Pet Drug Reports

Death: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From January 1987 to June 2026, FDA received 51,482 adverse event reports for animal drugs that list this sign. That is 3.7% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 2,015 reports that list this sign.

Of the 51,482 reports, 55.9% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 10 of 1,149 clinical signs with a page. Reports that list this sign fell by 20.0% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 55.9% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 238 drug pages.

Show the 238 drug pages
Drug pages with 20 or more reports that list this sign, in order of name
Active ingredientsReports that list the sign
(S) - methoprene103
Acepromazine Maleate314
Acetylsalicylic Acid32
Afoxolaner1,053
Afoxolaner + Moxidectin + Pyrantel Pamoate90
Albendazole244
Alfaxalone144
Amantadine34
Amitraz86
Amlodipine34
Amoxicillin504
Amoxicillin + Clavulanate Potassium131
Amoxicillin Trihydrate + Clavulanate Potassium193
Ampicillin Sodium56
Ampicillin Trihydrate91
Amprolium68
Arsenamide Sodium24
Aspirin21
Atipamezole Hydrochloride571
Atropine178
Avilamycin30
Bacitracin45
Bedinvetmab1,302
Benazepril30
Bexagliflozin67
Bupivacaine52
Buprenorphine623
Butorphanol Tartrate889
Capromorelin194
Carprofen4,346
Cefovecin sodium1,457
Cefpodoxime proxetil187
Ceftiofur Crystalline Free Acid573
Ceftiofur Hydrochloride76
Ceftiofur Sodium120
Cephalexin119
Cephapirin Benzathine78
Chlortetracycline45
Chlortetracycline Calcium Complex35
Clindamycin101
Clindamycin Hydrochloride48
Clomipramine Hydrochloride33
Cloprostenol Sodium26
Clorsulon + Ivermectin105
Cloxacillin Benzathine88
Cyclosporine302
Danofloxacin68
Decoquinate31
Deracoxib1,024
Desoxycorticosterone Pivalate76
Detomidine Hydrochloride66
Dexamethasone371
Dexamethasone + Neomycin Sulfate + Thiabendazole32
Dexamethasone Sodium Phosphate121
Dexmedetomidine270
Dexmedetomidine hydrochloride574
Dextran67
Dextrose89
Diazepam131
Dichlorophene + Toluene47
Dinoprost Tromethamine245
Diphenhydramine267
Dirlotapide72
Doramectin520
Doramectin + Levamisole Hydrochloride22
Doxycycline244
Emodepside + Praziquantel157
Enalapril Maleate117
Enrofloxacin638
Eprinomectin330
Eprinomectin + Esafoxolaner + Praziquantel112
Epsiprantel47
Estradiol133
Estradiol + Trenbolone Acetate60
Estradiol + Tylosin Tartrate37
Estradiol Benzoate + Progesterone66
Estradiol Benzoate + Trenbolone Acetate49
Estriol24
Etodolac94
Famotidine286
Famphur68
Febantel + Praziquantel + Pyrantel Pamoate160
Fenbendazole466
Fenprostalene33
Fentanyl66
Fenthion41
Firocoxib809
Florfenicol350
Florfenicol + Flunixin191
Florfenicol + Mometasone furoate + Terbinafine73
Flunixin40
Flunixin Meglumine317
Fluoxetine hydrochloride48
Fluralaner1,178
Fluralaner + Moxidectin68
Frunevetmab303
Furosemide257
Gabapentin556
Gamithromycin203
Gentamicin Sulfate34
Glycopyrrolate42
Grapiprant263
Griseofulvin27
Hydrocodone34
Hydromorphone134
Ilunocitinib43
Imidacloprid143
Imidacloprid + Moxidectin536
Imidocarb Dipropionate39
Insulin332
Isoflurane784
Ivermectin1,565
Ivermectin + Praziquantel70
Ivermectin + Praziquantel + Pyrantel Pamoate82
Ivermectin + Pyrantel Pamoate1,750
Ketamine Hydrochloride1,331
Ketoconazole51
Ketoprofen61
Ketoprofen + Tulathromycin152
Lactulose25
Lasalocid69
Lasalocid sodium80
Levamisole48
Levamisole Hydrochloride53
Levamisole Phosphate46
Levetiracetam36
Levothyroxine sodium74
Lidocaine78
Lincomycin Hydrochloride25
Lincomycin Hydrochloride Monohydrate + Spectinomycin Sulfate Tetrahydrate172
Lotilaner174
Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate41
Lubabegron56
Lufenuron118
Lufenuron + Milbemycin Oxime269
Lufenuron + Milbemycin Oxime + Praziquantel48
Lufenuron + Praziquantel23
Marbofloxacin118
Maropitant1,601
Medetomidine475
Melarsomine Dihydrochloride959
Melengestrol Acetate50
Meloxicam1,107
Methadone41
Methimazole68
Methocarbamol48
Methylprednisolone Acetate233
Metoclopramide88
Metronidazole269
Midazolam269
Milbemycin Oxime655
Milbemycin Oxime + Praziquantel541
Milbemycin Oxime + Spinosad1,952
Mirtazapine170
Molidustat30
Monensin2,338
Monensin + Tylosin36
Monensin + Tylosin Phosphate31
Moxidectin1,939
Moxidectin + Praziquantel28
Moxidectin + Pyrantel Pamoate + Sarolaner28
Narasin203
Narasin + Nicarbazin116
Neomycin Sulfate + Nystatin + Thiostrepton + Triamcinolone Acetonide23
Nitenpyram514
Oclacitinib633
Omeprazole75
Ondansetron82
opAFP-GHc2 rDNA construct69
Orbifloxacin107
Ormetoprim + Sulfadimethoxine74
Oxfendazole153
Oxibendazole139
Oxytetracycline346
Oxytetracycline + Oxytetracycline Dihydrate24
Oxytetracycline Dihydrate44
Oxytetracycline Hydrochloride58
Penicillin G Benzathine + Penicillin G Procaine100
Penicillin G Procaine165
Pergolide mesylate36
Phenobarbital82
Phenylbutazone26
Pimobendan429
Polysulfated Glycosaminoglycan154
Ponazuril41
Pradofloxacin48
Praziquantel138
Praziquantel + Pyrantel Pamoate244
Prednisolone130
Prednisolone + Trimeprazine Tartrate77
Prednisolone Sodium Succinate39
Prednisone428
Progesterone26
Propofol648
Pyrantel Pamoate674
Pyrantel Pamoate + Sarolaner462
Pyrantel Tartrate38
Rabacfosadine53
Ractopamine Hydrochloride148
Robenacoxib241
Sarolaner248
Sarolaner + Selamectin123
Selamectin1,377
Selegiline Hydrochloride114
Sevoflurane339
Sodium Chloride52
Spinosad1,098
Sucralfate124
Sulfadiazine + Trimethoprim53
Sulfadimethoxine146
Tepoxalin97
Tiamulin70
Tiamulin Hydrogen Fumarate35
Tigilanol tiglate60
Tildipirosin250
Tiletamine Hydrochloride115
Tiletamine Hydrochloride + Zolazepam Hydrochloride760
Tilmicosin141
Tilmicosin Phosphate718
Toceranib Phosphate66
Tramadol218
Trazodone69
Triamcinolone22
Triamcinolone Acetonide54
Trilostane381
Trimethoprim22
Tulathromycin1,156
Tylosin180
Tylosin Phosphate114
Tylosin Tartrate22
Ursodiol32
Velagliflozin80
Verdinexor52
Vitamin E260
Xylazine228
Zeranol72
Zilpaterol37
Zoalene29

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 226 ingredients.

Show the 226 ingredients

Reports by species

The share is of the 51,482 reports that list this sign. The sign is in 2.9% of all reports about the species dog. The sign is in 29.5% of all reports about the species cattle.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Death, by the year in which FDA received them
YearReports
2026859
20252,357
20242,598
20231,879
20221,767
20211,758
20201,833
20191,857
20181,712
20171,690
20161,700
20151,729
20141,656
20131,750
20121,810
20111,657
20101,722
20091,663
20081,669
20071,638
20061,563
20051,579
20041,855
20031,415
20021,108
20011,111
20001,095
1999924
19981,056
1997797
1996534
1995500
1994390
1993293
1992268
1991266
1990293
1989539
1988299
1987293

What these reports record

Outcome at the time of the report

  • Reports with this sign
  • All reports
  • Recovered/Normal1.8%924, All reports: 20.7%
  • Recovered with Sequela[recovered, with a lasting effect]0.2%115, All reports: 2.3%
  • Ongoing1.6%836, All reports: 17.4%
  • Died98.7%50,809, All reports: 4.9%
  • Euthanized0.9%467, All reports: 1.5%
  • Outcome Unknown4.1%2,104, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 51,482 reports that list this sign.

Age of the animal

  • Reports with this sign
  • All reports
  • Under 1 year18.6%9,571, All reports: 9.5%
  • 1 to 3 years12.2%6,283, All reports: 23.9%
  • 4 to 7 years14.3%7,376, All reports: 20.2%
  • 8 to 11 years16.4%8,441, All reports: 15.4%
  • 12 years and over13.4%6,904, All reports: 10.7%
  • Age not given25.1%12,907, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

All clinical signs

Cite this page

Pet Drug Reports. Death: adverse event reports for animal drugs. https://petdrugreports.com/reaction/death/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?

It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.

How does the count of the latest 12 months compare with the 12 months before?

FDA received 2,015 reports in the 12 months to June 2026. It received 2,518 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

How many of these reports have a serious flag?

Of the 25,741 reports that say if the event was serious, 99% have the serious flag. The person who sends a report sets the flag.

Does a drug in the table cause this sign?

The reports do not show that. A report can name more than one drug. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices