Index

Reported signs

1,130 coded terms with 200 or more reports, A to Z

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An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

Terms are from VeDDRA, the dictionary used to code veterinary adverse event reports, plus legacy FDA terms from older reports. Many describe a product not working as expected or a packaging defect, not illness.

Term	Plain language	Reports	Share of all reports	Latest 12 months
Abdominal cavity disorder NOS	NOS: not otherwise specified	535	0%	38
Abdominal cavity haemorrhage		675	0.1%	26
Abdominal discomfort		831	0.1%	73
Abdominal effusion		480	0%	54
Abdominal mass		913	0.1%	66
Abdominal pain		6,216	0.5%	153
Abnormal adrenocorticotropic hormone (ACTH) stimulation test		949	0.1%	66
Abnormal breathing		2,677	0.2%	129
Abnormal cytology		2,003	0.2%	393
Abnormal ECG		320	0%	0
Abnormal menace reflex test		995	0.1%	111
Abnormal movement NOS	NOS: not otherwise specified	1,018	0.1%	99
Abnormal posture		244	0%	42
Abnormal posture NOS	NOS: not otherwise specified	2,889	0.2%	171
Abnormal pupil light reflex		970	0.1%	73
Abnormal radiograph finding		9,990	0.7%	787
Abnormal red blood cell		456	0%	21
Abnormal stool colouration		1,099	0.1%	57
Abnormal test result		377	0%	0
Abnormal ultrasound finding		6,192	0.5%	401
Abnormal urine odour		424	0%	16
Abortion		899	0.1%	12
Abscess NOS	NOS: not otherwise specified	475	0%	44
Accidental drug intake by child		345	0%	2
Accidental exposure	exposure that was not intended	31,044	2.3%	830
Acidic urine		218	0%	28
Acidosis		324	0%	34
Active urine sediment		202	0%	23
Acute renal failure		651	0.1%	45
Addison's disease		316	0%	17
Adipsia	not drinking	5,028	0.4%	83
Administration device NOS, abnormal		207	0%	76
Administration device NOS, malfunction		367	0%	40
Administration error NOS	NOS: not otherwise specified	1,428	0.1%	654
Adrenal gland disorder NOS	NOS: not otherwise specified	576	0%	47
Aggression		5,589	0.4%	265
Agitation		5,779	0.4%	267
Alkaline urine		607	0%	60
Allergic dermatitis		416	0%	34
Allergic pruritus		374	0%	14
Allergic reaction		1,527	0.1%	91
Allergic skin reaction		249	0%	12
Allergy NOS	NOS: not otherwise specified	1,160	0.1%	89
Alopecia	hair loss	1,800	0.1%	120
Alopecia general		390	0%	16
Alopecia local		1,379	0.1%	117
Alopecia NOS	hair loss, type not specified	4,252	0.3%	30
Alteration of milk quality		867	0.1%	2
Anaemia NOS	low red blood cell count	12,844	1%	579
Anal irritation		300	0%	7
Anal sac disorder		560	0%	40
Anaphylactic shock		302	0%	20
Anaphylactic-type reaction		1,144	0.1%	33
Anaphylactoid reaction	sudden allergic-type reaction	2,318	0.2%	18
Anaphylaxis	sudden severe allergic-type reaction	11,300	0.8%	523
Anisocoria		992	0.1%	58
Anorexia	not eating	59,480	4.4%	1,257
Anuria		729	0.1%	32
Anxiety		5,638	0.4%	459
Apathy		257	0%	8
Apnoea	breathing stopped	2,653	0.2%	46
Appearance, Abnormal	a product quality report, not a sign in an animal	4,723	0.4%	375
Appetite disorder NOS	NOS: not otherwise specified	468	0%	58
Appetite loss		3,275	0.2%	279
Application site alopecia	hair loss where the product was applied	10,078	0.7%	222
Application site bleeding	bleeding where the product was applied	535	0%	56
Application site blister	blister where the product was applied	360	0%	32
Application site burn	burn where the product was applied	910	0.1%	85
Application site crust	crust where the product was applied	532	0%	42
Application site dermatitis	inflamed skin where the product was applied	290	0%	18
Application site erythema	reddened skin where the product was applied	3,518	0.3%	121
Application site greasy fur	greasy fur where the product was applied	448	0%	36
Application site hair change	hair change where the product was applied	907	0.1%	29
Application site hair coat discolouration	hair coat discolouration where the product was applied	207	0%	17
Application site hair loss	hair loss where the product was applied	8,118	0.6%	769
Application site inflammation	inflammation where the product was applied	1,984	0.2%	89
Application site irritation	irritation where the product was applied	1,928	0.1%	186
Application site itching	itching where the product was applied	797	0.1%	97
Application site lesion	lesion where the product was applied	2,682	0.2%	87
Application site pain	pain where the product was applied	1,014	0.1%	94
Application site pruritus	itching where the product was applied	2,717	0.2%	62
Application site rash	rash where the product was applied	368	0%	37
Application site reaction NOS	reaction nos where the product was applied	1,253	0.1%	53
Application site reddening	reddening where the product was applied	2,119	0.2%	286
Application site residue	residue where the product was applied	543	0%	42
Application site scab	scab where the product was applied	2,649	0.2%	229
Application site scratching	scratching where the product was applied	1,109	0.1%	112
Application site self trauma	self trauma where the product was applied	227	0%	18
Application site skin change NOS	skin change nos where the product was applied	720	0.1%	11
Application site skin scaling	skin scaling where the product was applied	209	0%	27
Application site sore	sore where the product was applied	390	0%	32
Application site stickiness	stickiness where the product was applied	502	0%	75
Application site swelling	swelling where the product was applied	1,261	0.1%	36
Application site ulcer	ulcer where the product was applied	506	0%	34
Applicator, Abnormal	a product quality report, not a sign in an animal	626	0.1%	22
Apprehension		1,666	0.1%	3
Arched back		449	0%	47
Arrhythmia		1,382	0.1%	58
Arthritis		1,711	0.1%	219
Ascites	fluid in the abdomen	1,749	0.1%	33
Aspiration pneumonia		214	0%	64
Ataxia	unsteady, uncoordinated movement	31,905	2.4%	1,511
Atopic allergy NOS	NOS: not otherwise specified	283	0%	22
Attention-seeking behaviour		262	0%	33
Aural haematoma		240	0%	36
Autoimmune disorder NOS	NOS: not otherwise specified	539	0%	24
Azotaemia	raised kidney values in blood	2,451	0.2%	174
Bacterial skin infection NOS	NOS: not otherwise specified	1,483	0.1%	126
Bad taste		281	0%	17
Balance impaired		725	0.1%	94
Balance problem		1,693	0.1%	115
Bands(neutrophils) high, blood		556	0%	0
Barking		527	0%	68
Basophilia		457	0%	56
Behavioural disorder NOS	behaviour change, type not specified	26,442	2%	1,488
Bilirubinuria		1,542	0.1%	76
Birth defect		246	0%	1
Biting - pruritus		590	0%	83
Biting -aggression		1,272	0.1%	74
Bladder incontinence		293	0%	27
Blepharospasm		623	0.1%	32
Blindness		4,395	0.3%	181
Blinking		237	0%	19
Blistering		345	0%	24
Bloated		505	0%	46
Bloated stomach		283	0%	27
Blood and lymphatic system disorder NOS	NOS: not otherwise specified	556	0%	5
Blood in faeces		2,322	0.2%	120
Blood in faeces NOS	NOS: not otherwise specified	307	0%	0
Blood in urine		1,974	0.2%	195
Blood in vomit		4,896	0.4%	195
Blood loss NOS	NOS: not otherwise specified	212	0%	17
Bloodshot eye		228	0%	16
Bloody diarrhoea	diarrhea with blood	14,286	1.1%	627
Bone and joint disorder NOS	NOS: not otherwise specified	1,377	0.1%	290
Bottles, Damaged	a product quality report, not a sign in an animal	582	0%	16
Bradycardia	slow heart rate	3,764	0.3%	215
Bradypnoea		542	0%	10
Brain disorder NOS	NOS: not otherwise specified	233	0%	18
Breathing difficulty		2,705	0.2%	209
Bronchitis		291	0%	23
Bruising		1,539	0.1%	128
Bumping into walls		519	0%	96
Bumps on skin		224	0%	99
Cachexia		206	0%	9
Calculi		377	0%	12
Caps, Abnormal	a product quality report, not a sign in an animal	3,840	0.3%	69
Cardiac arrest		3,777	0.3%	109
Cardiac disorder NOS	heart problem, type not specified	11,767	0.9%	100
Cardiac enlargement		1,489	0.1%	86
Cardiomyopathy		292	0%	30
Cardiorespiratory arrest		255	0%	31
Cataract		758	0.1%	36
Cellulitis		492	0%	50
Central nervous system disorder NOS	NOS: not otherwise specified	447	0%	9
Chattering of teeth		386	0%	45
Chewing - oral cavity disorder		221	0%	3
Chewing - pruritus		756	0.1%	97
Chronic renal failure		249	0%	11
Circling - behavioural disorder		333	0%	43
Circling - neurological disorder		2,720	0.2%	151
Circulatory collapse		641	0.1%	60
Circumstance or info capable of leading to medication error		224	0%	9
Claw / hoof / nail disorder NOS	NOS: not otherwise specified	467	0%	27
Closed eyelid		356	0%	26
Closure, Abnormal	a product quality report, not a sign in an animal	3,436	0.3%	293
Closure, Missing	a product quality report, not a sign in an animal	876	0.1%	107
Cloudy eye (for Miosis, Mydriasis, Anisocoria, Nystagmus		312	0%	35
Coagulopathy		1,303	0.1%	18
Cognitive disorder NOS	NOS: not otherwise specified	283	0%	58
Colic		770	0.1%	52
Colitis		795	0.1%	47
Collapse		5,865	0.4%	117
Collapse NOS	NOS: not otherwise specified	3,607	0.3%	308
Collapse of leg		523	0%	73
Color, Abnormal	a product quality report, not a sign in an animal	10,755	0.8%	344
Coma		358	0%	19
Confused		417	0%	1
Confusion		4,582	0.3%	223
Congested mucous membrane		255	0%	31
Congestion of mucous membrane		223	0%	4
Congestive heart failure		437	0%	59
Conjunctivitis		1,304	0.1%	48
Constipation		2,573	0.2%	160
Constricted pupils		255	0%	17
Containers, Abnormal	a product quality report, not a sign in an animal	3,744	0.3%	94
Containers, Damaged	a product quality report, not a sign in an animal	14,472	1.1%	1,025
Containers, Leaking	a product quality report, not a sign in an animal	7,288	0.5%	670
Contamination NOS	NOS: not otherwise specified	873	0.1%	36
Contamination, Foreign Object		1,520	0.1%	398
Contamination, Mold		246	0%	8
Contamination, Particulate Matter		736	0.1%	42
Convulsion	seizure	12,721	0.9%	72
Coprophagia		207	0%	15
Corneal disorder NOS	NOS: not otherwise specified	469	0%	33
Corneal oedema		254	0%	10
Corneal ulcer		1,330	0.1%	80
Cough		8,798	0.7%	431
Crackles on auscultation		335	0%	38
Crust		2,082	0.2%	169
Crying		1,750	0.1%	167
Crystalluria		1,083	0.1%	68
Culture/titer data abnormal		1,527	0.1%	6
Cushings disease NOS	NOS: not otherwise specified	314	0%	31
Cyanosis	bluish gums or skin from low oxygen	2,295	0.2%	82
Cystitis		533	0%	34
Deafness		6,661	0.5%	343
Deafness NOS	NOS: not otherwise specified	325	0%	16
Death		50,955	3.8%	2,129
Death by euthanasia	the animal was euthanized	29,798	2.2%	2,056
Death-slaughtered		227	0%	0
Death-treatment failure		744	0.1%	0
Decreased activity		1,857	0.1%	162
Decreased appetite		17,847	1.3%	1,580
Decreased body temperature		768	0.1%	74
Decreased bowel movements		827	0.1%	63
Decreased cholesterol (total)		522	0%	40
Decreased drinking		1,250	0.1%	168
Decreased haematocrit		1,043	0.1%	447
Decreased haemoglobin		1,010	0.1%	203
Decreased heart rate		426	0%	57
Decreased packed cell volume (PCV)	lower share of red cells in the blood	1,813	0.1%	116
Decreased percentage of reticulocytes		461	0%	127
Decreased red blood cell count		1,393	0.1%	224
Decreased urine concentration	dilute urine	4,725	0.4%	191
Defect Unknown/Not Specified	a product quality report, not a sign in an animal	1,677	0.1%	173
Dehydration		10,231	0.8%	683
Delayed healing		210	0%	17
Demodicosis		230	0%	3
Dental calculus		427	0%	36
Dental disease		580	0%	60
Dependent oedema		371	0%	5
Depression	dull, quiet or withdrawn	42,388	3.1%	159
Dermal cyst(s)		436	0%	29
Dermal mass		1,460	0.1%	78
Dermal thickening		306	0%	34
Dermatitis	inflamed skin	4,529	0.3%	176
Dermatosis NOS	NOS: not otherwise specified	342	0%	9
Device breakage/fracture		503	0%	60
Device Defective NOS	a product quality report, not a sign in an animal	2,731	0.2%	300
Diabetes		894	0.1%	65
Diabetes mellitus		1,189	0.1%	39
Diabetic ketoacidosis		630	0.1%	130
Diabetic ketonuria		395	0%	4
Diarrhoea	diarrhea	82,046	6.1%	4,563
Difficulty going up/down stairs		290	0%	98
Difficulty of Use	a product quality report, not a sign in an animal	3,260	0.2%	0
Difficulty standing		645	0.1%	202
Difficulty to rise		666	0.1%	142
Digestive tract disorder NOS	digestive problem, type not specified	21,171	1.6%	150
Digestive tract haemorrhage NOS	NOS: not otherwise specified	350	0%	8
Digestive tract hypomotility		268	0%	11
Dilated pupils		3,467	0.3%	339
Discoloured urine		1,535	0.1%	65
Discomfort NOS	NOS: not otherwise specified	1,131	0.1%	176
Disorder of gastrointestinal flora		201	0%	13
Disorder of red blood cell NOS	NOS: not otherwise specified	382	0%	36
Disorientation		5,533	0.4%	409
Disoriented state		672	0.1%	66
Dispenser, Abnormal	a product quality report, not a sign in an animal	3,091	0.2%	9
Disseminated intravascular coagulation		407	0%	7
Distension of abdomen		2,573	0.2%	130
Distress		824	0.1%	113
Drinking a lot		2,092	0.2%	112
Drooling		7,943	0.6%	724
Drooping eyelid		401	0%	32
Drug administered at inappropriate site		1,240	0.1%	182
Drug administration duration too long		941	0.1%	34
Drug administration error		4,799	0.4%	0
Drug dispensing error		289	0%	2
Drug dose administration interval too long		3,323	0.2%	136
Drug dose administration interval too short		2,901	0.2%	215
Drug dose omission	a scheduled administration was missed	3,957	0.3%	233
Drug dose prescribing error		213	0%	4
Drug label confusion		254	0%	25
Drug prescribing error		209	0%	0
Drug schedule prescribing error		238	0%	0
Drunken gait		557	0%	53
Dry eye		352	0%	23
Dry mouth		289	0%	9
Dry mucous membrane		1,224	0.1%	135
Dry nose		314	0%	21
Dry skin		1,252	0.1%	54
Dull		652	0.1%	118
Dullness		744	0.1%	62
Duodenal ulcer		208	0%	6
Dysphagia		401	0%	8
Dysphoria		693	0.1%	115
Dyspnoea	difficulty breathing	7,607	0.6%	136
Dysuria		236	0%	6
Ear canal erythema		328	0%	40
Ear canal inflammation		271	0%	47
Ear discharge		1,171	0.1%	100
Ear infection NOS	NOS: not otherwise specified	2,186	0.2%	230
Ear irritation		212	0%	16
Ear pain		469	0%	48
Ear pruritus		364	0%	36
Ear twitching		214	0%	16
Ecchymosis		1,118	0.1%	21
Electrolyte disorder		1,169	0.1%	66
Elevated alanine aminotransferase (ALT)	a liver enzyme above the normal range	26,969	2%	1,318
Elevated amylase	a pancreatic enzyme above the normal range	3,593	0.3%	174
Elevated aspartate aminotransferase (AST)	a liver and muscle enzyme above the normal range	5,339	0.4%	204
Elevated bile acids		1,316	0.1%	41
Elevated blood urea nitrogen (BUN)	a kidney value above the normal range	17,526	1.3%	791
Elevated cholesterol (total)		3,181	0.2%	333
Elevated creatine-kinase (CK)	a muscle enzyme above the normal range	1,676	0.1%	96
Elevated creatinine	a kidney value above the normal range	13,553	1%	564
Elevated gamma-glutamyl transferase (GGT)	a liver enzyme above the normal range	4,222	0.3%	262
Elevated globulins		2,948	0.2%	372
Elevated haematocrit		311	0%	129
Elevated lipase	a pancreatic enzyme above the normal range	2,936	0.2%	168
Elevated liver enzymes	liver enzymes above the normal range	8,231	0.6%	0
Elevated liver enzymes NOS	NOS: not otherwise specified	894	0.1%	347
Elevated pancreatic enzymes		412	0%	46
Elevated protein:creatinine ratio		395	0%	74
Elevated renal parameters	kidney values above the normal range	2,373	0.2%	165
Elevated serum alkaline phosphatase (ALP)	a liver and bone enzyme above the normal range	2,737	0.2%	1,168
Elevated serum alkaline phosphatase (SAP)	a liver and bone enzyme above the normal range	22,104	1.6%	0
Elevated symmetrical dimethylarginine (SDMA)	a kidney value above the normal range	1,963	0.1%	436
Elevated temperature		2,438	0.2%	212
Elevated thyroxine (T4)		230	0%	43
Elevated total bilirubin	bilirubin above the normal range	10,274	0.8%	463
Elevated triglyceride		983	0.1%	121
Embolism		209	0%	1
Emesis	vomiting	69,445	5.1%	292
Emesis (multiple)	vomiting more than once	19,169	1.4%	1,950
Enlarged liver		616	0.1%	62
Enlarged lymph node (localised)		592	0%	97
Enlarged lymph nodes (generalised)		344	0%	32
Enteritis		565	0%	22
Eosinopenia		722	0.1%	315
Eosinopenia		366	0%	0
Eosinophilia		1,540	0.1%	127
Epilepsy		217	0%	17
Epileptic seizure		217	0%	5
Epiphora		475	0%	32
Epistaxis	nosebleed	1,706	0.1%	47
Eruption		381	0%	3
Erythema (for urticaria see Immune SOC)		4,726	0.4%	150
Erythematous rash		432	0%	19
Excessive appetite		223	0%	23
Excessive chewing, licking and/or grooming		713	0.1%	167
Excessive licking and/or grooming		2,069	0.2%	0
Excessive thirst		1,147	0.1%	112
Excitation		379	0%	28
Excoriation		545	0%	60
Exercise intolerance		399	0%	13
Expired drug administered		700	0.1%	44
External ear disorder NOS	NOS: not otherwise specified	591	0%	11
Eye disorder NOS (for photophobia see 'neurological')		2,593	0.2%	0
Eye disorder NOS (for Photophobia see neurological)		478	0%	155
Eye haemorrhage		228	0%	5
Eye irritation		1,628	0.1%	55
Eye itching		201	0%	12
Eye pain		637	0.1%	18
Eye redness		1,382	0.1%	61
Eyelid oedema		1,084	0.1%	14
Eyes rolling back		785	0.1%	43
Face and neck swelling		244	0%	16
Facial oedema	swollen face	4,693	0.4%	12
Facial paralysis		697	0.1%	61
Facial pruritus		362	0%	85
Facial swelling		8,582	0.6%	721
Faecal incontinence		1,412	0.1%	138
Falling		4,574	0.3%	549
Fasciculation		398	0%	22
Fatigue		219	0%	25
Febrile		1,167	0.1%	64
Feeling depressed		321	0%	0
Female reproductive tract disorder NOS	NOS: not otherwise specified	233	0%	5
Fever		17,756	1.3%	838
Fixed pupil		619	0.1%	16
Flaking skin		1,102	0.1%	70
Flatulence	gas	1,594	0.1%	69
Fluid in abdomen NOS	NOS: not otherwise specified	727	0.1%	68
Fly biting behaviour		550	0%	53
Foam in the mouth		289	0%	34
Foaming at the mouth		3,616	0.3%	325
Focal seizure		404	0%	98
Food allergy		211	0%	10
Food refusal		432	0%	92
Found dead		612	0.1%	73
Fracture		298	0%	52
Frequent urination		1,578	0.1%	159
Fungal skin infection NOS	NOS: not otherwise specified	479	0%	25
Gagging		2,586	0.2%	143
Gait abnormality		1,520	0.1%	220
Gall bladder & bile duct disorder NOS	NOS: not otherwise specified	1,043	0.1%	83
Gastric bloat		348	0%	10
Gastric perforation		814	0.1%	17
Gastric ulcer		904	0.1%	32
Gastric ulceration NOS	NOS: not otherwise specified	254	0%	11
Gastric volvulus		237	0%	3
Gastritis		606	0%	27
Gastroenteritis		1,183	0.1%	74
Gastrointestinal foreign body NOS	NOS: not otherwise specified	282	0%	38
Gel/Paste, Abnormal		213	0%	3
General hair loss		1,034	0.1%	40
General illness		2,112	0.2%	323
General pain		773	0.1%	35
Generalised itching		1,555	0.1%	128
Generalised rash		387	0%	13
Generalised weakness		730	0.1%	51
Genital tract licking		216	0%	30
Gingival disorder		339	0%	7
Gingival hyperplasia		701	0.1%	18
Gingivitis		444	0%	36
Glaucoma		279	0%	16
Glazed eye		1,571	0.1%	60
Glucosuria	sugar in the urine	1,948	0.1%	228
Grand mal seizure		944	0.1%	151
Granules/Powder, Abnormal		730	0.1%	3
Granuloma		223	0%	12
Grooming disorder		240	0%	44
Growling		284	0%	71
Gum disorder NOS	NOS: not otherwise specified	206	0%	13
Gut sounds increased		533	0%	22
Haemangiosarcoma		215	0%	22
Haematemesis		796	0.1%	46
Haematochezia	fresh blood in the stool	2,342	0.2%	72
Haematuria	blood in the urine	5,038	0.4%	281
Haemoconcentration		290	0%	14
Haemolytic anaemia		291	0%	4
Haemoptysis		558	0%	1
Haemorrhage NOS	NOS: not otherwise specified	1,497	0.1%	79
Haemorrhagic diarrhoea		684	0.1%	45
Haemorrhagic gastroenteritis		473	0%	41
Hair change		600	0%	43
Hair coat discolouration		788	0.1%	29
Hair loss NOS	NOS: not otherwise specified	3,232	0.2%	300
Hair modification NOS	NOS: not otherwise specified	821	0.1%	10
Hair shedding		1,155	0.1%	35
Halitosis		657	0.1%	20
Hallucination		521	0%	31
Hard, clumping	a product quality report, not a sign in an animal	2,964	0.2%	79
Head bobbing		1,766	0.1%	139
Head down		571	0%	83
Head pressing		516	0%	35
Head shake - behavioural disorder		1,155	0.1%	107
Head shake - ear disorder		1,517	0.1%	154
Head tilt - ear disorder		2,759	0.2%	121
Head tilt - neurological disorder		1,775	0.1%	312
Head tremor		2,489	0.2%	213
Headache		682	0.1%	22
Hearing affected		254	0%	11
Hearing decreased		396	0%	29
Heart failure		741	0.1%	35
Heart murmur		2,338	0.2%	288
Heart valve disorder		205	0%	19
Heavy breathing		863	0.1%	202
Hematocrit(hct) high, blood		249	0%	0
Hepatic disorder NOS	NOS: not otherwise specified	329	0%	15
Hepatic neoplasm		433	0%	8
Hepatitis		773	0.1%	24
Hepatomegaly		1,494	0.1%	98
Hepatopathy	liver disorder	1,583	0.1%	61
Hiding		5,729	0.4%	511
High blood pressure		601	0%	87
High pancreatic-specific lipase		934	0.1%	237
High sodium-potassium ratio (Na:K ratio)		532	0%	80
Hind limb ataxia	uncoordinated hind legs	2,012	0.2%	218
Hind limb paralysis	paralysed hind legs	1,628	0.1%	132
Hind limb paresis	weak hind legs	3,771	0.3%	247
Histiocytoma		263	0%	17
Hives		8,339	0.6%	652
Horizontal nystagmus		727	0.1%	89
Horner's syndrome		689	0.1%	42
Hot spot (pyotraumatic dermatitis)	moist, inflamed patch of skin	1,608	0.1%	112
Hyperactivity		10,836	0.8%	477
Hyperadrenocorticism		310	0%	7
Hyperaemic mucous membrane		347	0%	21
Hyperaesthesia	over-sensitive to touch	1,587	0.1%	78
Hyperalbuminaemia		1,190	0.1%	143
Hypercalcaemia	high blood calcium	2,047	0.2%	211
Hyperchloraemia		559	0%	48
Hyperexcitation		955	0.1%	13
Hyperextension		549	0%	20
Hyperglycaemia	high blood sugar	7,863	0.6%	720
Hyperhidrosis		428	0%	0
Hyperkalaemia	high blood potassium	4,007	0.3%	203
Hyperkeratosis		243	0%	15
Hypermetria		205	0%	27
Hypernatremia		1,141	0.1%	109
Hyperphosphataemia	high blood phosphate	7,003	0.5%	388
Hyperpigmentation		846	0.1%	41
Hyperproteinaemia	high blood protein	2,275	0.2%	223
Hypersalivation	drooling	15,871	1.2%	502
Hypersensitivity NOS	NOS: not otherwise specified	353	0%	39
Hypersensitivity reaction		1,230	0.1%	497
Hypertension	high blood pressure	1,685	0.1%	153
Hyperthermia	raised body temperature	1,566	0.1%	135
Hyperthyroidism		357	0%	32
Hyperventilation		260	0%	20
Hyphaemia		234	0%	14
Hypoadrenocorticism		865	0.1%	5
Hypoaesthesia		366	0%	2
Hypoalbuminaemia	low blood albumin	6,055	0.5%	286
Hypocalcaemia		483	0%	134
Hypocalcaemic condition		1,018	0.1%	3
Hypochloraemia	low blood chloride	2,186	0.2%	325
Hypocortisolaemia		521	0%	94
Hypoglycaemia	low blood sugar	5,240	0.4%	415
Hypokalaemia	low blood potassium	1,995	0.2%	453
Hyponatremia	low blood sodium	2,364	0.2%	201
Hypophosphataemia		930	0.1%	123
Hypoproteinaemia	low blood protein	3,610	0.3%	151
Hyposthenuria		524	0%	99
Hypotension	low blood pressure	2,024	0.2%	215
Hypothermia	low body temperature	4,124	0.3%	188
Hypothyroidism	underactive thyroid	1,753	0.1%	79
Icterus	jaundice (yellowing)	5,388	0.4%	111
Ileus		213	0%	33
Immediate pain upon injection		586	0%	71
Immune mediated haemolytic anaemia	the immune system destroying red blood cells	2,252	0.2%	121
Immune mediated thrombocytopenia		753	0.1%	86
Impaired consciousness		559	0%	34
Impaired hearing		322	0%	19
Impaired proprioception		289	0%	31
Impaired vision		1,326	0.1%	72
Impaired vocalisation		280	0%	20
Implant, Abnormal		547	0%	10
Inappetence	reduced appetite	9,095	0.7%	501
Inappropriate defecation		2,179	0.2%	178
Inappropriate elimination NOS	NOS: not otherwise specified	252	0%	77
Inappropriate preparation of medication		578	0%	4
Inappropriate schedule of drug administration		1,119	0.1%	64
Inappropriate urination		5,701	0.4%	542
Incoordination		885	0.1%	57
Incorrect dose administered NOS	NOS: not otherwise specified	1,391	0.1%	42
Incorrect route of drug administration		1,268	0.1%	89
Incorrect storage of drug		415	0%	30
Increased appetite		827	0.1%	87
Increased borborygmus		549	0%	34
Increased bowel movements (frequency)		306	0%	28
Increased coagulation time		265	0%	22
Increased drinking		379	0%	205
Increased heart rate		1,659	0.1%	159
Increased mortality rate		250	0%	7
Increased packed cell volume (PCV)		698	0.1%	37
Increased percentage reticulocytes		1,154	0.1%	156
Increased red blood cell count		400	0%	74
Increased respiratory rate		1,540	0.1%	205
Increased salivation		623	0.1%	47
Increased seizure frequency		306	0%	45
Increased sensitivity to sound		248	0%	18
Increased sexual interest		319	0%	6
Increased skin sensitivity		291	0%	40
Increased sweating		239	0%	15
Increased urine concentration		411	0%	49
Increased weight		356	0%	26
Ineffective, analgesia	legacy FDA term: the product did not have the expected effect (analgesia)	995	0.1%	2
Ineffective, anesthesia	legacy FDA term: the product did not have the expected effect (anesthesia)	2,704	0.2%	11
Ineffective, antibiotic	legacy FDA term: the product did not have the expected effect (antibiotic)	596	0%	0
Ineffective, antiemetic	legacy FDA term: the product did not have the expected effect (antiemetic)	728	0.1%	4
Ineffective, antiinflammatory	legacy FDA term: the product did not have the expected effect (antiinflammatory)	1,812	0.1%	7
Ineffective, appetite suppression	legacy FDA term: the product did not have the expected effect (appetite suppression)	430	0%	0
Ineffective, ascarids	legacy FDA term: the product did not have the expected effect (ascarids)	290	0%	0
Ineffective, ascarids NOS	legacy FDA term: the product did not have the expected effect (ascarids nos)	19,031	1.4%	0
Ineffective, atopy control	legacy FDA term: the product did not have the expected effect (atopy control)	3,321	0.2%	12
Ineffective, coccidia	legacy FDA term: the product did not have the expected effect (coccidia)	1,334	0.1%	0
Ineffective, cognitive dysfunc	legacy FDA term: the product did not have the expected effect (cognitive dysfunc)	444	0%	0
Ineffective, cushings	legacy FDA term: the product did not have the expected effect (cushings)	1,277	0.1%	0
Ineffective, delayed effect	legacy FDA term: the product did not have the expected effect (delayed effect)	361	0%	3
Ineffective, estrus suppressio	legacy FDA term: the product did not have the expected effect (estrus suppressio)	578	0%	0
Ineffective, estrus synchroniz	legacy FDA term: the product did not have the expected effect (estrus synchroniz)	614	0.1%	0
Ineffective, euthanasia	legacy FDA term: the product did not have the expected effect (euthanasia)	895	0.1%	4
Ineffective, gastric ulcer(s)	legacy FDA term: the product did not have the expected effect (gastric ulcer(s))	809	0.1%	37
Ineffective, glycemic control	legacy FDA term: the product did not have the expected effect (glycemic control)	3,571	0.3%	58
Ineffective, heartworm adults	legacy FDA term: the product did not have the expected effect (heartworm adults)	4,328	0.3%	0
Ineffective, heartworm larvae	legacy FDA term: the product did not have the expected effect (heartworm larvae)	69,276	5.1%	0
Ineffective, heartworm microfi	legacy FDA term: the product did not have the expected effect (heartworm microfi)	285	0%	0
Ineffective, hooks	legacy FDA term: the product did not have the expected effect (hooks)	13,040	1%	0
Ineffective, lice biting	legacy FDA term: the product did not have the expected effect (lice biting)	659	0.1%	0
Ineffective, loss of effect	legacy FDA term: the product did not have the expected effect (loss of effect)	4,530	0.3%	87
Ineffective, other drug(s)	legacy FDA term: the product did not have the expected effect (other drug(s))	434	0%	19
Ineffective, parasite(s) NOS	legacy FDA term: the product did not have the expected effect (parasite(s) nos)	789	0.1%	7
Ineffective, production (milk)	legacy FDA term: the product did not have the expected effect (production (milk))	375	0%	0
Ineffective, reversal	legacy FDA term: the product did not have the expected effect (reversal)	480	0%	2
Ineffective, sedation	legacy FDA term: the product did not have the expected effect (sedation)	2,601	0.2%	36
Ineffective, strongyles	legacy FDA term: the product did not have the expected effect (strongyles)	627	0.1%	2
Ineffective, weight loss	legacy FDA term: the product did not have the expected effect (weight loss)	336	0%	0
Ineffective, whips	legacy FDA term: the product did not have the expected effect (whips)	2,008	0.2%	0
Ineffective, worms	legacy FDA term: the product did not have the expected effect (worms)	465	0%	0
Ineffective, worms NOS	legacy FDA term: the product did not have the expected effect (worms nos)	1,374	0.1%	16
Infectious disease NOS	NOS: not otherwise specified	242	0%	33
Infertility NOS	NOS: not otherwise specified	514	0%	1
Injected sclera		250	0%	27
Injection site abscess	abscess where the injection was given	1,796	0.1%	101
Injection site alopecia	hair loss where the injection was given	711	0.1%	34
Injection site bleeding	bleeding where the injection was given	1,141	0.1%	84
Injection site bruising	bruising where the injection was given	538	0%	60
Injection site complication NOS	complication nos where the injection was given	301	0%	37
Injection site erythema	reddened skin where the injection was given	410	0%	44
Injection site granuloma	granuloma where the injection was given	207	0%	23
Injection site hair loss	hair loss where the injection was given	317	0%	37
Injection site infection	infection where the injection was given	407	0%	24
Injection site inflammation	inflammation where the injection was given	1,514	0.1%	83
Injection site lesion	lesion where the injection was given	521	0%	41
Injection site lump	lump where the injection was given	2,254	0.2%	204
Injection site mass	mass where the injection was given	920	0.1%	0
Injection site mass NOS	mass nos where the injection was given	214	0%	67
Injection site mucopurulent discharge	mucopurulent discharge where the injection was given	257	0%	19
Injection site necrosis	necrosis where the injection was given	1,038	0.1%	45
Injection site oedema	oedema where the injection was given	721	0.1%	20
Injection site pain	pain where the injection was given	5,895	0.4%	236
Injection site pruritus	itching where the injection was given	340	0%	12
Injection site reaction NOS	reaction nos where the injection was given	1,180	0.1%	74
Injection site reddening	reddening where the injection was given	347	0%	55
Injection site scab	scab where the injection was given	408	0%	47
Injection site seroma	seroma where the injection was given	419	0%	11
Injection site serosanguinous discharge	serosanguinous discharge where the injection was given	283	0%	25
Injection site skin discolouration	skin discolouration where the injection was given	256	0%	53
Injection site swelling	swelling where the injection was given	8,411	0.6%	435
Injection site ulcer	ulcer where the injection was given	292	0%	27
Injection site warmth	warmth where the injection was given	265	0%	30
Injection site weeping	weeping where the injection was given	235	0%	21
Intentional misuse	use that was knowingly different from the label	4,445	0.3%	2,556
Intervertebral disc disease		419	0%	86
Intestinal disorder NOS	NOS: not otherwise specified	881	0.1%	109
Intestinal perforation		1,403	0.1%	14
Involuntary defecation		675	0.1%	75
Irregular breathing		401	0%	13
Irritability		360	0%	58
Isosthenuria		356	0%	81
Itching		10,747	0.8%	766
Itchy ears		219	0%	32
Itchy skin		1,006	0.1%	69
Jaundice		993	0.1%	71
Jaw disorder		372	0%	22
Joint effusion		352	0%	48
Joint pain		830	0.1%	91
Joint swelling		1,054	0.1%	170
Keratoconjunctivitis sicca		943	0.1%	26
Ketonuria		719	0.1%	230
Ketosis	ketones building up in the body	3,146	0.2%	992
Knuckling		923	0.1%	211
Labeled drug-species interaction		312	0%	14
Labelled drug-drug interaction medication error		3,362	0.3%	1
Labels, Abnormal	a product quality report, not a sign in an animal	212	0%	16
Laboured breathing		2,624	0.2%	195
Lack of coordination		235	0%	32
Lack of efficacy - NOS	the product did not have the expected effect	56,123	4.1%	4,084
Lack of efficacy (bacteria) - Anaplasma	the product did not have the expected effect: Anaplasma bacteria	3,860	0.3%	1,851
Lack of efficacy (bacteria) - Borrelia	the product did not have the expected effect: Borrelia (Lyme disease bacteria)	12,009	0.9%	2,816
Lack of efficacy (bacteria) - Ehrlichia	the product did not have the expected effect: Ehrlichia bacteria	2,922	0.2%	759
Lack of efficacy (bacteria) - NOS	the product did not have the expected effect: target not specified	11,076	0.8%	221
Lack of efficacy (ectoparasite) - Demodex	the product did not have the expected effect: Demodex	330	0%	20
Lack of efficacy (ectoparasite) - ear mite	the product did not have the expected effect: ear mites	1,714	0.1%	48
Lack of efficacy (ectoparasite) - flea	the product did not have the expected effect: fleas	63,352	4.7%	6,043
Lack of efficacy (ectoparasite) - lice	the product did not have the expected effect: lice	2,376	0.2%	23
Lack of efficacy (ectoparasite) - mite NOS	the product did not have the expected effect: mite NOS	616	0.1%	14
Lack of efficacy (ectoparasite) - NOS	the product did not have the expected effect: target not specified	2,282	0.2%	47
Lack of efficacy (ectoparasite) - Sarcoptes	the product did not have the expected effect: Sarcoptes	486	0%	15
Lack of efficacy (ectoparasite) - tick NOS	the product did not have the expected effect: ticks	17,092	1.3%	1,797
Lack of efficacy (endoparasite) - heartworm	the product did not have the expected effect: heartworm	52,940	3.9%	5,628
Lack of efficacy (endoparasite) - hookworm	the product did not have the expected effect: hookworms	49,844	3.7%	4,482
Lack of efficacy (endoparasite) - NOS	the product did not have the expected effect: target not specified	3,365	0.3%	172
Lack of efficacy (endoparasite) - roundworm NOS	the product did not have the expected effect: roundworms	13,976	1%	2,030
Lack of efficacy (endoparasite) - tapeworm	the product did not have the expected effect: tapeworms	8,900	0.7%	1,354
Lack of efficacy (endoparasite) - whipworm	the product did not have the expected effect: whipworms	8,930	0.7%	552
Lack of efficacy (flea)	the product did not have the expected effect: fleas	8,324	0.6%	0
Lack of efficacy (fungi) - NOS	the product did not have the expected effect: target not specified	293	0%	136
Lack of efficacy (heartworm)	the product did not have the expected effect: heartworm	1,001	0.1%	0
Lack of efficacy (lice)	the product did not have the expected effect: lice	450	0%	0
Lack of efficacy (protozoa)	the product did not have the expected effect: protozoa	291	0%	0
Lack of efficacy (protozoa) - Coccidia	the product did not have the expected effect: coccidia	4,943	0.4%	185
Lack of efficacy (protozoa) - Ehrlichia	the product did not have the expected effect: Ehrlichia bacteria	251	0%	0
Lack of efficacy (protozoa) - Giardia	the product did not have the expected effect: Giardia	606	0%	134
Lack of efficacy (protozoa) - NOS	the product did not have the expected effect: target not specified	738	0.1%	14
Lack of efficacy (roundworm)	the product did not have the expected effect: roundworms	2,765	0.2%	0
Lack of efficacy (tapeworm)	the product did not have the expected effect: tapeworms	990	0.1%	0
Lack of efficacy (tick)	the product did not have the expected effect: ticks	6,102	0.5%	0
Lack of efficacy (virus) - parvovirus (including feline panleukopenia)	the product did not have the expected effect: parvovirus (including feline panleukopenia)	310	0%	62
Lack of response to owner		455	0%	57
Lameness		5,579	0.4%	405
Laminitis		312	0%	5
Lateral recumbency	lying on the side, unable to rise	3,460	0.3%	353
Lethargy	unusually tired or inactive	93,420	6.9%	5,754
Leucocytosis NOS	high white blood cell count	11,935	0.9%	436
Leucopenia NOS	low white blood cell count	4,117	0.3%	278
Leukocytosis NOS	NOS: not otherwise specified	204	0%	200
Licking		2,509	0.2%	261
Licking at application site		1,049	0.1%	72
Licking at injection site		261	0%	37
Limb non-weight bearing		508	0%	139
Limb weakness		3,681	0.3%	527
Limping		2,550	0.2%	315
Limpness		487	0%	66
Lip licking		928	0.1%	58
Lip oedema		1,167	0.1%	1
Lip smacking		356	0%	44
Lipaemia		382	0%	41
Lipoma		365	0%	36
Listless		1,314	0.1%	76
Liver disorder NOS	NOS: not otherwise specified	1,351	0.1%	67
Liver failure		983	0.1%	35
Liver tumour		317	0%	26
Local erythema		233	0%	173
Local swelling (not application site)		1,325	0.1%	186
Localised hair loss		1,713	0.1%	189
Localised itching		718	0.1%	61
Localised oedema (not application site)		545	0%	50
Localised pain NOS	NOS: not otherwise specified	1,975	0.2%	162
Localised rash		580	0%	47
Locking Mechanism Abnormal		823	0.1%	10
Locomotor disturbance		838	0.1%	2
Loose stool		10,354	0.8%	405
Loss of bowel control		449	0%	55
Loss of condition		627	0.1%	14
Loss of consciousness		1,411	0.1%	31
Loss of hearing		1,707	0.1%	249
Loss of vision		409	0%	45
Loss of voluntary movement		202	0%	27
Lot # and /or Expiration date missing		535	0%	26
Lot # and/or Expiration date illegible		368	0%	14
Low blood pressure		627	0.1%	90
Low blood urea nitrogen (BUN)		955	0.1%	80
Low creatinine		527	0%	111
Low platelet count		2,283	0.2%	350
Low sodium-potassium ratio (Na:K ratio)		1,195	0.1%	106
Low thyroxine (T4)		656	0.1%	124
Lumbar pain		397	0%	44
Lung oedema		1,230	0.1%	16
Lung sound		245	0%	8
Lying down		907	0.1%	245
Lymphadenopathy	enlarged lymph nodes	1,629	0.1%	81
Lymphocytosis		1,356	0.1%	146
Lymphoma		1,125	0.1%	91
Lymphopenia	low lymphocyte count	3,241	0.2%	408
Malaise	generally unwell	4,968	0.4%	218
Malodour		1,295	0.1%	67
Mammary gland disorder NOS	NOS: not otherwise specified	348	0%	11
Mammary gland oedema		426	0%	4
Mass NOS	NOS: not otherwise specified	566	0%	197
Mast cell tumour		392	0%	83
Mastitis NOS	NOS: not otherwise specified	801	0.1%	12
Medication error		1,235	0.1%	0
Medication error NOS	a mistake in giving the product, type not specified	5,118	0.4%	3,252
Megaoesophagus		203	0%	9
Melaena	dark, tarry stool containing digested blood	3,734	0.3%	38
Mental confusion		257	0%	18
Mental impairment NOS	NOS: not otherwise specified	725	0.1%	61
Metastatic neoplasia		297	0%	32
Microorganisms, urine		746	0.1%	3
Milk production decrease		697	0.1%	14
Miosis		595	0%	31
Miscellaneous eating disorder NOS	NOS: not otherwise specified	359	0%	32
Missing Cap		823	0.1%	6
Missing Labels		466	0%	68
Mixed Product		242	0%	24
Moist dermatitis		1,320	0.1%	35
Monocytopenia		243	0%	102
Monocytopenia		224	0%	0
Monocytosis	high monocyte count	3,270	0.2%	455
Moribund		219	0%	8
Mouth pain		264	0%	19
Mucous stool		2,204	0.2%	105
Murmur		894	0.1%	6
Muscle atrophy		516	0%	127
Muscle shaking		726	0.1%	14
Muscle spasm NOS	NOS: not otherwise specified	630	0.1%	42
Muscle stiffness		1,059	0.1%	30
Muscle tremor		2,312	0.2%	100
Muscle wasting		1,044	0.1%	120
Muscle weakness NOS	NOS: not otherwise specified	859	0.1%	87
Musculoskeletal disorder NOS	NOS: not otherwise specified	3,682	0.3%	502
Musculoskeletal pain		2,013	0.2%	36
Mydriasis	dilated pupils	4,297	0.3%	56
Myoclonic jerk		306	0%	30
Myositis		264	0%	15
Nasal bleeding		369	0%	42
Nasal cavity and sinus disorder NOS	NOS: not otherwise specified	217	0%	3
Nasal congestion		353	0%	33
Nasal discharge		2,113	0.2%	137
Nausea		5,478	0.4%	383
Necropsy performed		973	0.1%	376
Needlestick injury		314	0%	146
Neoplasia NOS	tumour, type not specified	2,348	0.2%	93
Nephritis		207	0%	10
Neurological disorder NOS	NOS: not otherwise specified	601	0%	95
Neurological signs NOS	NOS: not otherwise specified	3,870	0.3%	278
Neurological symptoms NOS	NOS: not otherwise specified	814	0.1%	52
Neutropenia	low neutrophil count	2,727	0.2%	405
Neutrophilia	high neutrophil count	6,910	0.5%	658
No sign	no clinical sign was reported	11,326	0.8%	28
Non-regenerative anaemia		687	0.1%	122
Not drinking		6,227	0.5%	608
Not eating		21,012	1.6%	2,459
Not himself/herself		3,198	0.2%	858
Not sleeping		1,296	0.1%	152
Not urinating		585	0%	106
NT - Abnormal necropsy finding NOS	NOS: not otherwise specified	1,262	0.1%	0
Nystagmus	rapid involuntary eye movement	3,393	0.3%	229
Ocular discharge		2,404	0.2%	176
Odor, Abnormal	a product quality report, not a sign in an animal	4,308	0.3%	161
Oedema NOS	NOS: not otherwise specified	1,344	0.1%	42
Oedema of the extremities	swollen legs or paws	1,692	0.1%	21
Off colour		234	0%	5
Oliguria		300	0%	22
Open mouth breathing		814	0.1%	86
Opisthotonus		356	0%	13
Oral bleeding		1,012	0.1%	38
Oral cavity disorder NOS	NOS: not otherwise specified	475	0%	40
Oral mass		238	0%	23
Oral ulceration		797	0.1%	20
Other abnormal test result NOS	abnormal laboratory result, type not specified	20,880	1.5%	1,222
Other blood disorder NOS	NOS: not otherwise specified	268	0%	27
Other ear disorder NOS	NOS: not otherwise specified	708	0.1%	49
Other immune system disorder NOS	NOS: not otherwise specified	207	0%	7
Otitis externa	outer ear inflammation	1,703	0.1%	78
Otitis NOS	NOS: not otherwise specified	730	0.1%	60
Otorrhoea		217	0%	1
Overdose	more than the labelled amount was given	14,309	1.1%	1,227
Pacing		3,570	0.3%	295
Paddling		1,324	0.1%	78
Pain NOS	NOS: not otherwise specified	8,691	0.6%	637
Pale mucous membrane	pale gums	8,433	0.6%	454
Pallor		1,106	0.1%	20
Palpable mass NOS	NOS: not otherwise specified	615	0.1%	14
Palpebral disorder NOS	NOS: not otherwise specified	204	0%	23
Pancreas disorder		573	0%	27
Pancreatitis	inflamed pancreas	3,389	0.3%	0
Pancreatitis NOS	NOS: not otherwise specified	761	0.1%	315
Panting		15,139	1.1%	1,234
Papilloma		517	0%	35
Papule		648	0.1%	16
Paraesthesia		217	0%	1
Paralysis		791	0.1%	61
Paralysis NOS	NOS: not otherwise specified	364	0%	60
Paresis		1,203	0.1%	63
Partial anorexia		638	0.1%	93
Partial blindness		527	0%	8
Partial deafness		1,312	0.1%	41
Partial lack of efficacy	the product worked less well than expected	3,275	0.2%	534
Patient instructions for use on label confusing		647	0.1%	120
Pawing		354	0%	50
Peeling skin		340	0%	14
Pericardial effusion		361	0%	31
Perinatal mortality NOS	NOS: not otherwise specified	212	0%	0
Periorbital oedema		628	0.1%	52
Peripheral nervous system disorder NOS	NOS: not otherwise specified	761	0.1%	2
Peritonitis	inflamed abdominal lining	1,599	0.1%	27
Petechiae NOS	NOS: not otherwise specified	386	0%	34
Physical label missing		735	0.1%	15
Pica NOS	eating non-food items	2,251	0.2%	153
Pinnae disorder		362	0%	25
Pinnal erythema		1,103	0.1%	42
Pinnal irritation		280	0%	8
Pinnal oedema		556	0%	11
Pinnal reddening		645	0.1%	32
Platelet disorder NOS	NOS: not otherwise specified	372	0%	88
Pleural effusion		933	0.1%	69
Pneumonia	lung infection or inflammation	1,658	0.1%	86
Pododermatitis		427	0%	26
Pollakiuria		243	0%	20
Polycythaemia		1,106	0.1%	15
Polycythemia, relative		347	0%	0
Polydipsia	drinking more than usual	14,258	1.1%	847
Polyphagia		1,342	0.1%	73
Polypnoea	fast breathing	5,489	0.4%	2
Polyuria	passing more urine than usual	11,054	0.8%	804
Poor coat condition		228	0%	18
Potency, Low		597	0%	17
PR-bone marrow, lesion(s)	legacy FDA term: lesions found in the bone marrow	200	0%	1
PR-brain, lesion(s)	legacy FDA term: lesions found in the brain	295	0%	1
PR-colon, lesion(s)	legacy FDA term: lesions found in the colon	202	0%	1
PR-ear(s), lesion(s)	legacy FDA term: lesions found in the ears	406	0%	0
PR-gi, lesion(s)	legacy FDA term: lesions found in the gi	345	0%	0
PR-heart, lesion(s)	legacy FDA term: lesions found in the heart	1,263	0.1%	6
PR-injection site, lesion(s)	legacy FDA term: lesions found in the injection site	322	0%	3
PR-intest, lesion(s)	legacy FDA term: lesions found in the intest	411	0%	0
PR-kidney(s), lesion(s)	legacy FDA term: lesions found in the kidneys	1,482	0.1%	1
PR-liver, lesion(s)	legacy FDA term: lesions found in the liver	3,247	0.2%	7
PR-lung(s), edema		566	0%	0
PR-lung(s), lesion(s)	legacy FDA term: lesions found in the lungs	1,690	0.1%	3
PR-lymph node(s), lesion(s)	legacy FDA term: lesions found in the lymph nodes	482	0%	3
PR-pancreas, lesion(s)	legacy FDA term: lesions found in the pancreas	437	0%	0
PR-peritoneal effusion		204	0%	0
PR-skin, lesion(s)	legacy FDA term: lesions found in the skin	1,287	0.1%	11
PR-small intestine, lesion(s)	legacy FDA term: lesions found in the small intestine	745	0.1%	0
PR-spleen, lesion(s)	legacy FDA term: lesions found in the spleen	777	0.1%	3
PR-stomach, lesion(s)	legacy FDA term: lesions found in the stomach	855	0.1%	0
Precipitate, Sediment	a product quality report, not a sign in an animal	1,323	0.1%	177
Product defect NOS	a product quality report, not a sign in an animal	402	0%	279
Product Defect, General	a product quality report, not a sign in an animal	9,310	0.7%	1
Product defect, product difficult to use/handle	a product quality report, not a sign in an animal	1,914	0.1%	930
Product label issues	a product quality report, not a sign in an animal	2,413	0.2%	245
Product problem	a product quality report, not a sign in an animal	10,340	0.8%	0
Product syringe calibration unreadable	a product quality report, not a sign in an animal	289	0%	3
Product syringe issue	a product quality report, not a sign in an animal	1,470	0.1%	98
Product syringe missing	a product quality report, not a sign in an animal	498	0%	38
Prolapse of the nictitating membrane		434	0%	10
Prolonged activated partial thrombin time (APTT)		370	0%	48
Prolonged anaesthesia		203	0%	5
Prolonged capillary refill time		695	0.1%	56
Prolonged one stage prothrombin time (OSPT)		265	0%	41
Proprioception abnormality		1,153	0.1%	47
Proprioception deficit	reduced awareness of limb position	1,869	0.1%	340
Proprioception loss		382	0%	65
Proteinuria	protein in the urine	5,133	0.4%	515
Pruritus	itching	24,463	1.8%	470
Pulmonary congestion		967	0.1%	39
Pulmonary disorder NOS	NOS: not otherwise specified	894	0.1%	47
Pulmonary neoplasm		233	0%	5
Pulmonary oedema		1,022	0.1%	91
Puncture wound		209	0%	0
Purulent lesion(s)		354	0%	55
Pustules		953	0.1%	35
Pyoderma	bacterial skin infection	2,117	0.2%	64
Pyrexia	fever	645	0.1%	54
Pyuria		644	0.1%	98
Quiet		770	0.1%	172
Rash		3,386	0.3%	114
Recovery prolonged		1,444	0.1%	38
Rectal bleeding		834	0.1%	35
Rectal prolapse		207	0%	14
Recumbency	lying down and unable or unwilling to rise	7,088	0.5%	157
Red blood cell disorder		465	0%	21
Red blood cells(rbc) nucleated		268	0%	2
Red eye		621	0.1%	68
Reddening of the skin		4,134	0.3%	345
Reduced globulins		1,036	0.1%	82
Reduced responses		926	0.1%	55
Regenerative anaemia		818	0.1%	40
Regurgitation		1,284	0.1%	157
Reluctant to move		5,537	0.4%	415
Renal disorder NOS	kidney disorder, type not specified	2,118	0.2%	147
Renal failure	kidney failure	4,044	0.3%	164
Renal insufficiency		378	0%	23
Residues in meat/offal		446	0%	10
Residues in milk		1,484	0.1%	13
Respiratory arrest		683	0.1%	33
Respiratory distress		1,789	0.1%	90
Respiratory signs		481	0%	36
Respiratory sound		745	0.1%	20
Respiratory tract disorder NOS	NOS: not otherwise specified	1,341	0.1%	75
Respiratory tract infection NOS	NOS: not otherwise specified	421	0%	51
Restlessness		9,243	0.7%	432
Retching		2,510	0.2%	66
Retinal disorder NOS	NOS: not otherwise specified	649	0.1%	15
Reverse sneezing		306	0%	31
Rigidity		412	0%	27
Rigidity of limbs		277	0%	26
Rolling		525	0%	62
Rubbing		970	0.1%	107
Ruminal bloat		460	0%	8
Scale		622	0.1%	30
Schirmer tear test		200	0%	0
Scleritis		214	0%	3
Scooting		414	0%	45
Scratching		7,142	0.5%	490
Seal, Abnormal	a product quality report, not a sign in an animal	5,566	0.4%	159
Seborrhoea		338	0%	12
Sedation		1,830	0.1%	126
Sedation prolonged		1,100	0.1%	55
Seizure NOS	seizure, type not specified	33,459	2.5%	2,861
Self mutilation		272	0%	11
Self trauma		1,404	0.1%	47
Sensory abnormality NOS	NOS: not otherwise specified	452	0%	3
Septicaemia		667	0.1%	46
Shaking		14,415	1.1%	872
Shallow breathing		426	0%	49
Shivering		1,428	0.1%	88
Shock		1,902	0.1%	31
Sickness		491	0%	109
Skin abscess		389	0%	15
Skin and tissue infection NOS	NOS: not otherwise specified	778	0.1%	97
Skin and/or appendage neoplasm NOS	NOS: not otherwise specified	453	0%	8
Skin disorders NOS	NOS: not otherwise specified	5,054	0.4%	152
Skin haematoma		238	0%	3
Skin haemorrhage NOS	NOS: not otherwise specified	211	0%	40
Skin hyperaemia	reddened skin	2,947	0.2%	3
Skin inflammation NOS	NOS: not otherwise specified	1,005	0.1%	98
Skin irritation		1,100	0.1%	80
Skin lesion NOS	NOS: not otherwise specified	5,861	0.4%	322
Skin lump		1,582	0.1%	66
Skin necrosis		663	0.1%	24
Skin petechiae		1,024	0.1%	19
Skin scab		3,521	0.3%	327
Skin slough		1,019	0.1%	0
Skin sore		1,829	0.1%	140
Skin swelling		343	0%	13
Skin tumour NOS	NOS: not otherwise specified	354	0%	11
Skin ulcer		1,251	0.1%	108
Skin warmth		400	0%	21
Sleep disturbance NOS	NOS: not otherwise specified	631	0.1%	54
Sleepiness - neurological disorder		1,117	0.1%	37
Sleepiness - systemic disorder		1,664	0.1%	260
Small intestine ulcer		854	0.1%	3
Small liver		247	0%	1
Smelly breath		227	0%	15
Sneezing		2,160	0.2%	133
Soft stool		600	0%	403
Solution, Abnormal	a product quality report, not a sign in an animal	4,394	0.3%	90
Solution/Suspension, crystals	a product quality report, not a sign in an animal	696	0.1%	26
Somnolence		857	0.1%	4
Spasm		871	0.1%	19
Spleen and reticulo-endothelial system disorder NOS	NOS: not otherwise specified	400	0%	18
Splenic neoplasm		580	0%	0
Splenomegaly		1,120	0.1%	68
Spondylosis		375	0%	85
Squinting		873	0.1%	78
Staggering		2,560	0.2%	62
Star-gazing		903	0.1%	22
Staring		1,531	0.1%	275
Stiff gait		591	0%	58
Stiffness limb		804	0.1%	86
Stiffness NOS	NOS: not otherwise specified	1,827	0.1%	217
Stillbirth		417	0%	3
Stomach upset		1,265	0.1%	128
Stomatitis		494	0%	9
Stopper, abnormal		984	0.1%	294
Strabismus		218	0%	23
Straining to defecate		575	0%	76
Stranguria		537	0%	38
Stress leukogram		206	0%	36
Stroke		387	0%	43
Stumbling gait		2,582	0.2%	239
Stupor	barely responsive	1,692	0.1%	16
Sudden death		1,265	0.1%	56
Surgical site disorder		487	0%	22
Suspected infectious agent transmission		418	0%	0
Suspension, Abnormal	a product quality report, not a sign in an animal	5,239	0.4%	112
Swallowing difficult		302	0%	23
Swelling around eye		894	0.1%	84
Swelling NOS	NOS: not otherwise specified	1,955	0.1%	107
Swollen eye		864	0.1%	67
Swollen face		483	0%	30
Swollen feet		334	0%	28
Swollen limb		730	0.1%	142
Swollen lip		516	0%	35
Swollen lymph node		405	0%	23
Swollen mouth		413	0%	11
Swollen tongue		328	0%	23
Swollen vulva		483	0%	24
Syncope		578	0%	42
Syringe, Abnormal	a product quality report, not a sign in an animal	564	0%	26
Systemic disorder NOS	NOS: not otherwise specified	2,968	0.2%	72
Tablets, Abnormal	a product quality report, not a sign in an animal	19,589	1.4%	1,201
Tachycardia	fast heart rate	6,765	0.5%	338
Tachypnoea	fast breathing	4,666	0.3%	207
Tarry or black stool		1,401	0.1%	87
Temporary blindness		890	0.1%	19
Temporary deafness		647	0.1%	8
Tenesmus		645	0.1%	14
Tense abdomen		1,263	0.1%	144
Third eyelid protrusion		804	0.1%	113
Thrombocytopenia	low platelet count	7,338	0.5%	309
Thrombocytosis	high platelet count	1,749	0.1%	198
Tiredness		1,459	0.1%	156
Tongue disorder NOS	NOS: not otherwise specified	803	0.1%	56
Tongue oedema		452	0%	0
Tongue protrusion		514	0%	43
Tongue ulceration		474	0%	22
Tonic-clonic seizure		286	0%	17
Tooth disorder		698	0.1%	42
Torn ligament		237	0%	50
Toxicity		202	0%	0
Trauma NOS	NOS: not otherwise specified	796	0.1%	19
Trembling		12,544	0.9%	282
Tremor		8,028	0.6%	679
Tremor of limb		705	0.1%	64
Tubes, Abnormal	a product quality report, not a sign in an animal	2,078	0.2%	73
Tubes, Damaged	a product quality report, not a sign in an animal	1,419	0.1%	89
Tubes, Leaking	a product quality report, not a sign in an animal	5,199	0.4%	287
Twitching		6,998	0.5%	354
Tympanic rupture		237	0%	26
Ulceration NOS	NOS: not otherwise specified	659	0.1%	40
Ulcerative dermatitis		234	0%	19
Ultrasound, liver abnormal		1,362	0.1%	7
Unable to jump		699	0.1%	114
Unable to rise		1,488	0.1%	145
Unable to stand		3,722	0.3%	402
Unable to walk		1,485	0.1%	571
Unclassifiable adverse event	event that fits no dictionary term	10,311	0.8%	175
Uncoded sign	a sign with no matching dictionary term	10,160	0.8%	12
Uncomfortable		1,734	0.1%	260
Unconscious		336	0%	32
Underdose	less than the labelled amount was given	11,005	0.8%	733
Underfilling, Bottles	a product quality report, not a sign in an animal	1,338	0.1%	87
Underfilling, Container	a product quality report, not a sign in an animal	6,245	0.5%	541
Underfilling, Package	a product quality report, not a sign in an animal	10,640	0.8%	296
Underfilling, Tubes	a product quality report, not a sign in an animal	7,258	0.5%	188
Underfilling, Vials	a product quality report, not a sign in an animal	1,452	0.1%	40
Unexplained death		562	0%	38
Unpalatable	legacy FDA term: the animal would not take it	28,240	2.1%	866
Unrelated death		676	0.1%	58
Unresponsive to stimuli		1,695	0.1%	167
Unsteady gait		1,607	0.1%	180
Unusual stool colour		242	0%	23
Unwell		695	0.1%	272
Urinary bladder disorder NOS	NOS: not otherwise specified	689	0.1%	69
Urinary incontinence		6,097	0.5%	604
Urinary retention		460	0%	57
Urinary tract disorder NOS	NOS: not otherwise specified	1,840	0.1%	42
Urinary tract infection		5,156	0.4%	564
Urination		908	0.1%	32
Urination related to convulsion		391	0%	86
Urine abnormalities NOS	NOS: not otherwise specified	2,035	0.2%	184
Urine leakage		670	0.1%	71
Urolithiasis		337	0%	25
Urticaria	hives	5,768	0.4%	33
Uveitis		456	0%	33
Vaginal discharge		292	0%	25
Vaginal haemorrhage		217	0%	11
Vaginal swelling		206	0%	3
Vasculitis		436	0%	34
Vesicle		392	0%	4
Vestibular disorder NOS	NOS: not otherwise specified	2,001	0.2%	203
Vials, Abnormal	a product quality report, not a sign in an animal	1,125	0.1%	36
Vials, Damaged	a product quality report, not a sign in an animal	3,115	0.2%	180
Vials, Leaking	a product quality report, not a sign in an animal	5,451	0.4%	41
Vocalisation	crying out or unusual noise	14,106	1%	735
Vomiting		213,494	15.7%	8,157
Vomiting bile		715	0.1%	202
Walking difficulty		4,812	0.4%	409
Warm feeling to the touch		693	0.1%	102
Wbc, urine		875	0.1%	0
Weak pulse		637	0.1%	95
Weakness		10,660	0.8%	656
Weight fluctuation		378	0%	54
Weight gain		6,660	0.5%	347
Weight loss		24,015	1.8%	1,996
Welt		473	0%	40
Wheezing		1,082	0.1%	69
Whining		561	0%	148
Wobbliness		1,397	0.1%	501
Wound		1,048	0.1%	188
Wrong technique in drug usage process		373	0%	2