Diethylcarbamazine Citrate (Diro-Form, Nemacide): adverse event reports that FDA received

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 440 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

1. No sign[no clinical sign was reported]20.7%91 reports
2. Accidental exposure[exposure that was not intended]18.4%81 reports
3. Vomiting18.2%80 reports
4. Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]9.1%40 reports
5. Depression[dull, quiet or withdrawn]8.9%39 reports
6. Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]6.4%28 reports
7. Diarrhoea[diarrhea]5.9%26 reports
8. Anorexia[not eating]5.7%25 reports
9. Unpalatable[legacy FDA term: the animal would not take it]5.2%23 reports
10. Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]4.5%20 reports
11. Ineffective, heartworm adults[legacy FDA term: the product did not have the expected effect (heartworm adults)]3.9%17 reports
12. Product Defect, General[a product quality report, not a sign in an animal]3.2%14 reports
13. Convulsion[seizure]2.7%12 reports
14. Seal, Abnormal[a product quality report, not a sign in an animal]2.7%12 reports

The list shows 30 of 152 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

• Dog78.2%344
• Human exposure4.5%20
• Cat2.5%11
• Guinea Pig0.2%1

The share is of all 440 reports that name diethylcarbamazine citrate. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

• Dog
• Cat
• Horse
• Other or not given

2016 has the reports that FDA received through Dec 2016. Download the years (CSV)

What the reports record

Each bar is on a scale of 0 to 100%.

Next in the A to Z list

• Diazepam
• Dichlorophene + Toluene
• Diclazuril
• Diclofenac sodium
• Difloxacin Hydrochloride
• Diltiazem
• Dimethyl Sulfoxide + Fluocinolone Acetonide
• Dinoprost Tromethamine

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

• How to Report Animal Drug and Device Side Effects and Product ProblemsThe FDA page that tells an owner or a veterinarian how to send a report.
• Green Book record of NADA 092-836The FDA record of the application for Diethylcarbamazine Citrate Tab., Diro-Form.
• Green Book record of NADA 092-837The FDA record of the application for Nemacide Oral Syrup.
• Green Book record of NADA 093-512The FDA record of the application for Dirocide Tablets.
• Green Book record of NADA 104-493The FDA record of the application for Filaribits Chewable Tablets.
• Green Book record of NADA 107-506The FDA record of the application for Carbam Tablets.
• Green Book record of NADA 118-032The FDA record of the application for Carbam Palatabs.
• Animal Drugs @ FDAThe search page of the Green Book, the FDA list of approved animal drugs.

The site checked these addresses on 2 Oct 2026. The links open in a new tab.

Cite this page

Pet Drug Reports. Diethylcarbamazine Citrate: adverse event reports that FDA received. https://petdrugreports.com/drug/diethylcarbamazine-citrate/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with this active ingredient.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received no reports in the 12 months to June 2026. It received no reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 440 reports received from February 1987 to December 2016, 85.2% are about a safety issue only. 0.2% are about a lack of expected effectiveness, alone or with a safety issue. 14.5% are about a defect of the product or its package.