Active ingredient · pooled across combinations
Lincomycin Hydrochloride: adverse event reports, pooled
3 ingredient sets in reports · 29 FDA-approved applications in the Green Book
Lincomycin Hydrochloride appears, alone or combined with other ingredients, in 151 reports in FDA's animal adverse event database (December 1987 to September 2024). The figures here pool all 3 ingredient sets that include it.
The Green Book lists 29 FDA-approved applications containing it. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand.
0 reports arrived in the 12 months to March 2026, against 1 in the 12 months before. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. That is about 4 reports a year over its reporting history and 0% of all reports.
Pooled across every set, the terms listed most often are lack of efficacy (bacteria) - NOS (19.9%), death (17.9%) and diarrhoea (8.6%). Many drugs combine several ingredients, and many reports list several drugs, so a term on this page may relate to any of them or to none.
Of reports that state seriousness, 57.1% were classed as serious (38.6% across the whole database); 23.8% record a death or euthanasia (6.4% overall). Ingredients used in older or sicker animals, or in anaesthesia and cancer care, carry higher shares for that reason alone.
Ingredient sets that include lincomycin hydrochloride
| Active ingredients recorded for the drug | Reports | Share of this page's reports | Latest 12 months |
|---|---|---|---|
| Lincomycin Hydrochloride | 135 | 89.4% | 0 |
| Lincomycin Hydrochloride + Spectinomycin Sulfate Tetrahydrate | 12 | 7.9% | 0 |
| Lincomycin Hydrochloride + Spectinomycin dihydrochloride pentahydrate | 4 | 2.6% | 0 |
Ordered by report count. FDA states that these data "cannot be used to estimate the risk associated with the product or compare one drug or device product with another"; counts follow sales volume and years on the market. A report can list more than one set, so shares can add to more than 100%.
Signs listed in reports, pooled
share of lincomycin hydrochloride reports listing the termall reports in the database
- Lack of efficacy (bacteria) - NOS[the product did not have the expected effect: target not specified]19.9%30
- Death17.9%27
- Diarrhoea[diarrhea]8.6%13
- Depression[dull, quiet or withdrawn]5.3%8
- Lack of efficacy - NOS[the product did not have the expected effect]5.3%8
- Vomiting5.3%8
- Accidental exposure[exposure that was not intended]4.6%7
- No sign[no clinical sign was reported]4%6
- Ataxia[unsteady, uncoordinated movement]3.3%5
- Product Defect, General[a product quality report, not a sign in an animal]3.3%5
- Anorexia[not eating]2.6%4
- Bloody diarrhoea[diarrhea with blood]2.6%4
- Fever2.6%4
- Skin hyperaemia[reddened skin]2.6%4
- Thrombocytopenia[low platelet count]2.6%4
- Underfilling, Bottles[a product quality report, not a sign in an animal]2.6%4
- Underfilling, Package[a product quality report, not a sign in an animal]2.6%4
- Vials, Leaking[a product quality report, not a sign in an animal]2.6%4
- Anaphylaxis[sudden severe allergic-type reaction]2%3
- Containers, Damaged[a product quality report, not a sign in an animal]2%3
- Cough2%3
- Deafness2%3
- Dehydration2%3
- Polydipsia[drinking more than usual]2%3
- Pruritus[itching]2%3
- Unclassifiable adverse event[event that fits no dictionary term]2%3
- Underfilling, Container[a product quality report, not a sign in an animal]2%3
Pooled across every ingredient set and every report that names the ingredient. One report can list several terms and several drugs; a term here may relate to any of them or to none.
Monthly reports by species, five years
By month of receipt; each panel has its own scale. The newest months are incomplete because FDA posts reports with a delay of three to six months.
Outcomes, report types and ages
Outcome recorded in the report
What kind of report it was
Age of the animal
Coloured bar: reports naming lincomycin hydrochloride. Grey bar: all 1,357,245 reports. Outcomes are as stated by the reporter; FDA has not necessarily determined whether any product played a part.
In context
| Measure | Lincomycin Hydrochloride | All reports |
|---|---|---|
| Reports | 151 | 1,357,245 |
| Latest 12 months against the 12 before | -100% | -5% |
| Classed serious, of reports stating it | 57.1% | 38.6% |
| Death or euthanasia recorded, per 1,000 reports | 238.4 | 63.8 |
| Filed as lack of expected effectiveness (wholly or partly) | 5.3% | 23% |
Shares of reports, not of animals treated: how many animals receive the ingredient is not public. Ingredients used in anaesthesia, cancer care or in old animals carry more serious outcomes in their reports for that reason alone.
FDA-approved products containing lincomycin hydrochloride (Green Book)
Reference information, not report statistics. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand. The list below is the FDA Green Book as of 1 Oct 2026; nothing on this page says which of these products, if any, a report concerned.
| Trade name | Active ingredients | Sponsor | Approved for | Application |
|---|---|---|---|---|
| Lincomix Soluble Powder | Lincomycin Hydrochloride | Phibro Animal Health Corp. | Swine, Chickens | NADA 111-636 |
| Lincomix and Banminth | Lincomycin Hydrochloride, Pyrantel Tartrate | Phibro Animal Health Corp. | Swine | NADA 138-941 |
| Lincomycin Hydrochloride Soluble Powder | Lincomycin Hydrochloride | Huvepharma EOOD | Swine, Chickens | ANADA 200-189 |
| Linco Soluble | Lincomycin Hydrochloride | Phibro Animal Health Corp. | Swine, Chickens | ANADA 200-233 |
| Lincomycin Hydrochloride Soluble Powder | Lincomycin Hydrochloride | Quo Vademus, LLC | Swine, Chickens | ANADA 200-303 |
| LincoMed 100, LincoMed 300 | Lincomycin Hydrochloride | Bimeda Animal Health Ltd. | Swine | ANADA 200-368 |
| LinxMed-SP | Lincomycin Hydrochloride | Bimeda Animal Health Ltd. | Swine, Chickens | ANADA 200-377 |
| LINCOMYCIN-SPECTINOMYCIN | Lincomycin Hydrochloride, Spectinomycin dihydrochloride pentahydrate | Huvepharma EOOD | Chickens | ANADA 200-407 |
| Coban / Lincomixapproval voluntarily withdrawn | Lincomycin Hydrochloride, Monensin | Zoetis Inc. | Chickens | NADA 092-482 |
| Coban / Lincomix / Roxarsoneapproval voluntarily withdrawn | Lincomycin Hydrochloride, Monensin | Zoetis Inc. | Chickens | NADA 092-522 |
| Lincomix / Robenzapproval voluntarily withdrawn | Lincomycin Hydrochloride, Robenidine Hydrochloride | Zoetis Inc. | Chickens | NADA 093-106 |
| Avatec / Lincomixapproval voluntarily withdrawn | Lasalocid, Lincomycin Hydrochloride | Zoetis Inc. | Chickens | NADA 101-689 |
| Medicated Broiler Feedapproval voluntarily withdrawn | Lincomycin Hydrochloride, Nicarbazin, Roxarsone | Phibro Animal Health Corp. | Chickens | NADA 107-997 |
| Nicarbazin Lincomycin Premixapproval voluntarily withdrawn | Lincomycin Hydrochloride, Nicarbazin | Phibro Animal Health Corp. | Chickens | NADA 108-116 |
| 3-Nitro / Avatec / Lincomycinapproval voluntarily withdrawn | Lasalocid, Lincomycin Hydrochloride, Roxarsone | Zoetis Inc. | Chickens | NADA 112-661 |
| Linco-20; Linco-8approval voluntarily withdrawn | Lincomycin Hydrochloride | North American Nutrition Companies, Inc. | — | NADA 132-657 |
| Cadco Li-20; Cadco Li-8approval voluntarily withdrawn | Lincomycin Hydrochloride | Triple "F", Inc. | — | NADA 132-658 |
| Link-20; Link-8approval voluntarily withdrawn | Lincomycin Hydrochloride | Bioproducts, Inc. | — | NADA 132-659 |
| Swine L-20; Swine L-4; Swine L-8approval voluntarily withdrawn | Lincomycin Hydrochloride | Feed Specialties Co., Inc. | — | NADA 132-660 |
| Linco 20; Linco 8approval voluntarily withdrawn | Lincomycin Hydrochloride | International Nutrition, Inc. | Swine | NADA 132-923 |
| Lincomycin 10 Antibiotic Premix; Lincomycin 20 Antibiotic Premix; Lincomycin 4 Antibiotic Premix; Lincomycin 5 Antibiotic Premixapproval voluntarily withdrawn | Lincomycin Hydrochloride | Quali-Tech Products, Inc. | — | NADA 132-925 |
| Linco 20; Linco 8approval voluntarily withdrawn | Lincomycin Hydrochloride | I.M.S., Inc. | — | NADA 133-034 |
| Nutra-Mix Linco 4approval voluntarily withdrawn | Lincomycin Hydrochloride | Ag-Mark, Inc. | — | NADA 133-035 |
| Master Mix Linco Option 10; Master Mix Linco Option 5approval voluntarily withdrawn | Lincomycin Hydrochloride | ADM Alliance Nutrition, Inc. | — | NADA 133-508 |
| Micro-Pak LXapproval voluntarily withdrawn | Lincomycin Hydrochloride | Growmark, Inc. | — | NADA 133-832 |
| Linco 20; Linco 4approval voluntarily withdrawn | Lincomycin Hydrochloride | MAC-PAGE, Inc. | — | NADA 134-701 |
| Lincomix / Stenorolapproval voluntarily withdrawn | Halofuginone Hydrobromide, Lincomycin Hydrochloride | Huvepharma EOOD | Chickens | NADA 140-340 |
| 3-Nitro / Bio-Cox / Lincomixapproval voluntarily withdrawn | Lincomycin Hydrochloride, Roxarsone, Salinomycin Sodium | Zoetis Inc. | Chickens | NADA 140-581 |
| Lincosol Soluble Powderapproval voluntarily withdrawn | Lincomycin Hydrochloride | Med-Pharmex, Inc. | Swine, Chickens | ANADA 200-241 |
Species are the major species the Green Book search lists for the application ("—" where it lists another species or none). Approval dates are not part of the Green Book listing files and are not shown. Pioneer applications (NADA) come first, then generics (ANADA).
Questions about lincomycin hydrochloride reports
How many FDA adverse event reports mention lincomycin hydrochloride?
151 reports through March 2026, 0 of them in the latest 12 months, counting lincomycin hydrochloride alone and in combinations.
Which brands do these reports concern?
That cannot be known from the public data. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand. The Green Book reference list on this page names approved products containing lincomycin hydrochloride without any counts.
In which combinations is lincomycin hydrochloride reported?
Lincomycin Hydrochloride (89.4% of these reports), Lincomycin Hydrochloride + Spectinomycin Sulfate Tetrahydrate (7.9% of these reports) and Lincomycin Hydrochloride + Spectinomycin dihydrochloride pentahydrate (2.6% of these reports).
What reactions are reported for lincomycin hydrochloride?
lack of efficacy (bacteria) - NOS (19.9%), death (17.9%), diarrhoea (8.6%), depression (5.3%) and lack of efficacy - NOS (5.3%). Shares are of reports naming the ingredient; one report can list several terms.
Which animals are these reports about?
pig (32.5%), dog (22.5%) and cat (8.6%).
Does a high count mean lincomycin hydrochloride is a problem ingredient?
A count cannot show that. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources." Widely used ingredients collect more reports because more animals receive them.
How do I report a problem?
Call the drug company using the number on the label, or send Form FDA 1932a to FDA. See the guide on how to report.
Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. Ingredient names follow the Green Book; salts and forms are kept as FDA lists them. Drug entries are matched by the active ingredients their unmasked ingredient field discloses. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.