Pet Drug Reports

Imidacloprid (Advantus)adverse event reports that FDA received

Active ingredient

The name in brackets is a brand name with this active ingredient.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From January 2009 to June 2026, FDA received 7,093 adverse event reports that name a drug with imidacloprid as its active ingredient. Of the 7,093 reports, 5,355 (75.5%) are about dogs. 1,532 reports are about cats (21.6%).

In January to March 2026, FDA received 82 reports that name this drug. The signs that appear in the largest number of the 7,093 reports are "Lack of efficacy (ectoparasite) - flea", "Pruritus" and "Lethargy". A report is not proof that a drug caused a sign.

Reports that name this drug fell by 25.4% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cats are 21.6% of the reports that name this drug, and 11% of all reports.

Since the last update of the FDA data

The site recorded an update of the FDA data on . FDA changed these counts for January to March 2026:

  • All species: from 60 to 82.
  • Dog: from 48 to 66.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 82 reports that name imidacloprid: 66 dog, 12 cat, 0 horse, 4 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 7,093 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]37.6%2,668 reports
  2. Pruritus[itching]12.6%895 reports
  3. Lethargy[unusually tired or inactive]11.3%804 reports
  4. Vomiting8.9%630 reports
  5. Behavioural disorder NOS[behaviour change, type not specified]6.6%465 reports
  6. Diarrhoea[diarrhea]4.6%324 reports
  7. Anorexia[not eating]4.2%295 reports
  8. Other abnormal test result NOS[abnormal laboratory result, type not specified]3.7%263 reports
  9. Seizure NOS[seizure, type not specified]3.4%242 reports
  10. Scratching3.1%220 reports
  11. Application site pruritus[itching where the product was applied]2.7%194 reports
  12. Application site alopecia[hair loss where the product was applied]2.6%184 reports
  13. Emesis[vomiting]2.6%184 reports
  14. Lack of efficacy (ectoparasite) - tick NOS[the product did not have the expected effect: ticks]2.5%180 reports
Show the next 16 signs
  1. Weight loss2.5%178 reports
  2. Emesis (multiple)[vomiting more than once]2.4%173 reports
  3. Vocalisation[crying out or unusual noise]2.3%166 reports
  4. Overdose[more than the labelled amount was given]2.3%161 reports
  5. Ataxia[unsteady, uncoordinated movement]2.3%160 reports
  6. Lack of efficacy - NOS[the product did not have the expected effect]2.2%153 reports
  7. Panting2.1%148 reports
  8. Death2%143 reports
  9. Application site erythema[reddened skin where the product was applied]2%140 reports
  10. Skin lesion NOS[NOS: not otherwise specified]1.9%138 reports
  11. Not eating1.9%132 reports
  12. Decreased appetite1.8%131 reports
  13. Itching1.8%131 reports
  14. Agitation1.7%124 reports
  15. Hyperactivity1.7%123 reports
  16. Lack of efficacy (endoparasite) - tapeworm[the product did not have the expected effect: tapeworms]1.5%107 reports

The list shows 30 of 1,318 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

The share is of all 7,093 reports that name imidacloprid. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog2,650 reports. Largest count in one month: 110 (Aug 2022)
Cat594 reports. Largest count in one month: 28 (Nov 2022)
Horse0 reports

No chart: no month has 5 or more reports.

Other or not given128 reports. Largest count in one month: 6 (Aug 2023)

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name imidacloprid, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
202615821010189
202535861025444
2024528140035703
2023627116034777
2022581167012760
2021641122017780
2020481105025611
2019463107022592
2018379121014514
201727015006426
201620511500320
20151988502285
20141548801243
20131848502271
20121073000137
201119160136
201013004
200910001

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal19.1%1,358
  • Recovered with Sequela[recovered, with a lasting effect]0.4%31
  • Ongoing14.8%1,048
  • Died2.1%150
  • Euthanized1.5%103
  • Outcome Unknown59.4%4,216

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 7,093 reports that name imidacloprid.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue59%4,182
  • Lack of expected effectiveness17.6%1,247
  • Both safety and lack of expected effectiveness17.8%1,264
  • Manufacturing or product defect5.6%394
  • Other0.1%6

6,902 reports say if the event was serious. 24.9% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year8.3%590
  • 1 to 3 years22.8%1,617
  • 4 to 7 years21.2%1,507
  • 8 to 11 years16%1,136
  • 12 years and over11.2%797
  • Age not given20.4%1,446

Weight of the animal

  • Under 5 kg (11 lb)22.5%1,597
  • 5 to 9.9 kg (11 to 22 lb)21.7%1,539
  • 10 to 24.9 kg (22 to 55 lb)18.7%1,325
  • 25 to 44.9 kg (55 to 99 lb)16.5%1,170
  • 45 kg and over (99 lb and over)2.8%202
  • Weight not given17.8%1,260

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Topical68.3%4,846
  • Oral23.2%1,646
  • Cutaneous1%69
  • Other0.6%46
  • Transdermal0.1%4
  • Subcutaneousunder 0.1%2

Each bar is on a scale of 0 to 100%.

Approved animal drugs with this active ingredient (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • Advantus

What the Green Book records give

Applications with an approval in force
1
Approved species
Dogs
Dose forms
Chewable Tablets
Routes
Oral
Sale
OTC (over the counter)
Earliest approval date in the records

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
AdvantusImidaclopridElanco US Inc.DogsNADA 141-435

Other pages with this ingredient

A report names a drug by its set of active ingredients. Each set has its own page. The list is in order of name.

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Imidacloprid: adverse event reports that FDA received. https://petdrugreports.com/drug/imidacloprid/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

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Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with this active ingredient.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 426 reports in the 12 months to June 2026. It received 571 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 7,093 reports received from January 2009 to June 2026, 59% are about a safety issue only. 35.4% are about a lack of expected effectiveness, alone or with a safety issue. 5.6% are about a defect of the product or its package.