Breed · Dog

Gordon Setter: adverse event reports

FDA breed label "Setter - Gordon" · single-breed animals only

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

304reports, 1990–20260% of dog reports

9reports, 12 months to March 202619 in the 12 months before

43.3%classed serious, as reportedall dogs: 38.3%

14.1%name ivermectin + pyrantel pamoateall dogs: 14.9%

FDA's database holds 304 reports where the animal's breed is given as "Setter - Gordon", shown here as Gordon Setter: 0% of reports about dogs. Reports on crossbred animals are left out of breed pages.

9 reports arrived in the 12 months to March 2026, down 53% from 19 in the 12 months before. A breed's count mostly mirrors how common the breed is; registration and ownership figures by breed are not public data, so no per-animal rate can be given.

By active ingredient, the drugs named most often are ivermectin + pyrantel pamoate, carprofen and afoxolaner. Ivermectin + Pyrantel Pamoate is named in 14.1% of this breed's reports, about the same share as in reports about all dogs (14.9%).

The terms listed most often are vomiting (21.7%), diarrhoea (11.2%) and lack of efficacy (endoparasite) - hookworm (9.5%). Vomiting appears in 21.7% of reports, about the same share as in all dog reports (19.7%). 43.3% of reports stating seriousness were classed as serious, against 38.3% for dogs overall.

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of Gordon Setter reports	Share of all dog reports
Ivermectin + Pyrantel Pamoate	43	14.1%	14.9%
Carprofen	31	10.2%	4.8%
Afoxolaner	21	6.9%	5.7%
Milbemycin Oxime	17	5.6%	3%
Fluralaner	15	4.9%	6.7%
Lufenuron + Milbemycin Oxime	13	4.3%	2.7%
Pyrantel Pamoate + Sarolaner	13	4.3%	5.1%
Milbemycin Oxime + Spinosad	12	3.9%	13.1%
Oclacitinib	11	3.6%	2.9%
Selamectin	11	3.6%	3%
Spinosad	10	3.3%	5.8%
Moxidectin	8	2.6%	5%
Ivermectin	7	2.3%	1.3%
Ivermectin + Praziquantel + Pyrantel Pamoate	7	2.3%	0.9%
Milbemycin Oxime + Praziquantel	7	2.3%	3.1%
Bedinvetmab	6	2%	1.9%
Insulin	6	2%	0.7%
(S) - methoprene	6	2%	0.6%
Gabapentin	5	1.6%	0.9%
Imidacloprid + Moxidectin	5	1.6%	1.3%

Ordered by report count. Differences from the species column often come from body size (which drugs a breed is prescribed) and from how common the breed was in the years a drug sold most. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed in reports

share of Gordon Setter reports listing the termall dog reports

Vomiting21.7%66
Diarrhoea[diarrhea]11.2%34
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]9.5%29
Anorexia[not eating]8.9%27
Lack of efficacy - NOS[the product did not have the expected effect]6.6%20
Depression[dull, quiet or withdrawn]5.9%18
Lethargy[unusually tired or inactive]5.3%16
Death4.6%14
Digestive tract disorder NOS[digestive problem, type not specified]4.6%14
Lack of efficacy (endoparasite) - whipworm[the product did not have the expected effect: whipworms]4.6%14
Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]4.3%13
Seizure NOS[seizure, type not specified]4.3%13
Ineffective, ascarids NOS[legacy FDA term: the product did not have the expected effect (ascarids nos)]3.9%12
Ataxia[unsteady, uncoordinated movement]3.6%11
Emesis[vomiting]3.6%11
Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]3.3%10
Polydipsia[drinking more than usual]3%9
Pruritus[itching]3%9
Abnormal radiograph finding2.6%8
Death by euthanasia[the animal was euthanized]2.6%8
Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]2.6%8
Fever2.6%8
Behavioural disorder NOS[behaviour change, type not specified]2.3%7
Hypersalivation[drooling]2.3%7
Lack of efficacy (ectoparasite) - tick NOS[the product did not have the expected effect: ticks]2.3%7

Age and weight

Age of the animal

Under 1 year7.9%24

1 to 3 years22.7%69

4 to 7 years23.4%71

8 to 11 years27.6%84

12 years and over15.1%46

Age not given3.3%10

Weight of the animal

Under 5 kg (11 lb)0%0

5 to 9.9 kg (11–22 lb)2.3%7

10 to 24.9 kg (22–55 lb)32.9%100

25 to 44.9 kg (55–99 lb)60.2%183

45 kg and over (99 lb+)1%3

Weight not given3.6%11

Coloured bar: Gordon Setter reports. Grey bar: all dog reports.

Trend and outcomes

Reports by month FDA received them. The newest months are incomplete because FDA posts reports with a delay of three to six months.

Outcome recorded in the report

Recovered/Normal24%73

Recovered with Sequela1.6%5

Ongoing15.8%48

Died5.6%17

Euthanized1.6%5

Outcome Unknown19.4%59

Beside all dogs

Measure	Gordon Setter	All dogs
Reports	304	985,675
Latest 12 months	9	53,292
Classed serious, of reports stating it	43.3%	38.3%
Death or euthanasia recorded, per 1,000 reports	72.4	55

Questions about Gordon Setter reports

How many FDA adverse event reports involve Gordon Setters?

304 reports through March 2026, 0% of reports about dogs; 9 in the latest 12 months.

Which drugs are named most often in Gordon Setter reports?

By active ingredient: ivermectin + pyrantel pamoate (43), carprofen (31), afoxolaner (21), milbemycin oxime (17) and fluralaner (15). Brands are masked in the public data.

What signs are reported most for this breed?

vomiting (21.7%), diarrhoea (11.2%), lack of efficacy (endoparasite) - hookworm (9.5%), anorexia (8.9%) and lack of efficacy - NOS (6.6%).

Is the Gordon Setter more sensitive to certain drugs?

Report counts cannot answer that. They show what was reported, not what a drug did, and they are not adjusted for how many Gordon Setter animals exist or were treated. Breed-related drug sensitivities that are established are described on FDA-approved labels; a veterinarian is the person to ask about an individual animal.

Why are crossbreds not included?

FDA records crossbred animals with one or more component breeds. Counting them under each component would double count, so breed pages use single-breed reports only. Crossbreds remain in the species totals.

How do I report a problem?

Call the drug company using the number on the label, or send Form FDA 1932a to FDA. See the guide on how to report.

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. Breed names are FDA's labels rearranged into everyday order ("Setter - Gordon" becomes "Gordon Setter"). No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.