Skin lump: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From October 1988 to June 2026, FDA received 1,613 adverse event reports for animal drugs that list this sign. That is 0.1% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 78 reports that list this sign.

Of the 1,613 reports, 89.1% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 330 of 1,149 clinical signs with a page. Reports that list this sign rose by 11.4% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 89.1% of the reports that list this sign, and 72.6% of all reports.

Search engines list a sign page with 3,000 reports or more in all years. The page also needs 300 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 27 drug pages.

Show the 27 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
Afoxolaner	66
Amoxicillin	31
Bedinvetmab	46
Carprofen	134
Cefovecin sodium	45
Cefpodoxime proxetil	36
Cyclosporine	121
Deracoxib	42
Diphenhydramine	26
Fluralaner	83
Gabapentin	30
Imidacloprid + Moxidectin	22
Insulin	22
Ivermectin	21
Ivermectin + Pyrantel Pamoate	58
Lufenuron + Milbemycin Oxime	25
Maropitant	46
Melarsomine Dihydrochloride	79
Meloxicam	27
Milbemycin Oxime + Praziquantel	50
Milbemycin Oxime + Spinosad	92
Moxidectin	73
Oclacitinib	337
Prednisone	33
Sarolaner	20
Selamectin	50
Spinosad	28

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 30 ingredients.

Show the 30 ingredients

Reports by species

Dog89.1%1,437
Cat8.4%135
Horse1.1%18
Cattle0.6%10
Human exposure0.4%7
Chicken0.1%2

The share is of the 1,613 reports that list this sign. The sign is in 0.1% of all reports about the species dog. The sign is in 0.1% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Skin lump, by the year in which FDA received them
Year	Reports
2026	46
2025	70
2024	82
2023	63
2022	46
2021	59
2020	68
2019	63
2018	141
2017	150
2016	98
2015	90
2014	64
2013	52
2012	60
2011	50
2010	43
2009	52
2008	47
2007	51
2006	56
2005	37
2004	49
2003	19
2002	21
2001	10
2000	6
1999	5
1998	5
1997	3
1996	2
1991	1
1990	3
1988	1

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal8%129, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]1.7%28, All reports: 2.3%
Ongoing32.9%531, All reports: 17.4%
Died9.1%147, All reports: 4.9%
Euthanized4.5%73, All reports: 1.5%
Outcome Unknown21.1%341, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 1,613 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year4.5%72, All reports: 9.5%
1 to 3 years16.6%268, All reports: 23.9%
4 to 7 years26.2%423, All reports: 20.2%
8 to 11 years31.1%501, All reports: 15.4%
12 years and over17.2%277, All reports: 10.7%
Age not given4.5%72, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Skin hyperaemia[reddened skin]
Skin inflammation NOS[NOS: not otherwise specified]
Skin irritation
Skin lesion NOS[NOS: not otherwise specified]
Skin necrosis
Skin oedema
Skin petechiae
Skin scab

All clinical signs

Cite this page

Pet Drug Reports. Skin lump: adverse event reports for animal drugs. https://petdrugreports.com/reaction/skin-lump/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 78 reports in the 12 months to June 2026. It received 70 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 1,137 reports that say if the event was serious, 51.5% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices