Pet Drug Reports

Ingredients

Active ingredient · pooled across combinations

Penicillin G Procaine: adverse event reports, pooled

7 ingredient sets in reports · 34 FDA-approved applications in the Green Book

1,119reports naming the ingredient, 1987–20250.1% of all reports · about 29 a year
3reports, 12 months to March 202617 in the 12 months before
65.2%classed serious, as reportedall reports: 38.6%
25.6%of reports concern cattledog 16.3%

1,119 adverse event reports received by FDA list a drug containing penicillin g procaine, alone or in combination, from January 1987 to October 2025. This page pools every ingredient set that includes it; 7 such sets appear in reports.

The Green Book lists 34 FDA-approved applications containing it. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand.

3 reports arrived in the 12 months to March 2026, down 82% from 17 in the 12 months before. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. That is about 29 reports a year over its reporting history and 0.1% of all reports.

Pooled across every set, the terms listed most often are death (24.6%), suspension, Abnormal (14.9%) and anaphylaxis (13%). Many drugs combine several ingredients, and many reports list several drugs, so a term on this page may relate to any of them or to none.

Of reports that state seriousness, 65.2% were classed as serious (38.6% across the whole database); 26.5% record a death or euthanasia (6.4% overall). Ingredients used in older or sicker animals, or in anaesthesia and cancer care, carry higher shares for that reason alone.

Ingredient sets that include penicillin g procaine

Active ingredients recorded for the drugReportsShare of this page's reportsLatest 12 months
Penicillin G Procaine72965.1%2
Penicillin G Benzathine + Penicillin G Procaine31027.7%0
Novobiocin + Penicillin G Procaine544.8%0
Chlorobutanol + Novobiocin + Penicillin G Procaine80.7%0
Dexamethasone + Penicillin G Procaine70.6%0
Dihydrostreptomycin Sulfate + Penicillin G Procaine70.6%1
Hydrocortisone Acetate + Neomycin Sulfate + Penicillin G Procaine40.4%0

Ordered by report count. FDA states that these data "cannot be used to estimate the risk associated with the product or compare one drug or device product with another"; counts follow sales volume and years on the market. A report can list more than one set, so shares can add to more than 100%.

Signs listed in reports, pooled

share of penicillin g procaine reports listing the termall reports in the database

  1. Death24.6%275
  2. Suspension, Abnormal[a product quality report, not a sign in an animal]14.9%167
  3. Anaphylaxis[sudden severe allergic-type reaction]13%146
  4. Injection site swelling[swelling where the injection was given]5.8%65
  5. Collapse5.6%63
  6. Injection site abscess[abscess where the injection was given]4.3%48
  7. Vomiting4.3%48
  8. Dyspnoea[difficulty breathing]3.3%37
  9. Ataxia[unsteady, uncoordinated movement]3.1%35
  10. Convulsion[seizure]2.9%33
  11. Injection site pain[pain where the injection was given]2.6%29
  12. Shaking2.1%24
  13. Anorexia[not eating]1.9%21
  14. Depression[dull, quiet or withdrawn]1.7%19
  15. Diarrhoea[diarrhea]1.7%19
  16. Fever1.7%19
  17. No sign[no clinical sign was reported]1.7%19
  18. Lack of efficacy (bacteria) - NOS[the product did not have the expected effect: target not specified]1.6%18
  19. Recumbency[lying down and unable or unwilling to rise]1.6%18
  20. Product Defect, General[a product quality report, not a sign in an animal]1.5%17
  21. Urticaria[hives]1.4%16
  22. Accidental exposure[exposure that was not intended]1.3%15
  23. Hypersalivation[drooling]1.3%15
  24. Trembling1.3%15
  25. Vials, Damaged[a product quality report, not a sign in an animal]1.3%15

Pooled across every ingredient set and every report that names the ingredient. One report can list several terms and several drugs; a term here may relate to any of them or to none.

Monthly reports by species, five years

Dog4 · peak 1
Apr 2022: 1Jul 2022: 1Oct 2022: 1May 2024: 12022202320242025
Cat0 · peak 1
2022202320242025
Horse0 · peak 1
2022202320242025
Other47 · peak 4
Jun 2021: 1Jul 2021: 1Nov 2021: 2Dec 2021: 1Jan 2022: 1Feb 2022: 1Apr 2022: 2May 2022: 1Jun 2022: 1Sep 2022: 1Oct 2022: 1Dec 2022: 1Jan 2023: 1Feb 2023: 2Mar 2023: 2May 2023: 1Jun 2023: 1Sep 2023: 3Oct 2023: 1Nov 2023: 1Mar 2024: 2Apr 2024: 4Aug 2024: 1Sep 2024: 1Nov 2024: 4Jan 2025: 1Feb 2025: 1Mar 2025: 4Jun 2025: 1Oct 2025: 22022202320242025

By month of receipt; each panel has its own scale. The newest months are incomplete because FDA posts reports with a delay of three to six months.

044881987: 3119871988: 141989: 131990: 211991: 1719911992: 161993: 151994: 211995: 4119951996: 301997: 761998: 881999: 4319992000: 482001: 382002: 112003: 2920032004: 392005: 332006: 602007: 3520072008: 412009: 592010: 422011: 3520112012: 202013: 262014: 202015: 1120152016: 262017: 202018: 202019: 1820192020: 62021: 102022: 122023: 1220232024: 132025: 9

Outcomes, report types and ages

Outcome recorded in the report

Recovered/Normal4.1%46
Recovered with Sequela0.3%3
Ongoing0.8%9
Died26.3%294
Euthanized0.3%3
Outcome Unknown2%22

What kind of report it was

Safety issue69.8%781
Lack of expected effectiveness0.4%4
Both safety and lack of expected effectiveness0.2%2
Manufacturing or product defect29.4%329
Other0.3%3

Species

Cattle25.6%286
Dog16.3%182
Horse15.1%169
Pig6.6%74
Cat3.4%38
Sheep1%11

Age of the animal

Under 1 year12.4%139
1 to 3 years10.3%115
4 to 7 years8.8%98
8 to 11 years5.2%58
12 years and over3.8%43
Age not given59.5%666

Coloured bar: reports naming penicillin g procaine. Grey bar: all 1,357,245 reports. Outcomes are as stated by the reporter; FDA has not necessarily determined whether any product played a part.

In context

MeasurePenicillin G ProcaineAll reports
Reports1,1191,357,245
Latest 12 months against the 12 before-82%-5%
Classed serious, of reports stating it65.2%38.6%
Death or euthanasia recorded, per 1,000 reports265.463.8
Filed as lack of expected effectiveness (wholly or partly)0.5%23%

Shares of reports, not of animals treated: how many animals receive the ingredient is not public. Ingredients used in anaesthesia, cancer care or in old animals carry more serious outcomes in their reports for that reason alone.

FDA-approved products containing penicillin g procaine (Green Book)

Reference information, not report statistics. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand. The list below is the FDA Green Book as of 1 Oct 2026; nothing on this page says which of these products, if any, a report concerned.

Trade nameActive ingredientsSponsorApproved forApplication
Quartermaster SuspensionDihydrostreptomycin Sulfate, Penicillin G ProcaineHQ Specialty Pharma Corp.CattleNADA 055-028
Albacillin Suspension; Special Formula 17900-Forte SuspensionNovobiocin Sodium, Penicillin G ProcaineZoetis Inc.CattleNADA 055-072
Dry-MastDihydrostreptomycin Sulfate, Penicillin G ProcaineHQ Specialty Pharma Corp.CattleNADA 055-097
Albadry Plus SuspensionNovobiocin Sodium, Penicillin G ProcaineZoetis Inc.CattleNADA 055-098
NorocillinPenicillin G ProcaineNorbrook Laboratories, Ltd.Horses, Cattle, Swine, SheepNADA 065-010
Go-dry; MASTI-CLEARPenicillin G ProcaineHQ Specialty Pharma Corp.CattleNADA 065-081
Longicil FortifiedPenicillin G Benzathine, Penicillin G ProcaineZoetis Inc.CattleNADA 065-087
Pen-G MaxPenicillin G ProcaineHuvepharma EOODDogs, Cats, Horses, Cattle, Swine, SheepNADA 065-110
Forte Topical OintmentHydrocortisone Acetate, Neomycin Sulfate, Penicillin G Procaine, Polymyxin B SulfateZoetis Inc.Dogs, CatsNADA 065-119
Crystalline Pro Penicillin GPenicillin G ProcaineZoetis Inc.Dogs, Cats, HorsesNADA 065-130
Dura-Biotic; Flo-cillinPenicillin G Benzathine, Penicillin G ProcaineZoetis Inc.Dogs, Horses, CattleNADA 065-169
Crysticillin 300 A.S.Penicillin G ProcaineZoetis Inc.Dogs, Cats, Horses, Cattle, Swine, SheepNADA 065-174
Formula A-34; Uni-Biotic 4 Dose; Herdsman’s Choice; Dry-A-CillinPenicillin G ProcaineBimeda Animal Health Ltd.CattleNADA 065-383
Dual-Cillin; Pen BP-48Penicillin G Benzathine, Penicillin G ProcaineHuvepharma EOODCattleNADA 065-498
Pro-Pen-GPenicillin G ProcaineBimeda Animal Health Ltd.Horses, Cattle, Swine, SheepNADA 065-505
Combi-Pen-48Penicillin G Benzathine, Penicillin G ProcaineBimeda Animal Health Ltd.CattleNADA 065-506
Bonaid & Zinc Bacitracin & Penicillinapproval voluntarily withdrawnBacitracin Zinc, Buquinolate, Penicillin G ProcaineProctor & Gamble Pharmaceuticals, Inc.—NADA 035-315
Bonaid & Penicillinapproval voluntarily withdrawnBuquinolate, Penicillin G ProcaineProctor & Gamble Pharmaceuticals, Inc.—NADA 035-317
Bonaid & Bacitracin MD & Penapproval voluntarily withdrawnBacitracin methylenedisalicylate, Buquinolate, Penicillin G ProcaineProctor & Gamble Pharmaceuticals, Inc.—NADA 035-327
CSP 250; CSP 500approval voluntarily withdrawnChlortetracycline Hydrochloride, Penicillin G Procaine, SulfathiazoleZoetis Inc.SwineNADA 039-077
Penicillin 100 Type A Medicated Article; Penicillin G Procaine 50 Type A Medicated Articleapproval voluntarily withdrawnPenicillin G ProcaineZoetis Inc.Swine, Chickens, TurkeysNADA 046-666
Penicillin G Procaine 50% Type A Medicated Articleapproval voluntarily withdrawnPenicillin G ProcainePhibro Animal Health Corp.Swine, Chickens, TurkeysNADA 046-668
Rainbrook Broiler Premix No.1approval voluntarily withdrawnAmprolium, Arsanilic Acid, Ethopabate, Penicillin G Procaine, StreptomycinStockton Hay & Grain Co.ChickensNADA 049-462
Bicillin Fortifiedapproval voluntarily withdrawnPenicillin G Benzathine, Penicillin G ProcaineWyeth LaboratoriesDogs, Horses, CattleNADA 055-008
Aqua-Mast; Hanfords Four-Penapproval voluntarily withdrawnPenicillin G ProcaineG.C. Hanford Mfg. Co.CattleNADA 065-465
True Antibiotic Formula #10approval voluntarily withdrawnPenicillin G ProcaineBoehringer Ingelheim Animal Health USA Inc.—NADA 065-466
Benza-Penapproval voluntarily withdrawnPenicillin G Benzathine, Penicillin G ProcaineWalco International, Inc.Dogs, Horses, CattleNADA 065-488
Jetpen; Penicillin G Procaine Aqueous Suspensionapproval voluntarily withdrawnPenicillin G ProcaineNorbrook Laboratories, Ltd.Horses, Cattle, Swine, SheepNADA 065-493
Tandem Penapproval voluntarily withdrawnPenicillin G Benzathine, Penicillin G ProcaineNorbrook Laboratories, Ltd.Dogs, Horses, CattleNADA 065-500
Chlorachel 250 Swine; Pficlor 1000; Pficlor 250; Pficlor-SP 250approval voluntarily withdrawnChlortetracycline Calcium Complex, Penicillin G Procaine, SulfamethazineZoetis Inc.SwineNADA 091-668
Nicarbazin plus Penicillin G Procaine plus 3-Nitroapproval voluntarily withdrawnNicarbazin, Penicillin G Procaine, RoxarsonePhibro Animal Health Corp.ChickensNADA 098-371
Nicarbazin plus Penicillin G Procaineapproval voluntarily withdrawnNicarbazin, Penicillin G ProcainePhibro Animal Health Corp.ChickensNADA 098-374
Aureozolapproval voluntarily withdrawnChlortetracycline Hydrochloride, Penicillin G Procaine, SulfathiazoleZoetis Inc.SwineANADA 200-140
Aureozol 500 Granularapproval voluntarily withdrawnChlortetracycline Calcium Complex, Penicillin G Procaine, SulfathiazoleZoetis Inc.SwineANADA 200-167

Species are the major species the Green Book search lists for the application ("—" where it lists another species or none). Approval dates are not part of the Green Book listing files and are not shown. Pioneer applications (NADA) come first, then generics (ANADA).

Questions about penicillin g procaine reports

How many FDA adverse event reports mention penicillin g procaine?

1,119 reports through March 2026, 3 of them in the latest 12 months, counting penicillin g procaine alone and in combinations.

Which brands do these reports concern?

That cannot be known from the public data. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand. The Green Book reference list on this page names approved products containing penicillin g procaine without any counts.

In which combinations is penicillin g procaine reported?

Penicillin G Procaine (65.1% of these reports), Penicillin G Benzathine + Penicillin G Procaine (27.7% of these reports), Novobiocin + Penicillin G Procaine (4.8% of these reports), Chlorobutanol + Novobiocin + Penicillin G Procaine (0.7% of these reports) and Dexamethasone + Penicillin G Procaine (0.6% of these reports).

What reactions are reported for penicillin g procaine?

death (24.6%), suspension, Abnormal (14.9%), anaphylaxis (13%), residues in milk (6.9%) and injection site swelling (5.8%). Shares are of reports naming the ingredient; one report can list several terms.

Which animals are these reports about?

cattle (25.6%), dog (16.3%) and horse (15.1%).

Does a high count mean penicillin g procaine is a problem ingredient?

A count cannot show that. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources." Widely used ingredients collect more reports because more animals receive them.

How do I report a problem?

Call the drug company using the number on the label, or send Form FDA 1932a to FDA. See the guide on how to report.

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. Ingredient names follow the Green Book; salts and forms are kept as FDA lists them. Drug entries are matched by the active ingredients their unmasked ingredient field discloses. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.