Emesis (multiple): in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: vomiting more than once.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From October 2004 to June 2026, FDA received 19,851 adverse event reports for animal drugs that list this sign. That is 1.4% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 2,109 reports that list this sign.

Of the 19,851 reports, 87.9% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 27 of 1,149 clinical signs with a page. Reports that list this sign rose by 18.1% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 87.9% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 97 drug pages.

Show the 97 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	50
Acepromazine Maleate	22
Afoxolaner	518
Afoxolaner + Moxidectin + Pyrantel Pamoate	57
Amoxicillin	36
Amoxicillin + Clavulanate Potassium	29
Amoxicillin Trihydrate + Clavulanate Potassium	67
Atinvicitinib	34
Atipamezole Hydrochloride	32
Bedinvetmab	541
Bexagliflozin	58
Buprenorphine	50
Butorphanol Tartrate	90
Capromorelin	64
Carprofen	354
Cefovecin sodium	154
Cefpodoxime proxetil	65
Cephalexin	56
Clindamycin	23
Cyclosporine	360
Deracoxib	132
Dexamethasone	85
Dexamethasone Sodium Phosphate	56
Dexmedetomidine	29
Dexmedetomidine hydrochloride	26
Diphenhydramine	228
Doxycycline	76
Emodepside + Praziquantel	125
Enalapril Maleate	30
Enrofloxacin	105
Estriol	66
Famotidine	106
Febantel + Praziquantel + Pyrantel Pamoate	691
Fenbendazole	54
Firocoxib	36
Florfenicol + Mometasone furoate + Terbinafine	133
Fluoxetine hydrochloride	38
Fluralaner	6,336
Fluralaner + Moxidectin	204
Frunevetmab	212
Furosemide	27
Gabapentin	290
Grapiprant	132
Ilunocitinib	38
Imidacloprid	173
Imidacloprid + Moxidectin	374
Insulin	255
Isoflurane	44
Ivermectin	141
Ivermectin + Praziquantel + Pyrantel Pamoate	47
Ivermectin + Pyrantel Pamoate	1,094
Ketoconazole	71
Levothyroxine sodium	52
Lotilaner	220
Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate	148
Lufenuron + Milbemycin Oxime	404
Lufenuron + Milbemycin Oxime + Praziquantel	253
Lufenuron + Praziquantel	59
Maropitant	578
Melarsomine Dihydrochloride	104
Meloxicam	92
Methimazole	34
Metoclopramide	36
Metronidazole	135
Midazolam	26
Milbemycin Oxime	124
Milbemycin Oxime + Praziquantel	389
Milbemycin Oxime + Spinosad	2,514
Mirtazapine	37
Molidustat	20
Moxidectin	589
Moxidectin + Pyrantel Pamoate + Sarolaner	28
Nitenpyram	225
Oclacitinib	360
Omeprazole	48
Ondansetron	56
Orbifloxacin	33
Phenobarbital	24
Phenylpropanolamine hydrochloride	63
Pimobendan	68
Polysulfated Glycosaminoglycan	82
Praziquantel	116
Praziquantel + Pyrantel Pamoate	168
Prednisolone	56
Prednisone	206
Propofol	28
Pyrantel Pamoate	95
Pyrantel Pamoate + Sarolaner	1,081
Robenacoxib	61
Sarolaner	167
Sarolaner + Selamectin	96
Selamectin	116
Spinosad	934
Sucralfate	46
Tramadol	78
Trazodone	59
Trilostane	73

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 93 ingredients.

Show the 93 ingredients

Reports by species

Dog87.9%17,453
Cat11.9%2,372
Human exposure0.1%19
Pigunder 0.1%2
Dormouseunder 0.1%1
Wolfunder 0.1%1

The share is of the 19,851 reports that list this sign. The sign is in 1.7% of all reports about the species dog. The sign is in 1.6% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Emesis (multiple), by the year in which FDA received them
Year	Reports
2026	1,108
2025	1,885
2024	2,004
2023	1,137
2022	1,181
2021	1,405
2020	1,628
2019	1,480
2018	1,732
2017	1,603
2016	1,169
2015	1,008
2014	1,101
2013	978
2012	407
2011	10
2009	2
2006	2
2005	9
2004	2

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal49.8%9,882, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]1.6%313, All reports: 2.3%
Ongoing26.1%5,184, All reports: 17.4%
Died2.1%425, All reports: 4.9%
Euthanized3.1%614, All reports: 1.5%
Outcome Unknown17.3%3,442, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 19,851 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year16%3,168, All reports: 9.5%
1 to 3 years29.3%5,818, All reports: 23.9%
4 to 7 years23.6%4,683, All reports: 20.2%
8 to 11 years17.3%3,435, All reports: 15.4%
12 years and over11%2,192, All reports: 10.7%
Age not given2.8%555, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Elevated total bilirubin[bilirubin above the normal range]
Elevated triglyceride
Embolism
Emesis[vomiting]
Enlarged liver
Enlarged lymph node (localised)
Enlarged lymph nodes (generalised)
Enteritis

All clinical signs

Cite this page

Pet Drug Reports. Emesis (multiple): adverse event reports for animal drugs. https://petdrugreports.com/reaction/emesis-multiple/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: In plain words: vomiting more than once. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 2,109 reports in the 12 months to June 2026. It received 1,786 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 19,722 reports that say if the event was serious, 46.1% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices