Thiostrepton: adverse event reports in all combinations
Active ingredient, alone and in combinations
Brand names with this ingredient: Panolog, Animax, Derma 4, Derm-Otic.
The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.
Read this first. FDA says this about the data:
An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .
This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.
Contacting a veterinarianHow to report to FDAFDA reports received through . Counts include this ingredient alone and in combinations. Why brand names have no separate count.
From March 1990 to June 2026, FDA received 1,244 adverse event reports that name a drug with thiostrepton, alone or in a combination. 4 sets of active ingredients with thiostrepton have a drug page.
Of the 1,244 reports, 964 (77.5%) are about dogs. 209 reports are about cats (16.8%). In January to March 2026, FDA received 41 reports that name thiostrepton, alone or in a combination. The signs that appear in the largest number of the 1,244 reports are "Deafness", "Vomiting" and "Lethargy". A report is not proof that a drug caused a sign.
Reports that name this ingredient rose by 44.9% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cats are 16.8% of the reports that name this ingredient, and 11% of all reports.
Reports in the latest closed quarter
| Species | Jan to Mar 2026 | Oct to Dec 2025 | Jan to Mar 2025 |
|---|---|---|---|
| All species | 41 | 60 | 28 |
| Dog | 28 | 43 | 24 |
| Cat | 13 | 16 | 4 |
| Horse | 0 | 0 | 0 |
| Other or not given | 0 | 1 | 0 |
January to March 2026 is the latest closed quarter in the data.
Drug pages with thiostrepton
A report names a drug by its set of active ingredients. Each set with thiostrepton that has a drug page is in the table, in order of name. The table has 4 sets.
| Active ingredients | Reports, all years | Reports, latest 12 months |
|---|---|---|
| Neomycin Sulfate + Nystatin + Thiostrepton | 63 | 1 |
| Neomycin Sulfate + Nystatin + Thiostrepton + Triamcinolone Acetonide | 997 | 150 |
| Nystatin + Thiostrepton + Triamcinolone | 59 | 16 |
| Nystatin + Thiostrepton + Triamcinolone Acetonide | 95 | 16 |
A report can name more than one set, so the counts of the sets can add to more than the count of the page.
An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices
Signs that the reports list
A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 1,244 reports that list the sign. One report can list more than one sign and more than one drug.
The sign that is in the largest number of the reports comes first.
- Deafness27.4%341 reports
- Vomiting8.6%107 reports
- Lethargy[unusually tired or inactive]7.2%90 reports
- Loss of hearing7.1%88 reports
- Lack of efficacy - NOS[the product did not have the expected effect]6.4%80 reports
- Temporary deafness4.7%58 reports
- Diarrhoea[diarrhea]4.6%57 reports
- PR-ear(s), lesion(s)[legacy FDA term: lesions found in the ears]3.4%42 reports
- Anorexia[not eating]3.1%38 reports
- Partial deafness3.1%38 reports
- Not eating2.7%34 reports
- Behavioural disorder NOS[behaviour change, type not specified]2.7%33 reports
- Death by euthanasia[the animal was euthanized]2.7%33 reports
- Other abnormal test result NOS[abnormal laboratory result, type not specified]2.7%33 reports
Show the next 16 signs
- Skin lesion NOS[NOS: not otherwise specified]2.7%33 reports
- Emesis[vomiting]2.5%31 reports
- Pruritus[itching]2.5%31 reports
- Accidental exposure[exposure that was not intended]2.4%30 reports
- Ear discharge2.4%30 reports
- Weight loss2.4%30 reports
- Ataxia[unsteady, uncoordinated movement]2.3%29 reports
- Decreased appetite2.3%29 reports
- Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]2.3%29 reports
- Death2.3%28 reports
- Abnormal cytology2.1%26 reports
- Application site alopecia[hair loss where the product was applied]2.1%26 reports
- Medication error NOS[a mistake in giving the product, type not specified]2.1%26 reports
- Neutrophilia[high neutrophil count]1.9%24 reports
- Polyuria[passing more urine than usual]1.9%24 reports
- Seizure NOS[seizure, type not specified]1.9%24 reports
Reports by species
Reports for each month, Jul 2021 to Jun 2026
No chart: no month has 5 or more reports.
The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
Reports by year
- Dog
- Cat
- Horse
- Other or not given
| Year | Dog | Cat | Horse | Other or not given | All species |
|---|---|---|---|---|---|
| 2026 | 64 | 26 | 0 | 0 | 90 |
| 2025 | 125 | 41 | 0 | 2 | 168 |
| 2024 | 78 | 12 | 0 | 3 | 93 |
| 2023 | 59 | 18 | 1 | 4 | 82 |
| 2022 | 48 | 14 | 0 | 9 | 71 |
| 2021 | 53 | 5 | 0 | 1 | 59 |
| 2020 | 70 | 7 | 0 | 0 | 77 |
| 2019 | 37 | 10 | 0 | 0 | 47 |
| 2018 | 39 | 14 | 0 | 0 | 53 |
| 2017 | 28 | 6 | 0 | 0 | 34 |
| 2016 | 42 | 5 | 0 | 2 | 49 |
| 2015 | 37 | 6 | 0 | 2 | 45 |
| 2014 | 20 | 9 | 0 | 0 | 29 |
| 2013 | 40 | 7 | 0 | 1 | 48 |
| 2012 | 45 | 5 | 1 | 6 | 57 |
| 2011 | 20 | 2 | 0 | 3 | 25 |
| 2010 | 10 | 2 | 0 | 3 | 15 |
| 2009 | 23 | 5 | 0 | 1 | 29 |
| 2008 | 7 | 3 | 0 | 2 | 12 |
| 2007 | 6 | 2 | 0 | 1 | 9 |
| 2006 | 2 | 1 | 0 | 1 | 4 |
| 2005 | 5 | 2 | 0 | 3 | 10 |
| 2004 | 6 | 0 | 0 | 1 | 7 |
| 2003 | 6 | 0 | 0 | 0 | 6 |
| 2002 | 4 | 0 | 0 | 4 | 8 |
| 2001 | 6 | 1 | 0 | 7 | 14 |
| 2000 | 6 | 0 | 0 | 5 | 11 |
| 1999 | 5 | 1 | 0 | 7 | 13 |
| 1998 | 9 | 0 | 0 | 1 | 10 |
| 1997 | 7 | 0 | 0 | 0 | 7 |
| 1996 | 6 | 3 | 0 | 0 | 9 |
| 1995 | 9 | 1 | 0 | 0 | 10 |
| 1994 | 15 | 0 | 0 | 0 | 15 |
| 1993 | 15 | 1 | 0 | 0 | 16 |
| 1992 | 5 | 0 | 0 | 0 | 5 |
| 1991 | 6 | 0 | 0 | 0 | 6 |
| 1990 | 1 | 0 | 0 | 0 | 1 |
2026 has the reports that FDA received through Jun 2026. Download the years (CSV)
What the reports record
Outcome at the time of the report
- Recovered/Normal18.8%234
- Recovered with Sequela[recovered, with a lasting effect]7.4%92
- Ongoing19.1%237
- Died2.7%34
- Euthanized2.7%33
- Outcome Unknown25.5%317
An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 1,244 reports that name thiostrepton.
Kind of report
- Safety issue88.4%1,100
- Lack of expected effectiveness3.5%44
- Both safety and lack of expected effectiveness2.9%36
- Manufacturing or product defect5%62
- Other0.2%2
Age of the animal
- Under 1 year4.9%61
- 1 to 3 years12.3%153
- 4 to 7 years15.8%196
- 8 to 11 years28.1%350
- 12 years and over28%348
- Age not given10.9%136
Each share of kind and age is of the 1,244 reports that name thiostrepton.
Approved animal drugs with this active ingredient (FDA Green Book)
This section is reference data. It has no report count.
The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.
Brand names
- Panolog
- Animax
- Derma 4
- Derm-Otic
What the Green Book records give
- Applications with an approval in force
- 6
- Approved species
- Cats, Dogs
- Dose forms
- Ointment, Cream
- Routes
- Topical
- Sale
- RX (prescription)
- Earliest approval date in the records
The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.
| Brand name | Active ingredients | Sponsor | Approved species | Application |
|---|---|---|---|---|
| Panolog Ointment | Neomycin Sulfate, Nystatin, Thiostrepton, Triamcinolone Acetonide | Zoetis Inc. | Dogs, Cats | NADA 012-258 |
| Panolog Cream | Neomycin Sulfate, Nystatin, Thiostrepton, Triamcinolone Acetonide | Zoetis Inc. | Dogs, Cats | NADA 096-676 |
| Animax Ointment | Neomycin Sulfate, Nystatin, Thiostrepton, Triamcinolone Acetonide | Fougera Pharmaceuticals, LLC | Dogs, Cats | NADA 140-847 |
| Derma 4 Ointment | Neomycin Sulfate, Nystatin, Thiostrepton, Triamcinolone Acetonide | Zoetis Inc. | Dogs, Cats | NADA 140-879 |
| Derm-Otic Ointment | Neomycin Sulfate, Nystatin, Thiostrepton, Triamcinolone Acetonide | Zoetis Inc. | Dogs, Cats | NADA 141-003 |
| Animax Cream | Neomycin Sulfate, Nystatin, Thiostrepton, Triamcinolone Acetonide | Fougera Pharmaceuticals, LLC | Dogs, Cats | ANADA 200-330 |
| DERMA-VET Ointmentapproval withdrawn | Neomycin Sulfate, Nystatin, Thiostrepton, Triamcinolone Acetonide | Med-Pharmex, Inc. | Dogs, Cats | NADA 140-810 |
| Derm-Otic Ointmentapproval withdrawn | Neomycin Sulfate, Nystatin, Thiostrepton, Triamcinolone Acetonide | Biocraft Laboratories, Inc. | Dogs, Cats | NADA 140-889 |
| Derma-Vet Creamapproval withdrawn | Neomycin Sulfate, Nystatin, Thiostrepton, Triamcinolone Acetonide | Med-Pharmex, Inc. | Dogs, Cats | ANADA 200-245 |
FDA pages for this ingredient
- How to Report Animal Drug and Device Side Effects and Product ProblemsThe FDA page that tells an owner or a veterinarian how to send a report.
- Green Book record of NADA 012-258The FDA record of the application for Panolog Ointment.
- Green Book record of NADA 096-676The FDA record of the application for Panolog Cream.
- Green Book record of NADA 140-847The FDA record of the application for Animax Ointment.
- Green Book record of NADA 140-879The FDA record of the application for Derma 4 Ointment.
- Green Book record of NADA 141-003The FDA record of the application for Derm-Otic Ointment.
- Green Book record of ANADA 200-330The FDA record of the application for Animax Cream.
- Animal Drugs @ FDAThe search page of the Green Book, the FDA list of approved animal drugs.
The site checked these addresses on . The links open in a new tab.
Cite this page
Pet Drug Reports. Thiostrepton, all combinations: adverse event reports that FDA received. https://petdrugreports.com/ingredient/thiostrepton/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .
Where the data come from
The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. Ingredient names follow the Green Book, with salts and forms as FDA lists them.
The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.
Questions about these reports
- Which brand are these reports about?
The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists brand names with this active ingredient.
- Do the reports show that the ingredient caused the signs?
No. A report can name more than one drug, and a drug can have more than one active ingredient. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices
- How many reports did FDA receive in the latest 12 months?
FDA received 184 reports in the 12 months to June 2026. It received 127 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
- What kinds of report are in the count?
Of the 1,244 reports received from March 1990 to June 2026, 88.4% are about a safety issue only. 6.4% are about a lack of expected effectiveness, alone or with a safety issue. 5% are about a defect of the product or its package.