The latest update of the FDA data, recorded on , changed no count of this page.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 5 reports that name tiletamine hydrochloride: 2 dog, 1 cat, 0 horse, 2 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 891 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Lack of efficacy - NOS[the product did not have the expected effect]14.6%130 reports
  2. Death12.9%115 reports
  3. Ineffective, anesthesia[legacy FDA term: the product did not have the expected effect (anesthesia)]11.3%101 reports
  4. Cardiac arrest6.7%60 reports
  5. Lethargy[unusually tired or inactive]6.4%57 reports
  6. Recovery prolonged5.5%49 reports
  7. Underdose[less than the labelled amount was given]5.5%49 reports
  8. Vomiting5.4%48 reports
  9. Ataxia[unsteady, uncoordinated movement]5.2%46 reports
  10. Ineffective, sedation[legacy FDA term: the product did not have the expected effect (sedation)]4.5%40 reports
  11. Behavioural disorder NOS[behaviour change, type not specified]4.4%39 reports
  12. Death by euthanasia[the animal was euthanized]4.2%37 reports
  13. Incorrect route of drug administration4%36 reports
  14. Hypothermia[low body temperature]3.7%33 reports
Show the next 16 signs
  1. Respiratory arrest3.7%33 reports
  2. Vocalisation[crying out or unusual noise]3.7%33 reports
  3. Bradycardia[slow heart rate]3.6%32 reports
  4. Fever3.4%30 reports
  5. Seizure NOS[seizure, type not specified]3.4%30 reports
  6. Sedation prolonged3.3%29 reports
  7. Hyperthermia[raised body temperature]3%27 reports
  8. Unrelated death2.9%26 reports
  9. Other abnormal test result NOS[abnormal laboratory result, type not specified]2.8%25 reports
  10. Anorexia[not eating]2.7%24 reports
  11. Apnoea[breathing stopped]2.7%24 reports
  12. Cyanosis[bluish gums or skin from low oxygen]2.7%24 reports
  13. Tachycardia[fast heart rate]2.7%24 reports
  14. Decreased appetite2.5%22 reports
  15. Pale mucous membrane[pale gums]2.4%21 reports
  16. Color, Abnormal[a product quality report, not a sign in an animal]2.2%20 reports

The list shows 30 of 599 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

  • Dog47.4%422
  • Cat40.6%362
  • Human exposure1.7%15
  • Pig0.6%5
  • Monkey0.3%3
  • Bear0.2%2

The share is of all 891 reports that name tiletamine hydrochloride. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog83 reports. Largest count in one month: 7 (Oct 2025)
Cat66 reports

No chart: no month has 5 or more reports.

Horse2 reports

No chart: no month has 5 or more reports.

Other or not given22 reports

No chart: no month has 5 or more reports.

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name tiletamine hydrochloride, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
2026380415
202518150437
202412110528
202314120531
202226130342
202118152439
202026180751
2019341801163
2018262201159
201728230859
201636390782
2015444201096
20145439012105
2013495308110
201234340674

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal37.4%333
  • Recovered with Sequela[recovered, with a lasting effect]0.2%2
  • Ongoing22.6%201
  • Died13.8%123
  • Euthanized8.4%75
  • Outcome Unknown11.4%102

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 891 reports that name tiletamine hydrochloride.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue65.9%587
  • Lack of expected effectiveness13%116
  • Both safety and lack of expected effectiveness11.8%105
  • Manufacturing or product defect9.3%83
  • Other0%0

820 reports say if the event was serious. 46.3% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year17.2%153
  • 1 to 3 years14.9%133
  • 4 to 7 years14.3%127
  • 8 to 11 years10.3%92
  • 12 years and over6.4%57
  • Age not given36.9%329

Weight of the animal

  • Under 5 kg (11 lb)27%241
  • 5 to 9.9 kg (11 to 22 lb)12.8%114
  • 10 to 24.9 kg (22 to 55 lb)8.4%75
  • 25 to 44.9 kg (55 to 99 lb)10.9%97
  • 45 kg and over (99 lb and over)3.6%32
  • Weight not given37.3%332

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Intramuscular40.2%358
  • Intravenous24.7%220
  • Subcutaneous1.9%17
  • Other0.6%5
  • Ophthalmic0.4%4
  • Parenteral0.3%3

Each bar is on a scale of 0 to 100%.

Approved animal drugs with this active ingredient (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

No approved product has exactly this set of active ingredients. The ingredient field of a report can be incomplete. The approved products below have all the ingredients of this page and one or more other ingredients.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
TelazolTiletamine Hydrochloride, Zolazepam HydrochlorideZoetis Inc.Dogs, CatsNADA 106-111
TzedTiletamine Hydrochloride, Zolazepam HydrochlorideDechra Veterinary Products LLCDogs, CatsANADA 200-557
ZoletilTiletamine Hydrochloride, Zolazepam HydrochlorideVirbac AH, Inc.Dogs, CatsANADA 200-618

Other pages with this ingredient

A report names a drug by its set of active ingredients. Each set has its own page. The list is in order of name.

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Tiletamine Hydrochloride: adverse event reports that FDA received. https://petdrugreports.com/drug/tiletamine-hydrochloride/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

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Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book lists no brand name for exactly this active ingredient.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 37 reports in the 12 months to June 2026. It received 31 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 891 reports received from April 2012 to June 2026, 65.9% are about a safety issue only. 24.8% are about a lack of expected effectiveness, alone or with a safety issue. 9.3% are about a defect of the product or its package.