Pet Drug Reports

Afoxolaner + Moxidectin + Pyrantel Pamoate (NexGard Plus)adverse event reports that FDA received

Combination of 3 active ingredients

The name in brackets is a brand name with these active ingredients.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From August 2023 to June 2026, FDA received 10,096 adverse event reports that name this drug. Its active ingredients are afoxolaner, moxidectin and pyrantel pamoate. Of the 10,096 reports, 9,258 (91.7%) are about dogs.

In January to March 2026, FDA received 1,021 reports that name this drug. The signs that appear in the largest number of the 10,096 reports are "Vomiting" and "Lack of efficacy (endoparasite) - heartworm". A report is not proof that a drug caused a sign.

Reports that name this drug rose by 11.8% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 91.7% of the reports that name this drug, and 72.6% of all reports.

Since the last update of the FDA data

The site recorded an update of the FDA data on . FDA changed these counts for January to March 2026:

  • All species: from 825 to 1,021.
  • Dog: from 788 to 965.
  • Other species or species not given: from 37 to 55.

January to March 2026 is the latest closed quarter in the data. In that quarter FDA received 1,021 reports that name afoxolaner + moxidectin + pyrantel pamoate: 965 dog, 1 cat, 0 horse, 55 other or not given.

All updatesFeed of updates (RSS)

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 10,096 reports that list the sign. One report can list more than one sign.

The sign that is in the largest number of the reports comes first.

  1. Vomiting16.7%1,686 reports
  2. Lack of efficacy (endoparasite) - heartworm[the product did not have the expected effect: heartworm]11.6%1,168 reports
  3. Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]10.2%1,025 reports
  4. Lack of efficacy (bacteria) - Borrelia[the product did not have the expected effect: Borrelia (Lyme disease bacteria)]8.8%887 reports
  5. Diarrhoea[diarrhea]8.5%858 reports
  6. Lethargy[unusually tired or inactive]7.3%739 reports
  7. Tablets, Abnormal[a product quality report, not a sign in an animal]7%705 reports
  8. Lack of efficacy (endoparasite) - roundworm NOS[the product did not have the expected effect: roundworms]6.4%644 reports
  9. Seizure NOS[seizure, type not specified]4.5%457 reports
  10. Lack of efficacy (bacteria) - Anaplasma[the product did not have the expected effect: Anaplasma bacteria]4.3%439 reports
  11. Lack of efficacy (endoparasite) - tapeworm[the product did not have the expected effect: tapeworms]4.2%423 reports
  12. Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]3.7%372 reports
  13. Itching2.7%275 reports
  14. Lack of efficacy (ectoparasite) - tick NOS[the product did not have the expected effect: ticks]2.7%273 reports
Show the next 16 signs
  1. Not eating2.3%236 reports
  2. Lack of efficacy (bacteria) - Ehrlichia[the product did not have the expected effect: Ehrlichia bacteria]1.8%185 reports
  3. Unpalatable[legacy FDA term: the animal would not take it]1.7%174 reports
  4. Shaking1.4%141 reports
  5. Lack of efficacy (endoparasite) - whipworm[the product did not have the expected effect: whipworms]1.4%140 reports
  6. Panting1.2%124 reports
  7. Ataxia[unsteady, uncoordinated movement]1.2%117 reports
  8. Inappetence[reduced appetite]1%103 reports
  9. Decreased appetite1%101 reports
  10. Tremor1%97 reports
  11. Drooling0.9%95 reports
  12. Behavioural disorder NOS[behaviour change, type not specified]0.9%93 reports
  13. Death0.9%90 reports
  14. Hives0.9%89 reports
  15. Loose stool0.9%89 reports
  16. Bloody diarrhoea[diarrhea with blood]0.9%88 reports

The list shows 30 of 1,030 coded signs. A report is not proof that a drug caused a sign. Download all signs (CSV)

Reports by species

  • Dog91.7%9,258
  • Cat0.1%6
  • Human exposure0.1%6

The share is of all 10,096 reports that name afoxolaner + moxidectin + pyrantel pamoate. The other reports give a different species or no species.

Reports for each month, Jul 2021 to Jun 2026

Dog9,258 reports. Largest count in one month: 432 (Apr 2026)
Cat6 reports

No chart: no month has 5 or more reports.

Horse0 reports

No chart: no month has 5 or more reports.

Other or not given832 reports. Largest count in one month: 39 (May 2025)

The month is the month in which FDA received the report. Each chart has its own scale. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports by year

  • Dog
  • Cat
  • Horse
  • Other or not given
Reports that name afoxolaner + moxidectin + pyrantel pamoate, by the year in which FDA received them and by species
YearDogCatHorseOther or not givenAll species
20262,035301132,151
20253,994203494,345
20242,927003303,257
20233021040343

2026 has the reports that FDA received through Jun 2026. Download the years (CSV)

What the reports record

Outcome at the time of the report

  • Recovered/Normal23.9%2,411
  • Recovered with Sequela[recovered, with a lasting effect]0.1%6
  • Ongoing17.4%1,757
  • Died1%100
  • Euthanized0.7%68
  • Outcome Unknown48.8%4,931

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 10,096 reports that name afoxolaner + moxidectin + pyrantel pamoate.

A report about more than one animal can have more than one outcome.

Kind of report

  • Safety issue39.9%4,029
  • Lack of expected effectiveness49.1%4,959
  • Both safety and lack of expected effectiveness1.9%188
  • Manufacturing or product defect8.8%893
  • Other0.3%27

9,268 reports say if the event was serious. 7.8% of them have the serious flag. The person who sends the report sets the flag.

Show age, weight, breed and route

Age of the animal

  • Under 1 year14.3%1,440
  • 1 to 3 years35.3%3,565
  • 4 to 7 years21.3%2,147
  • 8 to 11 years11.4%1,147
  • 12 years and over4.5%457
  • Age not given13.3%1,340

Weight of the animal

  • Under 5 kg (11 lb)7%702
  • 5 to 9.9 kg (11 to 22 lb)15.7%1,590
  • 10 to 24.9 kg (22 to 55 lb)31.6%3,189
  • 25 to 44.9 kg (55 to 99 lb)28.6%2,889
  • 45 kg and over (99 lb and over)3.9%392
  • Weight not given13.2%1,334

Breed, where the report gives one breed

A breed with many animals has many reports.

Route in the report

  • Oral84.3%8,512
  • Topical0.1%9
  • Parenteralunder 0.1%2
  • Perineuralunder 0.1%2
  • Subcutaneousunder 0.1%2
  • Periarticularunder 0.1%1

Each bar is on a scale of 0 to 100%.

Approved animal drugs with these active ingredients (FDA Green Book)

This section is reference data. It has no report count.

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

Brand names

  • NexGard Plus

What the Green Book records give

Applications with an approval in force
1
Approved species
Dogs
Dose forms
Chewable Tablets
Routes
Oral
Sale
RX (prescription)
Earliest approval date in the records

The species, dose forms and routes are the words of the Green Book records for all the applications together. One product can have fewer. The label of a product gives its approved use.

Applications in the Green Book of 2 Nov 2026, pioneer applications (NADA) first
Brand nameActive ingredientsSponsorApproved speciesApplication
NexGard PlusAfoxolaner, Moxidectin, Pyrantel PamoateBoehringer Ingelheim Animal Health USA, Inc.DogsNADA 141-554

Other pages with one of these ingredients

A report names a drug by its set of active ingredients. Each set has its own page. The list is in order of name.

Next in the A to Z list

All drugs by active ingredient. Brand names A to Z

FDA pages for this drug

The site checked these addresses on . The links open in a new tab.

Cite this page

Pet Drug Reports. Afoxolaner + Moxidectin + Pyrantel Pamoate: adverse event reports that FDA received. https://petdrugreports.com/drug/afoxolaner-moxidectin-pyrantel-pamoate/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

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Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site does not use the application number that a record has.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

Which brand are these reports about?

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. The Green Book section of this page lists the brand names with these active ingredients.

Do the reports show that the drug caused the signs?

No. FDA states this about the data.

When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.

The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

How many reports did FDA receive in the latest 12 months?

FDA received 4,386 reports in the 12 months to June 2026. It received 3,924 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

What kinds of report are in the count?

Of the 10,096 reports received from August 2023 to June 2026, 39.9% are about a safety issue only. 51% are about a lack of expected effectiveness, alone or with a safety issue. 8.8% are about a defect of the product or its package.