Polyuria: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: passing more urine than usual.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From January 1987 to June 2026, FDA received 11,221 adverse event reports for animal drugs that list this sign. That is 0.8% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 750 reports that list this sign.

Of the 11,221 reports, 89.1% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 52 of 1,149 clinical signs with a page. Reports that list this sign fell by 29.9% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 89.1% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 109 drug pages.

Show the 109 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	27
Acepromazine Maleate	25
Afoxolaner	205
Amantadine	37
Amlodipine	21
Amoxicillin	118
Amoxicillin + Clavulanate Potassium	65
Amoxicillin Trihydrate + Clavulanate Potassium	82
Atipamezole Hydrochloride	20
Bedinvetmab	1,575
Benazepril	24
Bexagliflozin	245
Buprenorphine	46
Butorphanol Tartrate	67
Capromorelin	49
Carprofen	1,688
Cefovecin sodium	161
Cefpodoxime proxetil	163
Cephalexin	50
Clindamycin	26
Clodronate	68
Clomipramine Hydrochloride	47
Clotrimazole + Gentamicin Sulfate + Mometasone Furoate Monohydrate	22
Cyclosporine	464
Deracoxib	478
Desoxycorticosterone Pivalate	300
Dexamethasone	77
Dexamethasone + Neomycin Sulfate + Thiabendazole	20
Dexamethasone Sodium Phosphate	32
Dexmedetomidine	32
Diazepam	24
Diphenhydramine	68
Dirlotapide	54
Doxycycline	83
Enalapril Maleate	60
Enrofloxacin	92
Estriol	53
Etodolac	67
Famotidine	94
Febantel + Praziquantel + Pyrantel Pamoate	28
Fenbendazole	34
Firocoxib	188
Florfenicol + Mometasone furoate + Terbinafine	28
Florfenicol + Terbinafine	25
Flunixin Meglumine	22
Fluoxetine hydrochloride	41
Fluralaner	382
Frunevetmab	108
Furosemide	46
Gabapentin	411
Grapiprant	170
Hydroxyzine	27
Ilunocitinib	62
Imidacloprid	25
Imidacloprid + Moxidectin	54
Insulin	623
Isoflurane	44
Ivermectin	76
Ivermectin + Pyrantel Pamoate	198
Ketamine Hydrochloride	31
Ketoconazole	48
Ketoprofen	24
Levothyroxine sodium	134
Lotilaner	150
Lufenuron + Milbemycin Oxime	82
Marbofloxacin	35
Maropitant	283
Melarsomine Dihydrochloride	120
Meloxicam	272
Methocarbamol	21
Methylprednisolone Acetate	70
Metronidazole	92
Midazolam	25
Milbemycin Oxime	96
Milbemycin Oxime + Praziquantel	99
Milbemycin Oxime + Spinosad	271
Mirtazapine	32
Moxidectin	249
Nitenpyram	23
Oclacitinib	660
Omeprazole	49
Ondansetron	35
Ormetoprim + Sulfadimethoxine	22
Oxibendazole	37
Pergolide mesylate	20
Phenobarbital	26
Pimobendan	123
Polysulfated Glycosaminoglycan	89
Prednisolone	77
Prednisolone + Trimeprazine Tartrate	106
Prednisone	468
Propofol	29
Pyrantel Pamoate	30
Pyrantel Pamoate + Sarolaner	242
Robenacoxib	22
Sarolaner	54
Selamectin	141
Selegiline Hydrochloride	158
Spinosad	165
Sucralfate	35
Tigilanol tiglate	31
Tramadol	132
Trazodone	50
Triamcinolone Acetonide	36
Trilostane	773
Ursodiol	43
Velagliflozin	143
Verdinexor	33
Vitamin E	28

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 117 ingredients.

Show the 117 ingredients

Reports by species

Dog89.1%9,998
Cat9.6%1,073
Horse1.1%129
Cattle0.1%6
Otherunder 0.1%4
Human exposureunder 0.1%3

The share is of the 11,221 reports that list this sign. The sign is in 1% of all reports about the species dog. The sign is in 0.7% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Polyuria, by the year in which FDA received them
Year	Reports
2026	340
2025	934
2024	1,256
2023	446
2022	262
2021	258
2020	349
2019	354
2018	360
2017	395
2016	500
2015	538
2014	475
2013	370
2012	427
2011	294
2010	428
2009	514
2008	308
2007	321
2006	282
2005	303
2004	296
2003	193
2002	131
2001	125
2000	231
1999	215
1998	157
1997	59
1996	16
1995	10
1994	16
1993	5
1992	3
1991	6
1990	8
1989	2
1988	19
1987	15

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal8.7%973, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]1.6%181, All reports: 2.3%
Ongoing30%3,364, All reports: 17.4%
Died6.7%749, All reports: 4.9%
Euthanized4.4%499, All reports: 1.5%
Outcome Unknown18.3%2,051, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 11,221 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year5.1%575, All reports: 9.5%
1 to 3 years9.5%1,071, All reports: 23.9%
4 to 7 years19.8%2,227, All reports: 20.2%
8 to 11 years33.3%3,740, All reports: 15.4%
12 years and over29.2%3,271, All reports: 10.7%
Age not given3%337, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Polycythemia, relative
Polydipsia[drinking more than usual]
Polyphagia
Polypnoea[fast breathing]
Poor coat condition
Potency, Low
PR-bone marrow, lesion(s)[legacy FDA term: lesions found in the bone marrow]
PR-brain, lesion(s)[legacy FDA term: lesions found in the brain]

All clinical signs

Cite this page

Pet Drug Reports. Polyuria: adverse event reports for animal drugs. https://petdrugreports.com/reaction/polyuria/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: In plain words: passing more urine than usual. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 750 reports in the 12 months to June 2026. It received 1,070 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 7,148 reports that say if the event was serious, 53.4% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices