Cough: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From June 1987 to June 2026, FDA received 8,890 adverse event reports for animal drugs that list this sign. That is 0.6% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 405 reports that list this sign.

Of the 8,890 reports, 88.2% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 73 of 1,149 clinical signs with a page. Reports that list this sign fell by 13.1% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 88.2% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 98 drug pages.

Show the 98 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	50
Acepromazine Maleate	39
Afoxolaner	335
Afoxolaner + Moxidectin + Pyrantel Pamoate	34
Amoxicillin	87
Amoxicillin + Clavulanate Potassium	53
Amoxicillin Trihydrate + Clavulanate Potassium	69
Atipamezole Hydrochloride	25
Bedinvetmab	309
Benazepril	29
Buprenorphine	54
Butorphanol Tartrate	77
Capromorelin	34
Carprofen	459
Cefovecin sodium	125
Cefpodoxime proxetil	40
Cephalexin	50
Clindamycin	29
Cyclosporine	151
Deracoxib	143
Desoxycorticosterone Pivalate	28
Dexamethasone	70
Dexmedetomidine hydrochloride	35
Diphenhydramine	111
Dirlotapide	20
Doxycycline	242
Emodepside + Praziquantel	49
Enalapril Maleate	77
Enrofloxacin	110
Eprinomectin	27
Famotidine	51
Febantel + Praziquantel + Pyrantel Pamoate	46
Fenbendazole	70
Firocoxib	71
Florfenicol + Mometasone furoate + Terbinafine	47
Fluoxetine hydrochloride	22
Fluralaner	390
Frunevetmab	21
Furosemide	145
Gabapentin	178
Grapiprant	94
Hydrocodone	52
Ilunocitinib	45
Imidacloprid	73
Imidacloprid + Moxidectin	308
Insulin	67
Isoflurane	42
Ivermectin	164
Ivermectin + Praziquantel + Pyrantel Pamoate	57
Ivermectin + Pyrantel Pamoate	730
Ketamine Hydrochloride	32
Levothyroxine sodium	42
Lotilaner	100
Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate	37
Lufenuron + Milbemycin Oxime	166
Lufenuron + Milbemycin Oxime + Praziquantel	28
Lufenuron + Praziquantel	20
Marbofloxacin	38
Maropitant	269
Medetomidine	21
Melarsomine Dihydrochloride	938
Meloxicam	133
Metoclopramide	24
Metronidazole	64
Midazolam	27
Milbemycin Oxime	202
Milbemycin Oxime + Praziquantel	304
Milbemycin Oxime + Spinosad	860
Mirtazapine	20
Monensin	26
Moxidectin	464
Moxidectin + Pyrantel Pamoate + Sarolaner	24
Nitenpyram	69
Oclacitinib	332
Omeprazole	29
Ondansetron	22
Phenobarbital	20
Pimobendan	426
Polysulfated Glycosaminoglycan	50
Praziquantel	23
Praziquantel + Pyrantel Pamoate	50
Prednisolone	68
Prednisolone + Trimeprazine Tartrate	61
Prednisone	190
Propofol	35
Pyrantel Pamoate	127
Pyrantel Pamoate + Sarolaner	181
Rabacfosadine	22
Sarolaner	74
Sarolaner + Selamectin	33
Selamectin	356
Spinosad	333
Sucralfate	35
Theophylline	21
Tiletamine Hydrochloride + Zolazepam Hydrochloride	26
Tramadol	76
Trazodone	47
Trilostane	164

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 91 ingredients.

Show the 91 ingredients

Reports by species

Dog88.2%7,841
Cat7.4%662
Cattle1.7%149
Human exposure1.3%120
Horse0.9%76
Pig0.3%24

The share is of the 8,890 reports that list this sign. The sign is in 0.8% of all reports about the species dog. The sign is in 0.4% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Cough, by the year in which FDA received them
Year	Reports
2026	183
2025	441
2024	501
2023	364
2022	329
2021	341
2020	408
2019	399
2018	472
2017	540
2016	526
2015	545
2014	464
2013	435
2012	446
2011	307
2010	260
2009	309
2008	253
2007	235
2006	173
2005	171
2004	238
2003	85
2002	81
2001	69
2000	84
1999	58
1998	40
1997	21
1996	44
1995	11
1994	13
1993	2
1992	5
1991	6
1990	2
1989	18
1988	7
1987	4

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal15.3%1,364, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]3%271, All reports: 2.3%
Ongoing20.7%1,844, All reports: 17.4%
Died11.1%985, All reports: 4.9%
Euthanized4.8%430, All reports: 1.5%
Outcome Unknown24.2%2,147, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 8,890 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year9%796, All reports: 9.5%
1 to 3 years22.1%1,962, All reports: 23.9%
4 to 7 years21.7%1,931, All reports: 20.2%
8 to 11 years23.6%2,097, All reports: 15.4%
12 years and over18.1%1,613, All reports: 10.7%
Age not given5.5%491, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Coprophagia
Corneal disorder NOS[NOS: not otherwise specified]
Corneal oedema
Corneal ulcer
Crackles on auscultation
Crust
Crying
Crystalluria

All clinical signs

Cite this page

Pet Drug Reports. Cough: adverse event reports for animal drugs. https://petdrugreports.com/reaction/cough/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 405 reports in the 12 months to June 2026. It received 466 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 6,354 reports that say if the event was serious, 56.4% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices