Breed · Dog

Pug: adverse event reports

FDA breed label "Pug" · single-breed animals only

Read this first · FDA's caveat, in its words

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources. FDA Center for Veterinary Medicine

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Not veterinary advice. This site lists what was reported to FDA. For an animal that is unwell, contact a veterinarian.

9,166reports, 1987–20260.9% of dog reports

336reports, 12 months to March 2026323 in the 12 months before

38.5%classed serious, as reportedall dogs: 38.3%

15.4%name milbemycin oxime + spinosadall dogs: 13.1%

9,166 adverse event reports received by FDA describe an animal recorded as Pug (FDA breed label "Pug"). That is 0.9% of all reports about dogs. Crossbred animals are not counted here, only reports that give this single breed.

336 reports arrived in the 12 months to March 2026, close to the 323 of the 12 months before. A breed's count mostly mirrors how common the breed is; registration and ownership figures by breed are not public data, so no per-animal rate can be given.

By active ingredient, the drugs named most often are milbemycin oxime + spinosad, spinosad and ivermectin + pyrantel pamoate. Milbemycin Oxime + Spinosad is named in 15.4% of this breed's reports, about the same share as in reports about all dogs (13.1%).

The terms listed most often are vomiting (23.5%), emesis (9.8%) and lethargy (9.1%). Vomiting appears in 23.5% of reports, about the same share as in all dog reports (19.7%). 38.5% of reports stating seriousness were classed as serious, against 38.3% for dogs overall.

Drugs named most often, by active ingredient

Active ingredients recorded for the drug	Reports	Share of Pug reports	Share of all dog reports
Milbemycin Oxime + Spinosad	1,410	15.4%	13.1%
Spinosad	858	9.4%	5.8%
Ivermectin + Pyrantel Pamoate	833	9.1%	14.9%
Moxidectin	567	6.2%	5%
Fluralaner	498	5.4%	6.7%
Afoxolaner	445	4.9%	5.7%
Cyclosporine	434	4.7%	1.5%
Oclacitinib	393	4.3%	2.9%
Carprofen	330	3.6%	4.8%
Pyrantel Pamoate + Sarolaner	268	2.9%	5.1%
Selamectin	251	2.7%	3%
Lufenuron + Milbemycin Oxime	231	2.5%	2.7%
Insulin	222	2.4%	0.7%
Milbemycin Oxime	190	2.1%	3%
Maropitant	164	1.8%	1.2%
Milbemycin Oxime + Praziquantel	143	1.6%	3.1%
Melarsomine Dihydrochloride	125	1.4%	2.3%
Diphenhydramine	122	1.3%	0.5%
Sarolaner	122	1.3%	1.7%
Bedinvetmab	114	1.2%	1.9%

Ordered by report count. Differences from the species column often come from body size (which drugs a breed is prescribed) and from how common the breed was in the years a drug sold most. FDA states that these data cannot be used to estimate risk or to compare one product with another. Brand and manufacturer names are masked by FDA in these records.

Signs listed in reports

share of Pug reports listing the termall dog reports

Vomiting23.5%2,154
Emesis[vomiting]9.8%896
Lethargy[unusually tired or inactive]9.1%837
Diarrhoea[diarrhea]6.7%611
Lack of efficacy (ectoparasite) - flea[the product did not have the expected effect: fleas]4.9%451
Depression[dull, quiet or withdrawn]4.3%394
Lack of efficacy - NOS[the product did not have the expected effect]4.2%382
Anorexia[not eating]4.1%377
Death4.1%377
Seizure NOS[seizure, type not specified]3.6%332
Lack of efficacy (endoparasite) - hookworm[the product did not have the expected effect: hookworms]3.6%330
Ataxia[unsteady, uncoordinated movement]3.2%294
Ineffective, heartworm larvae[legacy FDA term: the product did not have the expected effect (heartworm larvae)]3.1%281
Pruritus[itching]2.8%254
Anaphylaxis[sudden severe allergic-type reaction]2.7%249
Deafness2.3%214
Behavioural disorder NOS[behaviour change, type not specified]2.3%208
Elevated alanine aminotransferase (ALT)[a liver enzyme above the normal range]2.2%200
Death by euthanasia[the animal was euthanized]2.1%189
Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]2.1%188
Facial swelling2%179
Leucocytosis NOS[high white blood cell count]1.9%175
Emesis (multiple)[vomiting more than once]1.9%170
Other abnormal test result NOS[abnormal laboratory result, type not specified]1.9%170
Shaking1.8%168

Age and weight

Age of the animal

Under 1 year9.7%892

1 to 3 years26.7%2,449

4 to 7 years28.5%2,612

8 to 11 years22.3%2,041

12 years and over9.3%855

Age not given3.5%317

Weight of the animal

Under 5 kg (11 lb)5.3%487

5 to 9.9 kg (11–22 lb)49.9%4,575

10 to 24.9 kg (22–55 lb)40.4%3,700

25 to 44.9 kg (55–99 lb)0%2

45 kg and over (99 lb+)0%1

Weight not given4.4%401

Coloured bar: Pug reports. Grey bar: all dog reports.

Trend and outcomes

Reports by month FDA received them. The newest months are incomplete because FDA posts reports with a delay of three to six months.

Outcome recorded in the report

Recovered/Normal30%2,751

Recovered with Sequela2.8%259

Ongoing16.8%1,539

Died4.9%451

Euthanized1.5%137

Outcome Unknown18.4%1,685

Beside all dogs

Measure	Pug	All dogs
Reports	9,166	985,675
Latest 12 months	336	53,292
Classed serious, of reports stating it	38.5%	38.3%
Death or euthanasia recorded, per 1,000 reports	64.2	55

Questions about Pug reports

How many FDA adverse event reports involve Pugs?

9,166 reports through March 2026, 0.9% of reports about dogs; 336 in the latest 12 months.

Which drugs are named most often in Pug reports?

By active ingredient: milbemycin oxime + spinosad (1,410), spinosad (858), ivermectin + pyrantel pamoate (833), moxidectin (567) and fluralaner (498). Brands are masked in the public data.

What signs are reported most for this breed?

vomiting (23.5%), emesis (9.8%), lethargy (9.1%), diarrhoea (6.7%) and lack of efficacy (ectoparasite) - flea (4.9%).

Is the Pug more sensitive to certain drugs?

Report counts cannot answer that. They show what was reported, not what a drug did, and they are not adjusted for how many Pug animals exist or were treated. Breed-related drug sensitivities that are established are described on FDA-approved labels; a veterinarian is the person to ask about an individual animal.

Why are crossbreds not included?

FDA records crossbred animals with one or more component breeds. Counting them under each component would double count, so breed pages use single-breed reports only. Crossbreds remain in the species totals.

How do I report a problem?

Call the drug company using the number on the label, or send Form FDA 1932a to FDA. See the guide on how to report.

Where this comes from. Counts are built from the openFDA Animal & Veterinary adverse event bulk files released 28 Sep 2026, which hold reports FDA's Center for Veterinary Medicine received through 31 Mar 2026. openFDA masks brand and manufacturer names in these files, so drugs are counted by the active ingredients each record discloses and no figure is attributed to a brand, application or company. Ingredient names, and the separate reference lists of approved products, follow the FDA Green Book as of 1 Oct 2026. Breed names are FDA's labels rearranged into everyday order ("Pug" becomes "Pug"). No report text, lot numbers or reporter details are published. See the methodology and sources; FDA's record is authoritative, and corrections are handled within five working days.