Pet Drug Reports

Insulin (ProZinc)adverse event reports that FDA received

Active ingredient

The name in brackets is a brand name with this active ingredient.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From October 2000 to June 2026, FDA received 13,716 adverse event reports that name a drug with insulin as its active ingredient. Of the 13,716 reports, 7,321 (53.4%) are about dogs. 3,682 reports are about cats (26.8%).

In January to March 2026, FDA received 252 reports that name this drug. The signs that appear in the largest number of the 13,716 reports are "Ineffective, glycemic control", "Hypoglycaemia" and "Lack of efficacy - NOS". A report is not proof that a drug caused a sign.

Reports that name this drug fell by 4.1% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 53.4% of the reports that name this drug, and 72.6% of all reports.

Since the last update of the FDA data

The site recorded an update of the FDA data on . FDA changed these counts for January to March 2026:

  • All species: from 150 to 252.
  • Dog: from 81 to 96.
  • Cat: from 61 to 72.
  • Other species or species not given: from 8 to 84.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 252 reports that name insulin: 96 dog, 72 cat, 0 horse, 84 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 13,716 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Ineffective, glycemic control[legacy FDA term: the product did not have the expected effect (glycemic control)]26%3,567 reports
  2. Hypoglycaemia[low blood sugar]14%1,914 reports
  3. Lack of efficacy - NOS[the product did not have the expected effect]13.3%1,821 reports
  4. Ineffective, loss of effect[legacy FDA term: the product did not have the expected effect (loss of effect)]7.8%1,069 reports
  5. Hyperglycaemia[high blood sugar]7.5%1,033 reports
  6. Lethargy[unusually tired or inactive]7%958 reports
  7. Vomiting7%957 reports
  8. Containers, Damaged[a product quality report, not a sign in an animal]5.9%811 reports
  9. Death by euthanasia[the animal was euthanized]5.3%726 reports
  10. Polydipsia[drinking more than usual]4.9%668 reports
  11. Vials, Damaged[a product quality report, not a sign in an animal]4.8%662 reports
  12. Suspension, Abnormal[a product quality report, not a sign in an animal]4.6%636 reports
  13. Polyuria[passing more urine than usual]4.5%623 reports
  14. Anorexia[not eating]4%546 reports
Show the next 16 signs
  1. Diarrhoea[diarrhea]3.7%505 reports
  2. Weight loss3.5%485 reports
  3. Decreased appetite3%406 reports
  4. Depression[dull, quiet or withdrawn]2.9%395 reports
  5. Seizure NOS[seizure, type not specified]2.6%356 reports
  6. Death2.4%332 reports
  7. Other abnormal test result NOS[abnormal laboratory result, type not specified]2.3%319 reports
  8. Appearance, Abnormal[a product quality report, not a sign in an animal]2.3%317 reports
  9. Not eating2.2%303 reports
  10. Ataxia[unsteady, uncoordinated movement]2%271 reports
  11. Emesis (multiple)[vomiting more than once]1.9%255 reports
  12. Elevated blood urea nitrogen (BUN)[a kidney value above the normal range]1.8%251 reports
  13. Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]1.8%250 reports
  14. Urinary tract infection1.7%238 reports
  15. Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]1.7%235 reports
  16. Behavioural disorder NOS[behaviour change, type not specified]1.7%233 reports

The list shows 30 of 1,522 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

  • Dog53.4%7,321
  • Cat26.8%3,682
  • Human exposure0.6%84
  • Horseunder 0.1%2
  • Otherunder 0.1%1
  • Other Porcineunder 0.1%1

The share is of all 13,716 reports that name insulin. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog1,867 reports. Largest count in one month: 45 (Jan 2025)
Cat1,118 reports. Largest count in one month: 33 (Feb 2024)
Horse2 reports

No chart: no month has 5 or more reports.

Other or not given980 reports. Largest count in one month: 30 (Feb 2026)

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name insulin, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
2026183117293395
20253832480250881
20244242830206913
20233802110168759
20223321730166671
20214111690183763
20204131960256865
20194761850298959
20184171710147735
20174401900118748
20166692170108994
20156811870111979
2014697186090973
2013231142055428
201272222035329
201192178042312
2010255304083642
20094902250144859
20089828079205
20075421057132
20067420021115
20054570153
200410001
200320002
200201001
200101001
200010001

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal18%2,475
  • Recovered with Sequela[recovered, with a lasting effect]4%554
  • Ongoing20.1%2,760
  • Died3.8%521
  • Euthanized4.1%556
  • Outcome Unknown15.9%2,181

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 13,716 reports that name insulin.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue48.4%6,635
  • Lack of expected effectiveness15.7%2,152
  • Both safety and lack of expected effectiveness15.2%2,078
  • Manufacturing or product defect20.8%2,848
  • Otherunder 0.1%3

8,693 reports say if the event was serious. 64% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year0.1%18
  • 1 to 3 years0.9%130
  • 4 to 7 years11.1%1,528
  • 8 to 11 years35.5%4,865
  • 12 years and over28.1%3,852
  • Age not given24.2%3,323

Weight of the animal

  • Under 5 kg (11 lb)15.3%2,095
  • 5 to 9.9 kg (11 to 22 lb)36.5%5,006
  • 10 to 24.9 kg (22 to 55 lb)12.9%1,767
  • 25 to 44.9 kg (55 to 99 lb)8.6%1,178
  • 45 kg and over (99 lb and over)1.1%154
  • Weight not given25.6%3,516

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Subcutaneous69.7%9,558
  • Parenteral1%142
  • Subconjunctival0.1%17
  • Oral0.1%16
  • Intramuscular0.1%14
  • Intravenous0.1%14

Each bar is on a scale of 0 to 100%.

Approved animal drugs with this active ingredient (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • ProZinc

What the Green Book records give

Applications with an approval in force
1
Approved species
Cats, Dogs
Dose forms
Liquid (Suspension)
Routes
Subcutaneous
Sale
RX (prescription)
Earliest approval date in the records

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
ProZincInsulinBoehringer Ingelheim Animal Health USA, Inc.Dogs, CatsNADA 141-297

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Insulin: adverse event reports that FDA received. https://petdrugreports.com/drug/insulin/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

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Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with this active ingredient.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 833 reports in the 12 months to June 2026. It received 869 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 13,716 reports received from October 2000 to June 2026, 48.4% are about a safety issue only. 30.8% are about a lack of expected effectiveness, alone or with a safety issue. 20.8% are about a defect of the product or its package.