Pet Drug Reports

Propofol (Rapanofal, PropoFlo)adverse event reports that FDA received

Active ingredient

Also sold as: Rapanofal, PropoFlo, PropoClear, PropofolVet Multidose.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From March 1997 to June 2026, FDA received 4,895 adverse event reports that name a drug with propofol as its active ingredient. Of the 4,895 reports, 3,072 (62.8%) are about dogs. 1,170 reports are about cats (23.9%).

In January to March 2026, FDA received 149 reports that name this drug. The signs that appear in the largest number of the 4,895 reports are "Death", "Lethargy" and "Cardiac arrest". A report is not proof that a drug caused a sign.

Reports that name this drug fell by 19.2% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cats are 23.9% of the reports that name this drug, and 11% of all reports.

Since the last update of the FDA data

The site recorded an update of the FDA data on . FDA changed these counts for January to March 2026:

  • All species: from 131 to 149.
  • Dog: from 36 to 50.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 149 reports that name propofol: 50 dog, 48 cat, 0 horse, 51 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 4,895 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Death13.2%648 reports
  2. Lethargy[unusually tired or inactive]8.4%409 reports
  3. Cardiac arrest7.5%369 reports
  4. Color, Abnormal[a product quality report, not a sign in an animal]7.4%363 reports
  5. Bradycardia[slow heart rate]7.3%358 reports
  6. Vomiting7%344 reports
  7. Ineffective, anesthesia[legacy FDA term: the product did not have the expected effect (anesthesia)]6.6%324 reports
  8. Apnoea[breathing stopped]6%294 reports
  9. Lack of efficacy - NOS[the product did not have the expected effect]5.6%274 reports
  10. Anorexia[not eating]4.7%229 reports
  11. Not eating4.5%222 reports
  12. Death by euthanasia[the animal was euthanized]4.5%218 reports
  13. Seizure NOS[seizure, type not specified]4.4%214 reports
  14. Diarrhoea[diarrhea]4%194 reports
Show the next 16 signs
  1. Tachycardia[fast heart rate]3.9%190 reports
  2. Behavioural disorder NOS[behaviour change, type not specified]3.8%187 reports
  3. Fever3.6%176 reports
  4. Other abnormal test result NOS[abnormal laboratory result, type not specified]3.3%160 reports
  5. Hypotension[low blood pressure]3.2%156 reports
  6. Cyanosis[bluish gums or skin from low oxygen]3.1%154 reports
  7. Pale mucous membrane[pale gums]3%146 reports
  8. Vocalisation[crying out or unusual noise]2.9%144 reports
  9. Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]2.7%132 reports
  10. Decreased appetite2.6%128 reports
  11. Hypothermia[low body temperature]2.6%128 reports
  12. Convulsion[seizure]2.6%127 reports
  13. Elevated blood urea nitrogen (BUN)[a kidney value above the normal range]2.6%125 reports
  14. Recovery prolonged2.5%123 reports
  15. Contamination, Foreign Object2.5%120 reports
  16. Ataxia[unsteady, uncoordinated movement]2.4%117 reports

The list shows 30 of 1,457 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

  • Dog62.8%3,072
  • Cat23.9%1,170
  • Other0.4%22
  • Human exposure0.3%13
  • Pig0.1%4
  • Turtle0.1%4

The share is of all 4,895 reports that name propofol. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog1,177 reports. Largest count in one month: 98 (Dec 2024)
Cat718 reports. Largest count in one month: 30 (Dec 2024)
Horse0 reports

No chart: no month has 5 or more reports.

Other or not given283 reports. Largest count in one month: 28 (Feb 2026)

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name propofol, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
202611479074267
2025303146064513
2024323186060569
2023206182036424
2022172113040325
202113029065224
202014315026184
201912927062218
201813830081249
201714733031211
201612430032186
201510943111164
2014952103119
20131523406192
20121604004204
2011872102110
2010512611593
200974110186
2008821702101
20078070289
200660260490
200547150668
200428150144
20032480032
20021760023
200112101124
20001610219
19991600117
19982580235
1997800715

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal25.2%1,233
  • Recovered with Sequela[recovered, with a lasting effect]0.3%13
  • Ongoing17.4%850
  • Died14.8%723
  • Euthanized4.2%204
  • Outcome Unknown10.1%493

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 4,895 reports that name propofol.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue79.6%3,897
  • Lack of expected effectiveness3.5%170
  • Both safety and lack of expected effectiveness3.6%176
  • Manufacturing or product defect13.2%648
  • Other0.1%4

3,090 reports say if the event was serious. 65.8% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year12%587
  • 1 to 3 years15.3%751
  • 4 to 7 years20.4%999
  • 8 to 11 years19.2%941
  • 12 years and over8.1%396
  • Age not given24.9%1,221

Weight of the animal

  • Under 5 kg (11 lb)20.3%993
  • 5 to 9.9 kg (11 to 22 lb)19%928
  • 10 to 24.9 kg (22 to 55 lb)15.2%745
  • 25 to 44.9 kg (55 to 99 lb)16.2%795
  • 45 kg and over (99 lb and over)2.2%107
  • Weight not given27.1%1,327

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Intravenous63.9%3,130
  • Parenteral1.4%67
  • Other0.5%24
  • Subcutaneous0.4%20
  • Intramuscular0.1%6
  • Respiratory (Inhalation)0.1%3

Each bar is on a scale of 0 to 100%.

Approved animal drugs with this active ingredient (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • Rapanofal
  • PropoFlo
  • PropoClear
  • PropofolVet Multidose

What the Green Book records give

Applications with an approval in force
4
Approved species
Dogs, Cats
Dose forms
Liquid (Emulsion), Injectable emulsion, Microemulsion
Routes
Intravenous
Sale
RX (prescription)
Earliest approval date in the records

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
RapanofalPropofolIVAOES, INC. DBA IVAOES ANIMAL HEALTHDogs, CatsNADA 141-070
PropoFlo; PropoFlo 28PropofolZoetis Inc.DogsNADA 141-098
PropoClearPropofolZoetis Inc.Dogs, CatsNADA 141-303
PropofolVet MultidosePropofolParnell Technologies Pty. Ltd.DogsANADA 200-793

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Propofol: adverse event reports that FDA received. https://petdrugreports.com/drug/propofol/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

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Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with this active ingredient.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 491 reports in the 12 months to June 2026. It received 608 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 4,895 reports received from March 1997 to June 2026, 79.6% are about a safety issue only. 7.1% are about a lack of expected effectiveness, alone or with a safety issue. 13.2% are about a defect of the product or its package.