Breed · Dog
Fox Wire Terrier: adverse event reports
FDA breed label "Terrier - Fox Wire" · single-breed animals only
FDA's database holds 394 reports where the animal's breed is given as "Terrier - Fox Wire", shown here as Fox Wire Terrier: 0% of reports about dogs. Reports on crossbred animals are left out of breed pages.
17 reports arrived in the 12 months to March 2026, down 26% from 23 in the 12 months before. A breed's count mostly mirrors how common the breed is; registration and ownership figures by breed are not public data, so no per-animal rate can be given.
By active ingredient, the drugs named most often are milbemycin oxime + spinosad, ivermectin + pyrantel pamoate and afoxolaner. Milbemycin Oxime + Spinosad is named in 20.6% of this breed's reports, a larger share than in reports about all dogs (13.1%).
The terms listed most often are vomiting (21.8%), lethargy (13.7%) and diarrhoea (6.9%). Vomiting appears in 21.8% of reports, about the same share as in all dog reports (19.7%). 39.8% of reports stating seriousness were classed as serious, against 38.3% for dogs overall.
Drugs named most often, by active ingredient
| Active ingredients recorded for the drug | Reports | Share of Fox Wire Terrier reports | Share of all dog reports |
|---|---|---|---|
| Milbemycin Oxime + Spinosad | 81 | 20.6% | 13.1% |
| Ivermectin + Pyrantel Pamoate | 47 | 11.9% | 14.9% |
| Afoxolaner | 33 | 8.4% | 5.7% |
| Oclacitinib | 33 | 8.4% | 2.9% |
| Fluralaner | 30 | 7.6% | 6.7% |
| Milbemycin Oxime + Praziquantel | 21 | 5.3% | 3.1% |
| Pyrantel Pamoate + Sarolaner | 18 | 4.6% | 5.1% |
| Cyclosporine | 16 | 4.1% | 1.5% |
| Trilostane | 14 | 3.6% | 1.2% |
| Spinosad | 13 | 3.3% | 5.8% |
| Carprofen | 11 | 2.8% | 4.8% |
| Moxidectin | 11 | 2.8% | 5% |
| Selamectin | 9 | 2.3% | 3% |
| Lufenuron + Milbemycin Oxime | 8 | 2% | 2.7% |
| Bedinvetmab | 7 | 1.8% | 1.9% |
| Sarolaner | 7 | 1.8% | 1.7% |
| Maropitant | 6 | 1.5% | 1.2% |
| Tramadol | 6 | 1.5% | 0.4% |
| Milbemycin Oxime | 5 | 1.3% | 3% |
| Nitenpyram | 5 | 1.3% | 1.1% |
Ordered by report count. Differences from the species column often come from body size (which drugs a breed is prescribed) and from how common the breed was in the years a drug sold most. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.
Signs listed in reports
share of Fox Wire Terrier reports listing the termall dog reports
- Vomiting21.8%86
- Lethargy[unusually tired or inactive]13.7%54
- Diarrhoea[diarrhea]6.9%27
- Emesis[vomiting]6.3%25
- Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]5.8%23
- Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]4.8%19
- Lack of efficacy - NOS[the product did not have the expected effect]4.8%19
- Seizure NOS[seizure, type not specified]4.3%17
- Ataxia[unsteady, uncoordinated movement]4.1%16
- Shaking4.1%16
- Behavioural disorder NOS[behaviour change, type not specified]3.8%15
- Other abnormal test result NOS[abnormal laboratory result, type not specified]3.8%15
- Anorexia[not eating]3.6%14
- Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]3.6%14
- Death3%12
- Death by euthanasia[the animal was euthanized]3%12
- Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]2.8%11
- Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]2.8%11
- Bloody diarrhoea[diarrhea with blood]2.5%10
- Decreased appetite2.5%10
- Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]2%8
- Lack of efficacy (bacteria) - Borrelia[the product did not have the expected effect: Borrelia (Lyme disease bacteria)]2%8
- Overdose[more than the labelled amount was given]2%8
- Ineffective, hooks[legacy FDA term: the product did not have the expected effect (hooks)]1.8%7
- Not eating1.8%7
Age and weight
Age of the animal
Weight of the animal
Coloured bar: Fox Wire Terrier reports. Grey bar: all dog reports.
Trend and outcomes
Reports by month FDA received them. The newest months are incomplete because FDA posts reports with a delay of three to six months.
Outcome recorded in the report
Beside all dogs
| Measure | Fox Wire Terrier | All dogs |
|---|---|---|
| Reports | 394 | 985,675 |
| Latest 12 months | 17 | 53,292 |
| Classed serious, of reports stating it | 39.8% | 38.3% |
| Death or euthanasia recorded, per 1,000 reports | 60.9 | 55 |
Questions about Fox Wire Terrier reports
How many FDA adverse event reports involve Fox Wire Terriers?
394 reports through March 2026, 0% of reports about dogs; 17 in the latest 12 months.
Which drugs are named most often in Fox Wire Terrier reports?
By active ingredient: milbemycin oxime + spinosad (81), ivermectin + pyrantel pamoate (47), afoxolaner (33), oclacitinib (33) and fluralaner (30). Brands are masked in the public data.
What signs are reported most for this breed?
vomiting (21.8%), lethargy (13.7%), diarrhoea (6.9%), emesis (6.3%) and lack of efficacy (endoparasite) - heartworm (5.8%).
Is the Fox Wire Terrier more sensitive to certain drugs?
Report counts cannot answer that. They show what was reported, not what a drug did, and they are not adjusted for how many Fox Wire Terrier animals exist or were treated. Breed-related drug sensitivities that are established are described on FDA-approved labels; a veterinarian is the person to ask about an individual animal.
Why are crossbreds not included?
FDA records crossbred animals with one or more component breeds. Counting them under each component would double count, so breed pages use single-breed reports only. Crossbreds remain in the species totals.
How do I report a problem?
Call the drug company using the number on the label, or send Form FDA 1932a to FDA. See the guide on how to report.
Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. Breed names are FDA's labels rearranged into everyday order ("Terrier - Fox Wire" becomes "Fox Wire Terrier"). No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.