Bloody diarrhoea: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: diarrhea with blood.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From February 1987 to June 2026, FDA received 14,463 adverse event reports for animal drugs that list this sign. That is 1.1% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 630 reports that list this sign.

Of the 14,463 reports, 94.7% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 37 of 1,149 clinical signs with a page. Reports that list this sign fell by 6.1% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 94.7% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 105 drug pages.

Show the 105 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	44
Acepromazine Maleate	43
Afoxolaner	712
Afoxolaner + Moxidectin + Pyrantel Pamoate	88
Amoxicillin	63
Amoxicillin + Clavulanate Potassium	23
Amoxicillin Trihydrate + Clavulanate Potassium	37
Atipamezole Hydrochloride	98
Bedinvetmab	222
Buprenorphine	88
Butorphanol Tartrate	187
Capromorelin	34
Carprofen	1,614
Cefovecin sodium	127
Cefpodoxime proxetil	57
Cephalexin	31
Clindamycin	20
Clomipramine Hydrochloride	24
Cyclosporine	289
Deracoxib	549
Desoxycorticosterone Pivalate	42
Dexamethasone	127
Dexamethasone Sodium Phosphate	28
Dexmedetomidine	63
Dexmedetomidine hydrochloride	84
Dextrose	22
Diazepam	27
Diphenhydramine	197
Dirlotapide	26
Doxycycline	52
Enrofloxacin	76
Etodolac	257
Famotidine	154
Febantel + Praziquantel + Pyrantel Pamoate	110
Fenbendazole	110
Firocoxib	316
Florfenicol + Mometasone furoate + Terbinafine	20
Fluralaner	833
Frunevetmab	27
Gabapentin	273
Grapiprant	400
Hydromorphone	40
Ilunocitinib	24
Imidacloprid	49
Imidacloprid + Moxidectin	194
Insulin	74
Isoflurane	101
Ivermectin	131
Ivermectin + Praziquantel + Pyrantel Pamoate	82
Ivermectin + Pyrantel Pamoate	1,061
Ketamine Hydrochloride	44
Ketoconazole	28
Levothyroxine sodium	39
Lotilaner	144
Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate	62
Lufenuron + Milbemycin Oxime	393
Lufenuron + Milbemycin Oxime + Praziquantel	83
Lufenuron + Praziquantel	56
Maropitant	644
Meclofenamic Acid	23
Medetomidine	23
Melarsomine Dihydrochloride	652
Meloxicam	476
Methylprednisolone Acetate	20
Metoclopramide	41
Metronidazole	314
Midazolam	48
Milbemycin Oxime	377
Milbemycin Oxime + Praziquantel	318
Milbemycin Oxime + Spinosad	800
Monensin	97
Moxidectin	1,016
Moxidectin + Pyrantel Pamoate + Sarolaner	25
Nitenpyram	125
Oclacitinib	330
Omeprazole	50
Ondansetron	42
Pimobendan	68
Polysulfated Glycosaminoglycan	162
Praziquantel	30
Praziquantel + Pyrantel Pamoate	207
Prednisolone	40
Prednisolone + Trimeprazine Tartrate	41
Prednisone	210
Propofol	73
Pyrantel Pamoate	147
Pyrantel Pamoate + Sarolaner	451
Rabacfosadine	28
Robenacoxib	28
Sarolaner	200
Selamectin	408
Selegiline Hydrochloride	48
Sevoflurane	32
Spinosad	330
Sucralfate	110
Sulfadimethoxine	30
Tepoxalin	103
Tigilanol tiglate	59
Toceranib Phosphate	43
Tramadol	149
Trazodone	64
Triamcinolone Acetonide	24
Trilostane	211
Ursodiol	22
Vitamin E	21

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 99 ingredients.

Show the 99 ingredients

Reports by species

Dog94.7%13,694
Cat3.7%536
Cattle1.1%159
Pig0.2%26
Horse0.1%17
Chicken0.1%9

The share is of the 14,463 reports that list this sign. The sign is in 1.4% of all reports about the species dog. The sign is in 0.4% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Bloody diarrhoea, by the year in which FDA received them
Year	Reports
2026	319
2025	657
2024	640
2023	583
2022	588
2021	556
2020	623
2019	599
2018	725
2017	816
2016	740
2015	645
2014	563
2013	576
2012	578
2011	540
2010	459
2009	521
2008	472
2007	472
2006	388
2005	355
2004	446
2003	287
2002	224
2001	184
2000	281
1999	254
1998	143
1997	74
1996	39
1995	16
1994	12
1993	6
1992	16
1991	10
1990	7
1989	12
1988	19
1987	18

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal18.9%2,728, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]1%142, All reports: 2.3%
Ongoing19.8%2,868, All reports: 17.4%
Died10.5%1,524, All reports: 4.9%
Euthanized3.1%454, All reports: 1.5%
Outcome Unknown18%2,604, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 14,463 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year11.7%1,694, All reports: 9.5%
1 to 3 years24.9%3,607, All reports: 23.9%
4 to 7 years24%3,466, All reports: 20.2%
8 to 11 years21.5%3,109, All reports: 15.4%
12 years and over13.3%1,920, All reports: 10.7%
Age not given4.6%667, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Blood in urine
Blood in vomit
Blood loss NOS[NOS: not otherwise specified]
Bloodshot eye
Bloody stool
Bone and joint disorder NOS[NOS: not otherwise specified]
Bottles, Damaged[a product quality report, not a sign in an animal]
Bradycardia[slow heart rate]

All clinical signs

Cite this page

Pet Drug Reports. Bloody diarrhoea: adverse event reports for animal drugs. https://petdrugreports.com/reaction/bloody-diarrhoea/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: In plain words: diarrhea with blood. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 630 reports in the 12 months to June 2026. It received 671 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 9,094 reports that say if the event was serious, 60.9% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices