Elevated total bilirubin: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: bilirubin above the normal range.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From February 1987 to June 2026, FDA received 10,390 adverse event reports for animal drugs that list this sign. That is 0.8% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 462 reports that list this sign.

Of the 10,390 reports, 87% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 62 of 1,149 clinical signs with a page. Reports that list this sign rose by 13.8% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 87% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 108 drug pages.

Show the 108 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	20
Acepromazine Maleate	64
Acetylsalicylic Acid	21
Afoxolaner	214
Afoxolaner + Moxidectin + Pyrantel Pamoate	24
Amoxicillin	225
Amoxicillin + Clavulanate Potassium	70
Amoxicillin Trihydrate + Clavulanate Potassium	80
Ampicillin Sodium	57
Atipamezole Hydrochloride	65
Atropine	29
Bedinvetmab	161
Bexagliflozin	99
Buprenorphine	158
Butorphanol Tartrate	143
Capromorelin	99
Carprofen	4,457
Cefovecin sodium	301
Cefpodoxime proxetil	111
Cephalexin	64
Clindamycin	52
Clomipramine Hydrochloride	87
Cyclosporine	234
Deracoxib	449
Dexamethasone	117
Dexamethasone + Neomycin Sulfate + Thiabendazole	43
Dexamethasone Sodium Phosphate	56
Dexmedetomidine	47
Dexmedetomidine hydrochloride	86
Dextrose	61
Diazepam	33
Diphenhydramine	91
Dirlotapide	32
Doxycycline	139
Emodepside + Praziquantel	24
Enalapril Maleate	23
Enrofloxacin	183
Etodolac	96
Famotidine	224
Fentanyl	32
Firocoxib	258
Fluoxetine hydrochloride	24
Fluralaner	318
Frunevetmab	46
Furosemide	37
Gabapentin	232
Grapiprant	95
Hydromorphone	65
Ilunocitinib	23
Imidacloprid	24
Imidacloprid + Moxidectin	26
Insulin	91
Isoflurane	113
Itraconazole	48
Ivermectin	78
Ivermectin + Pyrantel Pamoate	211
Ketamine Hydrochloride	54
Ketoconazole	23
Levothyroxine sodium	46
Lidocaine	22
Lotilaner	29
Lufenuron	21
Lufenuron + Milbemycin Oxime	70
Marbofloxacin	45
Maropitant	816
Medetomidine	38
Melarsomine Dihydrochloride	229
Meloxicam	273
Methadone	25
Methocarbamol	28
Methylprednisolone Acetate	44
Metoclopramide	76
Metronidazole	189
Midazolam	60
Milbemycin Oxime	75
Milbemycin Oxime + Praziquantel	55
Milbemycin Oxime + Spinosad	249
Mirtazapine	92
Moxidectin	415
Nitenpyram	29
Oclacitinib	245
Omeprazole	61
Ondansetron	118
Ormetoprim + Sulfadimethoxine	53
Oxibendazole	99
Pimobendan	36
Polysulfated Glycosaminoglycan	50
Prednisolone	56
Prednisolone + Trimeprazine Tartrate	30
Prednisone	170
Propofol	105
Pyrantel Pamoate	34
Pyrantel Pamoate + Sarolaner	102
Robenacoxib	69
Sarolaner	56
Sarolaner + Selamectin	34
Selamectin	220
Selegiline Hydrochloride	26
Sodium Chloride	20
Spinosad	129
Sucralfate	122
Toceranib Phosphate	21
Tramadol	181
Trazodone	48
Trilostane	129
Ursodiol	80
Velagliflozin	134
Vitamin E	149

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 107 ingredients.

Show the 107 ingredients

Reports by species

Dog87%9,036
Cat12.3%1,273
Horse0.7%68
Cattle0.1%7
Goatunder 0.1%2
Human exposureunder 0.1%2

The share is of the 10,390 reports that list this sign. The sign is in 0.9% of all reports about the species dog. The sign is in 0.8% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Elevated total bilirubin, by the year in which FDA received them
Year	Reports
2026	214
2025	460
2024	428
2023	272
2022	220
2021	230
2020	256
2019	278
2018	286
2017	303
2016	386
2015	376
2014	388
2013	370
2012	356
2011	373
2010	371
2009	352
2008	413
2007	440
2006	439
2005	395
2004	451
2003	252
2002	243
2001	257
2000	462
1999	436
1998	443
1997	99
1996	10
1995	12
1994	5
1993	3
1992	7
1991	7
1990	7
1989	19
1988	29
1987	42

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal4.2%433, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]0.8%88, All reports: 2.3%
Ongoing18.3%1,898, All reports: 17.4%
Died22.2%2,309, All reports: 4.9%
Euthanized10.1%1,052, All reports: 1.5%
Outcome Unknown7.6%787, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 10,390 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year3%307, All reports: 9.5%
1 to 3 years11.8%1,227, All reports: 23.9%
4 to 7 years30.8%3,203, All reports: 20.2%
8 to 11 years36.4%3,786, All reports: 15.4%
12 years and over16.8%1,749, All reports: 10.7%
Age not given1.1%118, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Elevated serum alkaline phosphatase (SAP)[a liver and bone enzyme above the normal range]
Elevated symmetrical dimethylarginine (SDMA)[a kidney value above the normal range]
Elevated temperature
Elevated thyroxine (T4)
Elevated triglyceride
Embolism
Emesis[vomiting]
Emesis (multiple)[vomiting more than once]

All clinical signs

Cite this page

Pet Drug Reports. Elevated total bilirubin: adverse event reports for animal drugs. https://petdrugreports.com/reaction/elevated-total-bilirubin/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: In plain words: bilirubin above the normal range. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 462 reports in the 12 months to June 2026. It received 406 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 4,681 reports that say if the event was serious, 75.2% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices