Pet Drug Reports

Polysulfated Glycosaminoglycan (Adequan)adverse event reports that FDA received

Active ingredient

The name in brackets is a brand name with this active ingredient.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

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From January 2006 to June 2026, FDA received 5,857 adverse event reports that name a drug with polysulfated glycosaminoglycan as its active ingredient. Of the 5,857 reports, 4,026 (68.7%) are about dogs. 415 reports are about horses (7.1%).

In January to March 2026, FDA received 60 reports that name this drug. The signs that appear in the largest number of the 5,857 reports are "Vomiting", "Lethargy" and "Diarrhoea". A report is not proof that a drug caused a sign.

Reports that name this drug fell by 39.7% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about horses are 7.1% of the reports that name this drug, and 1.4% of all reports.

Since the last update of the FDA data

The site recorded an update of the FDA data on . FDA changed these counts for January to March 2026:

  • All species: from 55 to 60.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 60 reports that name polysulfated glycosaminoglycan: 55 dog, 2 cat, 1 horse, 2 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 5,857 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Vomiting18.5%1,081 reports
  2. Lethargy[unusually tired or inactive]13.4%783 reports
  3. Diarrhoea[diarrhea]13.2%774 reports
  4. Product Defect, General[a product quality report, not a sign in an animal]10.3%604 reports
  5. Lack of efficacy - NOS[the product did not have the expected effect]9.9%579 reports
  6. Not eating6.6%385 reports
  7. Death by euthanasia[the animal was euthanized]5.2%306 reports
  8. Color, Abnormal[a product quality report, not a sign in an animal]4.6%267 reports
  9. Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]4.1%243 reports
  10. Anorexia[not eating]4.1%241 reports
  11. Other abnormal test result NOS[abnormal laboratory result, type not specified]4%236 reports
  12. Weight loss4%236 reports
  13. Decreased appetite3.4%198 reports
  14. Bloody diarrhoea[diarrhea with blood]2.8%162 reports
Show the next 16 signs
  1. Behavioural disorder NOS[behaviour change, type not specified]2.7%160 reports
  2. Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]2.7%157 reports
  3. Death2.6%154 reports
  4. Elevated blood urea nitrogen (BUN)[a kidney value above the normal range]2.5%149 reports
  5. Panting2.5%147 reports
  6. Abnormal radiograph finding2.4%138 reports
  7. Seizure NOS[seizure, type not specified]2.3%136 reports
  8. Pain NOS[NOS: not otherwise specified]2.3%133 reports
  9. Elevated creatinine[a kidney value above the normal range]2.3%132 reports
  10. Uncoded sign[a sign with no matching dictionary term]2.1%123 reports
  11. Injection site swelling[swelling where the injection was given]2%120 reports
  12. Emesis[vomiting]2%117 reports
  13. Incorrect route of drug administration2%115 reports
  14. Fever1.9%114 reports
  15. Anaemia NOS[low red blood cell count]1.9%112 reports
  16. Injection site pain[pain where the injection was given]1.9%111 reports

The list shows 30 of 1,442 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

  • Dog68.7%4,026
  • Horse7.1%415
  • Cat5.4%316
  • Human exposure0.5%27
  • Other Birds0.1%7
  • Other0.1%6

The share is of all 5,857 reports that name polysulfated glycosaminoglycan. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog1,548 reports. Largest count in one month: 44 (May 2025)
Cat119 reports. Largest count in one month: 6 (Apr 2023)
Horse210 reports. Largest count in one month: 11 (Feb 2025)
Other or not given113 reports. Largest count in one month: 7 (Mar 2025)

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name polysulfated glycosaminoglycan, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
2026101614112
2025346295621452
2024311192923382
2023335214624426
2022329336028450
2021273203327353
2020296163127370
2019263323481410
2018326301188455
20174932829204754
20163333214289668
2015230202557332
201421620945290
20138961435144
20126421523104
201115263053
20105023138
20090002323
20080001515
20070001414
20061001112

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal26.7%1,561
  • Recovered with Sequela[recovered, with a lasting effect]0.6%35
  • Ongoing16%939
  • Died3.2%187
  • Euthanized5.2%302
  • Outcome Unknown30.5%1,785

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 5,857 reports that name polysulfated glycosaminoglycan.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue68.3%4,001
  • Lack of expected effectiveness2%116
  • Both safety and lack of expected effectiveness9.2%541
  • Manufacturing or product defect20.4%1,197
  • Otherunder 0.1%2

4,796 reports say if the event was serious. 40.2% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year0.2%12
  • 1 to 3 years3.1%184
  • 4 to 7 years11.3%663
  • 8 to 11 years27.9%1,634
  • 12 years and over32.2%1,885
  • Age not given25.3%1,479

Weight of the animal

  • Under 5 kg (11 lb)5%295
  • 5 to 9.9 kg (11 to 22 lb)9%527
  • 10 to 24.9 kg (22 to 55 lb)15.5%906
  • 25 to 44.9 kg (55 to 99 lb)30.3%1,776
  • 45 kg and over (99 lb and over)7.6%447
  • Weight not given32.5%1,906

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Subcutaneous27.3%1,600
  • Intramuscular24.8%1,454
  • Parenteral15.7%919
  • Intra-Articular0.2%11
  • Oral0.2%10
  • Intravenous0.1%8

Each bar is on a scale of 0 to 100%.

Approved animal drugs with this active ingredient (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • Adequan

What the Green Book records give

Applications with an approval in force
3
Approved species
Horses, Dogs, Equids
Dose forms
Liquid (Solution)
Routes
Intramuscular, Intra-Articular
Sale
RX (prescription)
Earliest approval date in the records

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
Adequan InjectablePolysulfated GlycosaminoglycanAmerican Regent, Inc.HorsesNADA 136-383
Adequan i.m.; Adequan i.m. Multi-DosePolysulfated GlycosaminoglycanAmerican Regent, Inc.HorsesNADA 140-901
Adequan CaninePolysulfated GlycosaminoglycanAmerican Regent, Inc.DogsNADA 141-038

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Polysulfated Glycosaminoglycan: adverse event reports that FDA received. https://petdrugreports.com/drug/polysulfated-glycosaminoglycan/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

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Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with this active ingredient.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 286 reports in the 12 months to June 2026. It received 474 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 5,857 reports received from January 2006 to June 2026, 68.3% are about a safety issue only. 11.2% are about a lack of expected effectiveness, alone or with a safety issue. 20.4% are about a defect of the product or its package.