Pet Drug Reports

Pentobarbital Sodium + Phenytoin Sodium (Beuthanasia-D Special, Euthasol)adverse event reports that FDA received

Combination of 2 active ingredients

Also sold as: Beuthanasia-D Special, Euthasol, Euthanasia-III.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From July 2011 to June 2026, FDA received 607 adverse event reports that name this drug. Its active ingredients are pentobarbital sodium and phenytoin sodium. Of the 607 reports, 320 (52.7%) are about dogs. 108 reports are about cats (17.8%).

In January to March 2026, FDA received 15 reports that name this drug. The signs that appear in the largest number of the 607 reports are "Ineffective, euthanasia" and "Lack of efficacy - NOS". A report is not proof that a drug caused a sign.

Reports that name this drug rose by 3.7% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 52.7% of the reports that name this drug, and 72.6% of all reports.

Since the last update of the FDA data

The site recorded an update of the FDA data on . FDA changed these counts for January to March 2026:

  • All species: from 9 to 15.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 15 reports that name pentobarbital sodium + phenytoin sodium: 7 dog, 2 cat, 1 horse, 5 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 607 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Ineffective, euthanasia[legacy FDA term: the product did not have the expected effect (euthanasia)]45.1%274 reports
  2. Lack of efficacy - NOS[the product did not have the expected effect]33.9%206 reports
  3. Ineffective, delayed effect[legacy FDA term: the product did not have the expected effect (delayed effect)]10.7%65 reports
  4. Death by euthanasia[the animal was euthanized]8.9%54 reports
  5. Overdose[more than the labelled amount was given]8.7%53 reports
  6. Vocalisation[crying out or unusual noise]6.1%37 reports
  7. Accidental exposure[exposure that was not intended]4%24 reports
  8. Unrelated death4%24 reports
  9. Agonal breathing3.6%22 reports
  10. Abnormal breathing2.8%17 reports
  11. Drug administration error2.6%16 reports
  12. Injection site pain[pain where the injection was given]2.3%14 reports
  13. Product Defect, General[a product quality report, not a sign in an animal]2.1%13 reports
  14. Appearance, Abnormal[a product quality report, not a sign in an animal]2%12 reports
Show the next 16 signs
  1. Abnormal movement NOS[NOS: not otherwise specified]1.8%11 reports
  2. Respiratory tract disorder NOS[NOS: not otherwise specified]1.8%11 reports
  3. Incorrect route of drug administration1.6%10 reports
  4. Stopper, abnormal1.6%10 reports
  5. Color, Abnormal[a product quality report, not a sign in an animal]1.5%9 reports
  6. Containers, Damaged[a product quality report, not a sign in an animal]1.5%9 reports
  7. Excitation1.5%9 reports
  8. Twitching1.5%9 reports
  9. Closure, Abnormal[a product quality report, not a sign in an animal]1.3%8 reports
  10. Partial lack of efficacy[the product worked less well than expected]1.3%8 reports
  11. Potency, Low1.3%8 reports
  12. Product problem[a product quality report, not a sign in an animal]1.3%8 reports
  13. Administration error NOS[NOS: not otherwise specified]1.2%7 reports
  14. Injection site bleeding[bleeding where the injection was given]1.2%7 reports
  15. Injection site numbness[numbness where the injection was given]1.2%7 reports
  16. Lethargy[unusually tired or inactive]1.2%7 reports

The list shows 30 of 225 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

The share is of all 607 reports that name pentobarbital sodium + phenytoin sodium. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog104 reports. Largest count in one month: 7 (Jan 2022)
Cat41 reports. Largest count in one month: 7 (Sep 2025)
Horse20 reports

No chart: no month has 5 or more reports.

Other or not given67 reports

No chart: no month has 5 or more reports.

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name pentobarbital sodium + phenytoin sodium, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
20261032722
2025201362362
202426125750
202320411540
202221761448
20211730525
20201847837
20191923529
20181150622
20172586342
20162344233
20152562942
201432114754
201324133545
20121751730
20111281526

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal7.1%43
  • Recovered with Sequela[recovered, with a lasting effect]0%0
  • Ongoing0%0
  • Died1%6
  • Euthanized77.8%472
  • Outcome Unknown3.6%22

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 607 reports that name pentobarbital sodium + phenytoin sodium.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue18.6%113
  • Lack of expected effectiveness34.9%212
  • Both safety and lack of expected effectiveness32.6%198
  • Manufacturing or product defect13.8%84
  • Other0%0

542 reports say if the event was serious. 66.2% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year1.3%8
  • 1 to 3 years3.3%20
  • 4 to 7 years7.9%48
  • 8 to 11 years10.7%65
  • 12 years and over32.6%198
  • Age not given44.2%268

Weight of the animal

  • Under 5 kg (11 lb)14.8%90
  • 5 to 9.9 kg (11 to 22 lb)10.7%65
  • 10 to 24.9 kg (22 to 55 lb)13.3%81
  • 25 to 44.9 kg (55 to 99 lb)11.5%70
  • 45 kg and over (99 lb and over)9.1%55
  • Weight not given40.5%246

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Intravenous61%370
  • Intracardiac3.3%20
  • Oral2.5%15
  • Subcutaneous1.8%11
  • Intradermal1.3%8
  • Ophthalmic1.2%7

Each bar is on a scale of 0 to 100%.

Approved animal drugs with these active ingredients (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • Beuthanasia-D Special
  • Euthasol
  • Euthanasia-III

What the Green Book records give

Applications with an approval in force
4
Approved species
Dogs
Dose forms
Liquid (Solution), Injectable Solution
Routes
Intracardiac, Intravenous
Sale
RX (prescription)
Earliest approval date in the records

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
Beuthanasia-D SpecialPentobarbital Sodium, Phenytoin SodiumIntervet, Inc.DogsNADA 119-807
EuthasolPentobarbital Sodium, Phenytoin SodiumVirbac AH, Inc.DogsANADA 200-071
Euthanasia-III SolutionPentobarbital Sodium, Phenytoin SodiumDechra Veterinary Products LLCDogsANADA 200-280
Pentobarbital Sodium and Phenytoin SodiumPentobarbital Sodium, Phenytoin SodiumNoble Pharma, LLCDogsANADA 200-614

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Pentobarbital Sodium + Phenytoin Sodium: adverse event reports that FDA received. https://petdrugreports.com/drug/pentobarbital-sodium-phenytoin-sodium/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

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Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with these active ingredients.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 56 reports in the 12 months to June 2026. It received 54 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 607 reports received from July 2011 to June 2026, 18.6% are about a safety issue only. 67.5% are about a lack of expected effectiveness, alone or with a safety issue. 13.8% are about a defect of the product or its package.