Breed · Dog

Bulldog: adverse event reports

FDA breed label "Bulldog" · single-breed animals only

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

7,807reports, 1988–20230.8% of dog reports

0reports, 12 months to March 20260 in the 12 months before

37.4%classed serious, as reportedall dogs: 38.3%

19.8%name milbemycin oxime + spinosadall dogs: 13.1%

FDA's database holds 7,807 reports where the animal's breed is given as "Bulldog", shown here as Bulldog: 0.8% of reports about dogs. Reports on crossbred animals are left out of breed pages.

0 reports arrived in the 12 months to March 2026, and none in the 12 months before. A breed's count mostly mirrors how common the breed is; registration and ownership figures by breed are not public data, so no per-animal rate can be given.

By active ingredient, the drugs named most often are milbemycin oxime + spinosad, ivermectin + pyrantel pamoate and spinosad. Milbemycin Oxime + Spinosad is named in 19.8% of this breed's reports, a larger share than in reports about all dogs (13.1%).

The terms listed most often are vomiting (22.2%), emesis (11.2%) and lethargy (8.9%). Vomiting appears in 22.2% of reports, about the same share as in all dog reports (19.7%). 37.4% of reports stating seriousness were classed as serious, against 38.3% for dogs overall.

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of Bulldog reports	Share of all dog reports
Milbemycin Oxime + Spinosad	1,548	19.8%	13.1%
Ivermectin + Pyrantel Pamoate	784	10%	14.9%
Spinosad	603	7.7%	5.8%
Oclacitinib	593	7.6%	2.9%
Fluralaner	549	7%	6.7%
Afoxolaner	414	5.3%	5.7%
Moxidectin	391	5%	5%
Cyclosporine	354	4.5%	1.5%
Carprofen	272	3.5%	4.8%
Milbemycin Oxime	184	2.4%	3%
Pyrantel Pamoate + Sarolaner	181	2.3%	5.1%
Selamectin	170	2.2%	3%
Lufenuron + Milbemycin Oxime	148	1.9%	2.7%
Ivermectin	145	1.9%	1.3%
Melarsomine Dihydrochloride	139	1.8%	2.3%
Imidacloprid + Moxidectin	132	1.7%	1.3%
Sarolaner	114	1.5%	1.7%
Milbemycin Oxime + Praziquantel	109	1.4%	3.1%
Maropitant	105	1.3%	1.2%
Cefpodoxime proxetil	98	1.3%	0.4%

Ordered by report count. Differences from the species column often come from body size (which drugs a breed is prescribed) and from how common the breed was in the years a drug sold most. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed in reports

share of Bulldog reports listing the termall dog reports

Vomiting22.2%1,736
Emesis[vomiting]11.2%877
Lethargy[unusually tired or inactive]8.9%692
Diarrhoea[diarrhea]8%628
Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]4.7%369
Lack of efficacy - NOS[the product did not have the expected effect]4.6%363
Death4.2%328
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]4.2%325
Seizure NOS[seizure, type not specified]3.9%302
Anorexia[not eating]3.9%301
Depression[dull, quiet or withdrawn]3.3%254
Pruritus[itching]2.4%191
Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]2.4%188
Hives2.3%179
Ataxia[unsteady, uncoordinated movement]2.3%177
Emesis (multiple)[vomiting more than once]2.2%168
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]2.1%162
Behavioural disorder NOS[behaviour change, type not specified]2%157
Other abnormal test result NOS[abnormal laboratory result, type not specified]1.8%138
Fever1.7%136
Panting1.7%136
Urticaria[hives]1.7%133
Shaking1.7%131
Trembling1.6%126
Death by euthanasia[the animal was euthanized]1.6%123

Age and weight

Age of the animal

Under 1 year17.3%1,348

1 to 3 years37.1%2,895

4 to 7 years27.1%2,112

8 to 11 years13.3%1,041

12 years and over1.8%140

Age not given3.5%271

Weight of the animal

Under 5 kg (11 lb)1.2%94

5 to 9.9 kg (11–22 lb)3.7%288

10 to 24.9 kg (22–55 lb)40.7%3,175

25 to 44.9 kg (55–99 lb)47.7%3,721

45 kg and over (99 lb+)1.9%149

Weight not given4.9%380

Coloured bar: Bulldog reports. Grey bar: all dog reports.

Trend and outcomes

Reports by month FDA received them. The newest months are incomplete because FDA posts reports with a delay of three to six months.

Outcome recorded in the report

Recovered/Normal31.3%2,444

Recovered with Sequela2.8%222

Ongoing18.4%1,433

Died5.2%404

Euthanized1.1%84

Outcome Unknown20.1%1,569

Beside all dogs

Measure	Bulldog	All dogs
Reports	7,807	985,675
Latest 12 months	0	53,292
Classed serious, of reports stating it	37.4%	38.3%
Death or euthanasia recorded, per 1,000 reports	62.5	55

Questions about Bulldog reports

How many FDA adverse event reports involve Bulldogs?

7,807 reports through March 2026, 0.8% of reports about dogs; 0 in the latest 12 months.

Which drugs are named most often in Bulldog reports?

By active ingredient: milbemycin oxime + spinosad (1,548), ivermectin + pyrantel pamoate (784), spinosad (603), oclacitinib (593) and fluralaner (549). Brands are masked in the public data.

What signs are reported most for this breed?

vomiting (22.2%), emesis (11.2%), lethargy (8.9%), diarrhoea (8%) and ineffective, heartworm larvae (4.7%).

Is the Bulldog more sensitive to certain drugs?

Report counts cannot answer that. They show what was reported, not what a drug did, and they are not adjusted for how many Bulldog animals exist or were treated. Breed-related drug sensitivities that are established are described on FDA-approved labels; a veterinarian is the person to ask about an individual animal.

Why are crossbreds not included?

FDA records crossbred animals with one or more component breeds. Counting them under each component would double count, so breed pages use single-breed reports only. Crossbreds remain in the species totals.

How do I report a problem?

Call the drug company using the number on the label, or send Form FDA 1932a to FDA. See the guide on how to report.

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. Breed names are FDA's labels rearranged into everyday order ("Bulldog" becomes "Bulldog"). No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.