Pet Drug Reports

Cythioate (Proban)adverse event reports that FDA received

Active ingredient

The name in brackets is a brand name with this active ingredient.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From November 1987 to November 1996, FDA received 30 adverse event reports that name a drug with cythioate as its active ingredient. Of the 30 reports, 23 (76.7%) are about dogs. 4 reports are about cats (13.3%).

In January to March 2026, FDA received no reports that name this drug. The signs that appear in the largest number of the 30 reports are "Death", "Vomiting" and "Convulsion". A report is not proof that a drug caused a sign.

This page has fewer than 50 reports. The site keeps the page for its links and keeps it out of search engines.

Since the last update of the FDA data

No update is on record. The record starts when FDA adds the reports of April to June 2026.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 0 reports that name cythioate: 0 dog, 0 cat, 0 horse, 0 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 30 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Death30%9 reports
  2. Vomiting26.7%8 reports
  3. Convulsion[seizure]23.3%7 reports
  4. Hypersalivation[drooling]16.7%5 reports
  5. Depression[dull, quiet or withdrawn]13.3%4 reports
  6. Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]10%3 reports
  7. Behavioural disorder NOS[behaviour change, type not specified]6.7%2 reports
  8. Caps, Abnormal[a product quality report, not a sign in an animal]6.7%2 reports
  9. Diarrhoea[diarrhea]6.7%2 reports
  10. Dyspnoea[difficulty breathing]6.7%2 reports
  11. Mydriasis[dilated pupils]6.7%2 reports
  12. Shaking6.7%2 reports
  13. Trembling6.7%2 reports
  14. Weakness6.7%2 reports
Show the next 16 signs
  1. Aggression3.3%1 reports
  2. Anorexia[not eating]3.3%1 reports
  3. Apprehension3.3%1 reports
  4. Ataxia[unsteady, uncoordinated movement]3.3%1 reports
  5. Bloody diarrhoea[diarrhea with blood]3.3%1 reports
  6. Cholinesterase(che) low, serum3.3%1 reports
  7. Cyanosis[bluish gums or skin from low oxygen]3.3%1 reports
  8. Epiphora3.3%1 reports
  9. Gastroenteritis3.3%1 reports
  10. Head tilt - ear disorder3.3%1 reports
  11. Hind limb paresis[weak hind legs]3.3%1 reports
  12. Hyperactivity3.3%1 reports
  13. Hypoglycaemia[low blood sugar]3.3%1 reports
  14. Hypothyroidism[underactive thyroid]3.3%1 reports
  15. Lack of efficacy - NOS[the product did not have the expected effect]3.3%1 reports
  16. Leucocytosis NOS[high white blood cell count]3.3%1 reports

The list shows 30 of 35 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

The share is of all 30 reports that name cythioate. The other reports give a different species or no species.

Reports for each month, Apr 2021 to Mar 2026

Dog0 reports

No chart: no month has 5 or more reports.

Cat0 reports

No chart: no month has 5 or more reports.

Horse0 reports

No chart: no month has 5 or more reports.

Other or not given0 reports

No chart: no month has 5 or more reports.

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name cythioate, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
199610034
1995730010
199420002
199350005
199241005
198830003
198710001

1996 has the reports that FDA received through Nov 1996. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal0%0
  • Recovered with Sequela[recovered, with a lasting effect]0%0
  • Ongoing0%0
  • Died30%9
  • Euthanized0%0
  • Outcome Unknown0%0

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 30 reports that name cythioate.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue90%27
  • Lack of expected effectiveness0%0
  • Both safety and lack of expected effectiveness0%0
  • Manufacturing or product defect10%3
  • Other0%0
Show age, weight, breed and route

Age of the animal

  • Under 1 year3.3%1
  • 1 to 3 years30%9
  • 4 to 7 years20%6
  • 8 to 11 years16.7%5
  • 12 years and over0%0
  • Age not given30%9

Weight of the animal

  • Under 5 kg (11 lb)33.3%10
  • 5 to 9.9 kg (11 to 22 lb)3.3%1
  • 10 to 24.9 kg (22 to 55 lb)23.3%7
  • 25 to 44.9 kg (55 to 99 lb)10%3
  • 45 kg and over (99 lb and over)0%0
  • Weight not given30%9

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Oral90%27

Each bar is on a scale of 0 to 100%.

Approved animal drugs with this active ingredient (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • Proban

What the Green Book records give

Applications with an approval in force
4
Approved species
Dogs
Dose forms
Liquid, Tablet
Routes
Oral
Sale
RX (prescription)

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 1 Oct 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
Proban Cythioate Tablets 30 mgCythioateZoetis Inc.DogsNADA 033-342
Proban Oral LiquidCythioateZoetis Inc.DogsNADA 033-606
Proban Oral LiquidCythioateElanco US Inc.DogsNADA 132-336
Proban TabletsCythioateElanco US Inc.DogsNADA 132-337

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Cythioate: adverse event reports that FDA received. https://petdrugreports.com/drug/cythioate/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 28 Sep 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 31 Mar 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 1 Oct 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with this active ingredient.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received no reports in the 12 months to March 2026. It received no reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 30 reports received from November 1987 to November 1996, 90% are about a safety issue only. 10% are about a defect of the product or its package.