Selamectin (Revolution, Selarid): adverse event reports that FDA received

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 62,378 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

1. Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]13.1%8,169 reports
2. Application site alopecia[hair loss where the product was applied]9.3%5,771 reports
3. Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]9.1%5,679 reports
4. Vomiting8.3%5,149 reports
5. Underfilling, Tubes[a product quality report, not a sign in an animal]6.6%4,092 reports
6. Depression[dull, quiet or withdrawn]5.7%3,579 reports
7. Anorexia[not eating]5.5%3,409 reports
8. Diarrhoea[diarrhea]4.4%2,744 reports
9. Lethargy[unusually tired or inactive]4.1%2,544 reports
10. Pruritus[itching]3.9%2,445 reports
11. Application site hair loss[hair loss where the product was applied]3.6%2,266 reports
12. Accidental exposure[exposure that was not intended]3.6%2,226 reports
13. Tubes, Leaking[a product quality report, not a sign in an animal]3.1%1,903 reports
14. Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]2.9%1,780 reports

The list shows 30 of 1,807 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

• Dog47.3%29,476
• Cat35.3%22,042
• Human exposure3.6%2,222
• Other0.5%293
• Rabbit0.2%101
• Ferret0.1%36

The share is of all 62,378 reports that name selamectin. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

• Dog
• Cat
• Horse
• Other or not given

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Each bar is on a scale of 0 to 100%.

Other pages with this ingredient

A report names a drug by its set of active ingredients. Each set has its own page. The list is in order of name.

• Selamectin, all combinations
• Sarolaner + Selamectin

Next in the A to Z list

• Ropinirole
• Salicylic Acid
• Sarolaner
• Selegiline Hydrochloride
• Sevoflurane
• Sildenafil
• Silver sulfadiazine

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

• How to Report Animal Drug and Device Side Effects and Product ProblemsThe FDA page that tells an owner or a veterinarian how to send a report.
• Green Book record of NADA 141-152The FDA record of the application for Revolution.Client Information Sheet of Revolution (PDF): a label document that FDA posts with the record.Package Insert of Revolution (PDF): a label document that FDA posts with the record.
• Green Book record of ANADA 200-663The FDA record of the application for Selarid.Client Information Sheet of Selarid (PDF): a label document that FDA posts with the record.Package Insert of Selarid (PDF): a label document that FDA posts with the record.
• Green Book record of ANADA 200-670The FDA record of the application for Senergy.Client Information Sheet of Senergy (PDF): a label document that FDA posts with the record.Package Insert of Senergy (PDF): a label document that FDA posts with the record.
• Green Book record of ANADA 200-673The FDA record of the application for Revolt.Client Information Sheet of Revolt (PDF): a label document that FDA posts with the record.Package Insert of Revolt (PDF): a label document that FDA posts with the record.
• Green Book record of ANADA 200-696The FDA record of the application for SelaSpot.Client Information Sheet of SelaSpot (PDF): a label document that FDA posts with the record.Package Insert of SelaSpot (PDF): a label document that FDA posts with the record.
• Green Book record of ANADA 200-769The FDA record of the application for Selamectin.
• Animal Drugs @ FDAThe search page of the Green Book, the FDA list of approved animal drugs.

The site checked these addresses on 2 Oct 2026. The links open in a new tab.

Cite this page

Pet Drug Reports. Selamectin: adverse event reports that FDA received. https://petdrugreports.com/drug/selamectin/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with this active ingredient.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 819 reports in the 12 months to June 2026. It received 893 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 62,378 reports received from May 1999 to June 2026, 72.7% are about a safety issue only. 13.7% are about a lack of expected effectiveness, alone or with a safety issue. 13.5% are about a defect of the product or its package.