Collapse: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From January 1987 to June 2026, FDA received 5,881 adverse event reports for animal drugs that list this sign. That is 0.4% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 92 reports that list this sign.

Of the 5,881 reports, 73.2% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 107 of 1,149 clinical signs with a page. Reports that list this sign fell by 31.3% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cattle are 11% of the reports that list this sign, and 2.3% of all reports.

Search engines list a sign page with 3,000 reports or more in all years. The page also needs 300 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 63 drug pages.

Show the 63 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
Acepromazine Maleate	27
Afoxolaner	123
Amoxicillin	58
Atipamezole Hydrochloride	44
Bedinvetmab	90
Butorphanol Tartrate	68
Carprofen	587
Cefovecin sodium	81
Cefpodoxime proxetil	32
Ceftiofur Crystalline Free Acid	46
Cyclosporine	129
Deracoxib	158
Desoxycorticosterone Pivalate	46
Detomidine Hydrochloride	49
Dexamethasone	38
Dexmedetomidine hydrochloride	31
Diphenhydramine	40
Doxycycline	21
Enrofloxacin	51
Fenbendazole	31
Firocoxib	113
Florfenicol	28
Flunixin Meglumine	89
Fluralaner	130
Gabapentin	49
Grapiprant	23
Imidacloprid + Moxidectin	38
Insulin	64
Ivermectin	146
Ivermectin + Praziquantel + Pyrantel Pamoate	35
Ivermectin + Pyrantel Pamoate	214
Ketamine Hydrochloride	35
Lufenuron + Milbemycin Oxime	59
Maropitant	127
Medetomidine	53
Melarsomine Dihydrochloride	419
Meloxicam	91
Methylprednisolone Acetate	32
Metronidazole	20
Milbemycin Oxime	116
Milbemycin Oxime + Praziquantel	47
Milbemycin Oxime + Spinosad	209
Moxidectin	537
Nitenpyram	45
Oclacitinib	48
Oxytetracycline	84
Penicillin G Procaine	45
Pimobendan	48
Prednisone	44
Pyrantel Pamoate	33
Pyrantel Pamoate + Sarolaner	56
Sarolaner	27
Selamectin	138
Selegiline Hydrochloride	56
Spinosad	141
Sulfadiazine + Trimethoprim	24
Tepoxalin	34
Tilmicosin Phosphate	131
Tramadol	22
Triamcinolone Acetonide	39
Trilostane	36
Vitamin E	68
Xylazine	40

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 64 ingredients.

Show the 64 ingredients

Reports by species

Dog73.2%4,302
Cattle11%649
Cat7%413
Horse6.9%408
Pig0.6%36
Sheep0.4%26

The share is of the 5,881 reports that list this sign. The sign is in 0.4% of all reports about the species dog. The sign is in 2.1% of all reports about the species cattle.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Collapse, by the year in which FDA received them
Year	Reports
2026	32
2025	133
2024	148
2023	111
2022	91
2021	72
2020	95
2019	97
2018	92
2017	148
2016	160
2015	153
2014	161
2013	164
2012	238
2011	296
2010	303
2009	352
2008	299
2007	257
2006	235
2005	256
2004	336
2003	261
2002	237
2001	177
2000	165
1999	171
1998	169
1997	78
1996	49
1995	69
1994	52
1993	37
1992	31
1991	38
1990	35
1989	29
1988	26
1987	28

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal9.6%567, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]0.9%51, All reports: 2.3%
Ongoing6.1%357, All reports: 17.4%
Died39.3%2,309, All reports: 4.9%
Euthanized3.3%197, All reports: 1.5%
Outcome Unknown4.1%241, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 5,881 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year11.3%666, All reports: 9.5%
1 to 3 years22.3%1,314, All reports: 23.9%
4 to 7 years20.2%1,189, All reports: 20.2%
8 to 11 years20.4%1,201, All reports: 15.4%
12 years and over17%1,001, All reports: 10.7%
Age not given8.7%510, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Coagulopathy
Cognitive disorder NOS[NOS: not otherwise specified]
Colic
Colitis
Collapse NOS[NOS: not otherwise specified]
Collapse of leg
Color, Abnormal[a product quality report, not a sign in an animal]
Coma

All clinical signs

Cite this page

Pet Drug Reports. Collapse: adverse event reports for animal drugs. https://petdrugreports.com/reaction/collapse/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 92 reports in the 12 months to June 2026. It received 134 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 1,753 reports that say if the event was serious, 91.6% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices