Breed · Dog

Collie: adverse event reports

FDA breed label "Collie (unspecified)" · single-breed animals only

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

3,442reports, 1987–20260.4% of dog reports

80reports, 12 months to March 2026119 in the 12 months before

39%classed serious, as reportedall dogs: 38.3%

10%name milbemycin oxime + spinosadall dogs: 13.1%

3,442 adverse event reports received by FDA describe an animal recorded as Collie (FDA breed label "Collie (unspecified)"). That is 0.4% of all reports about dogs. Crossbred animals are not counted here, only reports that give this single breed.

80 reports arrived in the 12 months to March 2026, down 33% from 119 in the 12 months before. A breed's count mostly mirrors how common the breed is; registration and ownership figures by breed are not public data, so no per-animal rate can be given.

By active ingredient, the drugs named most often are milbemycin oxime + spinosad, ivermectin + pyrantel pamoate and carprofen. Milbemycin Oxime + Spinosad is named in 10% of this breed's reports, a smaller share than in reports about all dogs (13.1%).

The terms listed most often are vomiting (17.8%), diarrhoea (10.2%) and ataxia (7.8%). Vomiting appears in 17.8% of reports, about the same share as in all dog reports (19.7%). 39% of reports stating seriousness were classed as serious, against 38.3% for dogs overall.

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of Collie reports	Share of all dog reports
Milbemycin Oxime + Spinosad	344	10%	13.1%
Ivermectin + Pyrantel Pamoate	314	9.1%	14.9%
Carprofen	311	9%	4.8%
Ivermectin	255	7.4%	1.3%
Milbemycin Oxime	254	7.4%	3%
Spinosad	179	5.2%	5.8%
Selamectin	176	5.1%	3%
Afoxolaner	166	4.8%	5.7%
Lufenuron + Milbemycin Oxime	150	4.4%	2.7%
Fluralaner	140	4.1%	6.7%
Moxidectin	105	3.1%	5%
Deracoxib	78	2.3%	1.1%
Milbemycin Oxime + Praziquantel	75	2.2%	3.1%
Pyrantel Pamoate + Sarolaner	72	2.1%	5.1%
Melarsomine Dihydrochloride	67	1.9%	2.3%
Imidacloprid + Moxidectin	61	1.8%	1.3%
Meloxicam	56	1.6%	0.8%
Firocoxib	52	1.5%	0.8%
Bedinvetmab	47	1.4%	1.9%
Sarolaner	46	1.3%	1.7%

Ordered by report count. Differences from the species column often come from body size (which drugs a breed is prescribed) and from how common the breed was in the years a drug sold most. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed in reports

share of Collie reports listing the termall dog reports

Vomiting17.8%612
Diarrhoea[diarrhea]10.2%352
Ataxia[unsteady, uncoordinated movement]7.8%267
Anorexia[not eating]7.7%264
Depression[dull, quiet or withdrawn]7.6%260
Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]7%240
Death6.7%229
Emesis[vomiting]6.3%218
Lethargy[unusually tired or inactive]5.8%199
Hypersalivation[drooling]4.2%146
Death by euthanasia[the animal was euthanized]4%138
Convulsion[seizure]3.8%132
Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]3.6%125
Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]3.2%110
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]3.1%107
Lack of efficacy - NOS[the product did not have the expected effect]3.1%105
Seizure NOS[seizure, type not specified]3%103
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]2.5%86
Fever2.3%78
Polydipsia[drinking more than usual]2.1%74
Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]2.1%72
Weakness2.1%71
Recumbency[lying down and unable or unwilling to rise]2%70
Trembling2%70
Accidental exposure[exposure that was not intended]2%68

Age and weight

Age of the animal

Under 1 year8.6%295

1 to 3 years24.2%834

4 to 7 years25.8%889

8 to 11 years24.5%843

12 years and over11.7%401

Age not given5.2%180

Weight of the animal

Under 5 kg (11 lb)0.8%26

5 to 9.9 kg (11–22 lb)1.7%58

10 to 24.9 kg (22–55 lb)32.2%1,107

25 to 44.9 kg (55–99 lb)56.6%1,949

45 kg and over (99 lb+)2.6%88

Weight not given6.2%214

Coloured bar: Collie reports. Grey bar: all dog reports.

Trend and outcomes

Reports by month FDA received them. The newest months are incomplete because FDA posts reports with a delay of three to six months.

Outcome recorded in the report

Recovered/Normal20.7%711

Recovered with Sequela1.9%66

Ongoing11.1%382

Died9.8%338

Euthanized1.2%43

Outcome Unknown15.9%546

Beside all dogs

Measure	Collie	All dogs
Reports	3,442	985,675
Latest 12 months	80	53,292
Classed serious, of reports stating it	39%	38.3%
Death or euthanasia recorded, per 1,000 reports	110.7	55

Questions about Collie reports

How many FDA adverse event reports involve Collies?

3,442 reports through March 2026, 0.4% of reports about dogs; 80 in the latest 12 months.

Which drugs are named most often in Collie reports?

By active ingredient: milbemycin oxime + spinosad (344), ivermectin + pyrantel pamoate (314), carprofen (311), ivermectin (255) and milbemycin oxime (254). Brands are masked in the public data.

What signs are reported most for this breed?

vomiting (17.8%), diarrhoea (10.2%), ataxia (7.8%), anorexia (7.7%) and depression (7.6%).

Is the Collie more sensitive to certain drugs?

Report counts cannot answer that. They show what was reported, not what a drug did, and they are not adjusted for how many Collie animals exist or were treated. Breed-related drug sensitivities that are established are described on FDA-approved labels; a veterinarian is the person to ask about an individual animal.

Why are crossbreds not included?

FDA records crossbred animals with one or more component breeds. Counting them under each component would double count, so breed pages use single-breed reports only. Crossbreds remain in the species totals.

How do I report a problem?

Call the drug company using the number on the label, or send Form FDA 1932a to FDA. See the guide on how to report.

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. Breed names are FDA's labels rearranged into everyday order ("Collie (unspecified)" becomes "Collie"). No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.