Hyperglycaemia: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: high blood sugar.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From February 1987 to June 2026, FDA received 8,056 adverse event reports for animal drugs that list this sign. That is 0.6% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 720 reports that list this sign.

Of the 8,056 reports, 62.5% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 84 of 1,149 clinical signs with a page. Reports that list this sign fell by 7.7% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about cats are 36% of the reports that list this sign, and 11% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 106 drug pages.

Show the 106 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	22
Acepromazine Maleate	44
Afoxolaner	252
Afoxolaner + Moxidectin + Pyrantel Pamoate	33
Amlodipine	33
Amoxicillin	118
Amoxicillin + Clavulanate Potassium	68
Amoxicillin Trihydrate + Clavulanate Potassium	61
Ampicillin Sodium	29
Atipamezole Hydrochloride	60
Atropine	26
Bedinvetmab	143
Bexagliflozin	912
Buprenorphine	191
Butorphanol Tartrate	141
Capromorelin	112
Carprofen	590
Cefovecin sodium	410
Cefpodoxime proxetil	51
Cephalexin	36
Clindamycin	37
Cyclosporine	295
Deracoxib	215
Dexamethasone	122
Dexamethasone + Neomycin Sulfate + Thiabendazole	34
Dexamethasone Sodium Phosphate	48
Dexmedetomidine	49
Dexmedetomidine hydrochloride	61
Dextrose	44
Diazepam	34
Diphenhydramine	93
Dirlotapide	35
Doxycycline	66
Emodepside + Praziquantel	49
Enalapril Maleate	32
Enrofloxacin	123
Eprinomectin + Esafoxolaner + Praziquantel	86
Famotidine	89
Fentanyl	28
Firocoxib	125
Florfenicol + Mometasone furoate + Terbinafine	38
Fluoxetine hydrochloride	30
Fluralaner	385
Fluralaner + Moxidectin	29
Frunevetmab	146
Furosemide	57
Gabapentin	213
Grapiprant	44
Hydromorphone	32
Ilunocitinib	33
Imidacloprid + Moxidectin	72
Insulin	1,033
Isoflurane	96
Itraconazole	20
Ivermectin	105
Ivermectin + Praziquantel + Pyrantel Pamoate	23
Ivermectin + Pyrantel Pamoate	226
Ketamine Hydrochloride	62
Ketoconazole	21
Ketoprofen	21
Levothyroxine sodium	34
Lotilaner	50
Lufenuron	27
Lufenuron + Milbemycin Oxime	45
Marbofloxacin	33
Maropitant	529
Medetomidine	33
Melarsomine Dihydrochloride	150
Meloxicam	250
Methimazole	33
Methylprednisolone Acetate	145
Metoclopramide	25
Metronidazole	81
Midazolam	57
Milbemycin Oxime	55
Milbemycin Oxime + Praziquantel	77
Milbemycin Oxime + Spinosad	364
Mirtazapine	91
Moxidectin	214
Nitenpyram	45
Oclacitinib	207
Omeprazole	33
Ondansetron	59
Orbifloxacin	21
Pimobendan	49
Polysulfated Glycosaminoglycan	38
Prednisolone	93
Prednisolone + Trimeprazine Tartrate	31
Prednisone	163
Propofol	76
Pyrantel Pamoate	41
Pyrantel Pamoate + Sarolaner	91
Robenacoxib	125
Sarolaner	58
Sarolaner + Selamectin	61
Selamectin	209
Selegiline Hydrochloride	37
Sodium Chloride	30
Spinosad	224
Sucralfate	40
Tigilanol tiglate	27
Tramadol	66
Trazodone	27
Trilostane	543
Ursodiol	25
Velagliflozin	31

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 105 ingredients.

Show the 105 ingredients

Reports by species

Dog62.5%5,039
Cat36%2,901
Horse1.1%86
Human exposure0.2%17
Cattleunder 0.1%3
Ferretunder 0.1%3

The share is of the 8,056 reports that list this sign. The sign is in 0.5% of all reports about the species dog. The sign is in 1.9% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Hyperglycaemia, by the year in which FDA received them
Year	Reports
2026	362
2025	753
2024	768
2023	494
2022	222
2021	266
2020	265
2019	292
2018	321
2017	335
2016	323
2015	441
2014	380
2013	299
2012	302
2011	253
2010	348
2009	337
2008	217
2007	193
2006	147
2005	121
2004	143
2003	80
2002	55
2001	73
2000	89
1999	53
1998	41
1997	19
1996	9
1995	8
1994	6
1993	4
1992	2
1991	4
1990	1
1989	7
1988	17
1987	6

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal8.7%698, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]2.7%216, All reports: 2.3%
Ongoing28%2,253, All reports: 17.4%
Died13.4%1,081, All reports: 4.9%
Euthanized9.4%758, All reports: 1.5%
Outcome Unknown17.9%1,441, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 8,056 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year7.1%574, All reports: 9.5%
1 to 3 years12.4%1,000, All reports: 23.9%
4 to 7 years21.1%1,698, All reports: 20.2%
8 to 11 years33%2,660, All reports: 15.4%
12 years and over23.9%1,929, All reports: 10.7%
Age not given2.4%195, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

All clinical signs

Cite this page

Pet Drug Reports. Hyperglycaemia: adverse event reports for animal drugs. https://petdrugreports.com/reaction/hyperglycaemia/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: In plain words: high blood sugar. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 720 reports in the 12 months to June 2026. It received 780 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 5,751 reports that say if the event was serious, 71.3% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices