Pet Drug Reports

Emodepside + Praziquantel (Profender)adverse event reports that FDA received

Combination of 2 active ingredients

The name in brackets is a brand name with these active ingredients.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From September 2007 to June 2026, FDA received 6,144 adverse event reports that name a drug with emodepside and praziquantel as its active ingredients. Of the 6,144 reports, 5,730 (93.3%) are about cats. 97 reports are about people who were exposed to the drug (1.6%).

In January to March 2026, FDA received 45 reports that name this drug. The signs that appear in the largest number of the 6,144 reports are "Application site alopecia", "Hypersalivation" and "Lethargy". A report is not proof that a drug caused a sign.

Reports that name this drug fell by 9.5% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cats are 93.3% of the reports that name this drug, and 11% of all reports.

Since the last update of the FDA data

The latest update of the FDA data, recorded on , changed no count of this page.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 45 reports that name emodepside + praziquantel: 0 dog, 42 cat, 0 horse, 3 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 6,144 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Application site alopecia[hair loss where the product was applied]22.9%1,405 reports
  2. Hypersalivation[drooling]17.7%1,085 reports
  3. Lethargy[unusually tired or inactive]12.6%775 reports
  4. Vomiting9.9%608 reports
  5. Ataxia[unsteady, uncoordinated movement]8.1%500 reports
  6. Anorexia[not eating]6.7%413 reports
  7. Lack of efficacy (endoparasite) - tapeworm[the product did not have the expected effect: tapeworms]6.3%390 reports
  8. Behavioural disorder NOS[behaviour change, type not specified]5.7%350 reports
  9. Application site pruritus[itching where the product was applied]5.3%328 reports
  10. Application site erythema[reddened skin where the product was applied]5.3%325 reports
  11. Diarrhoea[diarrhea]3.8%235 reports
  12. Accidental exposure[exposure that was not intended]3.7%228 reports
  13. Licking at application site3.7%227 reports
  14. Application site hair loss[hair loss where the product was applied]3.3%205 reports
Show the next 16 signs
  1. Application site scab[scab where the product was applied]3%182 reports
  2. Death2.6%157 reports
  3. Hiding2.5%154 reports
  4. Depression[dull, quiet or withdrawn]2.4%147 reports
  5. Weight loss2.4%146 reports
  6. Application site lesion[lesion where the product was applied]2.3%140 reports
  7. Foaming at the mouth2.3%140 reports
  8. Muscle tremor2.1%129 reports
  9. Other abnormal test result NOS[abnormal laboratory result, type not specified]2.1%129 reports
  10. Emesis (multiple)[vomiting more than once]2%125 reports
  11. Pruritus[itching]1.9%119 reports
  12. Vocalisation[crying out or unusual noise]1.9%119 reports
  13. Application site inflammation[inflammation where the product was applied]1.9%116 reports
  14. Drooling1.9%116 reports
  15. Agitation1.8%113 reports
  16. Death by euthanasia[the animal was euthanized]1.8%110 reports

The list shows 30 of 1,118 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

  • Cat93.3%5,730
  • Human exposure1.6%97
  • Dog0.7%46
  • Rabbitunder 0.1%1
  • Whaleunder 0.1%1

The share is of all 6,144 reports that name emodepside + praziquantel. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog25 reports

No chart: no month has 5 or more reports.

Cat1,048 reports. Largest count in one month: 33 (Jan 2023)
Horse0 reports

No chart: no month has 5 or more reports.

Other or not given73 reports. Largest count in one month: 6 (Mar 2025)

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name emodepside + praziquantel, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
20264690578
20256158022186
20247209013229
20235244011260
2022224309254
20212283019304
20201286016303
20190394030424
20181429042472
20171423052476
20162371018391
20153329019351
20142328032362
20133330021354
20121324016341
20115311017333
2010035306359
20090348010358
2008124707255
20070510354

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal26.9%1,652
  • Recovered with Sequela[recovered, with a lasting effect]0.1%8
  • Ongoing6.3%385
  • Died3.1%191
  • Euthanized1.6%96
  • Outcome Unknown44.2%2,718

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 6,144 reports that name emodepside + praziquantel.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue91.6%5,626
  • Lack of expected effectiveness2.4%149
  • Both safety and lack of expected effectiveness1.2%72
  • Manufacturing or product defect4.8%296
  • Otherunder 0.1%1

4,895 reports say if the event was serious. 58.1% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year17.8%1,092
  • 1 to 3 years27.1%1,664
  • 4 to 7 years19.9%1,221
  • 8 to 11 years13.3%816
  • 12 years and over9.2%564
  • Age not given12.8%787

Weight of the animal

  • Under 5 kg (11 lb)52.1%3,199
  • 5 to 9.9 kg (11 to 22 lb)32.1%1,970
  • 10 to 24.9 kg (22 to 55 lb)0.4%26
  • 25 to 44.9 kg (55 to 99 lb)0.2%10
  • 45 kg and over (99 lb and over)0.2%13
  • Weight not given15.1%926

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Topical88.5%5,439
  • Oral4.1%249
  • Other0.7%43
  • Ophthalmic0.1%4
  • Subcutaneousunder 0.1%2
  • Transdermalunder 0.1%2

Each bar is on a scale of 0 to 100%.

Approved animal drugs with these active ingredients (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • Profender

What the Green Book records give

Applications with an approval in force
1
Approved species
Cats
Dose forms
Liquid
Routes
Topical
Sale
RX (prescription)
Earliest approval date in the records

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
ProfenderEmodepside, PraziquantelElanco US Inc.CatsNADA 141-275

Other pages with one of these ingredients

A report names a drug by its set of active ingredients. Each set has its own page. The list is in order of name.

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Emodepside + Praziquantel: adverse event reports that FDA received. https://petdrugreports.com/drug/emodepside-praziquantel/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

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Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with these active ingredients.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 182 reports in the 12 months to June 2026. It received 201 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 6,144 reports received from September 2007 to June 2026, 91.6% are about a safety issue only. 3.6% are about a lack of expected effectiveness, alone or with a safety issue. 4.8% are about a defect of the product or its package.