Pet Drug Reports

Diarrhoea: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: diarrhea.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From January 1987 to June 2026, FDA received 83,314 adverse event reports for animal drugs that list this sign. That is 6% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 4,531 reports that list this sign.

Of the 83,314 reports, 88% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 3 of 1,149 clinical signs with a page. Reports that list this sign fell by 2.6% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 88% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 205 drug pages.

Show the 205 drug pages
Drug pages with 20 or more reports that list this sign, in order of name
Active ingredientsReports that list the sign
(S) - methoprene421
Acepromazine Maleate127
Acetylsalicylic Acid23
Afoxolaner5,412
Afoxolaner + Moxidectin + Pyrantel Pamoate858
Albendazole57
Alfaxalone59
Alprazolam36
Amantadine53
Amitraz65
Amitraz + (S) - methoprene31
Amlodipine99
Amoxicillin494
Amoxicillin + Clavulanate Potassium201
Amoxicillin Trihydrate + Clavulanate Potassium274
Ampicillin Sodium66
Amprolium25
Aspirin37
Atinvicitinib51
Atipamezole Hydrochloride210
Atropine43
Attapulgite42
Bacitracin31
Bedinvetmab1,526
Benazepril57
Betamethasone Acetate + Florfenicol + Terbinafine26
Betamethasone Valerate + Clotrimazole + Gentamicin Sulfate45
Betamethasone Valerate + Gentamicin Sulfate22
Bexagliflozin762
Bismuth Subsalicylate22
Budesonide45
Bupivacaine26
Buprenorphine356
Butorphanol Tartrate453
Capromorelin207
Carprofen5,252
Cefovecin sodium982
Cefpodoxime proxetil337
Ceftiofur Crystalline Free Acid48
Ceftiofur Sodium41
Cephalexin224
Cetirizine80
Ciprofloxacin33
Clindamycin77
Clindamycin Hydrochloride77
Clomipramine Hydrochloride139
Clotrimazole + Gentamicin31
Clotrimazole + Gentamicin + Mometasone furoate25
Clotrimazole + Gentamicin Sulfate + Mometasone Furoate Monohydrate24
Cyclosporine2,869
Deracoxib1,488
Desoxycorticosterone Pivalate219
Dexamethasone372
Dexamethasone + Neomycin Sulfate + Thiabendazole42
Dexamethasone Sodium Phosphate114
Dexmedetomidine148
Dexmedetomidine hydrochloride192
Dextrose48
Diazepam48
Dichlorophene + Toluene23
Diethylcarbamazine Citrate26
Diphenhydramine666
Dirlotapide370
Doramectin52
Doxycycline276
Emodepside + Praziquantel235
Enalapril Maleate218
Enrofloxacin370
Eprinomectin56
Eprinomectin + Esafoxolaner + Praziquantel113
Epsiprantel41
Estriol85
Etodolac276
Famotidine529
Febantel + Praziquantel + Pyrantel Pamoate734
Fenbendazole657
Fentanyl66
Firocoxib972
Florfenicol60
Florfenicol + Mometasone furoate + Terbinafine188
Florfenicol + Terbinafine45
Fluconazole36
Flunixin Meglumine47
Fluoxetine hydrochloride195
Fluralaner4,780
Fluralaner + Moxidectin84
Frunevetmab466
Furosemide225
Gabapentin1,225
Gentamicin26
Gentamicin Sulfate + Hydrocortisone aceponate + Miconazole Nitrate21
Grapiprant1,303
Griseofulvin22
Hydrocodone38
Hydromorphone74
Hydroxyzine91
Ilunocitinib240
Imidacloprid324
Imidacloprid + Moxidectin1,263
Imidocarb Dipropionate22
Insulin505
Isoflurane232
Itraconazole38
Ivermectin972
Ivermectin + Praziquantel127
Ivermectin + Praziquantel + Pyrantel Pamoate885
Ivermectin + Pyrantel Pamoate8,178
Ketamine Hydrochloride123
Ketoconazole185
Ketoprofen23
Lactulose27
Levetiracetam35
Levothyroxine sodium314
Lidocaine39
Lincomycin Hydrochloride Monohydrate + Spectinomycin Sulfate Tetrahydrate25
Loperamide41
Lotilaner1,196
Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate626
Lufenuron238
Lufenuron + Milbemycin Oxime2,243
Lufenuron + Milbemycin Oxime + Praziquantel371
Lufenuron + Praziquantel315
Marbofloxacin105
Maropitant2,000
Mebendazole + Trichlorfon31
Medetomidine64
Medetomidine hydrochloride + Vatinoxan hydrochloride55
Melarsomine Dihydrochloride1,193
Melatonin41
Meloxicam1,289
Methadone41
Methimazole83
Methocarbamol72
Methylprednisolone Acetate111
Metoclopramide132
Metronidazole1,035
Midazolam133
Milbemycin Oxime2,652
Milbemycin Oxime + Praziquantel2,462
Milbemycin Oxime + Spinosad6,629
Mirtazapine169
Molidustat20
Monensin608
Moxidectin3,567
Moxidectin + Praziquantel39
Moxidectin + Pyrantel Pamoate + Sarolaner110
Mupirocin22
Neomycin Sulfate + Nystatin + Thiostrepton + Triamcinolone Acetonide43
Nitenpyram792
Oclacitinib2,374
Omeprazole229
Ondansetron181
Orbifloxacin47
Ormetoprim + Sulfadimethoxine39
Oxibendazole201
Pergolide mesylate118
Phenobarbital92
Phenylpropanolamine hydrochloride97
Pimobendan856
Polysulfated Glycosaminoglycan774
Ponazuril31
Potassium bromide20
Pradofloxacin51
Praziquantel252
Praziquantel + Pyrantel Pamoate632
Prednisolone234
Prednisolone + Trimeprazine Tartrate139
Prednisone1,052
Propofol194
Pyrantel Pamoate761
Pyrantel Pamoate + Sarolaner4,003
Pyrantel Tartrate40
Rabacfosadine168
Robenacoxib177
Sarolaner1,345
Sarolaner + Selamectin271
Selamectin2,744
Selegiline Hydrochloride340
Sevoflurane54
Sodium Chloride31
Spinosad2,435
Spironolactone28
Sucralfate233
Sulfadiazine + Trimethoprim28
Sulfadimethoxine174
Telmisartan61
Tepoxalin173
Tigilanol tiglate170
Tiletamine Hydrochloride + Zolazepam Hydrochloride32
Tilmicosin Phosphate43
Toceranib Phosphate229
Tramadol459
Trazodone208
Triamcinolone26
Triamcinolone Acetonide57
Trilostane1,458
Tulathromycin25
Tylosin94
Tylosin Tartrate55
Ursodiol119
Velagliflozin780
Verdinexor72
Vincristine21
Vitamin E103
Zonisamide29

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 202 ingredients.

Show the 202 ingredients

Reports by species

The share is of the 83,314 reports that list this sign. The sign is in 7.3% of all reports about the species dog. The sign is in 4.8% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Diarrhoea, by the year in which FDA received them
YearReports
20262,140
20254,638
20245,033
20233,901
20223,260
20213,662
20203,785
20194,002
20184,241
20175,002
20164,514
20154,298
20144,119
20133,973
20123,964
20112,756
20102,402
20092,659
20082,289
20072,046
20061,503
20051,464
20041,471
2003947
2002857
2001815
20001,161
1999648
1998551
1997273
1996205
1995136
199466
199354
199248
199157
199068
1989102
198893
1987111

What these reports record

Outcome at the time of the report

  • Reports with this sign
  • All reports
  • Recovered/Normal26.1%21,710, All reports: 20.7%
  • Recovered with Sequela[recovered, with a lasting effect]1.3%1,104, All reports: 2.3%
  • Ongoing18.7%15,550, All reports: 17.4%
  • Died5.8%4,839, All reports: 4.9%
  • Euthanized2.4%1,996, All reports: 1.5%
  • Outcome Unknown22.5%18,776, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 83,314 reports that list this sign.

Age of the animal

  • Reports with this sign
  • All reports
  • Under 1 year15.8%13,203, All reports: 9.5%
  • 1 to 3 years23.4%19,488, All reports: 23.9%
  • 4 to 7 years20.6%17,132, All reports: 20.2%
  • 8 to 11 years19.4%16,131, All reports: 15.4%
  • 12 years and over14.6%12,182, All reports: 10.7%
  • Age not given6.2%5,178, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

All clinical signs

Cite this page

Pet Drug Reports. Diarrhoea: adverse event reports for animal drugs. https://petdrugreports.com/reaction/diarrhoea/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?

In plain words: diarrhea. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.

How does the count of the latest 12 months compare with the 12 months before?

FDA received 4,531 reports in the 12 months to June 2026. It received 4,650 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

How many of these reports have a serious flag?

Of the 59,855 reports that say if the event was serious, 42.8% have the serious flag. The person who sends a report sets the flag.

Does a drug in the table cause this sign?

The reports do not show that. A report can name more than one drug. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices