Ingredients, all combinations: adverse event reports that FDA received

85 active ingredients, A to Z

A page on this list counts one ingredient alone and in every combination. An ingredient has such a page only when the count is different from the count of a drug page. 248 ingredients have a drug page only.

Search engines list 44 of these pages. Each has 500 reports or more in all years and 30 reports or more in the latest 12 months.

Browse drug ingredient sets or species. What affects a count of reports explains the limits of comparisons.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

The list

Active ingredients with 50 or more reports, in order of name
Active ingredient	Species in the largest number of reports	Sets of ingredients	Reports, all years	Reports, latest 12 months	Listed by search engines
Acetaminophen	Dog	2	111	28	No
Afoxolaner	Dog	3	71,148	7,084	Yes
Amitraz	Dog	2	1,567	0	No
Amoxicillin	Dog	3	11,287	399	Yes
Bacitracin	Dog	2	486	22	No
Bacitracin Zinc	Dog	1	81	7	No
Benazepril hydrochloride	Dog	2	186	15	No
Betamethasone Acetate	Dog	2	706	131	Yes
Betamethasone Valerate	Dog	2	2,745	31	Yes
Chlortetracycline	Cattle	1	146	6	No
Chlortetracycline Calcium Complex	Cattle	1	89	0	No
Chorionic Gonadotropin	Horse	1	52	1	No
Citric Acid	Dog	2	74	1	No
Clavulanate Potassium	Dog	4	8,219	590	Yes
Clotrimazole	Dog	7	5,399	214	Yes
Codeine	Dog	2	98	18	No
Dexamethasone	Dog	4	5,146	520	Yes
Dextrose	Dog	3	410	32	No
Eprinomectin	Cat	3	6,344	1,103	Yes
Estradiol	Cattle	7	913	34	Yes
Estradiol Benzoate	Cattle	3	661	28	No
Florfenicol	Dog	5	9,997	615	Yes
Flunixin	Cattle	2	662	26	No
Gentamicin	Dog	4	1,785	150	Yes
Gentamicin Sulfate	Dog	7	6,453	372	Yes
Hydrocortisone	Dog	3	343	41	No
Imidacloprid	Dog	2	29,337	886	Yes
Isoflupredone Acetate	Dog	2	169	8	No
Ivermectin	Dog	5	195,736	4,953	Yes
Ketoprofen	Dog	2	637	62	Yes
Levamisole Hydrochloride	Cattle	2	257	60	No
Lincomycin Hydrochloride	Pig	1	151	0	No
Lotilaner	Dog	2	14,878	4,196	Yes
Lufenuron	Dog	4	39,985	1,093	Yes
Mebendazole	Horse	2	137	0	No
Medetomidine hydrochloride	Dog	2	635	115	Yes
Miconazole Nitrate	Dog	4	2,450	253	Yes
Milbemycin Oxime	Dog	6	237,768	4,308	Yes
Moxidectin	Dog	7	100,770	13,072	Yes
Narasin	Chicken	2	715	27	No
Neomycin Sulfate	Dog	8	2,653	359	Yes
Novobiocin	Cattle	2	91	0	No
Nystatin	Dog	6	1,367	186	Yes
Orbifloxacin	Dog	3	1,996	96	Yes
Oxytetracycline	Cattle	3	1,830	31	Yes
Oxytetracycline Dihydrate	Cattle	2	389	16	No
Penicillin G Procaine	Cattle	3	1,119	2	No
Piperazine	Horse	1	68	0	No
Piperonyl Butoxide	Dog	2	156	6	No
Polymyxin B Sulfate	Dog	3	747	31	Yes
Posaconazole	Dog	3	506	65	Yes
Potassium Citrate	Dog	2	135	11	No
Praziquantel	Dog	14	85,618	7,903	Yes
Prednisolone	Dog	3	5,489	464	Yes
Prednisolone Acetate	Dog	3	345	17	No
Progesterone	Cattle	3	1,169	32	Yes
Pyrantel Pamoate	Dog	9	257,396	22,739	Yes
Pyrethrins	Dog	2	108	3	No
Pyrimethamine	Horse	2	55	0	No
Salicylic Acid	Dog	2	758	85	Yes
Sarolaner	Dog	4	83,355	12,749	Yes
Selamectin	Cat	2	72,099	2,123	Yes
Silver sulfadiazine	Dog	2	837	64	Yes
Spinosad	Dog	2	212,481	717	Yes
Spironolactone	Dog	2	321	77	No
Sulfadiazine	Horse	2	335	15	No
Sulfadimethoxine	Dog	2	2,849	65	Yes
Sulfamethazine	Cattle	1	169	0	No
Terbinafine	Dog	5	8,694	637	Yes
Testosterone	Cattle	1	80	3	No
Tetracaine	Dog	2	159	3	No
Tetracaine Hydrochloride	Dog	2	241	29	No
Tetracycline	Dog	2	69	1	No
Thiabendazole	Cat	3	2,098	192	Yes
Thiostrepton	Dog	4	1,244	184	Yes
Tiletamine Hydrochloride	Cat	3	4,082	109	Yes
Trenbolone Acetate	Cattle	3	645	42	Yes
Triamcinolone	Dog	3	494	68	No
Triamcinolone Acetonide	Dog	3	2,546	187	Yes
Trichlorfon	Horse	2	137	0	No
Trimethoprim	Dog	2	468	27	No
Tylosin Phosphate	Cattle	2	314	18	No
Tylosin Tartrate	Dog	3	630	41	Yes
Vitamin A	Dog	1	64	6	No
Vitamin D	Human exposure	1	75	10	No

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
Commonly used products may have a higher number of reported adverse events due to the higher total number of animals being given the product.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices