Pet Drug Reports

Pug: adverse event reports for animal drugs

Breed of dog

The FDA breed label is "Pug". The count has only the reports that give this one breed.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.

FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on . The data have the reports that FDA received through .

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarianHow to report to FDA

From February 1987 to June 2026, FDA received 9,269 reports that give the breed Pug. That is 0.9% of the reports about dogs. In the 12 months to June 2026, FDA received 335 reports for this breed.

The count has only the reports that give this one breed. Reports about crossbred animals are in the count for the species. The signs that appear in the largest number of the 9,269 reports are "Vomiting", "Emesis" and "Lethargy". A report is not proof that a drug caused a sign.

By number of reports in all years, this breed is number 14 of 167 breeds of dogs with a page. Reports that give this breed fell by 1.2% in the 12 months to June 2026, compared with the 12 months before. Reports about dogs fell by 2.3% in the same periods. The newest months can get more reports in a later update. The sign "Ineffective, heartworm larvae" is in 3% of the reports that give this breed, and in 6.9% of the reports about dogs.

Drug pages with reports for this breed

The table has every drug page with 5 or more reports that give this breed, in order of name. No count decides which drug is in the table. The table has 142 drug pages.

Show the 142 drug pages
Drug pages with 5 or more reports that give the breed Pug, in order of name
Active ingredientsReports that give this breed
(S) - methoprene49
Acepromazine Maleate14
Afoxolaner447
Afoxolaner + Moxidectin + Pyrantel Pamoate35
Alfaxalone9
Amitraz15
Amoxicillin60
Amoxicillin + Clavulanate Potassium21
Amoxicillin Trihydrate + Clavulanate Potassium29
Atipamezole Hydrochloride26
Atropine12
Azithromycin5
Bedinvetmab120
Betamethasone Acetate + Florfenicol + Terbinafine11
Betamethasone Valerate + Clotrimazole + Gentamicin Sulfate59
Buprenorphine17
Butorphanol Tartrate45
Capromorelin10
Carprofen333
Cefovecin sodium75
Cefpodoxime proxetil53
Cephalexin32
Cetirizine8
Clindamycin11
Clomipramine Hydrochloride9
Clotrimazole + Gentamicin22
Clotrimazole + Gentamicin Sulfate + Mometasone Furoate Monohydrate50
Cyclosporine436
Deracoxib79
Desoxycorticosterone Pivalate16
Dexamethasone49
Dexamethasone + Neomycin Sulfate + Thiabendazole7
Dexamethasone + Thiabendazole17
Dexamethasone Sodium Phosphate9
Dexmedetomidine19
Dexmedetomidine hydrochloride33
Diazepam5
Diphenhydramine129
Dirlotapide96
Doxycycline25
Enalapril Maleate8
Enrofloxacin67
Enrofloxacin + Silver sulfadiazine9
Estriol13
Etodolac10
Famotidine37
Febantel + Praziquantel + Pyrantel Pamoate55
Fenbendazole38
Fentanyl7
Firocoxib49
Florfenicol + Mometasone furoate + Terbinafine84
Florfenicol + Terbinafine42
Fluconazole6
Fluoxetine hydrochloride22
Fluralaner522
Furosemide15
Gabapentin54
Gentamicin Sulfate + Hydrocortisone aceponate + Miconazole Nitrate40
Grapiprant53
Hydrocodone11
Hydrocortisone6
Hydromorphone14
Hydroxyzine27
Ilunocitinib12
Imidacloprid49
Imidacloprid + Moxidectin90
Insulin224
Isoflurane34
Ivermectin105
Ivermectin + Praziquantel + Pyrantel Pamoate61
Ivermectin + Pyrantel Pamoate835
Ketamine Hydrochloride16
Ketoconazole39
Lactic Acid + Salicylic Acid7
Levetiracetam7
Levothyroxine sodium11
Lotilaner78
Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate11
Lufenuron14
Lufenuron + Milbemycin Oxime232
Lufenuron + Milbemycin Oxime + Praziquantel38
Lufenuron + Praziquantel24
Marbofloxacin21
Maropitant169
Medetomidine17
Melarsomine Dihydrochloride126
Meloxicam103
Methadone6
Methocarbamol6
Methylprednisolone Acetate8
Metronidazole22
Miconazole Nitrate5
Midazolam23
Milbemycin Oxime190
Milbemycin Oxime + Praziquantel145
Milbemycin Oxime + Spinosad1,411
Mometasone Furoate Monohydrate + Orbifloxacin + Posaconazole7
Moxidectin573
Moxidectin + Pyrantel Pamoate + Sarolaner5
Neomycin Sulfate + Nystatin + Thiostrepton + Triamcinolone Acetonide14
Nitenpyram91
Oclacitinib398
Omeprazole8
Ondansetron6
Orbifloxacin6
Orbifloxacin + Posaconazole9
Ormetoprim + Sulfadimethoxine7
Oxibendazole5
Phenobarbital18
Phenylpropanolamine hydrochloride5
Pimobendan15
Polysulfated Glycosaminoglycan30
Praziquantel9
Praziquantel + Pyrantel Pamoate29
Prednisolone45
Prednisolone + Trimeprazine Tartrate35
Prednisone96
Propofol40
Pyrantel Pamoate43
Pyrantel Pamoate + Sarolaner284
Rabacfosadine6
Salicylic Acid11
Sarolaner124
Selamectin253
Selegiline Hydrochloride20
Sevoflurane17
Sodium Chloride5
Spinosad858
Sucralfate8
Sulfadimethoxine7
Tepoxalin9
Theophylline8
Tigilanol tiglate50
Tiletamine Hydrochloride + Zolazepam Hydrochloride8
Toceranib Phosphate32
Tramadol31
Trazodone13
Triamcinolone Acetonide16
Trilostane35
Ursodiol6
Vitamin E9
Xylazine7

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.

Commonly used products may have a higher number of reported adverse events due to the higher total number of animals being given the product.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Signs that the reports list

A sign is a coded term from the report. The words in brackets are a plain gloss of the term. The percentage is the share of the 9,269 reports that list the sign.

The sign that is in the largest number of the reports comes first.

  1. Vomiting23.4%2,168 reports
  2. Emesis[vomiting]9.7%896 reports
  3. Lethargy[unusually tired or inactive]9.1%846 reports
  4. Diarrhoea[diarrhea]6.6%616 reports
  5. Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]5%465 reports
  6. Depression[dull, quiet or withdrawn]4.3%395 reports
  7. Lack of efficacy - NOS[the product did not have the expected effect]4.2%387 reports
  8. Death4.1%381 reports
  9. Anorexia[not eating]4.1%378 reports
  10. Seizure NOS[seizure, type not specified]3.6%338 reports
  11. Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]3.6%332 reports
  12. Ataxia[unsteady, uncoordinated movement]3.2%295 reports
  13. Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]3%281 reports
  14. Pruritus[itching]2.7%254 reports
Show the next 11 signs
  1. Anaphylaxis[sudden severe allergic-type reaction]2.7%253 reports
  2. Deafness2.3%217 reports
  3. Behavioural disorder NOS[behaviour change, type not specified]2.3%211 reports
  4. Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]2.2%202 reports
  5. Death by euthanasia[the animal was euthanized]2%188 reports
  6. Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]2%188 reports
  7. Facial swelling2%186 reports
  8. Emesis (multiple)[vomiting more than once]1.9%178 reports
  9. Leucocytosis NOS[high white blood cell count]1.9%174 reports
  10. Other abnormal test result NOS[abnormal laboratory result, type not specified]1.8%171 reports
  11. Shaking1.8%169 reports

What the reports record

Age of the animal

  • Pug reports
  • All reports about dogs
  • Under 1 year9.6%893, All reports about dogs: 10.3%
  • 1 to 3 years26.7%2,476, All reports about dogs: 29.2%
  • 4 to 7 years28.7%2,656, All reports about dogs: 24.5%
  • 8 to 11 years22.2%2,058, All reports about dogs: 18.4%
  • 12 years and over9.3%866, All reports about dogs: 10.1%
  • Age not given3.5%320, All reports about dogs: 7.6%

Weight of the animal

  • Pug reports
  • All reports about dogs
  • Under 5 kg (11 lb)5.3%488, All reports about dogs: 11.6%
  • 5 to 9.9 kg (11 to 22 lb)49.9%4,624, All reports about dogs: 18.7%
  • 10 to 24.9 kg (22 to 55 lb)40.5%3,750, All reports about dogs: 27.5%
  • 25 to 44.9 kg (55 to 99 lb)under 0.1%2, All reports about dogs: 30.4%
  • 45 kg and over (99 lb and over)under 0.1%1, All reports about dogs: 3.9%
  • Weight not given4.4%404, All reports about dogs: 7.9%

Outcome at the time of the report

  • Recovered/Normal29.9%2,773
  • Recovered with Sequela[recovered, with a lasting effect]2.8%262
  • Ongoing17.1%1,582
  • Died4.9%455
  • Euthanized1.5%136
  • Outcome Unknown18.5%1,717

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 9,269 reports that give this breed.

Each share of age and weight is of the 9,269 reports that give this breed. The thin bar is the same share in the 1,001,350 reports about dogs.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that give the breed Pug, by the year in which FDA received them
YearReports
2026173
2025323
2024344
2023293
2022285
2021326
2020365
2019438
2018439
2017538
2016563
2015565
2014587
2013672
2012639
2011524
2010413
2009364
2008327
2007210
2006149
2005138
2004161
200392
200285
200176
200072
199934
199825
199712
199613
19953
19945
19933
19925
19911
19901
19892
19881
19873

Next in the A to Z list of breeds

All reports about dogs. All breeds

Cite this page

Pet Drug Reports. Pug: adverse event reports for animal drugs. https://petdrugreports.com/breed/dog/pug/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of . Reports received through .

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site puts the FDA breed label in the usual order of the words.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about these reports

What ages are the animals in the reports?

The figures are shares of the 9,269 reports about this breed received from February 1987 to June 2026. 28.7% give an age of 4 to 7 years. 26.7% give an age of 1 to 3 years. 3.5% give no age.

How does the count of the latest 12 months compare with the 12 months before?

FDA received 335 reports in the 12 months to June 2026. It received 339 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Why are crossbred animals not in the count?

The site counts a report for a breed only when the report gives one breed. A report for a crossbred animal can give more than one breed, and a count for each breed would count the report more than once. The reports about crossbred animals are in the count for dogs.

Do the reports show that this breed reacts more to a drug?

No. The reports do not give the number of animals of the breed. FDA states this about the data.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.

FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices