Active ingredient · pooled across combinations
Pyrantel Pamoate: adverse event reports, pooled
19 ingredient sets in reports · 28 FDA-approved applications in the Green Book
250,618 adverse event reports received by FDA list a drug containing pyrantel pamoate, alone or in combination, from August 1987 to March 2026. This page pools every ingredient set that includes it; 19 such sets appear in reports.
The Green Book lists 28 FDA-approved applications containing it. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand.
22,697 reports arrived in the 12 months to March 2026, up 10% from 20,558 in the 12 months before. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. That is about 6,482 reports a year over its reporting history and 18.5% of all reports.
Pooled across every set, the terms listed most often are vomiting (15.1%), ineffective, heartworm larvae (14.3%) and lack of efficacy (endoparasite) - hookworm (12.7%). Many drugs combine several ingredients, and many reports list several drugs, so a term on this page may relate to any of them or to none.
Of reports that state seriousness, 46.6% were classed as serious (38.6% across the whole database); 2.2% record a death or euthanasia (6.4% overall). Ingredients used in older or sicker animals, or in anaesthesia and cancer care, carry higher shares for that reason alone.
Ingredient sets that include pyrantel pamoate
| Active ingredients recorded for the drug | Reports | Share of this page's reports | Latest 12 months |
|---|---|---|---|
| Ivermectin + Pyrantel Pamoate | 161,643 | 64.5% | 4,876 |
| Pyrantel Pamoate + Sarolaner | 52,066 | 20.8% | 10,626 |
| Ivermectin + Praziquantel + Pyrantel Pamoate | 8,999 | 3.6% | 100 |
| Afoxolaner + Moxidectin + Pyrantel Pamoate | 8,769 | 3.5% | 4,349 |
| Febantel + Praziquantel + Pyrantel Pamoate | 7,061 | 2.8% | 415 |
| Pyrantel Pamoate | 5,867 | 2.3% | 250 |
| Praziquantel + Pyrantel Pamoate | 5,037 | 2% | 206 |
| Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate | 2,261 | 0.9% | 2,231 |
| Moxidectin + Pyrantel Pamoate + Sarolaner | 1,090 | 0.4% | 344 |
| Fenbendazole + Praziquantel + Pyrantel Pamoate | 13 | 0% | 0 |
| Moxidectin + Pyrantel Pamoate | 12 | 0% | 8 |
| Mebendazole + Praziquantel + Pyrantel Pamoate | 8 | 0% | 1 |
| Ivermectin + Mebendazole + Pyrantel Pamoate | 4 | 0% | 0 |
| Milbemycin Oxime + Pyrantel Pamoate | 4 | 0% | 0 |
| Ivermectin + Lufenuron + Praziquantel + Pyrantel Pamoate | 1 | 0% | 0 |
| Fenbendazole + Ivermectin + Lufenuron + Praziquantel + Pyrantel Pamoate | 1 | 0% | 0 |
| Fenbendazole + Pyrantel Pamoate | 1 | 0% | 1 |
| Afoxolaner + Pyrantel Pamoate | 1 | 0% | 1 |
| Lotilaner + Moxidectin + Pyrantel Pamoate | 1 | 0% | 1 |
Ordered by report count. FDA states that these data "cannot be used to estimate the risk associated with the product or compare one drug or device product with another"; counts follow sales volume and years on the market. A report can list more than one set, so shares can add to more than 100%.
Signs listed in reports, pooled
share of pyrantel pamoate reports listing the termall reports in the database
- Vomiting15.1%37,775
- Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]14.3%35,856
- Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]12.7%31,833
- Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]11.6%28,956
- Digestive tract disorder NOS[digestive problem, type not specified]6.7%16,820
- Diarrhoea[diarrhea]6.4%16,104
- Lethargy[unusually tired or inactive]5.2%12,972
- Ineffective, ascarids NOS[legacy FDA term: the product did not have the expected effect (ascarids nos)]4.8%11,989
- Cardiac disorder NOS[heart problem, type not specified]4%10,073
- Lack of efficacy (endoparasite) - roundworm NOS[the product did not have the expected effect: roundworms]3.7%9,213
- Lack of efficacy - NOS[the product did not have the expected effect]3.5%8,793
- Tablets, Abnormal[a product quality report, not a sign in an animal]3.5%8,750
- Seizure NOS[seizure, type not specified]3%7,596
- Ineffective, hooks[legacy FDA term: the product did not have the expected effect (hooks)]2.9%7,211
- Lack of efficacy (bacteria) - Borrelia[the product did not have the expected effect: Borrelia (Lyme disease bacteria)]2.8%7,000
- Anorexia[not eating]1.7%4,303
- Lack of efficacy (endoparasite) - tapeworm[the product did not have the expected effect: tapeworms]1.7%4,211
- Lack of efficacy (ectoparasite) - tick NOS[the product did not have the expected effect: ticks]1.4%3,555
- Death1.4%3,416
- Containers, Damaged[a product quality report, not a sign in an animal]1.4%3,406
- Emesis[vomiting]1.3%3,326
- Ataxia[unsteady, uncoordinated movement]1.3%3,289
- Emesis (multiple)[vomiting more than once]1.3%3,183
- Not eating1.2%3,113
- Behavioural disorder NOS[behaviour change, type not specified]1.1%2,876
- Lack of efficacy (endoparasite) - whipworm[the product did not have the expected effect: whipworms]1.1%2,849
- Overdose[more than the labelled amount was given]1.1%2,736
- Lack of efficacy (protozoa) - Coccidia[the product did not have the expected effect: coccidia]1.1%2,724
- Depression[dull, quiet or withdrawn]1.1%2,706
- Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]1%2,602
Pooled across every ingredient set and every report that names the ingredient. One report can list several terms and several drugs; a term here may relate to any of them or to none.
Monthly reports by species, five years
By month of receipt; each panel has its own scale. The newest months are incomplete because FDA posts reports with a delay of three to six months.
Outcomes, report types and ages
Outcome recorded in the report
What kind of report it was
Age of the animal
Coloured bar: reports naming pyrantel pamoate. Grey bar: all 1,357,245 reports. Outcomes are as stated by the reporter; FDA has not necessarily determined whether any product played a part.
In context
| Measure | Pyrantel Pamoate | All reports |
|---|---|---|
| Reports | 250,618 | 1,357,245 |
| Latest 12 months against the 12 before | +10% | -5% |
| Classed serious, of reports stating it | 46.6% | 38.6% |
| Death or euthanasia recorded, per 1,000 reports | 22.1 | 63.8 |
| Filed as lack of expected effectiveness (wholly or partly) | 46.2% | 23% |
Shares of reports, not of animals treated: how many animals receive the ingredient is not public. Ingredients used in anaesthesia, cancer care or in old animals carry more serious outcomes in their reports for that reason alone.
FDA-approved products containing pyrantel pamoate (Green Book)
Reference information, not report statistics. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand. The list below is the FDA Green Book as of 30 Sep 2026; nothing on this page says which of these products, if any, a report concerned.
| Trade name | Active ingredients | Sponsor | Approved for | Application |
|---|---|---|---|---|
| Strongid T | Pyrantel Pamoate | Zoetis Inc. | Horses | NADA 091-739 |
| Nemex; Nemex-2; RFD Liquid Wormer | Pyrantel Pamoate | Zoetis Inc. | Dogs | NADA 100-237 |
| Dog Wormer Tablets | Pyrantel Pamoate | Farnam Companies, Inc. | Dogs | NADA 101-331 |
| Banminth-P Paste; Strongid Paste | Pyrantel Pamoate | Zoetis Inc. | Horses | NADA 129-831 |
| Adams; D-Worm; Dog Wormer Chewable Tablets | Pyrantel Pamoate | Farnam Companies, Inc. | Dogs | NADA 139-191 |
| Heartgard Plus | Ivermectin, Pyrantel Pamoate | Boehringer Ingelheim Animal Health USA, Inc. | Dogs | NADA 140-971 |
| Drontal Plus; Drontal Plus Taste Tabs; Quad Dewormer | Febantel, Praziquantel, Pyrantel Pamoate | Elanco US Inc. | Dogs | NADA 141-007 |
| Drontal Tablets | Praziquantel, Pyrantel Pamoate | Elanco US Inc. | Cats | NADA 141-008 |
| Iverhart MAX | Ivermectin, Praziquantel, Pyrantel Pamoate | Virbac AH, Inc. | Dogs | NADA 141-257 |
| Virbantel; Worm X Plus | Praziquantel, Pyrantel Pamoate | Virbac AH, Inc. | Dogs | NADA 141-261 |
| Iverhart MAX Chew | Ivermectin, Praziquantel, Pyrantel Pamoate | Virbac AH, Inc. | Dogs | NADA 141-441 |
| Simparica Trio | Moxidectin, Pyrantel Pamoate, Sarolaner | Zoetis Inc. | Dogs | NADA 141-521 |
| NexGard Plus | Afoxolaner, Moxidectin, Pyrantel Pamoate | Boehringer Ingelheim Animal Health USA, Inc. | Dogs | NADA 141-554 |
| Credelio Quattro | Lotilaner, Moxidectin, Praziquantel, Pyrantel Pamoate | Elanco US Inc. | Dogs | NADA 141-581 |
| Credelio Quattro-CA1 | Lotilaner, Moxidectin, Praziquantel, Pyrantel Pamoate | Elanco US Inc. | Dogs | NADA 141-619 |
| Liqui-Vict 2X | Pyrantel Pamoate | Happy Jack, Inc. | Dogs | ANADA 200-007 |
| Anthelban V | Pyrantel Pamoate | Elanco US Inc. | Horses | ANADA 200-246 |
| Pyrantel Pamoate Suspension; Pyrantel Pamoate Suspension-2.27mg; Pyrantel Pamoate Suspension-4.54mg | Pyrantel Pamoate | Cronus Pharma Specialities India Private Ltd. | Dogs | ANADA 200-248 |
| Pyrantel Pamoate Chewable Tablets | Pyrantel Pamoate | Virbac AH, Inc. | Dogs | ANADA 200-281 |
| Iverhart Plus Flavored Chewables | Ivermectin, Pyrantel Pamoate | Virbac AH, Inc. | Dogs | ANADA 200-302 |
| Tri-Heart Plus Chewable Tablets | Ivermectin, Pyrantel Pamoate | Diamond Animal Health, Inc. | Dogs | ANADA 200-338 |
| Pyrantel Pamoate Paste | Pyrantel Pamoate | Farnam Companies, Inc. | Horses | ANADA 200-342 |
| Exodus Paste; Exodus Multi Dose | Pyrantel Pamoate | Bimeda Animal Health Ltd. | Horses | ANADA 200-350 |
| Primex 2-X; Primex Canine | Pyrantel Pamoate | First Priority, Inc. | Dogs | ANADA 200-352 |
| Primex Equine | Pyrantel Pamoate | First Priority, Inc. | Horses | ANADA 200-353 |
| Primex | Pyrantel Pamoate | First Priority, Inc. | Horses | ANADA 200-445 |
| Evictapproval voluntarily withdrawn | Pyrantel Pamoate | Pegasus Laboratories, Inc. | Dogs | ANADA 200-028 |
| WormXapproval voluntarily withdrawn | Pyrantel Pamoate | Sergeant’s Pet Care Products Inc. | Dogs | ANADA 200-600 |
Species are the major species the Green Book search lists for the application ("—" where it lists another species or none). Approval dates are not part of the Green Book listing files and are not shown. Pioneer applications (NADA) come first, then generics (ANADA).
Questions about pyrantel pamoate reports
How many FDA adverse event reports mention pyrantel pamoate?
250,618 reports through March 2026, 22,697 of them in the latest 12 months, counting pyrantel pamoate alone and in combinations.
Which brands do these reports concern?
That cannot be known from the public data. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand. The Green Book reference list on this page names approved products containing pyrantel pamoate without any counts.
In which combinations is pyrantel pamoate reported?
Ivermectin + Pyrantel Pamoate (64.5% of these reports), Pyrantel Pamoate + Sarolaner (20.8% of these reports), Ivermectin + Praziquantel + Pyrantel Pamoate (3.6% of these reports), Afoxolaner + Moxidectin + Pyrantel Pamoate (3.5% of these reports) and Febantel + Praziquantel + Pyrantel Pamoate (2.8% of these reports).
What reactions are reported for pyrantel pamoate?
vomiting (15.1%), ineffective, heartworm larvae (14.3%), lack of efficacy (endoparasite) - hookworm (12.7%), lack of efficacy (endoparasite) - heartworm (11.6%) and digestive tract disorder NOS (6.7%). Shares are of reports naming the ingredient; one report can list several terms.
Which animals are these reports about?
dog (91.6%), cat (0.8%) and human exposure (0.1%).
Does a high count mean pyrantel pamoate is a problem ingredient?
A count cannot show that. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources." Widely used ingredients collect more reports because more animals receive them.
How do I report a problem?
Call the drug company using the number on the label, or send Form FDA 1932a to FDA. See the guide on how to report.
Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 30 Sep 2026. Ingredient names follow the Green Book; salts and forms are kept as FDA lists them. Drug entries are matched by the active ingredients their unmasked ingredient field discloses. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.