Pet Drug Reports

Eprinomectin: adverse event reports in all combinations

Active ingredient, alone and in combinations

Brand names with this ingredient: Centragard, NexGard Combo, Eprinex, Longrange, Eprizero, Eprimectin Pour-On, and 1 more.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

FDA reports received through . Counts include this ingredient alone and in combinations. Why brand names have no separate count.

From June 1997 to June 2026, FDA received 6,344 adverse event reports that name a drug with eprinomectin, alone or in a combination. 3 sets of active ingredients with eprinomectin have a drug page.

Of the 6,344 reports, 3,856 (60.8%) are about cats. 1,507 reports are about cattle (23.8%). In January to March 2026, FDA received 245 reports that name eprinomectin, alone or in a combination. The signs that appear in the largest number of the 6,344 reports are "Lethargy", "Vomiting" and "Death". A report is not proof that a drug caused a sign.

Reports that name this ingredient fell by 10.0% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 2% of the reports that name this ingredient, and 72.6% of all reports.

Reports in the latest closed quarter

Reports that name eprinomectin, by the quarter in which FDA received them
SpeciesJan to Mar 2026Oct to Dec 2025Jan to Mar 2025
All species245310198
Dog120
Cat224285187
Horse000
Other or not given202311

January to March 2026 is the latest closed quarter in the data.

All updatesFeed of updates (RSS)

Drug pages with eprinomectin

A report names a drug by its set of active ingredients. Each set with eprinomectin that has a drug page is in the table, in order of name. The table has 3 sets.

Drug pages with eprinomectin, in order of name, with the reports of each page
Active ingredientsReports, all yearsReports, latest 12 months
Eprinomectin2,26936
Eprinomectin + Esafoxolaner + Praziquantel3,4451,062
Eprinomectin + Praziquantel6295

A report can name more than one set, so the counts of the sets can add to more than the count of the page.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 6,344 reports that list the sign. One report can list more than one sign and more than one drug.

The sign that is in the largest number of the reports comes first.

  1. Lethargy[unusually tired or inactive]10.2%644 reports
  2. Vomiting8.4%535 reports
  3. Death7.2%459 reports
  4. Hypersalivation[drooling]6.7%425 reports
  5. Accidental exposure[exposure that was not intended]5.9%376 reports
  6. Application site hair loss[hair loss where the product was applied]5.2%330 reports
  7. Foaming at the mouth5.2%328 reports
  8. Ataxia[unsteady, uncoordinated movement]4.6%293 reports
  9. Drooling4.2%268 reports
  10. Lack of efficacy (ectoparasite) - lice[the product did not have the expected effect: lice]4%254 reports
  11. Not eating3.9%248 reports
  12. Lack of efficacy (endoparasite) - tapeworm[the product did not have the expected effect: tapeworms]3.8%239 reports
  13. Lack of efficacy (endoparasite) - roundworm NOS[the product did not have the expected effect: roundworms]3.5%224 reports
  14. Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]3.4%215 reports
Show the next 16 signs
  1. Lack of efficacy - NOS[the product did not have the expected effect]3.2%200 reports
  2. Diarrhoea[diarrhea]2.9%183 reports
  3. Death by euthanasia[the animal was euthanized]2.8%178 reports
  4. Behavioural disorder NOS[behaviour change, type not specified]2.4%153 reports
  5. Anorexia[not eating]2.4%152 reports
  6. Seizure NOS[seizure, type not specified]2.3%149 reports
  7. Dilated pupils2.2%142 reports
  8. Hiding2.2%140 reports
  9. Lack of efficacy (endoparasite) - NOS[the product did not have the expected effect: target not specified]2.1%133 reports
  10. Tremor2.1%131 reports
  11. Pruritus[itching]1.8%117 reports
  12. Scratching1.8%112 reports
  13. Fever1.7%105 reports
  14. Hair loss NOS[NOS: not otherwise specified]1.6%100 reports

Download all signs (CSV)

Reports by species

Reports for each month, Jul 2021 to Jun 2026

Dog25 reports

No chart: no month has 5 or more reports.

Cat3,459 reports. Largest count in one month: 158 (Aug 2024)
Horse0 reports

No chart: no month has 5 or more reports.

Other or not given459 reports. Largest count in one month: 18 (Apr 2022)

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name eprinomectin, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
20262418038458
202551,0640831,152
202481,23001171,355
20238635098741
2022166086153
2021198084183
202021350144281
201951531139298
20182400127169
2017310133137
2016301189193
2015810172181
20141110148160
2013330131137
20125106167
20118127586
20107016472
20098006977
20087224758
20072203741
20066105966
20053107579
20048104857
20036104552
20021002122
200110023
200010179
19990003636
19980101415
199700066

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal20.1%1,272
  • Recovered with Sequela[recovered, with a lasting effect]0.4%27
  • Ongoing6.3%397
  • Died8%506
  • Euthanized2.6%163
  • Outcome Unknown48.1%3,050

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 6,344 reports that name eprinomectin.

Kind of report

  • Safety issue64.7%4,107
  • Lack of expected effectiveness23.3%1,477
  • Both safety and lack of expected effectiveness1.7%110
  • Manufacturing or product defect10.2%646
  • Other0.1%4

Age of the animal

  • Under 1 year20.3%1,288
  • 1 to 3 years20.4%1,297
  • 4 to 7 years11.4%723
  • 8 to 11 years6.9%438
  • 12 years and over7.3%462
  • Age not given33.7%2,136

Each share of kind and age is of the 6,344 reports that name eprinomectin.

Approved animal drugs with this active ingredient (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • Centragard
  • NexGard Combo
  • Eprinex
  • Longrange
  • Eprizero
  • Eprimectin Pour-On
  • EpriGard

What the Green Book records give

Applications with an approval in force
7
Approved species
Cattle, Cats
Dose forms
Topical Solution, Liquid, Liquid (Solution), Transdermal Solution
Routes
Topical, Subcutaneous, Transdermal
Sale
OTC (over the counter), RX (prescription)
Earliest approval date in the records

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
EprinexEprinomectinBoehringer Ingelheim Animal Health USA, Inc.CattleNADA 141-079
LongrangeEprinomectinBoehringer Ingelheim Animal Health USA, Inc.CattleNADA 141-327
CentragardEprinomectin, PraziquantelBoehringer Ingelheim Animal Health USA, Inc.CatsNADA 141-492
NexGard ComboEprinomectin, Esafoxolaner, PraziquantelBoehringer Ingelheim Animal Health USA, Inc.CatsNADA 141-570
EprizeroEprinomectinNorbrook Laboratories, Ltd.CattleANADA 200-563
Eprimectin Pour-OnEprinomectinBimeda Animal Health Ltd.CattleANADA 200-626
EpriGardEprinomectinAurora Pharmaceutical, Inc.CattleANADA 200-741

FDA pages for this ingredient

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Eprinomectin, all combinations: adverse event reports that FDA received. https://petdrugreports.com/ingredient/eprinomectin/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

Embed this card on your site

Copy this code into your page. The card shows the figures above with their source. A line under the card links to this page.

How embedding works. It is free. Keep the link in the card and the link line under it.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. Ingredient names follow the Green Book, with salts and forms as FDA lists them.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists brand names with this active ingredient.

Do the reports show that the ingredient caused the signs?

No. A report can name more than one drug, and a drug can have more than one active ingredient. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 1,103 reports in the 12 months to June 2026. It received 1,225 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 6,344 reports received from June 1997 to June 2026, 64.7% are about a safety issue only. 25% are about a lack of expected effectiveness, alone or with a safety issue. 10.2% are about a defect of the product or its package.