Pet Drug Reports

Tramadoladverse event reports that FDA received

Active ingredient

The Green Book lists no brand name for exactly this active ingredient.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From November 2006 to June 2026, FDA received 3,821 adverse event reports that name a drug with tramadol as its active ingredient. Of the 3,821 reports, 3,769 (98.6%) are about dogs.

In January to March 2026, FDA received 28 reports that name this drug. The signs that appear in the largest number of the 3,821 reports are "Vomiting", "Lethargy" and "Other abnormal test result NOS". A report is not proof that a drug caused a sign.

Reports that name this drug fell by 44.9% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 98.6% of the reports that name this drug, and 72.6% of all reports.

Since the last update of the FDA data

The latest update of the FDA data, recorded on , changed no count of this page.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 28 reports that name tramadol: 25 dog, 3 cat, 0 horse, 0 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 3,821 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Vomiting21.6%826 reports
  2. Lethargy[unusually tired or inactive]20.8%795 reports
  3. Other abnormal test result NOS[abnormal laboratory result, type not specified]13.3%508 reports
  4. Anorexia[not eating]12.5%477 reports
  5. Diarrhoea[diarrhea]12%459 reports
  6. Death by euthanasia[the animal was euthanized]10.9%415 reports
  7. Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]9.3%356 reports
  8. Emesis[vomiting]8.6%327 reports
  9. Lack of efficacy - NOS[the product did not have the expected effect]8.1%309 reports
  10. Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]8%306 reports
  11. Weight loss7.2%276 reports
  12. Decreased appetite6.8%260 reports
  13. Elevated blood urea nitrogen (BUN)[a kidney value above the normal range]6.4%243 reports
  14. Elevated liver enzymes[liver enzymes above the normal range]5.8%220 reports
Show the next 16 signs
  1. Death5.7%218 reports
  2. Panting5.6%215 reports
  3. Elevated creatinine[a kidney value above the normal range]5.6%214 reports
  4. Abnormal radiograph finding5.3%204 reports
  5. Not eating5.2%198 reports
  6. Abnormal ultrasound finding5%190 reports
  7. Seizure NOS[seizure, type not specified]4.9%189 reports
  8. Elevated total bilirubin[bilirubin above the normal range]4.7%181 reports
  9. Behavioural disorder NOS[behaviour change, type not specified]4.4%167 reports
  10. Leucocytosis NOS[high white blood cell count]4.3%163 reports
  11. Polydipsia[drinking more than usual]4.2%161 reports
  12. Pain NOS[NOS: not otherwise specified]4.2%160 reports
  13. Inappetence[reduced appetite]4%153 reports
  14. Anaemia NOS[low red blood cell count]4%152 reports
  15. Bloody diarrhoea[diarrhea with blood]3.9%149 reports
  16. Dehydration3.7%141 reports

The list shows 30 of 1,488 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

  • Dog98.6%3,769
  • Cat0.9%35
  • Human exposure0.2%9
  • Parrot0.1%2
  • Otherunder 0.1%1
  • Other Birdsunder 0.1%1

The share is of all 3,821 reports that name tramadol. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog612 reports. Largest count in one month: 26 (Apr 2024)
Cat8 reports

No chart: no month has 5 or more reports.

Horse0 reports

No chart: no month has 5 or more reports.

Other or not given5 reports

No chart: no month has 5 or more reports.

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name tramadol, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
20264840052
2025132004136
2024221200223
20238110082
20228400084
20219610198
2020117000117
2019192002194
2018359201362
2017550401555
2016399602407
2015281100282
2014293101295
2013479702488
2012406202410
20112310125
201011002
200922004
200830003
200620002

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal25.8%985
  • Recovered with Sequela[recovered, with a lasting effect]1.8%70
  • Ongoing34%1,299
  • Died6.3%240
  • Euthanized11%420
  • Outcome Unknown20.8%796

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 3,821 reports that name tramadol.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue86.3%3,299
  • Lack of expected effectiveness5.7%216
  • Both safety and lack of expected effectiveness6.5%247
  • Manufacturing or product defect1.5%58
  • Otherunder 0.1%1

3,788 reports say if the event was serious. 47.8% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year2.3%89
  • 1 to 3 years11.4%435
  • 4 to 7 years19.7%752
  • 8 to 11 years33.9%1,296
  • 12 years and over30.9%1,182
  • Age not given1.8%67

Weight of the animal

  • Under 5 kg (11 lb)5.8%221
  • 5 to 9.9 kg (11 to 22 lb)14.3%548
  • 10 to 24.9 kg (22 to 55 lb)24.5%935
  • 25 to 44.9 kg (55 to 99 lb)44.5%1,701
  • 45 kg and over (99 lb and over)8.2%314
  • Weight not given2.7%102

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Oral67.6%2,583
  • Subcutaneous0.1%4
  • Transdermal0.1%4
  • Other0.1%3
  • Topical0.1%3
  • Ophthalmic0.1%2

Each bar is on a scale of 0 to 100%.

Approved animal drugs with this active ingredient (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

The Green Book lists no approved animal drug with this active ingredient. FDA also receives reports for human drugs and compounded drugs that veterinarians prescribe.

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Tramadol: adverse event reports that FDA received. https://petdrugreports.com/drug/tramadol/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

Embed this card on your site

Copy this code into your page. The card shows the figures above with their source. A line under the card links to this page.

How embedding works. It is free. Keep the link in the card and the link line under it.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book lists no brand name for exactly this active ingredient.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 103 reports in the 12 months to June 2026. It received 187 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 3,821 reports received from November 2006 to June 2026, 86.3% are about a safety issue only. 12.1% are about a lack of expected effectiveness, alone or with a safety issue. 1.5% are about a defect of the product or its package.