Pet Drug Reports

Ingredients

Active ingredient · pooled across combinations

Lincomycin Hydrochloride: adverse event reports, pooled

3 ingredient sets in reports · 29 FDA-approved applications in the Green Book

151reports naming the ingredient, 1987–20240% of all reports · about 4 a year
0reports, 12 months to March 20261 in the 12 months before
57.1%classed serious, as reportedall reports: 38.6%
32.5%of reports concern pigsdog 22.5%

Lincomycin Hydrochloride appears, alone or combined with other ingredients, in 151 reports in FDA's animal adverse event database (December 1987 to September 2024). The figures here pool all 3 ingredient sets that include it.

The Green Book lists 29 FDA-approved applications containing it. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand.

0 reports arrived in the 12 months to March 2026, against 1 in the 12 months before. FDA posts reports quarterly with a delay of three to six months, so the newest months are incomplete and usually grow in later releases. That is about 4 reports a year over its reporting history and 0% of all reports.

Pooled across every set, the terms listed most often are lack of efficacy (bacteria) - NOS (19.9%), death (17.9%) and diarrhoea (8.6%). Many drugs combine several ingredients, and many reports list several drugs, so a term on this page may relate to any of them or to none.

Of reports that state seriousness, 57.1% were classed as serious (38.6% across the whole database); 23.8% record a death or euthanasia (6.4% overall). Ingredients used in older or sicker animals, or in anaesthesia and cancer care, carry higher shares for that reason alone.

Ingredient sets that include lincomycin hydrochloride

Active ingredients recorded for the drugReportsShare of this page's reportsLatest 12 months
Lincomycin Hydrochloride13589.4%0
Lincomycin Hydrochloride + Spectinomycin Sulfate Tetrahydrate127.9%0
Lincomycin Hydrochloride + Spectinomycin dihydrochloride pentahydrate42.6%0

Ordered by report count. FDA states that these data "cannot be used to estimate the risk associated with the product or compare one drug or device product with another"; counts follow sales volume and years on the market. A report can list more than one set, so shares can add to more than 100%.

Signs listed in reports, pooled

share of lincomycin hydrochloride reports listing the termall reports in the database

  1. Lack of efficacy (bacteria) - NOS[the product did not have the expected effect: target not specified]19.9%30
  2. Death17.9%27
  3. Diarrhoea[diarrhea]8.6%13
  4. Depression[dull, quiet or withdrawn]5.3%8
  5. Lack of efficacy - NOS[the product did not have the expected effect]5.3%8
  6. Accidental exposure[exposure that was not intended]4.6%7
  7. No sign[no clinical sign was reported]4%6
  8. Ataxia[unsteady, uncoordinated movement]3.3%5
  9. Product Defect, General[a product quality report, not a sign in an animal]3.3%5
  10. Anorexia[not eating]2.6%4
  11. Bloody diarrhoea[diarrhea with blood]2.6%4
  12. Fever2.6%4
  13. Skin hyperaemia[reddened skin]2.6%4
  14. Thrombocytopenia[low platelet count]2.6%4
  15. Underfilling, Bottles[a product quality report, not a sign in an animal]2.6%4
  16. Underfilling, Package[a product quality report, not a sign in an animal]2.6%4
  17. Vials, Leaking[a product quality report, not a sign in an animal]2.6%4
  18. Anaphylaxis[sudden severe allergic-type reaction]2%3
  19. Containers, Damaged[a product quality report, not a sign in an animal]2%3
  20. Polydipsia[drinking more than usual]2%3
  21. Pruritus[itching]2%3
  22. Unclassifiable adverse event[event that fits no dictionary term]2%3
  23. Underfilling, Container[a product quality report, not a sign in an animal]2%3

Pooled across every ingredient set and every report that names the ingredient. One report can list several terms and several drugs; a term here may relate to any of them or to none.

Monthly reports by species, five years

Dog0 · peak 1
2022202320242025
Cat1 · peak 1
Jul 2023: 12022202320242025
Horse0 · peak 1
2022202320242025
Other10 · peak 1
Oct 2021: 1Dec 2021: 1Jun 2022: 1Jul 2022: 1Jan 2023: 1Feb 2023: 1Aug 2023: 1Sep 2023: 1Nov 2023: 1Sep 2024: 12022202320242025

By month of receipt; each panel has its own scale. The newest months are incomplete because FDA posts reports with a delay of three to six months.

07131987: 119871988: 21989: 11990: 119901991: 11992: 81993: 319931994: 21995: 21996: 319961998: 11999: 12000: 220002001: 12003: 32004: 620042005: 132006: 112007: 820072008: 92009: 112010: 1320102011: 62012: 92013: 720132014: 32015: 22016: 120162017: 22018: 12019: 220192020: 32021: 32022: 220222023: 62024: 1

Outcomes, report types and ages

Outcome recorded in the report

Recovered/Normal2.6%4
Recovered with Sequela0%0
Ongoing2.6%4
Died23.8%36
Euthanized0%0
Outcome Unknown12.6%19

What kind of report it was

Safety issue71.5%108
Lack of expected effectiveness4%6
Both safety and lack of expected effectiveness1.3%2
Manufacturing or product defect23.2%35
Other0%0

Species

Pig32.5%49
Dog22.5%34
Cat8.6%13
Cattle5.3%8
Human exposure3.3%5
Quail1.3%2

Age of the animal

Under 1 year21.9%33
1 to 3 years3.3%5
4 to 7 years10.6%16
8 to 11 years2.6%4
12 years and over4%6
Age not given57.6%87

Coloured bar: reports naming lincomycin hydrochloride. Grey bar: all 1,357,245 reports. Outcomes are as stated by the reporter; FDA has not necessarily determined whether any product played a part.

In context

MeasureLincomycin HydrochlorideAll reports
Reports1511,357,245
Latest 12 months against the 12 before-100%-5%
Classed serious, of reports stating it57.1%38.6%
Death or euthanasia recorded, per 1,000 reports238.463.8
Filed as lack of expected effectiveness (wholly or partly)5.3%23%

Shares of reports, not of animals treated: how many animals receive the ingredient is not public. Ingredients used in anaesthesia, cancer care or in old animals carry more serious outcomes in their reports for that reason alone.

FDA-approved products containing lincomycin hydrochloride (Green Book)

Reference information, not report statistics. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand. The list below is the FDA Green Book as of 1 Oct 2026; nothing on this page says which of these products, if any, a report concerned.

Trade nameActive ingredientsSponsorApproved forApplication
Lincomix Soluble PowderLincomycin HydrochloridePhibro Animal Health Corp.Swine, ChickensNADA 111-636
Lincomix and BanminthLincomycin Hydrochloride, Pyrantel TartratePhibro Animal Health Corp.SwineNADA 138-941
Lincomycin Hydrochloride Soluble PowderLincomycin HydrochlorideHuvepharma EOODSwine, ChickensANADA 200-189
Linco SolubleLincomycin HydrochloridePhibro Animal Health Corp.Swine, ChickensANADA 200-233
Lincomycin Hydrochloride Soluble PowderLincomycin HydrochlorideQuo Vademus, LLCSwine, ChickensANADA 200-303
LincoMed 100, LincoMed 300Lincomycin HydrochlorideBimeda Animal Health Ltd.SwineANADA 200-368
LinxMed-SPLincomycin HydrochlorideBimeda Animal Health Ltd.Swine, ChickensANADA 200-377
LINCOMYCIN-SPECTINOMYCINLincomycin Hydrochloride, Spectinomycin dihydrochloride pentahydrateHuvepharma EOODChickensANADA 200-407
Coban / Lincomixapproval voluntarily withdrawnLincomycin Hydrochloride, MonensinZoetis Inc.ChickensNADA 092-482
Coban / Lincomix / Roxarsoneapproval voluntarily withdrawnLincomycin Hydrochloride, MonensinZoetis Inc.ChickensNADA 092-522
Lincomix / Robenzapproval voluntarily withdrawnLincomycin Hydrochloride, Robenidine HydrochlorideZoetis Inc.ChickensNADA 093-106
Avatec / Lincomixapproval voluntarily withdrawnLasalocid, Lincomycin HydrochlorideZoetis Inc.ChickensNADA 101-689
Medicated Broiler Feedapproval voluntarily withdrawnLincomycin Hydrochloride, Nicarbazin, RoxarsonePhibro Animal Health Corp.ChickensNADA 107-997
Nicarbazin Lincomycin Premixapproval voluntarily withdrawnLincomycin Hydrochloride, NicarbazinPhibro Animal Health Corp.ChickensNADA 108-116
3-Nitro / Avatec / Lincomycinapproval voluntarily withdrawnLasalocid, Lincomycin Hydrochloride, RoxarsoneZoetis Inc.ChickensNADA 112-661
Linco-20; Linco-8approval voluntarily withdrawnLincomycin HydrochlorideNorth American Nutrition Companies, Inc.—NADA 132-657
Cadco Li-20; Cadco Li-8approval voluntarily withdrawnLincomycin HydrochlorideTriple "F", Inc.—NADA 132-658
Link-20; Link-8approval voluntarily withdrawnLincomycin HydrochlorideBioproducts, Inc.—NADA 132-659
Swine L-20; Swine L-4; Swine L-8approval voluntarily withdrawnLincomycin HydrochlorideFeed Specialties Co., Inc.—NADA 132-660
Linco 20; Linco 8approval voluntarily withdrawnLincomycin HydrochlorideInternational Nutrition, Inc.SwineNADA 132-923
Lincomycin 10 Antibiotic Premix; Lincomycin 20 Antibiotic Premix; Lincomycin 4 Antibiotic Premix; Lincomycin 5 Antibiotic Premixapproval voluntarily withdrawnLincomycin HydrochlorideQuali-Tech Products, Inc.—NADA 132-925
Linco 20; Linco 8approval voluntarily withdrawnLincomycin HydrochlorideI.M.S., Inc.—NADA 133-034
Nutra-Mix Linco 4approval voluntarily withdrawnLincomycin HydrochlorideAg-Mark, Inc.—NADA 133-035
Master Mix Linco Option 10; Master Mix Linco Option 5approval voluntarily withdrawnLincomycin HydrochlorideADM Alliance Nutrition, Inc.—NADA 133-508
Micro-Pak LXapproval voluntarily withdrawnLincomycin HydrochlorideGrowmark, Inc.—NADA 133-832
Linco 20; Linco 4approval voluntarily withdrawnLincomycin HydrochlorideMAC-PAGE, Inc.—NADA 134-701
Lincomix / Stenorolapproval voluntarily withdrawnHalofuginone Hydrobromide, Lincomycin HydrochlorideHuvepharma EOODChickensNADA 140-340
3-Nitro / Bio-Cox / Lincomixapproval voluntarily withdrawnLincomycin Hydrochloride, Roxarsone, Salinomycin SodiumZoetis Inc.ChickensNADA 140-581
Lincosol Soluble Powderapproval voluntarily withdrawnLincomycin HydrochlorideMed-Pharmex, Inc.Swine, ChickensANADA 200-241

Species are the major species the Green Book search lists for the application ("—" where it lists another species or none). Approval dates are not part of the Green Book listing files and are not shown. Pioneer applications (NADA) come first, then generics (ANADA).

Questions about lincomycin hydrochloride reports

How many FDA adverse event reports mention lincomycin hydrochloride?

151 reports through March 2026, 0 of them in the latest 12 months, counting lincomycin hydrochloride alone and in combinations.

Which brands do these reports concern?

That cannot be known from the public data. openFDA masks brand and manufacturer names in adverse event records, so the reports counted here cannot be attributed to a particular brand. The Green Book reference list on this page names approved products containing lincomycin hydrochloride without any counts.

In which combinations is lincomycin hydrochloride reported?

Lincomycin Hydrochloride (89.4% of these reports), Lincomycin Hydrochloride + Spectinomycin Sulfate Tetrahydrate (7.9% of these reports) and Lincomycin Hydrochloride + Spectinomycin dihydrochloride pentahydrate (2.6% of these reports).

What reactions are reported for lincomycin hydrochloride?

lack of efficacy (bacteria) - NOS (19.9%), death (17.9%), diarrhoea (8.6%), depression (5.3%) and lack of efficacy - NOS (5.3%). Shares are of reports naming the ingredient; one report can list several terms.

Which animals are these reports about?

pig (32.5%), dog (22.5%) and cat (8.6%).

Does a high count mean lincomycin hydrochloride is a problem ingredient?

A count cannot show that. FDA states that "there is no certainty that the reported drug or device caused the adverse event" and that the event "may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources." Widely used ingredients collect more reports because more animals receive them.

How do I report a problem?

Call the drug company using the number on the label, or send Form FDA 1932a to FDA. See the guide on how to report.

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. Ingredient names follow the Green Book; salts and forms are kept as FDA lists them. Drug entries are matched by the active ingredients their unmasked ingredient field discloses. No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.