Milbemycin Oxime: adverse event reports in all combinations

Drug pages with milbemycin oxime

A report names a drug by its set of active ingredients. Each set with milbemycin oxime that has a drug page is in the table, in order of name. The table has 6 sets.

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 237,768 reports that list the sign. One report can list more than one sign and more than one drug.

The sign that is in the largest number of the reports comes first.

1. Vomiting19.5%46,468 reports
2. Emesis[vomiting]18.1%43,057 reports
3. Lethargy[unusually tired or inactive]9.9%23,428 reports
4. Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]9.3%22,060 reports
5. Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]7%16,759 reports
6. Diarrhoea[diarrhea]6%14,159 reports
7. Unpalatable[legacy FDA term: the animal would not take it]5.9%14,002 reports
8. Lack of efficacy - NOS[the product did not have the expected effect]5.5%13,099 reports
9. Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]4.8%11,425 reports
10. Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]3.6%8,483 reports
11. Seizure NOS[seizure, type not specified]2.5%6,044 reports
12. Ineffective, ascarids NOS[legacy FDA term: the product did not have the expected effect (ascarids nos)]2.2%5,225 reports
13. Behavioural disorder NOS[behaviour change, type not specified]2.1%5,098 reports
14. Ineffective, hooks[legacy FDA term: the product did not have the expected effect (hooks)]2.1%4,974 reports

Download all signs (CSV)

Reports by species

• Dog92.7%220,330
• Cat0.3%759
• Human exposure0.2%491
• Otherunder 0.1%64
• Other Canidsunder 0.1%10
• Rabbitunder 0.1%4

Reports for each month, Jul 2021 to Jun 2026

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

• Dog
• Cat
• Horse
• Other or not given

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Each share of kind and age is of the 237,768 reports that name milbemycin oxime.

FDA pages for this ingredient

• How to Report Animal Drug and Device Side Effects and Product ProblemsThe FDA page that tells an owner or a veterinarian how to send a report.
• Green Book record of NADA 140-915The FDA record of the application for Interceptor.
• Green Book record of NADA 141-084The FDA record of the application for Sentinel Flavor Tabs.
• Green Book record of NADA 141-204The FDA record of the application for Sentinel Flavor Tabs and Capstar Flea Management System.
• Green Book record of NADA 141-321The FDA record of the application for Trifexis.Client Information Sheet of Trifexis (PDF): a label document that FDA posts with the record.
• Green Book record of NADA 141-333The FDA record of the application for Sentinel Spectrum.
• Green Book record of NADA 141-338The FDA record of the application for Interceptor Plus.
• Animal Drugs @ FDAThe search page of the Green Book, the FDA list of approved animal drugs.

The site checked these addresses on 2 Oct 2026. The links open in a new tab.

Cite this page

Pet Drug Reports. Milbemycin Oxime, all combinations: adverse event reports that FDA received. https://petdrugreports.com/ingredient/milbemycin-oxime/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists brand names with this active ingredient.

Do the reports show that the ingredient caused the signs?

No. A report can name more than one drug, and a drug can have more than one active ingredient. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 4,308 reports in the 12 months to June 2026. It received 5,348 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 237,768 reports received from August 1990 to June 2026, 65% are about a safety issue only. 24.5% are about a lack of expected effectiveness, alone or with a safety issue. 10.5% are about a defect of the product or its package.