Pet Drug Reports

Tiletamine Hydrochloride + Zolazepam Hydrochloride (Telazol, Tzed)adverse event reports that FDA received

Combination of 2 active ingredients

Also sold as: Telazol, Tzed, Zoletil.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From March 1988 to June 2026, FDA received 3,149 adverse event reports that name this drug. Its active ingredients are tiletamine hydrochloride and zolazepam hydrochloride. Of the 3,149 reports, 1,575 (50%) are about cats. 1,230 reports are about dogs (39.1%).

In January to March 2026, FDA received 14 reports that name this drug. The signs that appear in the largest number of the 3,149 reports are "Death", "Ineffective, anesthesia" and "Recovery prolonged". A report is not proof that a drug caused a sign.

Reports that name this drug rose by 12.1% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cats are 50% of the reports that name this drug, and 11% of all reports.

Since the last update of the FDA data

The latest update of the FDA data, recorded on , changed no count of this page.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 14 reports that name tiletamine hydrochloride + zolazepam hydrochloride: 5 dog, 8 cat, 0 horse, 1 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 3,149 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Death24.1%760 reports
  2. Ineffective, anesthesia[legacy FDA term: the product did not have the expected effect (anesthesia)]10.1%319 reports
  3. Recovery prolonged10.1%319 reports
  4. Lack of efficacy - NOS[the product did not have the expected effect]8.6%272 reports
  5. Apnoea[breathing stopped]8.2%259 reports
  6. Fever7.8%247 reports
  7. Cardiac arrest7.6%240 reports
  8. Ataxia[unsteady, uncoordinated movement]7.4%232 reports
  9. Hyperexcitation4.6%145 reports
  10. Death by euthanasia[the animal was euthanized]4.4%138 reports
  11. Depression[dull, quiet or withdrawn]4.3%134 reports
  12. Lung oedema4.2%131 reports
  13. Dyspnoea[difficulty breathing]4.1%128 reports
  14. Vomiting3.8%120 reports
Show the next 16 signs
  1. Anorexia[not eating]3.7%115 reports
  2. Vocalisation[crying out or unusual noise]3.6%114 reports
  3. Cyanosis[bluish gums or skin from low oxygen]3.5%109 reports
  4. Convulsion[seizure]3.1%99 reports
  5. Hypothermia[low body temperature]2.9%92 reports
  6. Unrelated death2.5%78 reports
  7. Bradycardia[slow heart rate]2.2%68 reports
  8. Hyperactivity2.2%68 reports
  9. Solution, Abnormal[a product quality report, not a sign in an animal]2.1%66 reports
  10. Mydriasis[dilated pupils]2.1%65 reports
  11. Recumbency[lying down and unable or unwilling to rise]1.9%61 reports
  12. Trembling1.9%59 reports
  13. Blindness1.7%55 reports
  14. Nystagmus[rapid involuntary eye movement]1.7%54 reports
  15. Polypnoea[fast breathing]1.6%50 reports
  16. Tachycardia[fast heart rate]1.5%48 reports

The list shows 30 of 778 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

  • Cat50%1,575
  • Dog39.1%1,230
  • Other2.6%82
  • Human exposure0.6%20
  • Pig0.5%15
  • Other Deer0.3%8

The share is of all 3,149 reports that name tiletamine hydrochloride + zolazepam hydrochloride. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog149 reports. Largest count in one month: 8 (May 2022)
Cat193 reports. Largest count in one month: 11 (Jan 2023)
Horse0 reports

No chart: no month has 5 or more reports.

Other or not given40 reports

No chart: no month has 5 or more reports.

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name tiletamine hydrochloride + zolazepam hydrochloride, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
202614160434
202529410676
202425380972
202331570896
2022312401065
202134350675
202016130231
201921170543
201839170561
2017221401046
201633230561
201522210447
201430115
2013440513
201233360473
20114047016103
20105242016110
20093756022115
2008373401485
20074143022106
2006327208112
2005384601094
20044856114119
20035172020143
20022867010105
2001304401690
20003062017109
19993063017110
19984860016124
19975573011139
1996466707120
1995496005114
199442450794
1993456505115
199225340261
199120380159
199015330149
198924320157
19881080018

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal10.1%317
  • Recovered with Sequela[recovered, with a lasting effect]0.1%2
  • Ongoing1.7%55
  • Died27.4%864
  • Euthanized4.8%150
  • Outcome Unknown2.7%84

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 3,149 reports that name tiletamine hydrochloride + zolazepam hydrochloride.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue84.7%2,668
  • Lack of expected effectiveness4.3%134
  • Both safety and lack of expected effectiveness4.8%152
  • Manufacturing or product defect6.2%195
  • Other0%0

684 reports say if the event was serious. 72.8% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year24.2%761
  • 1 to 3 years14.6%461
  • 4 to 7 years10.6%335
  • 8 to 11 years7.5%235
  • 12 years and over5%159
  • Age not given38%1,198

Weight of the animal

  • Under 5 kg (11 lb)31.5%991
  • 5 to 9.9 kg (11 to 22 lb)9.1%288
  • 10 to 24.9 kg (22 to 55 lb)7.7%243
  • 25 to 44.9 kg (55 to 99 lb)9.2%289
  • 45 kg and over (99 lb and over)2.4%77
  • Weight not given40%1,261

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Intramuscular52.3%1,648
  • Intravenous23.8%751
  • Subcutaneous2.1%65
  • Parenteral0.9%27
  • Other0.8%24
  • Oral0.2%6

Each bar is on a scale of 0 to 100%.

Approved animal drugs with these active ingredients (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • Telazol
  • Tzed
  • Zoletil

What the Green Book records give

Applications with an approval in force
3
Approved species
Cats, Dogs
Dose forms
Injectable Solution
Routes
Intravenous, Intramuscular
Sale
RX (prescription)
Earliest approval date in the records

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
TelazolTiletamine Hydrochloride, Zolazepam HydrochlorideZoetis Inc.Dogs, CatsNADA 106-111
TzedTiletamine Hydrochloride, Zolazepam HydrochlorideDechra Veterinary Products LLCDogs, CatsANADA 200-557
ZoletilTiletamine Hydrochloride, Zolazepam HydrochlorideVirbac AH, Inc.Dogs, CatsANADA 200-618

Other pages with one of these ingredients

A report names a drug by its set of active ingredients. Each set has its own page. The list is in order of name.

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Tiletamine Hydrochloride + Zolazepam Hydrochloride: adverse event reports that FDA received. https://petdrugreports.com/drug/tiletamine-hydrochloride-zolazepam-hydrochloride/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

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Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with these active ingredients.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 74 reports in the 12 months to June 2026. It received 66 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 3,149 reports received from March 1988 to June 2026, 84.7% are about a safety issue only. 9.1% are about a lack of expected effectiveness, alone or with a safety issue. 6.2% are about a defect of the product or its package.