Pet Drug Reports

Atipamezole Hydrochloride (Antisedan, Revertidine)adverse event reports that FDA received

Active ingredient

Also sold as: Antisedan, Revertidine, Cropamezole, Contrased.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From December 1996 to June 2026, FDA received 3,952 adverse event reports that name a drug with atipamezole hydrochloride as its active ingredient. Of the 3,952 reports, 2,656 (67.2%) are about dogs. 1,037 reports are about cats (26.2%).

In January to March 2026, FDA received 79 reports that name this drug. The signs that appear in the largest number of the 3,952 reports are "Death", "Ineffective, reversal" and "Vomiting". A report is not proof that a drug caused a sign.

Reports that name this drug fell by 10.6% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cats are 26.2% of the reports that name this drug, and 11% of all reports.

Since the last update of the FDA data

The site recorded an update of the FDA data on . FDA changed these counts for January to March 2026:

  • All species: from 60 to 79.
  • Dog: from 32 to 42.
  • Cat: from 28 to 36.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 79 reports that name atipamezole hydrochloride: 42 dog, 36 cat, 0 horse, 1 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 3,952 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Death14.4%571 reports
  2. Ineffective, reversal[legacy FDA term: the product did not have the expected effect (reversal)]11.8%468 reports
  3. Vomiting8.2%326 reports
  4. Lack of efficacy - NOS[the product did not have the expected effect]7.9%312 reports
  5. Lethargy[unusually tired or inactive]7.1%279 reports
  6. Hypersalivation[drooling]6.8%269 reports
  7. Bradycardia[slow heart rate]6.3%248 reports
  8. Cardiac arrest5.3%210 reports
  9. Diarrhoea[diarrhea]5.3%210 reports
  10. Sedation prolonged5%199 reports
  11. Anorexia[not eating]4.8%188 reports
  12. Fever4.3%171 reports
  13. Tachycardia[fast heart rate]4.3%171 reports
  14. Accidental exposure[exposure that was not intended]3.8%149 reports
Show the next 16 signs
  1. Death by euthanasia[the animal was euthanized]3.7%148 reports
  2. No sign[no clinical sign was reported]3.7%145 reports
  3. Ataxia[unsteady, uncoordinated movement]3.6%142 reports
  4. Injection site swelling[swelling where the injection was given]3.6%142 reports
  5. Panting3.6%141 reports
  6. Hypothermia[low body temperature]3.5%138 reports
  7. Vocalisation[crying out or unusual noise]3.5%138 reports
  8. Depression[dull, quiet or withdrawn]3.4%136 reports
  9. Not eating3.4%133 reports
  10. Behavioural disorder NOS[behaviour change, type not specified]3.2%126 reports
  11. Hyperactivity3.2%126 reports
  12. Seizure NOS[seizure, type not specified]3.1%124 reports
  13. Convulsion[seizure]2.9%116 reports
  14. Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]2.9%114 reports
  15. Apnoea[breathing stopped]2.9%113 reports
  16. Recovery prolonged2.7%107 reports

The list shows 30 of 1,365 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

  • Dog67.2%2,656
  • Cat26.2%1,037
  • Human exposure0.3%12
  • Other0.3%10
  • Monkey0.2%6
  • Turtle0.2%6

The share is of all 3,952 reports that name atipamezole hydrochloride. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog785 reports. Largest count in one month: 29 (Jun 2025)
Cat365 reports. Largest count in one month: 20 (Apr 2025)
Horse4 reports

No chart: no month has 5 or more reports.

Other or not given43 reports. Largest count in one month: 5 (Feb 2022)

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name atipamezole hydrochloride, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
2026774647134
20252149708319
20242068608300
20231696908246
20227948010137
2021693209110
20207031018119
20197336018127
20186940013122
2017934408145
20168143010134
20158139015135
20147439012125
2013784506129
20128734017138
2011653509109
20109842010150
20098030014124
20087330011114
200761140782
2006921606114
200558180379
200461170684
20033040438
200269140588
200168260397
200070170390
1999912002113
19981011104116
19971171401132
199620002

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal18%713
  • Recovered with Sequela[recovered, with a lasting effect]0.2%8
  • Ongoing19%751
  • Died16.7%659
  • Euthanized2.5%99
  • Outcome Unknown10.3%407

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 3,952 reports that name atipamezole hydrochloride.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue82.8%3,274
  • Lack of expected effectiveness3.8%149
  • Both safety and lack of expected effectiveness7.9%311
  • Manufacturing or product defect5.4%214
  • Other0.1%4

2,247 reports say if the event was serious. 53.4% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year12.8%506
  • 1 to 3 years20.2%798
  • 4 to 7 years25.2%995
  • 8 to 11 years18.8%744
  • 12 years and over8.2%325
  • Age not given14.8%584

Weight of the animal

  • Under 5 kg (11 lb)21.1%834
  • 5 to 9.9 kg (11 to 22 lb)16%634
  • 10 to 24.9 kg (22 to 55 lb)16.2%639
  • 25 to 44.9 kg (55 to 99 lb)26.2%1,034
  • 45 kg and over (99 lb and over)5.6%220
  • Weight not given15%591

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Intramuscular56.7%2,241
  • Intravenous10%396
  • Parenteral2.6%101
  • Subcutaneous1.5%59
  • Other0.5%21
  • Oral0.3%11

Each bar is on a scale of 0 to 100%.

Approved animal drugs with this active ingredient (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • Antisedan
  • Revertidine
  • Cropamezole
  • Contrased

What the Green Book records give

Applications with an approval in force
5
Approved species
Dogs
Dose forms
Sterile Injectable Solution, Liquid (Solution)
Routes
Intramuscular
Sale
RX (prescription)
Earliest approval date in the records

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
AntisedanAtipamezole HydrochlorideOrion Corp.DogsNADA 141-033
RevertidineAtipamezole HydrochlorideModern Veterinary Therapeutics, LLCDogsANADA 200-624
CropamezoleAtipamezole HydrochlorideCronus Pharma Specialities India Private Ltd.DogsANADA 200-753
ContrasedAtipamezole HydrochlorideParnell Technologies Pty. Ltd.DogsANADA 200-772
Atipamezole Hydrochloride InjectionAtipamezole HydrochlorideFelix Pharmaceuticals Pvt. Ltd.DogsANADA 200-838

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Atipamezole Hydrochloride: adverse event reports that FDA received. https://petdrugreports.com/drug/atipamezole-hydrochloride/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

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Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with this active ingredient.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 286 reports in the 12 months to June 2026. It received 320 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 3,952 reports received from December 1996 to June 2026, 82.8% are about a safety issue only. 11.6% are about a lack of expected effectiveness, alone or with a safety issue. 5.4% are about a defect of the product or its package.