Pet Drug Reports

Prednisolone + Trimeprazine Tartrate (Temaril-P)adverse event reports that FDA received

Combination of 2 active ingredients

The name in brackets is a brand name with these active ingredients.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From February 1991 to June 2026, FDA received 2,092 adverse event reports that name a drug with prednisolone and trimeprazine tartrate as its active ingredients. Of the 2,092 reports, 1,970 (94.2%) are about dogs.

In January to March 2026, FDA received 8 reports that name this drug. The signs that appear in the largest number of the 2,092 reports are "Lack of efficacy - NOS", "Vomiting" and "Emesis". A report is not proof that a drug caused a sign.

Reports that name this drug fell by 10.2% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 94.2% of the reports that name this drug, and 72.6% of all reports.

Since the last update of the FDA data

The latest update of the FDA data, recorded on , changed no count of this page.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 8 reports that name prednisolone + trimeprazine tartrate: 8 dog, 0 cat, 0 horse, 0 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 2,092 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Lack of efficacy - NOS[the product did not have the expected effect]14.1%294 reports
  2. Vomiting12.6%264 reports
  3. Emesis[vomiting]10.4%218 reports
  4. Lethargy[unusually tired or inactive]10%210 reports
  5. Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]7.4%154 reports
  6. Diarrhoea[diarrhea]6.6%139 reports
  7. Anorexia[not eating]6.4%134 reports
  8. Polydipsia[drinking more than usual]5.7%119 reports
  9. Other abnormal test result NOS[abnormal laboratory result, type not specified]5.4%112 reports
  10. Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]5.1%107 reports
  11. Ineffective, loss of effect[legacy FDA term: the product did not have the expected effect (loss of effect)]5.1%106 reports
  12. Polyuria[passing more urine than usual]5.1%106 reports
  13. Ineffective, atopy control[legacy FDA term: the product did not have the expected effect (atopy control)]4.2%88 reports
  14. Depression[dull, quiet or withdrawn]4%83 reports
Show the next 16 signs
  1. Death by euthanasia[the animal was euthanized]3.8%80 reports
  2. Death3.7%77 reports
  3. Seizure NOS[seizure, type not specified]3.3%68 reports
  4. Abnormal radiograph finding3.2%66 reports
  5. Behavioural disorder NOS[behaviour change, type not specified]3.2%66 reports
  6. Ataxia[unsteady, uncoordinated movement]3.1%65 reports
  7. Fever3.1%65 reports
  8. Cough2.9%61 reports
  9. Anaemia NOS[low red blood cell count]2.7%57 reports
  10. Elevated liver enzymes[liver enzymes above the normal range]2.7%56 reports
  11. Ineffective, antiinflammatory[legacy FDA term: the product did not have the expected effect (antiinflammatory)]2.6%55 reports
  12. Elevated blood urea nitrogen (BUN)[a kidney value above the normal range]2.6%54 reports
  13. Leucocytosis NOS[high white blood cell count]2.5%52 reports
  14. Weight loss2.4%51 reports
  15. Panting2.2%47 reports
  16. Pruritus[itching]2.2%47 reports

The list shows 30 of 986 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

  • Dog94.2%1,970
  • Cat0.8%17
  • Human exposure0.7%15
  • Other0.1%2

The share is of all 2,092 reports that name prednisolone + trimeprazine tartrate. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog180 reports. Largest count in one month: 8 (Oct 2025)
Cat1 report

No chart: no month has 5 or more reports.

Horse0 reports

No chart: no month has 5 or more reports.

Other or not given9 reports

No chart: no month has 5 or more reports.

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name prednisolone + trimeprazine tartrate, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
20261800018
20254100243
20244900352
20232910030
20222900231
20213000333
20205100253
20194200446
20188500792
2017138005143
2016203101205
2015285003288
2014249105255
2013180109190
2012189306198
20115900463
20103210235
200940301154
20084420248
200741101355
20063700239
20052100324
20041600117
2003700310
200280019
2001710311
20001000111
19991110113
1998600410
199750005
199630003
199501012
199420013
199210001
199120002

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal21.7%454
  • Recovered with Sequela[recovered, with a lasting effect]2%41
  • Ongoing34.7%726
  • Died4.8%101
  • Euthanized3%63
  • Outcome Unknown14.3%300

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 2,092 reports that name prednisolone + trimeprazine tartrate.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue74.1%1,550
  • Lack of expected effectiveness10.4%218
  • Both safety and lack of expected effectiveness10.1%211
  • Manufacturing or product defect5.4%113
  • Other0%0

1,643 reports say if the event was serious. 25.1% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year4%83
  • 1 to 3 years18.2%381
  • 4 to 7 years28.7%600
  • 8 to 11 years26.2%548
  • 12 years and over14.1%295
  • Age not given8.8%185

Weight of the animal

  • Under 5 kg (11 lb)13.1%275
  • 5 to 9.9 kg (11 to 22 lb)27.4%574
  • 10 to 24.9 kg (22 to 55 lb)25%522
  • 25 to 44.9 kg (55 to 99 lb)21.7%455
  • 45 kg and over (99 lb and over)2.8%59
  • Weight not given9.9%207

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Oral85.3%1,784
  • Subcutaneous0.1%3
  • Ophthalmic0.1%2
  • Topicalunder 0.1%1

Each bar is on a scale of 0 to 100%.

Approved animal drugs with these active ingredients (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • Temaril-P

What the Green Book records give

Applications with an approval in force
3
Approved species
Dogs
Dose forms
Capsule, Tablet
Routes
Oral
Sale
RX (prescription)
Earliest approval date in the records

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
Temaril-P TabletsPrednisolone, Trimeprazine TartrateZoetis Inc.DogsNADA 012-437
Temaril-P Spansule Capsule No. 1; Temaril-P Spansule Capsule No. 2Prednisolone, Trimeprazine TartrateZoetis Inc.DogsNADA 035-161
Trimeprazine with PrednisolonePrednisolone, Trimeprazine TartrateZyVet Animal Health, Inc.DogsANADA 200-784

Other pages with one of these ingredients

A report names a drug by its set of active ingredients. Each set has its own page. The list is in order of name.

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Prednisolone + Trimeprazine Tartrate: adverse event reports that FDA received. https://petdrugreports.com/drug/prednisolone-trimeprazine-tartrate/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

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Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with these active ingredients.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 44 reports in the 12 months to June 2026. It received 49 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 2,092 reports received from February 1991 to June 2026, 74.1% are about a safety issue only. 20.5% are about a lack of expected effectiveness, alone or with a safety issue. 5.4% are about a defect of the product or its package.