Depression: in adverse event reports for animal drugs
Clinical sign, a VeDDRA term
In plain words: dull, quiet or withdrawn.
Read this first. FDA says this about the data:
An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .
This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.
Contacting a veterinarianHow to report to FDAFrom January 1987 to June 2026, FDA received 42,447 adverse event reports for animal drugs that list this sign. That is 3.1% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 173 reports that list this sign.
Of the 42,447 reports, 81.2% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.
By number of reports in all years, this sign is number 12 of 1,149 clinical signs with a page. Reports that list this sign fell by 10.8% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 81.2% of the reports that list this sign, and 72.6% of all reports.
Search engines list a sign page with 3,000 reports or more in all years. The page also needs 300 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.
Drug pages with reports that list this sign
The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 129 drug pages.
Show the 129 drug pages
The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.
An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices
Ingredients, all combinations
The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 132 ingredients.
Show the 132 ingredients
- (S) - methoprene
- Acepromazine Maleate
- Afoxolaner
- Albendazole
- Amitraz
- Amoxicillin
- Amoxicillin Trihydrate
- Ampicillin Sodium
- Atipamezole Hydrochloride
- Bedinvetmab
- Betamethasone Valerate
- Bexagliflozin
- Buprenorphine
- Butorphanol Tartrate
- Capromorelin
- Carprofen
- Cefovecin sodium
- Cefpodoxime proxetil
- Ceftiofur Crystalline Free Acid
- Ceftiofur Sodium
- Cephalexin
- Clavulanate Potassium
- Clindamycin
- Clindamycin Hydrochloride
- Clomipramine Hydrochloride
- Clotrimazole
- Cyclosporine
- Deracoxib
- Desoxycorticosterone Pivalate
- Detomidine Hydrochloride
- Dexamethasone
- Dexmedetomidine
- Dexmedetomidine hydrochloride
- Dextrose
- Diazepam
- Dichlorophene
- Diethylcarbamazine Citrate
- Diphenhydramine
- Dirlotapide
- Doramectin
- Doxycycline
- Emodepside
- Enalapril Maleate
- Enrofloxacin
- Eprinomectin
- Epsiprantel
- Estriol
- Etodolac
- Famotidine
- Febantel
- Fenbendazole
- Fenthion
- Firocoxib
- Florfenicol
- Flunixin Meglumine
- Fluoxetine hydrochloride
- Fluralaner
- Furosemide
- Gabapentin
- Gentamicin Sulfate
- Grapiprant
- Griseofulvin
- Imidacloprid
- Insulin
- Isoflurane
- Ivermectin
- Ketamine Hydrochloride
- Ketoconazole
- Ketoprofen
- Levothyroxine sodium
- Lotilaner
- Lufenuron
- Marbofloxacin
- Maropitant
- Mebendazole
- Medetomidine
- Melarsomine Dihydrochloride
- Meloxicam
- Methimazole
- Methylprednisolone Acetate
- Metoclopramide
- Metronidazole
- Midazolam
- Milbemycin Oxime
- Mirtazapine
- Mometasone Furoate Monohydrate
- Monensin
- Moxidectin
- Neomycin Sulfate
- Nitenpyram
- Oclacitinib
- Omeprazole
- Ondansetron
- Orbifloxacin
- Ormetoprim
- Oxibendazole
- Oxytetracycline
- Pergolide mesylate
- Pimobendan
- Polysulfated Glycosaminoglycan
- Praziquantel
- Prednisolone
- Prednisone
- Primidone
- Propofol
- Pyrantel Pamoate
- Pyrantel Tartrate
- Robenacoxib
- Sarolaner
- Selamectin
- Selegiline Hydrochloride
- Sevoflurane
- Spinosad
- Sucralfate
- Sulfadiazine
- Sulfadimethoxine
- Tepoxalin
- Terbinafine
- Thiabendazole
- Tiletamine Hydrochloride
- Tilmicosin Phosphate
- Toceranib Phosphate
- Toluene
- Tramadol
- Triamcinolone Acetonide
- Trilostane
- Trimeprazine Tartrate
- Trimethoprim
- Tulathromycin
- Tylosin
- Vitamin E
- Zolazepam Hydrochloride
Reports by species
The share is of the 42,447 reports that list this sign. The sign is in 3.4% of all reports about the species dog. The sign is in 4.1% of all reports about the species cat.
Reports by month and by year
FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
| Year | Reports |
|---|---|
| 2026 | 89 |
| 2025 | 181 |
| 2024 | 183 |
| 2023 | 131 |
| 2022 | 130 |
| 2021 | 148 |
| 2020 | 170 |
| 2019 | 192 |
| 2018 | 227 |
| 2017 | 270 |
| 2016 | 279 |
| 2015 | 332 |
| 2014 | 513 |
| 2013 | 661 |
| 2012 | 1,321 |
| 2011 | 3,914 |
| 2010 | 4,686 |
| 2009 | 4,355 |
| 2008 | 3,379 |
| 2007 | 2,976 |
| 2006 | 2,391 |
| 2005 | 2,319 |
| 2004 | 2,635 |
| 2003 | 1,684 |
| 2002 | 1,631 |
| 2001 | 1,741 |
| 2000 | 1,928 |
| 1999 | 1,097 |
| 1998 | 930 |
| 1997 | 420 |
| 1996 | 284 |
| 1995 | 204 |
| 1994 | 122 |
| 1993 | 92 |
| 1992 | 86 |
| 1991 | 92 |
| 1990 | 110 |
| 1989 | 196 |
| 1988 | 148 |
| 1987 | 200 |
What these reports record
Outcome at the time of the report
- Reports with this sign
- All reports
- Recovered/Normal2.4%1,002, All reports: 20.7%
- Recovered with Sequela[recovered, with a lasting effect]0.4%159, All reports: 2.3%
- Ongoing2.1%875, All reports: 17.4%
- Died18.3%7,785, All reports: 4.9%
- Euthanized1%432, All reports: 1.5%
- Outcome Unknown1.8%773, All reports: 22.7%
An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 42,447 reports that list this sign.
Age of the animal
- Reports with this sign
- All reports
- Under 1 year15%6,361, All reports: 9.5%
- 1 to 3 years22.8%9,666, All reports: 23.9%
- 4 to 7 years23.6%10,029, All reports: 20.2%
- 8 to 11 years21.2%9,012, All reports: 15.4%
- 12 years and over12.6%5,333, All reports: 10.7%
- Age not given4.8%2,046, All reports: 20.3%
The outcome is for the full report, not for this sign only.
Next in the A to Z list of signs
Cite this page
Pet Drug Reports. Depression: adverse event reports for animal drugs. https://petdrugreports.com/reaction/depression/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .
Where the data come from
The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.
The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.
Questions about this sign
- What does this term mean in a report?
In plain words: dull, quiet or withdrawn. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
- How does the count of the latest 12 months compare with the 12 months before?
FDA received 173 reports in the 12 months to June 2026. It received 194 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
- How many of these reports have a serious flag?
Of the 3,449 reports that say if the event was serious, 63.4% have the serious flag. The person who sends a report sets the flag.
- Does a drug in the table cause this sign?
The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices