Pruritus: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: itching.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From January 1987 to June 2026, FDA received 24,579 adverse event reports for animal drugs that list this sign. That is 1.8% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 466 reports that list this sign.

Of the 24,579 reports, 77.2% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 20 of 1,149 clinical signs with a page. Reports that list this sign fell by 12.4% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 77.2% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 104 drug pages.

Show the 104 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	191
Acepromazine Maleate	22
Afoxolaner	2,413
Afoxolaner + Moxidectin + Pyrantel Pamoate	45
Amitraz	71
Amoxicillin	125
Amoxicillin + Clavulanate Potassium	44
Amoxicillin Trihydrate + Clavulanate Potassium	70
Bedinvetmab	145
Buprenorphine	54
Butorphanol Tartrate	43
Carprofen	662
Cefovecin sodium	336
Cefpodoxime proxetil	175
Cephalexin	97
Cetirizine	33
Clindamycin	21
Clotrimazole + Gentamicin Sulfate + Mometasone Furoate Monohydrate	20
Cyclosporine	1,162
Deracoxib	195
Desoxycorticosterone Pivalate	61
Dexamethasone	104
Dexamethasone + Neomycin Sulfate + Thiabendazole	21
Dexamethasone + Thiabendazole	22
Dexamethasone Sodium Phosphate	27
Dexmedetomidine hydrochloride	28
Diphenhydramine	248
Dirlotapide	37
Doramectin	550
Doxycycline	64
Emodepside + Praziquantel	119
Enalapril Maleate	31
Enrofloxacin	103
Enrofloxacin + Silver sulfadiazine	28
Eprinomectin	102
Famotidine	32
Febantel + Praziquantel + Pyrantel Pamoate	79
Fenbendazole	44
Firocoxib	145
Florfenicol + Mometasone furoate + Terbinafine	87
Fluoxetine hydrochloride	35
Fluralaner	901
Frunevetmab	667
Gabapentin	134
Grapiprant	33
Hydroxyzine	36
Ilunocitinib	57
Imidacloprid	895
Imidacloprid + Moxidectin	2,547
Insulin	120
Isoflurane	37
Ivermectin	499
Ivermectin + Praziquantel	36
Ivermectin + Praziquantel + Pyrantel Pamoate	36
Ivermectin + Pyrantel Pamoate	952
Ketamine Hydrochloride	32
Ketoconazole	83
Levothyroxine sodium	77
Lotilaner	150
Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate	36
Lufenuron	223
Lufenuron + Milbemycin Oxime	760
Lufenuron + Praziquantel	53
Marbofloxacin	37
Maropitant	158
Melarsomine Dihydrochloride	139
Meloxicam	227
Methimazole	54
Methylprednisolone Acetate	74
Metronidazole	56
Miconazole Nitrate	22
Milbemycin Oxime	360
Milbemycin Oxime + Praziquantel	125
Milbemycin Oxime + Spinosad	1,947
Moxidectin	1,524
Neomycin Sulfate + Nystatin + Thiostrepton + Triamcinolone Acetonide	27
Nitenpyram	1,045
Oclacitinib	518
Omeprazole	20
Orbifloxacin	22
Phenobarbital	31
Pimobendan	80
Polysulfated Glycosaminoglycan	28
Praziquantel	59
Praziquantel + Pyrantel Pamoate	51
Prednisolone	97
Prednisolone + Trimeprazine Tartrate	47
Prednisone	217
Propofol	28
Pyrantel Pamoate	73
Pyrantel Pamoate + Sarolaner	271
Rabacfosadine	25
Robenacoxib	22
Sarolaner	252
Sarolaner + Selamectin	139
Selamectin	2,445
Selegiline Hydrochloride	62
Spinosad	2,104
Sulfadimethoxine	38
Tepoxalin	20
Tramadol	60
Triamcinolone Acetonide	37
Trilostane	106
Tylosin	21

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 99 ingredients.

Show the 99 ingredients

Reports by species

Dog77.2%18,980
Cat15.5%3,799
Cattle4.1%1,007
Human exposure2.1%522
Horse0.7%181
Pig0.1%36

The share is of the 24,579 reports that list this sign. The sign is in 1.9% of all reports about the species dog. The sign is in 2.5% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Pruritus, by the year in which FDA received them
Year	Reports
2026	194
2025	506
2024	625
2023	579
2022	349
2021	553
2020	792
2019	869
2018	1,076
2017	1,542
2016	1,357
2015	1,504
2014	1,671
2013	1,536
2012	1,448
2011	1,557
2010	1,251
2009	1,157
2008	972
2007	680
2006	556
2005	535
2004	551
2003	315
2002	451
2001	458
2000	700
1999	229
1998	316
1997	83
1996	72
1995	35
1994	11
1993	7
1992	2
1991	3
1990	7
1989	10
1988	10
1987	10

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal15.9%3,914, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]5%1,234, All reports: 2.3%
Ongoing14.9%3,658, All reports: 17.4%
Died1%235, All reports: 4.9%
Euthanized0.5%115, All reports: 1.5%
Outcome Unknown24.3%5,963, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 24,579 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year10.4%2,567, All reports: 9.5%
1 to 3 years25.2%6,183, All reports: 23.9%
4 to 7 years25.9%6,360, All reports: 20.2%
8 to 11 years17.6%4,326, All reports: 15.4%
12 years and over11%2,706, All reports: 10.7%
Age not given9.9%2,437, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Proprioception abnormality
Proprioception deficit[reduced awareness of limb position]
Proprioception loss
Proteinuria[protein in the urine]
Pulmonary congestion
Pulmonary disorder NOS[NOS: not otherwise specified]
Pulmonary neoplasm
Pulmonary oedema

All clinical signs

Cite this page

Pet Drug Reports. Pruritus: adverse event reports for animal drugs. https://petdrugreports.com/reaction/pruritus/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: In plain words: itching. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 466 reports in the 12 months to June 2026. It received 532 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 14,738 reports that say if the event was serious, 43.3% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices