Clinical signs: in adverse event reports for animal drugs

1,149 coded terms, A to Z

The terms are from VeDDRA, the list of terms for veterinary reports, and from older FDA reports. Some terms are about a product that did not have the expected effect, or about a defect of a package.

Search engines list 115 of these pages. Each has 3,000 reports or more in all years and 300 reports or more in the latest 12 months. The other pages stay on the site and are in the table.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

The list

Clinical signs with 200 or more reports, in order of name
Sign	In plain words	Reports, all years	Share of all reports	Reports, latest 12 months	Listed by search engines
Abdominal cavity disorder NOS	NOS: not otherwise specified	542	0%	36	No
Abdominal cavity haemorrhage		688	0.1%	33	No
Abdominal discomfort		848	0.1%	76	No
Abdominal effusion		507	0%	65	No
Abdominal mass		928	0.1%	52	No
Abdominal pain		6,257	0.5%	148	No
Abnormal adrenocorticotropic hormone (ACTH) stimulation test		962	0.1%	56	No
Abnormal breathing		2,713	0.2%	128	No
Abnormal cytology		2,140	0.2%	425	No
Abnormal ECG		320	0%	0	No
Abnormal menace reflex test		1,021	0.1%	101	No
Abnormal movement NOS	NOS: not otherwise specified	1,042	0.1%	91	No
Abnormal posture		254	0%	42	No
Abnormal posture NOS	NOS: not otherwise specified	2,957	0.2%	191	No
Abnormal pupil light reflex		985	0.1%	66	No
Abnormal radiograph finding		10,142	0.7%	722	Yes
Abnormal red blood cell		467	0%	26	No
Abnormal stool colouration		1,115	0.1%	59	No
Abnormal test result		377	0%	0	No
Abnormal ultrasound finding		6,313	0.5%	406	Yes
Abnormal urine odour		433	0%	21	No
Abortion		909	0.1%	19	No
Abscess NOS	NOS: not otherwise specified	487	0%	48	No
Accidental drug intake by child		345	0%	1	No
Accidental exposure	exposure that was not intended	31,275	2.3%	847	Yes
Acidic urine		224	0%	23	No
Acidosis		329	0%	26	No
Active urine sediment		213	0%	29	No
Acute renal failure		665	0.1%	43	No
Addison's disease		319	0%	16	No
Adipsia	not drinking	5,060	0.4%	96	No
Administration device NOS, abnormal		218	0%	59	No
Administration device NOS, malfunction		372	0%	31	No
Administration error NOS	NOS: not otherwise specified	1,649	0.1%	695	No
Adrenal gland disorder NOS	NOS: not otherwise specified	586	0%	41	No
Aggression		5,669	0.4%	278	No
Agitation		5,865	0.4%	279	No
Alkaline urine		621	0.1%	59	No
Allergic dermatitis		436	0%	49	No
Allergic pruritus		374	0%	12	No
Allergic reaction		1,550	0.1%	92	No
Allergic skin reaction		251	0%	11	No
Allergy NOS	NOS: not otherwise specified	1,183	0.1%	88	No
Alopecia	hair loss	1,842	0.1%	131	No
Alopecia general		393	0%	17	No
Alopecia local		1,407	0.1%	116	No
Alopecia NOS	hair loss, type not specified	4,260	0.3%	34	No
Alteration of milk quality		867	0.1%	2	No
Anaemia NOS	low red blood cell count	12,972	0.9%	547	Yes
Anal and rectal disorder NOS	NOS: not otherwise specified	209	0%	32	No
Anal irritation		301	0%	8	No
Anal sac disorder		580	0%	49	No
Anaphylactic shock		311	0%	26	No
Anaphylactic-type reaction		1,150	0.1%	37	No
Anaphylactoid reaction	sudden allergic-type reaction	2,322	0.2%	15	No
Anaphylaxis	sudden severe allergic-type reaction	11,460	0.8%	548	Yes
Anisocoria		1,006	0.1%	52	No
Anorexia	not eating	59,805	4.3%	1,186	Yes
Anuria		736	0.1%	29	No
Anxiety		5,761	0.4%	459	Yes
Apathy		258	0%	8	No
Apnoea	breathing stopped	2,670	0.2%	50	No
Appearance, Abnormal	a product quality report, not a sign in an animal	4,881	0.4%	404	Yes
Appetite disorder NOS	NOS: not otherwise specified	482	0%	51	No
Appetite loss		3,346	0.2%	261	No
Application site alopecia	hair loss where the product was applied	10,146	0.7%	212	No
Application site bleeding	bleeding where the product was applied	549	0%	60	No
Application site blister	blister where the product was applied	367	0%	29	No
Application site burn	burn where the product was applied	940	0.1%	81	No
Application site crust	crust where the product was applied	540	0%	41	No
Application site dermatitis	inflamed skin where the product was applied	295	0%	18	No
Application site erythema	reddened skin where the product was applied	3,558	0.3%	123	No
Application site greasy fur	greasy fur where the product was applied	457	0%	30	No
Application site hair change	hair change where the product was applied	918	0.1%	30	No
Application site hair coat discolouration	hair coat discolouration where the product was applied	212	0%	21	No
Application site hair loss	hair loss where the product was applied	8,339	0.6%	719	Yes
Application site inflammation	inflammation where the product was applied	2,000	0.2%	83	No
Application site irritation	irritation where the product was applied	1,982	0.1%	196	No
Application site itching	itching where the product was applied	821	0.1%	86	No
Application site lesion	lesion where the product was applied	2,702	0.2%	76	No
Application site pain	pain where the product was applied	1,024	0.1%	93	No
Application site pruritus	itching where the product was applied	2,731	0.2%	61	No
Application site rash	rash where the product was applied	383	0%	46	No
Application site reaction NOS	reaction nos where the product was applied	1,265	0.1%	52	No
Application site reddening	reddening where the product was applied	2,183	0.2%	267	No
Application site residue	residue where the product was applied	554	0%	41	No
Application site scab	scab where the product was applied	2,705	0.2%	206	No
Application site scratching	scratching where the product was applied	1,149	0.1%	124	No
Application site self trauma	self trauma where the product was applied	234	0%	22	No
Application site skin change NOS	skin change nos where the product was applied	723	0.1%	11	No
Application site skin scaling	skin scaling where the product was applied	218	0%	27	No
Application site sore	sore where the product was applied	399	0%	33	No
Application site stickiness	stickiness where the product was applied	529	0%	79	No
Application site swelling	swelling where the product was applied	1,272	0.1%	41	No
Application site ulcer	ulcer where the product was applied	518	0%	39	No
Applicator, Abnormal	a product quality report, not a sign in an animal	647	0.1%	29	No
Apprehension		1,666	0.1%	2	No
Arched back		462	0%	46	No
Arrhythmia		1,403	0.1%	65	No
Arthritis		1,778	0.1%	226	No
Ascites	fluid in the abdomen	1,765	0.1%	42	No
Aspiration pneumonia		232	0%	69	No
Ataxia	unsteady, uncoordinated movement	32,286	2.3%	1,409	Yes
Atopic allergy NOS	NOS: not otherwise specified	285	0%	18	No
Attention-seeking behaviour		278	0%	40	No
Aural haematoma		248	0%	27	No
Autoimmune disorder NOS	NOS: not otherwise specified	545	0%	28	No
Azotaemia	raised kidney values in blood	2,503	0.2%	173	No
Bacterial skin infection NOS	NOS: not otherwise specified	1,506	0.1%	111	No
Bad taste		285	0%	17	No
Balance impaired		758	0.1%	98	No
Balance problem		1,724	0.1%	109	No
Bands(neutrophils) high, blood		556	0%	0	No
Barking		542	0%	66	No
Basophilia		470	0%	59	No
Behavioural disorder NOS	behaviour change, type not specified	26,919	2%	1,526	Yes
Bilirubinuria		1,571	0.1%	83	No
Birth defect		246	0%	0	No
Biting - pruritus		616	0%	91	No
Biting -aggression		1,299	0.1%	79	No
Bladder incontinence		299	0%	20	No
Blepharospasm		634	0.1%	34	No
Blindness		4,431	0.3%	166	No
Blinking		243	0%	20	No
Blistering		351	0%	24	No
Bloated		512	0%	45	No
Bloated stomach		289	0%	27	No
Blood and lymphatic system disorder NOS	NOS: not otherwise specified	558	0%	4	No
Blood in faeces		2,353	0.2%	117	No
Blood in faeces NOS	NOS: not otherwise specified	307	0%	0	No
Blood in urine		2,017	0.2%	183	No
Blood in vomit		4,935	0.4%	177	No
Blood loss NOS	NOS: not otherwise specified	214	0%	15	No
Bloodshot eye		230	0%	13	No
Bloody diarrhoea	diarrhea with blood	14,463	1.1%	630	Yes
Bloody stool		240	0%	143	No
Bone and joint disorder NOS	NOS: not otherwise specified	1,450	0.1%	296	No
Bottles, Damaged	a product quality report, not a sign in an animal	586	0%	20	No
Bradycardia	slow heart rate	3,816	0.3%	201	No
Bradypnoea		546	0%	12	No
Brain disorder NOS	NOS: not otherwise specified	239	0%	17	No
Breathing difficulty		2,762	0.2%	205	No
Bronchitis		295	0%	22	No
Bruising		1,574	0.1%	114	No
Bumping into walls		535	0%	84	No
Bumps on skin		250	0%	102	No
Burning sensation of eye		203	0%	12	No
Cachexia		211	0%	13	No
Calculi		383	0%	15	No
Caps, Abnormal	a product quality report, not a sign in an animal	3,851	0.3%	51	No
Cardiac arrest		3,818	0.3%	113	No
Cardiac disorder NOS	heart problem, type not specified	11,791	0.9%	92	No
Cardiac enlargement		1,508	0.1%	80	No
Cardiomyopathy		296	0%	26	No
Cardiorespiratory arrest		265	0%	30	No
Cataract		766	0.1%	34	No
Cellulitis		503	0%	49	No
Central nervous system disorder NOS	NOS: not otherwise specified	450	0%	11	No
Chattering of teeth		396	0%	35	No
Chewing - oral cavity disorder		221	0%	3	No
Chewing - pruritus		780	0.1%	93	No
Chronic renal failure		250	0%	5	No
Circling - behavioural disorder		346	0%	42	No
Circling - neurological disorder		2,756	0.2%	137	No
Circulatory collapse		662	0.1%	58	No
Circumstance or info capable of leading to medication error		226	0%	11	No
Claw / hoof / nail disorder NOS	NOS: not otherwise specified	482	0%	36	No
Closed eyelid		359	0%	19	No
Closure, Abnormal	a product quality report, not a sign in an animal	3,522	0.3%	299	No
Closure, Missing	a product quality report, not a sign in an animal	911	0.1%	117	No
Cloudy eye (for Miosis, Mydriasis, Anisocoria, Nystagmus		329	0%	45	No
Coagulopathy		1,303	0.1%	11	No
Cognitive disorder NOS	NOS: not otherwise specified	293	0%	50	No
Colic		780	0.1%	49	No
Colitis		811	0.1%	49	No
Collapse		5,881	0.4%	92	No
Collapse NOS	NOS: not otherwise specified	3,723	0.3%	325	Yes
Collapse of leg		535	0%	54	No
Color, Abnormal	a product quality report, not a sign in an animal	10,856	0.8%	360	Yes
Coma		369	0%	24	No
Confused		417	0%	0	No
Confusion		4,639	0.3%	212	No
Congested mucous membrane		260	0%	32	No
Congestion of mucous membrane		227	0%	7	No
Congestive heart failure		450	0%	52	No
Conjunctivitis		1,329	0.1%	66	No
Constipation		2,624	0.2%	166	No
Constricted pupils		259	0%	15	No
Containers, Abnormal	a product quality report, not a sign in an animal	3,773	0.3%	90	No
Containers, Damaged	a product quality report, not a sign in an animal	14,838	1.1%	1,042	Yes
Containers, Leaking	a product quality report, not a sign in an animal	7,440	0.5%	604	Yes
Contamination NOS	NOS: not otherwise specified	889	0.1%	41	No
Contamination, Foreign Object		1,616	0.1%	449	No
Contamination, Mold		251	0%	11	No
Contamination, Particulate Matter		754	0.1%	57	No
Convulsion	seizure	12,747	0.9%	77	No
Coprophagia		212	0%	16	No
Corneal disorder NOS	NOS: not otherwise specified	478	0%	36	No
Corneal oedema		257	0%	12	No
Corneal ulcer		1,347	0.1%	80	No
Cough		8,890	0.6%	405	Yes
Crackles on auscultation		344	0%	38	No
Crust		2,133	0.2%	174	No
Crying		1,804	0.1%	163	No
Crystalluria		1,105	0.1%	70	No
Culture/titer data abnormal		1,532	0.1%	10	No
Cushings disease NOS	NOS: not otherwise specified	323	0%	34	No
Cyanosis	bluish gums or skin from low oxygen	2,320	0.2%	82	No
Cystitis		542	0%	34	No
Dazed		201	0%	111	No
Deafness		6,736	0.5%	340	Yes
Deafness NOS	NOS: not otherwise specified	329	0%	19	No
Death		51,482	3.7%	2,015	Yes
Death by euthanasia	the animal was euthanized	30,265	2.2%	1,829	Yes
Death-slaughtered		227	0%	0	No
Death-treatment failure		744	0.1%	0	No
Decreased activity		1,909	0.1%	173	No
Decreased appetite		18,300	1.3%	1,586	Yes
Decreased body temperature		793	0.1%	86	No
Decreased bowel movements		843	0.1%	58	No
Decreased cholesterol (total)		540	0%	46	No
Decreased drinking		1,316	0.1%	187	No
Decreased haematocrit		1,171	0.1%	486	No
Decreased haemoglobin		1,074	0.1%	225	No
Decreased heart rate		440	0%	57	No
Decreased packed cell volume (PCV)	lower share of red cells in the blood	1,839	0.1%	110	No
Decreased percentage of reticulocytes		496	0%	126	No
Decreased pulse oxygenation		200	0%	23	No
Decreased red blood cell count		1,476	0.1%	261	No
Decreased urine concentration	dilute urine	4,768	0.4%	177	No
Defect Unknown/Not Specified	a product quality report, not a sign in an animal	1,735	0.1%	168	No
Dehydration		10,412	0.8%	670	Yes
Delayed healing		214	0%	17	No
Demodicosis		232	0%	4	No
Dental calculus		442	0%	40	No
Dental disease		603	0%	73	No
Dependent oedema		371	0%	4	No
Depression	dull, quiet or withdrawn	42,447	3.1%	173	No
Dermal cyst(s)		438	0%	24	No
Dermal mass		1,489	0.1%	81	No
Dermal thickening		324	0%	44	No
Dermatitis	inflamed skin	4,585	0.3%	188	No
Dermatosis NOS	NOS: not otherwise specified	345	0%	9	No
Device breakage/fracture		510	0%	45	No
Device Defective NOS	a product quality report, not a sign in an animal	2,752	0.2%	176	No
Diabetes		907	0.1%	62	No
Diabetes mellitus		1,196	0.1%	38	No
Diabetic ketoacidosis		663	0.1%	119	No
Diabetic ketonuria		394	0%	0	No
Diarrhoea	diarrhea	83,314	6%	4,531	Yes
Difficulty going up/down stairs		314	0%	82	No
Difficulty of Use	a product quality report, not a sign in an animal	3,260	0.2%	0	No
Difficulty standing		692	0.1%	192	No
Difficulty to rise		701	0.1%	123	No
Digestive tract disorder NOS	digestive problem, type not specified	21,212	1.5%	144	No
Digestive tract haemorrhage NOS	NOS: not otherwise specified	353	0%	10	No
Digestive tract hypomotility		277	0%	19	No
Dilated pupils		3,544	0.3%	321	Yes
Discoloured urine		1,558	0.1%	69	No
Discomfort NOS	NOS: not otherwise specified	1,180	0.1%	172	No
Disorder of gastrointestinal flora		207	0%	15	No
Disorder of red blood cell NOS	NOS: not otherwise specified	389	0%	35	No
Disorientation		5,646	0.4%	406	Yes
Disoriented state		682	0.1%	57	No
Dispenser, Abnormal	a product quality report, not a sign in an animal	3,091	0.2%	6	No
Disseminated intravascular coagulation		409	0%	9	No
Distension of abdomen		2,618	0.2%	136	No
Distress		848	0.1%	112	No
Drinking a lot		2,108	0.2%	98	No
Drooling		8,130	0.6%	700	Yes
Drooping eyelid		412	0%	38	No
Drowsiness - systemic disorder		213	0%	37	No
Drug administered at inappropriate site		1,321	0.1%	221	No
Drug administration duration too long		959	0.1%	45	No
Drug administration error		4,798	0.4%	0	No
Drug dispensing error		290	0%	2	No
Drug dose administration interval too long		3,360	0.2%	129	No
Drug dose administration interval too short		2,961	0.2%	236	No
Drug dose omission	a scheduled administration was missed	4,047	0.3%	261	No
Drug dose prescribing error		213	0%	4	No
Drug label confusion		273	0%	43	No
Drug prescribing error		209	0%	0	No
Drug schedule prescribing error		238	0%	0	No
Drunken gait		576	0%	57	No
Dry eye		364	0%	31	No
Dry mouth		289	0%	4	No
Dry mucous membrane		1,255	0.1%	126	No
Dry nose		323	0%	22	No
Dry skin		1,268	0.1%	58	No
Dull		684	0.1%	118	No
Dullness		758	0.1%	55	No
Duodenal ulcer		210	0%	8	No
Dysphagia		405	0%	12	No
Dysphoria		728	0.1%	125	No
Dyspnoea	difficulty breathing	7,646	0.6%	120	No
Dysuria		237	0%	6	No
Ear canal erythema		339	0%	37	No
Ear canal inflammation		283	0%	49	No
Ear discharge		1,192	0.1%	98	No
Ear infection NOS	NOS: not otherwise specified	2,256	0.2%	240	No
Ear irritation		217	0%	15	No
Ear pain		477	0%	40	No
Ear pruritus		373	0%	36	No
Ear twitching		219	0%	17	No
Ecchymosis		1,121	0.1%	20	No
Electrolyte disorder		1,181	0.1%	61	No
Elevated alanine aminotransferase (ALT)	a liver enzyme above the normal range	27,296	2%	1,264	Yes
Elevated amylase	a pancreatic enzyme above the normal range	3,653	0.3%	174	No
Elevated aspartate aminotransferase (AST)	a liver and muscle enzyme above the normal range	5,390	0.4%	207	No
Elevated betahydroxybutyrate (BHBA)		239	0%	235	No
Elevated bile acids		1,322	0.1%	40	No
Elevated blood urea nitrogen (BUN)	a kidney value above the normal range	17,743	1.3%	815	Yes
Elevated cholesterol (total)		3,295	0.2%	357	Yes
Elevated creatine-kinase (CK)	a muscle enzyme above the normal range	1,703	0.1%	100	No
Elevated creatinine	a kidney value above the normal range	13,702	1%	557	Yes
Elevated gamma-glutamyl transferase (GGT)	a liver enzyme above the normal range	4,276	0.3%	245	No
Elevated globulins		3,089	0.2%	421	Yes
Elevated haematocrit		346	0%	119	No
Elevated lipase	a pancreatic enzyme above the normal range	2,990	0.2%	162	No
Elevated liver enzymes	liver enzymes above the normal range	8,230	0.6%	0	No
Elevated liver enzymes NOS	NOS: not otherwise specified	997	0.1%	343	No
Elevated pancreatic enzymes		423	0%	42	No
Elevated protein:creatinine ratio		415	0%	75	No
Elevated renal parameters	kidney values above the normal range	2,412	0.2%	147	No
Elevated serum alkaline phosphatase (ALP)	a liver and bone enzyme above the normal range	3,034	0.2%	1,125	Yes
Elevated serum alkaline phosphatase (SAP)	a liver and bone enzyme above the normal range	22,106	1.6%	0	No
Elevated symmetrical dimethylarginine (SDMA)	a kidney value above the normal range	2,073	0.2%	428	No
Elevated temperature		2,494	0.2%	207	No
Elevated thyroxine (T4)		245	0%	53	No
Elevated total bilirubin	bilirubin above the normal range	10,390	0.8%	462	Yes
Elevated triglyceride		1,012	0.1%	128	No
Embolism		210	0%	1	No
Emesis	vomiting	69,533	5%	300	Yes
Emesis (multiple)	vomiting more than once	19,851	1.4%	2,109	Yes
Enlarged liver		629	0.1%	51	No
Enlarged lymph node (localised)		627	0.1%	110	No
Enlarged lymph nodes (generalised)		352	0%	34	No
Enteritis		574	0%	24	No
Eosinopenia		813	0.1%	347	No
Eosinopenia		366	0%	0	No
Eosinophilia		1,578	0.1%	138	No
Epilepsy		223	0%	17	No
Epileptic seizure		221	0%	8	No
Epiphora		488	0%	35	No
Epistaxis	nosebleed	1,711	0.1%	36	No
Eruption		382	0%	3	No
Erythema (for urticaria see Immune SOC)		4,771	0.4%	157	No
Erythematous rash		439	0%	19	No
Excessive appetite		233	0%	29	No
Excessive chewing, licking and/or grooming		762	0.1%	177	No
Excessive licking and/or grooming		2,070	0.2%	0	No
Excessive thirst		1,166	0.1%	97	No
Excitation		386	0%	30	No
Excoriation		552	0%	54	No
Exercise intolerance		410	0%	20	No
Expired drug administered		715	0.1%	49	No
External ear disorder NOS	NOS: not otherwise specified	591	0%	8	No
Eye disorder NOS (for photophobia see 'neurological')		2,593	0.2%	0	No
Eye disorder NOS (for Photophobia see neurological)		521	0%	152	No
Eye haemorrhage		230	0%	5	No
Eye irritation		1,642	0.1%	58	No
Eye itching		205	0%	14	No
Eye pain		640	0.1%	15	No
Eye redness		1,405	0.1%	68	No
Eyelid oedema		1,085	0.1%	11	No
Eyes rolling back		794	0.1%	38	No
Face and neck swelling		250	0%	15	No
Facial oedema	swollen face	4,696	0.3%	12	No
Facial paralysis		706	0.1%	51	No
Facial pruritus		396	0%	98	No
Facial swelling		8,815	0.6%	766	Yes
Faecal incontinence		1,443	0.1%	115	No
Falling		4,729	0.3%	532	Yes
Fasciculation		402	0%	18	No
Fatigue		229	0%	25	No
Febrile		1,183	0.1%	56	No
Feeling depressed		321	0%	0	No
Female reproductive tract disorder NOS	NOS: not otherwise specified	236	0%	8	No
Fever		17,984	1.3%	848	Yes
Fixed pupil		621	0.1%	14	No
Flaking skin		1,113	0.1%	63	No
Flatulence	gas	1,628	0.1%	84	No
Fluid in abdomen NOS	NOS: not otherwise specified	748	0.1%	69	No
Fly biting behaviour		562	0%	48	No
Foam in the mouth		305	0%	43	No
Foaming at the mouth		3,703	0.3%	334	Yes
Focal seizure		435	0%	90	No
Food allergy		211	0%	8	No
Food refusal		456	0%	93	No
Found dead		630	0.1%	83	No
Fracture		311	0%	51	No
Frequent urination		1,601	0.1%	135	No
Fungal skin infection NOS	NOS: not otherwise specified	484	0%	22	No
Gagging		2,636	0.2%	154	No
Gait abnormality		1,570	0.1%	202	No
Gall bladder & bile duct disorder NOS	NOS: not otherwise specified	1,074	0.1%	95	No
Gastric bloat		349	0%	10	No
Gastric dilation		200	0%	17	No
Gastric perforation		818	0.1%	18	No
Gastric ulcer		918	0.1%	43	No
Gastric ulceration NOS	NOS: not otherwise specified	254	0%	8	No
Gastric volvulus		238	0%	2	No
Gastritis		630	0.1%	45	No
Gastroenteritis		1,207	0.1%	74	No
Gastrointestinal foreign body NOS	NOS: not otherwise specified	299	0%	43	No
Gel/Paste, Abnormal		213	0%	3	No
General hair loss		1,050	0.1%	48	No
General illness		2,168	0.2%	286	No
General pain		797	0.1%	51	No
Generalised itching		1,595	0.1%	149	No
Generalised rash		392	0%	17	No
Generalised weakness		741	0.1%	47	No
Genital tract licking		221	0%	21	No
Gingival disorder		340	0%	6	No
Gingival hyperplasia		708	0.1%	19	No
Gingivitis		456	0%	39	No
Glaucoma		282	0%	16	No
Glazed eye		1,588	0.1%	53	No
Glucosuria	sugar in the urine	2,025	0.2%	250	No
Grand mal seizure		1,004	0.1%	159	No
Granules/Powder, Abnormal		730	0.1%	3	No
Granuloma		225	0%	12	No
Grooming disorder		250	0%	42	No
Growling		301	0%	72	No
Gum disorder NOS	NOS: not otherwise specified	212	0%	16	No
Gut sounds increased		538	0%	20	No
Haemangiosarcoma		225	0%	28	No
Haematemesis		812	0.1%	53	No
Haematochezia	fresh blood in the stool	2,356	0.2%	64	No
Haematuria	blood in the urine	5,098	0.4%	266	No
Haemoconcentration		305	0%	26	No
Haemolytic anaemia		291	0%	2	No
Haemoptysis		558	0%	0	No
Haemorrhage NOS	NOS: not otherwise specified	1,522	0.1%	78	No
Haemorrhagic diarrhoea		700	0.1%	47	No
Haemorrhagic gastroenteritis		488	0%	39	No
Hair change		619	0%	44	No
Hair coat discolouration		800	0.1%	35	No
Hair loss NOS	NOS: not otherwise specified	3,308	0.2%	299	No
Hair modification NOS	NOS: not otherwise specified	823	0.1%	10	No
Hair shedding		1,163	0.1%	39	No
Halitosis		656	0.1%	14	No
Hallucination		527	0%	25	No
Hard, clumping	a product quality report, not a sign in an animal	2,981	0.2%	63	No
Harsh lung sounds		208	0%	26	No
Head bobbing		1,788	0.1%	121	No
Head down		597	0%	83	No
Head pressing		525	0%	30	No
Head shake - behavioural disorder		1,195	0.1%	116	No
Head shake - ear disorder		1,554	0.1%	164	No
Head tilt - ear disorder		2,782	0.2%	116	No
Head tilt - neurological disorder		1,851	0.1%	290	No
Head tremor		2,532	0.2%	183	No
Headache		687	0.1%	18	No
Hearing affected		255	0%	9	No
Hearing decreased		402	0%	30	No
Heart failure		755	0.1%	32	No
Heart murmur		2,404	0.2%	266	No
Heart valve disorder		211	0%	19	No
Heavy breathing		918	0.1%	202	No
Hematocrit(hct) high, blood		249	0%	0	No
Hepatic disorder NOS	NOS: not otherwise specified	336	0%	17	No
Hepatic neoplasm		438	0%	9	No
Hepatitis		783	0.1%	30	No
Hepatomegaly		1,510	0.1%	89	No
Hepatopathy	liver disorder	1,600	0.1%	64	No
Hiding		5,861	0.4%	505	Yes
High blood pressure		622	0.1%	72	No
High pancreatic-specific lipase		1,006	0.1%	242	No
High sodium-potassium ratio (Na:K ratio)		557	0%	85	No
Hind limb ataxia	uncoordinated hind legs	2,072	0.2%	213	No
Hind limb paralysis	paralysed hind legs	1,659	0.1%	115	No
Hind limb paresis	weak hind legs	3,832	0.3%	219	No
Histiocytoma		272	0%	23	No
Hives		8,568	0.6%	716	Yes
Horizontal nystagmus		747	0.1%	96	No
Horner's syndrome		694	0.1%	41	No
Hot spot (pyotraumatic dermatitis)	moist, inflamed patch of skin	1,638	0.1%	108	No
Hyperactivity		10,958	0.8%	475	Yes
Hyperadrenocorticism		310	0%	5	No
Hyperaemic mucous membrane		351	0%	18	No
Hyperaesthesia	over-sensitive to touch	1,617	0.1%	88	No
Hyperalbuminaemia		1,230	0.1%	138	No
Hypercalcaemia	high blood calcium	2,114	0.2%	222	No
Hyperchloraemia		574	0%	47	No
Hyperexcitation		960	0.1%	13	No
Hyperextension		558	0%	23	No
Hyperglycaemia	high blood sugar	8,056	0.6%	720	Yes
Hyperhidrosis		428	0%	0	No
Hyperkalaemia	high blood potassium	4,048	0.3%	205	No
Hyperkeratosis		253	0%	20	No
Hypermetria		210	0%	22	No
Hypernatremia		1,138	0.1%	67	No
Hyperphosphataemia	high blood phosphate	7,087	0.5%	371	Yes
Hyperpigmentation		853	0.1%	37	No
Hyperproteinaemia	high blood protein	2,374	0.2%	266	No
Hypersalivation	drooling	16,000	1.2%	500	Yes
Hypersensitivity NOS	NOS: not otherwise specified	363	0%	38	No
Hypersensitivity reaction		1,461	0.1%	640	No
Hypertension	high blood pressure	1,732	0.1%	149	No
Hyperthermia	raised body temperature	1,609	0.1%	139	No
Hyperthyroidism		360	0%	26	No
Hyperventilation		266	0%	21	No
Hyphaemia		233	0%	10	No
Hypoadrenocorticism		866	0.1%	5	No
Hypoaesthesia		366	0%	1	No
Hypoalbuminaemia	low blood albumin	6,141	0.5%	303	Yes
Hypocalcaemia		519	0%	139	No
Hypocalcaemic condition		1,019	0.1%	3	No
Hypochloraemia	low blood chloride	2,260	0.2%	319	No
Hypocortisolaemia		538	0%	81	No
Hypoglycaemia	low blood sugar	5,339	0.4%	398	Yes
Hypokalaemia	low blood potassium	2,107	0.2%	450	No
Hyponatremia	low blood sodium	2,402	0.2%	191	No
Hypophosphataemia		960	0.1%	126	No
Hypoproteinaemia	low blood protein	3,659	0.3%	167	No
Hyposthenuria		545	0%	91	No
Hypotension	low blood pressure	2,072	0.2%	209	No
Hypothermia	low body temperature	4,190	0.3%	205	No
Hypothyroidism	underactive thyroid	1,768	0.1%	70	No
Icterus	jaundice (yellowing)	5,419	0.4%	107	No
Ileus		228	0%	44	No
Immediate pain upon injection		609	0%	78	No
Immune mediated haemolytic anaemia	the immune system destroying red blood cells	2,270	0.2%	102	No
Immune mediated thrombocytopenia		762	0.1%	66	No
Impaired consciousness		565	0%	39	No
Impaired hearing		325	0%	20	No
Impaired proprioception		293	0%	24	No
Impaired vision		1,339	0.1%	59	No
Impaired vocalisation		283	0%	20	No
Implant, Abnormal		544	0%	6	No
Inappetence	reduced appetite	9,225	0.7%	470	Yes
Inappropriate defecation		2,225	0.2%	175	No
Inappropriate elimination NOS	NOS: not otherwise specified	260	0%	52	No
Inappropriate preparation of medication		578	0%	4	No
Inappropriate schedule of drug administration		1,146	0.1%	73	No
Inappropriate urination		5,825	0.4%	519	Yes
Incoordination		900	0.1%	52	No
Incorrect dose administered NOS	NOS: not otherwise specified	1,431	0.1%	75	No
Incorrect route of drug administration		1,287	0.1%	73	No
Incorrect storage of drug		447	0%	58	No
Increased appetite		843	0.1%	83	No
Increased borborygmus		573	0%	48	No
Increased bowel movements (frequency)		312	0%	27	No
Increased coagulation time		266	0%	14	No
Increased drinking		423	0%	194	No
Increased heart rate		1,701	0.1%	162	No
Increased mortality rate		252	0%	9	No
Increased packed cell volume (PCV)		714	0.1%	43	No
Increased percentage reticulocytes		1,192	0.1%	147	No
Increased red blood cell count		422	0%	67	No
Increased respiratory rate		1,583	0.1%	187	No
Increased salivation		632	0.1%	50	No
Increased seizure frequency		313	0%	31	No
Increased sensitivity to sound		257	0%	25	No
Increased sexual interest		318	0%	4	No
Increased skin sensitivity		299	0%	39	No
Increased sweating		241	0%	15	No
Increased urine concentration		422	0%	45	No
Increased weight		358	0%	19	No
Ineffective, analgesia	legacy FDA term: the product did not have the expected effect (analgesia)	998	0.1%	5	No
Ineffective, anesthesia	legacy FDA term: the product did not have the expected effect (anesthesia)	2,704	0.2%	11	No
Ineffective, antibiotic	legacy FDA term: the product did not have the expected effect (antibiotic)	596	0%	0	No
Ineffective, antiemetic	legacy FDA term: the product did not have the expected effect (antiemetic)	730	0.1%	5	No
Ineffective, antiinflammatory	legacy FDA term: the product did not have the expected effect (antiinflammatory)	1,813	0.1%	7	No
Ineffective, appetite suppression	legacy FDA term: the product did not have the expected effect (appetite suppression)	430	0%	0	No
Ineffective, ascarids	legacy FDA term: the product did not have the expected effect (ascarids)	290	0%	0	No
Ineffective, ascarids NOS	legacy FDA term: the product did not have the expected effect (ascarids nos)	19,031	1.4%	0	No
Ineffective, atopy control	legacy FDA term: the product did not have the expected effect (atopy control)	3,326	0.2%	15	No
Ineffective, coccidia	legacy FDA term: the product did not have the expected effect (coccidia)	1,334	0.1%	0	No
Ineffective, cognitive dysfunc	legacy FDA term: the product did not have the expected effect (cognitive dysfunc)	444	0%	0	No
Ineffective, cushings	legacy FDA term: the product did not have the expected effect (cushings)	1,277	0.1%	1	No
Ineffective, delayed effect	legacy FDA term: the product did not have the expected effect (delayed effect)	363	0%	4	No
Ineffective, estrus suppressio	legacy FDA term: the product did not have the expected effect (estrus suppressio)	578	0%	0	No
Ineffective, estrus synchroniz	legacy FDA term: the product did not have the expected effect (estrus synchroniz)	614	0%	0	No
Ineffective, euthanasia	legacy FDA term: the product did not have the expected effect (euthanasia)	896	0.1%	5	No
Ineffective, gastric ulcer(s)	legacy FDA term: the product did not have the expected effect (gastric ulcer(s))	816	0.1%	33	No
Ineffective, glycemic control	legacy FDA term: the product did not have the expected effect (glycemic control)	3,582	0.3%	60	No
Ineffective, heartworm adults	legacy FDA term: the product did not have the expected effect (heartworm adults)	4,328	0.3%	0	No
Ineffective, heartworm larvae	legacy FDA term: the product did not have the expected effect (heartworm larvae)	69,277	5%	0	No
Ineffective, heartworm microfi	legacy FDA term: the product did not have the expected effect (heartworm microfi)	285	0%	0	No
Ineffective, hooks	legacy FDA term: the product did not have the expected effect (hooks)	13,041	1%	0	No
Ineffective, lice biting	legacy FDA term: the product did not have the expected effect (lice biting)	659	0.1%	0	No
Ineffective, loss of effect	legacy FDA term: the product did not have the expected effect (loss of effect)	4,550	0.3%	96	No
Ineffective, other drug(s)	legacy FDA term: the product did not have the expected effect (other drug(s))	445	0%	30	No
Ineffective, parasite(s) NOS	legacy FDA term: the product did not have the expected effect (parasite(s) nos)	788	0.1%	6	No
Ineffective, production (milk)	legacy FDA term: the product did not have the expected effect (production (milk))	375	0%	0	No
Ineffective, reversal	legacy FDA term: the product did not have the expected effect (reversal)	480	0%	2	No
Ineffective, sedation	legacy FDA term: the product did not have the expected effect (sedation)	2,602	0.2%	23	No
Ineffective, strongyles	legacy FDA term: the product did not have the expected effect (strongyles)	627	0.1%	2	No
Ineffective, weight loss	legacy FDA term: the product did not have the expected effect (weight loss)	336	0%	0	No
Ineffective, whips	legacy FDA term: the product did not have the expected effect (whips)	2,008	0.2%	0	No
Ineffective, worms	legacy FDA term: the product did not have the expected effect (worms)	465	0%	0	No
Ineffective, worms NOS	legacy FDA term: the product did not have the expected effect (worms nos)	1,386	0.1%	23	No
Infectious disease NOS	NOS: not otherwise specified	251	0%	29	No
Infertility NOS	NOS: not otherwise specified	514	0%	0	No
Injected sclera		255	0%	27	No
Injection site abscess	abscess where the injection was given	1,818	0.1%	102	No
Injection site alopecia	hair loss where the injection was given	714	0.1%	30	No
Injection site bleeding	bleeding where the injection was given	1,163	0.1%	79	No
Injection site bruising	bruising where the injection was given	549	0%	52	No
Injection site complication NOS	complication nos where the injection was given	302	0%	23	No
Injection site erythema	reddened skin where the injection was given	414	0%	35	No
Injection site granuloma	granuloma where the injection was given	217	0%	24	No
Injection site hair loss	hair loss where the injection was given	328	0%	44	No
Injection site infection	infection where the injection was given	415	0%	25	No
Injection site inflammation	inflammation where the injection was given	1,548	0.1%	99	No
Injection site lesion	lesion where the injection was given	530	0%	37	No
Injection site lump	lump where the injection was given	2,322	0.2%	221	No
Injection site mass	mass where the injection was given	920	0.1%	0	No
Injection site mass NOS	mass nos where the injection was given	226	0%	63	No
Injection site mucopurulent discharge	mucopurulent discharge where the injection was given	266	0%	21	No
Injection site necrosis	necrosis where the injection was given	1,047	0.1%	41	No
Injection site oedema	oedema where the injection was given	725	0.1%	19	No
Injection site pain	pain where the injection was given	5,949	0.4%	222	No
Injection site pruritus	itching where the injection was given	344	0%	16	No
Injection site reaction NOS	reaction nos where the injection was given	1,209	0.1%	88	No
Injection site reddening	reddening where the injection was given	355	0%	48	No
Injection site scab	scab where the injection was given	416	0%	42	No
Injection site seroma	seroma where the injection was given	430	0%	21	No
Injection site serosanguinous discharge	serosanguinous discharge where the injection was given	287	0%	24	No
Injection site skin discolouration	skin discolouration where the injection was given	271	0%	50	No
Injection site swelling	swelling where the injection was given	8,528	0.6%	435	Yes
Injection site ulcer	ulcer where the injection was given	298	0%	25	No
Injection site warmth	warmth where the injection was given	273	0%	28	No
Injection site weeping	weeping where the injection was given	238	0%	16	No
Intentional misuse	use that was knowingly different from the label	5,045	0.4%	2,412	Yes
Intervertebral disc disease		432	0%	79	No
Intestinal disorder NOS	NOS: not otherwise specified	907	0.1%	97	No
Intestinal perforation		1,404	0.1%	14	No
Involuntary defecation		689	0.1%	74	No
Irregular breathing		406	0%	14	No
Irritability		380	0%	64	No
Isosthenuria		373	0%	82	No
Itching		10,970	0.8%	777	Yes
Itchy ears		234	0%	35	No
Itchy skin		1,024	0.1%	69	No
Jaundice		1,001	0.1%	65	No
Jaw disorder		381	0%	24	No
Joint effusion		360	0%	48	No
Joint pain		853	0.1%	92	No
Joint swelling		1,091	0.1%	162	No
Keratoconjunctivitis sicca		946	0.1%	22	No
Ketonuria		792	0.1%	240	No
Ketosis	ketones building up in the body	3,356	0.2%	910	Yes
Knuckling		965	0.1%	187	No
Labeled drug-species interaction		314	0%	12	No
Labelled drug-drug interaction medication error		3,362	0.2%	1	No
Labels, Abnormal	a product quality report, not a sign in an animal	217	0%	12	No
Laboured breathing		2,677	0.2%	191	No
Lack of coordination		241	0%	23	No
Lack of efficacy - NOS	the product did not have the expected effect	57,451	4.2%	4,330	Yes
Lack of efficacy (bacteria) - Anaplasma	the product did not have the expected effect: Anaplasma bacteria	4,557	0.3%	1,994	Yes
Lack of efficacy (bacteria) - Borrelia	the product did not have the expected effect: Borrelia (Lyme disease bacteria)	12,926	0.9%	2,791	Yes
Lack of efficacy (bacteria) - Ehrlichia	the product did not have the expected effect: Ehrlichia bacteria	3,131	0.2%	764	Yes
Lack of efficacy (bacteria) - NOS	the product did not have the expected effect: target not specified	11,124	0.8%	239	No
Lack of efficacy (ectoparasite) - Demodex	the product did not have the expected effect: Demodex	331	0%	16	No
Lack of efficacy (ectoparasite) - ear mite	the product did not have the expected effect: ear mites	1,726	0.1%	53	No
Lack of efficacy (ectoparasite) - flea	the product did not have the expected effect: fleas	65,571	4.8%	6,828	Yes
Lack of efficacy (ectoparasite) - lice	the product did not have the expected effect: lice	2,378	0.2%	21	No
Lack of efficacy (ectoparasite) - mite NOS	the product did not have the expected effect: mite NOS	619	0%	15	No
Lack of efficacy (ectoparasite) - NOS	the product did not have the expected effect: target not specified	2,298	0.2%	55	No
Lack of efficacy (ectoparasite) - Sarcoptes	the product did not have the expected effect: Sarcoptes	492	0%	16	No
Lack of efficacy (ectoparasite) - tick NOS	the product did not have the expected effect: ticks	17,925	1.3%	1,968	Yes
Lack of efficacy (endoparasite) - heartworm	the product did not have the expected effect: heartworm	54,242	3.9%	5,433	Yes
Lack of efficacy (endoparasite) - hookworm	the product did not have the expected effect: hookworms	50,969	3.7%	4,195	Yes
Lack of efficacy (endoparasite) - NOS	the product did not have the expected effect: target not specified	3,394	0.3%	151	No
Lack of efficacy (endoparasite) - roundworm NOS	the product did not have the expected effect: roundworms	14,372	1%	1,864	Yes
Lack of efficacy (endoparasite) - tapeworm	the product did not have the expected effect: tapeworms	9,207	0.7%	1,279	Yes
Lack of efficacy (endoparasite) - whipworm	the product did not have the expected effect: whipworms	9,029	0.7%	471	Yes
Lack of efficacy (flea)	the product did not have the expected effect: fleas	8,324	0.6%	0	No
Lack of efficacy (fungi) - NOS	the product did not have the expected effect: target not specified	327	0%	154	No
Lack of efficacy (heartworm)	the product did not have the expected effect: heartworm	1,001	0.1%	0	No
Lack of efficacy (lice)	the product did not have the expected effect: lice	450	0%	0	No
Lack of efficacy (neoplasia, no remission)	the product did not have the expected effect: neoplasia, no remission	212	0%	101	No
Lack of efficacy (protozoa)	the product did not have the expected effect: protozoa	291	0%	0	No
Lack of efficacy (protozoa) - Coccidia	the product did not have the expected effect: coccidia	4,984	0.4%	177	No
Lack of efficacy (protozoa) - Ehrlichia	the product did not have the expected effect: Ehrlichia bacteria	251	0%	0	No
Lack of efficacy (protozoa) - Giardia	the product did not have the expected effect: Giardia	647	0.1%	139	No
Lack of efficacy (protozoa) - NOS	the product did not have the expected effect: target not specified	740	0.1%	16	No
Lack of efficacy (roundworm)	the product did not have the expected effect: roundworms	2,765	0.2%	0	No
Lack of efficacy (tapeworm)	the product did not have the expected effect: tapeworms	990	0.1%	0	No
Lack of efficacy (tick)	the product did not have the expected effect: ticks	6,102	0.4%	0	No
Lack of efficacy (virus) - parvovirus (including feline panleukopenia)	the product did not have the expected effect: parvovirus (including feline panleukopenia)	320	0%	54	No
Lack of response to owner		466	0%	54	No
Lameness		5,702	0.4%	413	Yes
Laminitis		319	0%	11	No
Lateral recumbency	lying on the side, unable to rise	3,554	0.3%	345	Yes
Less social		205	0%	24	No
Lethargy	unusually tired or inactive	95,112	6.9%	5,732	Yes
Leucocytosis NOS	high white blood cell count	11,921	0.9%	270	No
Leucopenia NOS	low white blood cell count	4,100	0.3%	161	No
Leukocytosis NOS	NOS: not otherwise specified	394	0%	384	No
Leukopenia NOS	NOS: not otherwise specified	288	0%	281	No
Licking		2,561	0.2%	242	No
Licking at application site		1,067	0.1%	68	No
Licking at injection site		272	0%	36	No
Limb non-weight bearing		535	0%	127	No
Limb weakness		3,817	0.3%	478	Yes
Limping		2,647	0.2%	328	No
Limpness		503	0%	67	No
Lip licking		958	0.1%	74	No
Lip oedema		1,168	0.1%	2	No
Lip smacking		363	0%	41	No
Lipaemia		387	0%	36	No
Lipoma		379	0%	43	No
Listless		1,342	0.1%	81	No
Liver disorder NOS	NOS: not otherwise specified	1,389	0.1%	80	No
Liver failure		989	0.1%	32	No
Liver tumour		322	0%	25	No
Local erythema		289	0%	193	No
Local swelling (not application site)		1,373	0.1%	181	No
Localised hair loss		1,767	0.1%	183	No
Localised itching		736	0.1%	62	No
Localised oedema (not application site)		558	0%	56	No
Localised pain NOS	NOS: not otherwise specified	2,018	0.2%	142	No
Localised rash		595	0%	51	No
Localised skin reaction		202	0%	17	No
Locking Mechanism Abnormal		826	0.1%	13	No
Locomotor disturbance		839	0.1%	3	No
Loose stool		10,456	0.8%	391	Yes
Loss of bowel control		460	0%	49	No
Loss of condition		632	0.1%	11	No
Loss of consciousness		1,421	0.1%	34	No
Loss of hearing		1,763	0.1%	247	No
Loss of vision		411	0%	40	No
Loss of voluntary movement		208	0%	21	No
Lot # and /or Expiration date missing		541	0%	26	No
Lot # and/or Expiration date illegible		372	0%	12	No
Low blood pressure		652	0.1%	92	No
Low blood urea nitrogen (BUN)		970	0.1%	82	No
Low creatinine		550	0%	104	No
Low platelet count		2,348	0.2%	315	No
Low serum alkaline phosphatase (ALP)		227	0%	109	No
Low sodium-potassium ratio (Na:K ratio)		1,209	0.1%	100	No
Low thyroxine (T4)		693	0.1%	122	No
Lumbar pain		403	0%	43	No
Lung oedema		1,233	0.1%	17	No
Lung sound		245	0%	5	No
Lying down		973	0.1%	253	No
Lymphadenopathy	enlarged lymph nodes	1,649	0.1%	81	No
Lymphocytosis		1,392	0.1%	147	No
Lymphoma		1,151	0.1%	91	No
Lymphopenia	low lymphocyte count	3,347	0.2%	428	Yes
Malaise	generally unwell	5,039	0.4%	241	No
Malodour		1,310	0.1%	63	No
Mammary gland disorder NOS	NOS: not otherwise specified	352	0%	11	No
Mammary gland oedema		427	0%	4	No
Mass NOS	NOS: not otherwise specified	614	0%	201	No
Mast cell tumour		428	0%	96	No
Mastitis NOS	NOS: not otherwise specified	803	0.1%	10	No
Medication error		1,235	0.1%	0	No
Medication error NOS	a mistake in giving the product, type not specified	6,044	0.4%	3,250	Yes
Megaoesophagus		206	0%	11	No
Melaena	dark, tarry stool containing digested blood	3,740	0.3%	33	No
Mental confusion		266	0%	25	No
Mental impairment NOS	NOS: not otherwise specified	750	0.1%	66	No
Metastatic neoplasia		303	0%	26	No
Microorganisms, urine		747	0.1%	3	No
Milk production decrease		699	0.1%	15	No
Miosis		600	0%	28	No
Miscellaneous eating disorder NOS	NOS: not otherwise specified	377	0%	43	No
Missing Cap		823	0.1%	4	No
Missing Labels		486	0%	76	No
Mixed Product		246	0%	21	No
Moist dermatitis		1,336	0.1%	43	No
Monocytopenia		263	0%	97	No
Monocytopenia		224	0%	0	No
Monocytosis	high monocyte count	3,394	0.3%	487	Yes
Moribund		220	0%	9	No
Mouth pain		267	0%	18	No
Mucous stool		2,238	0.2%	110	No
Murmur		897	0.1%	8	No
Muscle atrophy		562	0%	143	No
Muscle shaking		731	0.1%	14	No
Muscle spasm NOS	NOS: not otherwise specified	634	0.1%	38	No
Muscle stiffness		1,064	0.1%	22	No
Muscle tremor		2,338	0.2%	99	No
Muscle wasting		1,072	0.1%	107	No
Muscle weakness NOS	NOS: not otherwise specified	869	0.1%	67	No
Musculoskeletal disorder NOS	NOS: not otherwise specified	3,779	0.3%	438	Yes
Musculoskeletal pain		2,017	0.2%	29	No
Mydriasis	dilated pupils	4,320	0.3%	62	No
Myoclonic jerk		310	0%	25	No
Myositis		268	0%	11	No
Nasal bleeding		375	0%	32	No
Nasal cavity and sinus disorder NOS	NOS: not otherwise specified	218	0%	3	No
Nasal congestion		364	0%	29	No
Nasal discharge		2,139	0.2%	128	No
Nausea		5,594	0.4%	390	Yes
Necropsy performed		1,072	0.1%	381	No
Needlestick injury		336	0%	137	No
Neoplasia NOS	tumour, type not specified	2,371	0.2%	95	No
Nephritis		210	0%	9	No
Neurological disorder NOS	NOS: not otherwise specified	616	0%	80	No
Neurological signs NOS	NOS: not otherwise specified	3,971	0.3%	278	No
Neurological symptoms NOS	NOS: not otherwise specified	829	0.1%	49	No
Neutropenia	low neutrophil count	2,841	0.2%	435	No
Neutrophilia	high neutrophil count	7,090	0.5%	653	Yes
No sign	no clinical sign was reported	11,275	0.8%	22	No
Non-regenerative anaemia		714	0.1%	124	No
Not drinking		6,417	0.5%	617	Yes
Not eating		21,646	1.6%	2,375	Yes
Not himself/herself		3,413	0.3%	825	Yes
Not sleeping		1,328	0.1%	145	No
Not urinating		606	0%	94	No
NT - Abnormal necropsy finding NOS	NOS: not otherwise specified	1,262	0.1%	0	No
Nystagmus	rapid involuntary eye movement	3,445	0.3%	209	No
Ocular discharge		2,462	0.2%	183	No
Odor, Abnormal	a product quality report, not a sign in an animal	4,353	0.3%	170	No
Oedema NOS	NOS: not otherwise specified	1,351	0.1%	38	No
Oedema of the extremities	swollen legs or paws	1,698	0.1%	19	No
Off colour		237	0%	8	No
Oliguria		309	0%	25	No
Open mouth breathing		839	0.1%	86	No
Opisthotonus		362	0%	15	No
Oral bleeding		1,016	0.1%	26	No
Oral cavity disorder NOS	NOS: not otherwise specified	486	0%	33	No
Oral mass		240	0%	18	No
Oral ulceration		802	0.1%	18	No
Other abnormal test result NOS	abnormal laboratory result, type not specified	21,187	1.5%	1,195	Yes
Other blood disorder NOS	NOS: not otherwise specified	271	0%	24	No
Other ear disorder NOS	NOS: not otherwise specified	720	0.1%	43	No
Other immune system disorder NOS	NOS: not otherwise specified	210	0%	8	No
Otitis externa	outer ear inflammation	1,727	0.1%	75	No
Otitis NOS	NOS: not otherwise specified	738	0.1%	56	No
Otorrhoea		217	0%	1	No
Overdose	more than the labelled amount was given	14,293	1%	749	Yes
Pacing		3,663	0.3%	305	Yes
Paddling		1,349	0.1%	76	No
Pain NOS	NOS: not otherwise specified	8,846	0.6%	608	Yes
Pale mucous membrane	pale gums	8,579	0.6%	481	Yes
Pallor		1,105	0.1%	15	No
Palpable mass NOS	NOS: not otherwise specified	619	0%	14	No
Palpebral disorder NOS	NOS: not otherwise specified	211	0%	27	No
Pancreas disorder		580	0%	26	No
Pancreatitis	inflamed pancreas	3,389	0.3%	0	No
Pancreatitis NOS	NOS: not otherwise specified	840	0.1%	304	No
Panting		15,433	1.1%	1,143	Yes
Papilloma		540	0%	50	No
Papule		652	0.1%	17	No
Paraesthesia		217	0%	1	No
Paralysis		793	0.1%	35	No
Paralysis NOS	NOS: not otherwise specified	377	0%	57	No
Paresis		1,219	0.1%	61	No
Partial anorexia		653	0.1%	88	No
Partial blindness		529	0%	6	No
Partial deafness		1,330	0.1%	52	No
Partial lack of efficacy	the product worked less well than expected	3,410	0.3%	513	Yes
Patient instructions for use on label confusing		662	0.1%	107	No
Pawing		375	0%	61	No
Peeling skin		343	0%	13	No
Pericardial effusion		382	0%	44	No
Perinatal mortality NOS	NOS: not otherwise specified	212	0%	0	No
Periorbital oedema		651	0.1%	60	No
Peripheral nervous system disorder NOS	NOS: not otherwise specified	761	0.1%	2	No
Peritonitis	inflamed abdominal lining	1,611	0.1%	34	No
Petechiae NOS	NOS: not otherwise specified	391	0%	29	No
Pharyngeal oedema		200	0%	2	No
Physical label missing		737	0.1%	13	No
Pica NOS	eating non-food items	2,299	0.2%	155	No
Pinnae disorder		367	0%	24	No
Pinnal erythema		1,115	0.1%	44	No
Pinnal irritation		280	0%	7	No
Pinnal oedema		559	0%	11	No
Pinnal reddening		655	0.1%	35	No
Platelet disorder NOS	NOS: not otherwise specified	399	0%	98	No
Pleural effusion		955	0.1%	73	No
Pneumonia	lung infection or inflammation	1,670	0.1%	73	No
Pododermatitis		431	0%	27	No
Pollakiuria		251	0%	26	No
Polycythaemia		1,103	0.1%	9	No
Polycythemia, relative		347	0%	0	No
Polydipsia	drinking more than usual	14,441	1.1%	785	Yes
Polyphagia		1,357	0.1%	73	No
Polypnoea	fast breathing	5,491	0.4%	4	No
Polyuria	passing more urine than usual	11,221	0.8%	750	Yes
Poor coat condition		231	0%	18	No
Potency, Low		602	0%	22	No
PR-bone marrow, lesion(s)	legacy FDA term: lesions found in the bone marrow	200	0%	0	No
PR-brain, lesion(s)	legacy FDA term: lesions found in the brain	295	0%	1	No
PR-colon, lesion(s)	legacy FDA term: lesions found in the colon	202	0%	1	No
PR-ear(s), lesion(s)	legacy FDA term: lesions found in the ears	406	0%	0	No
PR-gi, lesion(s)	legacy FDA term: lesions found in the gi	346	0%	0	No
PR-heart, lesion(s)	legacy FDA term: lesions found in the heart	1,261	0.1%	3	No
PR-injection site, lesion(s)	legacy FDA term: lesions found in the injection site	324	0%	4	No
PR-intest, lesion(s)	legacy FDA term: lesions found in the intest	411	0%	0	No
PR-kidney(s), lesion(s)	legacy FDA term: lesions found in the kidneys	1,482	0.1%	1	No
PR-liver, lesion(s)	legacy FDA term: lesions found in the liver	3,247	0.2%	6	No
PR-lung(s), edema		566	0%	0	No
PR-lung(s), lesion(s)	legacy FDA term: lesions found in the lungs	1,690	0.1%	3	No
PR-lymph node(s), lesion(s)	legacy FDA term: lesions found in the lymph nodes	484	0%	4	No
PR-pancreas, lesion(s)	legacy FDA term: lesions found in the pancreas	437	0%	0	No
PR-peritoneal effusion		204	0%	0	No
PR-skin, lesion(s)	legacy FDA term: lesions found in the skin	1,290	0.1%	12	No
PR-small intestine, lesion(s)	legacy FDA term: lesions found in the small intestine	745	0.1%	0	No
PR-spleen, lesion(s)	legacy FDA term: lesions found in the spleen	778	0.1%	3	No
PR-stomach, lesion(s)	legacy FDA term: lesions found in the stomach	855	0.1%	0	No
Precipitate, Sediment	a product quality report, not a sign in an animal	1,381	0.1%	180	No
Product defect NOS	a product quality report, not a sign in an animal	448	0%	336	No
Product Defect, General	a product quality report, not a sign in an animal	9,322	0.7%	0	No
Product defect, product difficult to use/handle	a product quality report, not a sign in an animal	2,228	0.2%	928	No
Product label issues	a product quality report, not a sign in an animal	2,480	0.2%	281	No
Product problem	a product quality report, not a sign in an animal	10,341	0.8%	0	No
Product syringe calibration unreadable	a product quality report, not a sign in an animal	289	0%	2	No
Product syringe issue	a product quality report, not a sign in an animal	1,495	0.1%	101	No
Product syringe missing	a product quality report, not a sign in an animal	510	0%	37	No
Prolapse of the nictitating membrane		436	0%	10	No
Prolonged activated partial thrombin time (APTT)		377	0%	44	No
Prolonged anaesthesia		211	0%	10	No
Prolonged capillary refill time		708	0.1%	49	No
Prolonged one stage prothrombin time (OSPT)		272	0%	35	No
Proprioception abnormality		1,160	0.1%	33	No
Proprioception deficit	reduced awareness of limb position	1,940	0.1%	310	No
Proprioception loss		396	0%	55	No
Proteinuria	protein in the urine	5,276	0.4%	510	Yes
Pruritus	itching	24,579	1.8%	466	Yes
Pulmonary congestion		969	0.1%	33	No
Pulmonary disorder NOS	NOS: not otherwise specified	905	0.1%	44	No
Pulmonary neoplasm		236	0%	6	No
Pulmonary oedema		1,040	0.1%	83	No
Puncture wound		210	0%	0	No
Purulent lesion(s)		365	0%	49	No
Pustules		967	0.1%	39	No
Pyloric ulcer		200	0%	2	No
Pyoderma	bacterial skin infection	2,132	0.2%	65	No
Pyrexia	fever	657	0.1%	52	No
Pyuria		674	0.1%	101	No
Quiet		807	0.1%	157	No
Rash		3,416	0.3%	116	No
Recovery prolonged		1,460	0.1%	37	No
Rectal bleeding		844	0.1%	34	No
Rectal prolapse		210	0%	12	No
Recumbency	lying down and unable or unwilling to rise	7,129	0.5%	150	No
Red blood cell disorder		474	0%	25	No
Red blood cells(rbc) nucleated		268	0%	2	No
Red eye		634	0.1%	63	No
Reddening of the skin		4,226	0.3%	356	Yes
Reduced globulins		1,064	0.1%	91	No
Reduced responses		938	0.1%	55	No
Regenerative anaemia		833	0.1%	47	No
Regurgitation		1,332	0.1%	166	No
Reluctant to move		5,671	0.4%	446	Yes
Renal disorder NOS	kidney disorder, type not specified	2,148	0.2%	138	No
Renal failure	kidney failure	4,070	0.3%	140	No
Renal insufficiency		383	0%	23	No
Residues in meat/offal		448	0%	8	No
Residues in milk		1,487	0.1%	12	No
Respiratory arrest		698	0.1%	34	No
Respiratory distress		1,817	0.1%	94	No
Respiratory signs		486	0%	28	No
Respiratory sound		751	0.1%	21	No
Respiratory tract disorder NOS	NOS: not otherwise specified	1,356	0.1%	68	No
Respiratory tract infection NOS	NOS: not otherwise specified	428	0%	50	No
Restlessness		9,372	0.7%	449	Yes
Retching		2,529	0.2%	56	No
Retinal disorder NOS	NOS: not otherwise specified	649	0.1%	14	No
Reverse sneezing		310	0%	26	No
Rigidity		422	0%	25	No
Rigidity of limbs		288	0%	25	No
Rolling		541	0%	59	No
Rubbing		1,001	0.1%	111	No
Ruminal bloat		461	0%	9	No
Scale		632	0.1%	32	No
Schirmer tear test		201	0%	0	No
Scleritis		214	0%	3	No
Scooting		421	0%	39	No
Scratching		7,271	0.5%	485	Yes
Seal, Abnormal	a product quality report, not a sign in an animal	5,608	0.4%	156	No
Seborrhoea		344	0%	15	No
Sedation		1,856	0.1%	111	No
Sedation prolonged		1,117	0.1%	57	No
Seizure NOS	seizure, type not specified	34,259	2.5%	2,784	Yes
Self mutilation		272	0%	5	No
Self trauma		1,422	0.1%	49	No
Sensory abnormality NOS	NOS: not otherwise specified	452	0%	1	No
Septicaemia		686	0.1%	50	No
Shaking		14,613	1.1%	831	Yes
Shallow breathing		442	0%	49	No
Shivering		1,453	0.1%	95	No
Shock		1,909	0.1%	33	No
Sickness		523	0%	113	No
Skin abscess		395	0%	14	No
Skin and tissue infection NOS	NOS: not otherwise specified	805	0.1%	101	No
Skin and/or appendage neoplasm NOS	NOS: not otherwise specified	455	0%	8	No
Skin disorders NOS	NOS: not otherwise specified	5,073	0.4%	139	No
Skin haematoma		238	0%	3	No
Skin haemorrhage NOS	NOS: not otherwise specified	227	0%	49	No
Skin hyperaemia	reddened skin	2,951	0.2%	6	No
Skin inflammation NOS	NOS: not otherwise specified	1,036	0.1%	98	No
Skin irritation		1,117	0.1%	77	No
Skin lesion NOS	NOS: not otherwise specified	5,955	0.4%	327	Yes
Skin lump		1,613	0.1%	78	No
Skin necrosis		672	0.1%	31	No
Skin oedema		204	0%	9	No
Skin petechiae		1,029	0.1%	19	No
Skin scab		3,619	0.3%	323	Yes
Skin slough		1,019	0.1%	0	No
Skin sore		1,847	0.1%	116	No
Skin swelling		347	0%	14	No
Skin tumour NOS	NOS: not otherwise specified	359	0%	15	No
Skin ulcer		1,280	0.1%	110	No
Skin warmth		410	0%	21	No
Sleep disturbance NOS	NOS: not otherwise specified	647	0.1%	49	No
Sleepiness - neurological disorder		1,125	0.1%	38	No
Sleepiness - systemic disorder		1,724	0.1%	242	No
Small intestine ulcer		855	0.1%	4	No
Small liver		252	0%	6	No
Smelly breath		236	0%	19	No
Sneezing		2,184	0.2%	120	No
Soft stool		710	0.1%	397	No
Solution, Abnormal	a product quality report, not a sign in an animal	4,431	0.3%	112	No
Solution/Suspension, crystals	a product quality report, not a sign in an animal	707	0.1%	27	No
Somnolence		861	0.1%	8	No
Spasm		876	0.1%	22	No
Spleen and reticulo-endothelial system disorder NOS	NOS: not otherwise specified	411	0%	26	No
Splenic neoplasm		581	0%	0	No
Splenomegaly		1,136	0.1%	63	No
Spondylosis		389	0%	73	No
Squinting		887	0.1%	70	No
Staggering		2,580	0.2%	60	No
Star-gazing		909	0.1%	24	No
Staring		1,604	0.1%	249	No
Stiff gait		603	0%	62	No
Stiffness limb		836	0.1%	93	No
Stiffness NOS	NOS: not otherwise specified	1,897	0.1%	228	No
Stillbirth		419	0%	3	No
Stomach pain		201	0%	14	No
Stomach upset		1,297	0.1%	126	No
Stomatitis		495	0%	8	No
Stopper, abnormal		1,031	0.1%	316	No
Strabismus		221	0%	18	No
Straining to defecate		590	0%	69	No
Stranguria		552	0%	39	No
Stress leukogram		214	0%	39	No
Stroke		394	0%	30	No
Stumbling gait		2,654	0.2%	252	No
Stupor	barely responsive	1,697	0.1%	18	No
Sudden death		1,275	0.1%	45	No
Surgical site disorder		492	0%	22	No
Suspected infectious agent transmission		418	0%	0	No
Suspension, Abnormal	a product quality report, not a sign in an animal	5,315	0.4%	140	No
Swallowing difficult		317	0%	27	No
Swelling around eye		918	0.1%	87	No
Swelling NOS	NOS: not otherwise specified	1,980	0.1%	97	No
Swollen eye		882	0.1%	67	No
Swollen face		491	0%	34	No
Swollen feet		344	0%	33	No
Swollen limb		768	0.1%	147	No
Swollen lip		526	0%	40	No
Swollen lymph node		415	0%	26	No
Swollen mouth		415	0%	9	No
Swollen tongue		336	0%	23	No
Swollen vulva		486	0%	20	No
Syncope		590	0%	42	No
Syringe, Abnormal	a product quality report, not a sign in an animal	572	0%	28	No
Systemic disorder NOS	NOS: not otherwise specified	2,983	0.2%	65	No
Tablets, Abnormal	a product quality report, not a sign in an animal	19,982	1.5%	1,183	Yes
Tachycardia	fast heart rate	6,860	0.5%	333	Yes
Tachypnoea	fast breathing	4,730	0.3%	214	No
Tarry or black stool		1,430	0.1%	96	No
Temporary blindness		889	0.1%	13	No
Temporary deafness		646	0.1%	5	No
Tenesmus		647	0.1%	12	No
Tense abdomen		1,298	0.1%	135	No
Tense muscles		204	0%	28	No
Third eyelid protrusion		822	0.1%	101	No
Thrombocytopenia	low platelet count	7,414	0.5%	294	No
Thrombocytosis	high platelet count	1,803	0.1%	212	No
Tiredness		1,515	0.1%	172	No
Tongue disorder NOS	NOS: not otherwise specified	820	0.1%	63	No
Tongue oedema		453	0%	1	No
Tongue protrusion		525	0%	41	No
Tongue ulceration		474	0%	16	No
Tonic-clonic seizure		292	0%	16	No
Tooth disorder		712	0.1%	45	No
Torn ligament		244	0%	42	No
Toxicity		203	0%	0	No
Trauma NOS	NOS: not otherwise specified	804	0.1%	23	No
Trembling		12,613	0.9%	262	No
Tremor		8,218	0.6%	666	Yes
Tremor of limb		721	0.1%	58	No
Tubes, Abnormal	a product quality report, not a sign in an animal	2,086	0.2%	40	No
Tubes, Damaged	a product quality report, not a sign in an animal	1,439	0.1%	70	No
Tubes, Leaking	a product quality report, not a sign in an animal	5,343	0.4%	376	Yes
Twitching		7,088	0.5%	324	Yes
Tympanic rupture		246	0%	25	No
Ulceration NOS	NOS: not otherwise specified	667	0.1%	43	No
Ulcerative dermatitis		239	0%	15	No
Ultrasound, liver abnormal		1,365	0.1%	6	No
Unable to jump		732	0.1%	111	No
Unable to rise		1,522	0.1%	139	No
Unable to stand		3,827	0.3%	379	Yes
Unable to walk		1,603	0.1%	495	No
Unclassifiable adverse event	event that fits no dictionary term	10,344	0.8%	159	No
Uncoded sign	a sign with no matching dictionary term	10,167	0.7%	15	No
Uncomfortable		1,810	0.1%	261	No
Unconscious		346	0%	31	No
Underdose	less than the labelled amount was given	10,996	0.8%	425	Yes
Underfilling, Bottles	a product quality report, not a sign in an animal	1,366	0.1%	89	No
Underfilling, Container	a product quality report, not a sign in an animal	6,407	0.5%	508	Yes
Underfilling, Package	a product quality report, not a sign in an animal	10,765	0.8%	323	Yes
Underfilling, Tubes	a product quality report, not a sign in an animal	7,322	0.5%	178	No
Underfilling, Vials	a product quality report, not a sign in an animal	1,497	0.1%	69	No
Unexplained death		567	0%	43	No
Unpalatable	legacy FDA term: the animal would not take it	28,524	2.1%	897	Yes
Unrelated death		696	0.1%	60	No
Unresponsive to stimuli		1,749	0.1%	180	No
Unsteady gait		1,652	0.1%	177	No
Unusual stool colour		246	0%	20	No
Unwell		773	0.1%	290	No
Urinary bladder disorder NOS	NOS: not otherwise specified	707	0.1%	69	No
Urinary incontinence		6,216	0.5%	515	Yes
Urinary retention		476	0%	62	No
Urinary tract disorder NOS	NOS: not otherwise specified	1,852	0.1%	42	No
Urinary tract infection		5,307	0.4%	544	Yes
Urination		914	0.1%	30	No
Urination related to convulsion		419	0%	88	No
Urine abnormalities NOS	NOS: not otherwise specified	2,083	0.2%	170	No
Urine leakage		695	0.1%	74	No
Urolithiasis		349	0%	33	No
Urticaria	hives	5,785	0.4%	41	No
Uveitis		463	0%	32	No
Vaginal discharge		298	0%	23	No
Vaginal haemorrhage		220	0%	8	No
Vaginal swelling		206	0%	2	No
Vasculitis		451	0%	43	No
Vesicle		392	0%	1	No
Vestibular disorder NOS	NOS: not otherwise specified	2,034	0.2%	167	No
Vials, Abnormal	a product quality report, not a sign in an animal	1,142	0.1%	41	No
Vials, Damaged	a product quality report, not a sign in an animal	3,249	0.2%	250	No
Vials, Leaking	a product quality report, not a sign in an animal	5,489	0.4%	70	No
Vocalisation	crying out or unusual noise	14,299	1%	702	Yes
Vomiting		215,752	15.7%	7,871	Yes
Vomiting bile		770	0.1%	193	No
Walking difficulty		4,903	0.4%	376	Yes
Warm feeling to the touch		725	0.1%	100	No
Wbc, urine		875	0.1%	0	No
Weak pulse		659	0.1%	84	No
Weakness		10,825	0.8%	639	Yes
Weight fluctuation		392	0%	53	No
Weight gain		6,758	0.5%	355	Yes
Weight loss		24,554	1.8%	2,042	Yes
Welt		480	0%	38	No
Wheezing		1,107	0.1%	78	No
Whining		613	0%	159	No
Wobbliness		1,529	0.1%	488	No
Wound		1,111	0.1%	206	No
Wrong technique in drug usage process		373	0%	2	No