Pet Drug Reports

Febantel + Praziquantel + Pyrantel Pamoate (Drontal Plus, Quad Dewormer)adverse event reports that FDA received

Combination of 3 active ingredients

The names in brackets are brand names with these active ingredients.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From January 1996 to June 2026, FDA received 7,171 adverse event reports that name this drug. Its active ingredients are febantel, praziquantel and pyrantel pamoate. Of the 7,171 reports, 6,706 (93.5%) are about dogs. 70 reports are about cats (1%).

In January to March 2026, FDA received 96 reports that name this drug. The signs that appear in the largest number of the 7,171 reports are "Vomiting", "Diarrhoea" and "Emesis". A report is not proof that a drug caused a sign.

Reports that name this drug fell by 3.4% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 93.5% of the reports that name this drug, and 72.6% of all reports.

Since the last update of the FDA data

The site recorded an update of the FDA data on . FDA changed these counts for January to March 2026:

  • All species: from 89 to 96.
  • Dog: from 79 to 86.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 96 reports that name febantel + praziquantel + pyrantel pamoate: 86 dog, 0 cat, 0 horse, 10 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 7,171 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Vomiting35.4%2,535 reports
  2. Diarrhoea[diarrhea]10.2%734 reports
  3. Emesis[vomiting]10.1%722 reports
  4. Emesis (multiple)[vomiting more than once]9.6%691 reports
  5. Lethargy[unusually tired or inactive]8.3%593 reports
  6. Lack of efficacy (endoparasite) - tapeworm[the product did not have the expected effect: tapeworms]6.3%450 reports
  7. Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]5.4%386 reports
  8. Anorexia[not eating]4.4%318 reports
  9. Hyperactivity4.3%307 reports
  10. Overdose[more than the labelled amount was given]3.7%265 reports
  11. Underdose[less than the labelled amount was given]3.4%247 reports
  12. Behavioural disorder NOS[behaviour change, type not specified]3.4%246 reports
  13. Ineffective, hooks[legacy FDA term: the product did not have the expected effect (hooks)]2.8%198 reports
  14. Vocalisation[crying out or unusual noise]2.4%173 reports
Show the next 16 signs
  1. Other abnormal test result NOS[abnormal laboratory result, type not specified]2.4%171 reports
  2. Product label issues[a product quality report, not a sign in an animal]2.4%169 reports
  3. Death2.2%160 reports
  4. Lack of efficacy (endoparasite) - roundworm NOS[the product did not have the expected effect: roundworms]2.2%156 reports
  5. Loose stool2%147 reports
  6. Decreased appetite1.8%130 reports
  7. Lack of efficacy (endoparasite) - NOS[the product did not have the expected effect: target not specified]1.8%126 reports
  8. Restlessness1.7%121 reports
  9. Bloody diarrhoea[diarrhea with blood]1.5%110 reports
  10. Ataxia[unsteady, uncoordinated movement]1.5%109 reports
  11. Not eating1.5%104 reports
  12. Agitation1.4%103 reports
  13. Tablets, Abnormal[a product quality report, not a sign in an animal]1.4%97 reports
  14. Patient instructions for use on label confusing1.3%94 reports
  15. Shaking1.2%89 reports
  16. Seizure NOS[seizure, type not specified]1.2%83 reports

The list shows 30 of 1,031 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

  • Dog93.5%6,706
  • Cat1%70
  • Human exposure0.1%9
  • Cockatiel0.1%4
  • Crustaceaunder 0.1%1
  • Other Birdsunder 0.1%1

The share is of all 7,171 reports that name febantel + praziquantel + pyrantel pamoate. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog1,926 reports. Largest count in one month: 64 (Jul 2021)
Cat14 reports

No chart: no month has 5 or more reports.

Horse0 reports

No chart: no month has 5 or more reports.

Other or not given249 reports. Largest count in one month: 15 (May 2024)

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name febantel + praziquantel + pyrantel pamoate, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
20261750025200
20253723061436
20243683097468
20234073045455
20223383014355
2021532209543
2020498103502
2019552507564
20185976012615
2017572409585
201645810011479
20153992010411
2014233308244
20133004012316
20122424011257
2011179208189
20101702012184
20098020385
20084110446
20074520350
20062000020
20052200729
20041400620
2003400812
20022840133
20011030417
2000910010
199970018
19981200113
19971600016
199660039

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal44.3%3,178
  • Recovered with Sequela[recovered, with a lasting effect]0.2%15
  • Ongoing6.1%438
  • Died2.5%180
  • Euthanized0.6%44
  • Outcome Unknown34.9%2,506

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 7,171 reports that name febantel + praziquantel + pyrantel pamoate.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue82.6%5,925
  • Lack of expected effectiveness7.3%520
  • Both safety and lack of expected effectiveness3.9%279
  • Manufacturing or product defect6.2%444
  • Otherunder 0.1%3

6,296 reports say if the event was serious. 40.6% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year39.9%2,859
  • 1 to 3 years21.6%1,549
  • 4 to 7 years13.1%939
  • 8 to 11 years7.5%540
  • 12 years and over4.3%307
  • Age not given13.6%977

Weight of the animal

  • Under 5 kg (11 lb)26.3%1,884
  • 5 to 9.9 kg (11 to 22 lb)20.1%1,438
  • 10 to 24.9 kg (22 to 55 lb)22.3%1,601
  • 25 to 44.9 kg (55 to 99 lb)15.3%1,099
  • 45 kg and over (99 lb and over)1.7%119
  • Weight not given14.4%1,030

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Oral91.5%6,559
  • Topical0.3%24
  • Other0.1%9
  • Parenteralunder 0.1%1

Each bar is on a scale of 0 to 100%.

Approved animal drugs with these active ingredients (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • Drontal Plus
  • Quad Dewormer

What the Green Book records give

Applications with an approval in force
1
Approved species
Dogs
Dose forms
Tablet
Routes
Oral
Sale
RX (prescription), OTC (over the counter)
Earliest approval date in the records

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
Drontal Plus; Drontal Plus Taste Tabs; Quad DewormerFebantel, Praziquantel, Pyrantel PamoateElanco US Inc.DogsNADA 141-007

Other pages with one of these ingredients

A report names a drug by its set of active ingredients. Each set has its own page. The list is in order of name.

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Febantel + Praziquantel + Pyrantel Pamoate: adverse event reports that FDA received. https://petdrugreports.com/drug/febantel-praziquantel-pyrantel-pamoate/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

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Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with these active ingredients.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 426 reports in the 12 months to June 2026. It received 441 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 7,171 reports received from January 1996 to June 2026, 82.6% are about a safety issue only. 11.1% are about a lack of expected effectiveness, alone or with a safety issue. 6.2% are about a defect of the product or its package.