Pain NOS: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: NOS: not otherwise specified.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From January 1987 to June 2026, FDA received 8,846 adverse event reports for animal drugs that list this sign. That is 0.6% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 608 reports that list this sign.

Of the 8,846 reports, 81.7% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 74 of 1,149 clinical signs with a page. Reports that list this sign fell by 17.5% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 81.7% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 104 drug pages.

Show the 104 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	50
Acepromazine Maleate	45
Afoxolaner	264
Afoxolaner + Moxidectin + Pyrantel Pamoate	23
Amantadine	32
Amoxicillin	79
Amoxicillin + Clavulanate Potassium	57
Amoxicillin Trihydrate + Clavulanate Potassium	65
Atipamezole Hydrochloride	98
Atropine	20
Bedinvetmab	578
Bupivacaine	23
Buprenorphine	242
Butorphanol Tartrate	221
Capromorelin	62
Carprofen	811
Cefovecin sodium	269
Cefpodoxime proxetil	92
Ceftiofur Crystalline Free Acid	21
Cephalexin	35
Clindamycin	37
Cyclosporine	165
Deracoxib	200
Desoxycorticosterone Pivalate	27
Dexamethasone	100
Dexamethasone Sodium Phosphate	42
Dexmedetomidine	91
Dexmedetomidine hydrochloride	85
Diazepam	24
Diphenhydramine	194
Doxycycline	136
Emodepside + Praziquantel	40
Enrofloxacin	123
Famotidine	160
Febantel + Praziquantel + Pyrantel Pamoate	32
Fenbendazole	43
Fentanyl	41
Firocoxib	142
Florfenicol + Mometasone furoate + Terbinafine	77
Flunixin Meglumine	22
Fluoxetine hydrochloride	28
Fluralaner	277
Frunevetmab	111
Furosemide	24
Gabapentin	543
Grapiprant	155
Hydromorphone	56
Ilunocitinib	36
Imidacloprid	54
Imidacloprid + Moxidectin	136
Insulin	60
Isoflurane	91
Ivermectin	131
Ivermectin + Praziquantel	53
Ivermectin + Pyrantel Pamoate	330
Ketamine Hydrochloride	88
Ketoconazole	43
Levothyroxine sodium	30
Lotilaner	86
Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate	21
Lufenuron	20
Lufenuron + Milbemycin Oxime	80
Marbofloxacin	38
Maropitant	394
Melarsomine Dihydrochloride	1,288
Meloxicam	224
Methadone	30
Methocarbamol	52
Methylprednisolone Acetate	35
Metoclopramide	23
Metronidazole	77
Midazolam	60
Milbemycin Oxime	135
Milbemycin Oxime + Praziquantel	129
Milbemycin Oxime + Spinosad	576
Mirtazapine	27
Moxidectin	463
Nitenpyram	72
Oclacitinib	210
Omeprazole	49
Ondansetron	44
Pimobendan	66
Polysulfated Glycosaminoglycan	133
Praziquantel + Pyrantel Pamoate	35
Prednisolone	64
Prednisolone + Trimeprazine Tartrate	20
Prednisone	322
Propofol	96
Pyrantel Pamoate	74
Pyrantel Pamoate + Sarolaner	148
Robenacoxib	104
Sarolaner	80
Sarolaner + Selamectin	53
Selamectin	331
Sevoflurane	25
Sodium Chloride	24
Spinosad	215
Sucralfate	34
Tigilanol tiglate	302
Tilmicosin Phosphate	44
Toceranib Phosphate	24
Tramadol	160
Trazodone	47
Trilostane	108

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 105 ingredients.

Show the 105 ingredients

Reports by species

Dog81.7%7,229
Cat11.3%996
Horse2.7%237
Human exposure2.4%212
Cattle1.1%101
Pig0.4%31

The share is of the 8,846 reports that list this sign. The sign is in 0.7% of all reports about the species dog. The sign is in 0.7% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Pain NOS, by the year in which FDA received them
Year	Reports
2026	270
2025	729
2024	673
2023	432
2022	358
2021	371
2020	281
2019	261
2018	285
2017	364
2016	396
2015	430
2014	397
2013	379
2012	335
2011	324
2010	338
2009	343
2008	304
2007	257
2006	218
2005	144
2004	208
2003	156
2002	128
2001	81
2000	90
1999	69
1998	61
1997	32
1996	40
1995	17
1994	10
1993	7
1992	6
1991	6
1990	10
1989	15
1988	13
1987	8

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal14.6%1,288, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]1.1%98, All reports: 2.3%
Ongoing21.3%1,885, All reports: 17.4%
Died10.9%966, All reports: 4.9%
Euthanized7.4%656, All reports: 1.5%
Outcome Unknown18.6%1,643, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 8,846 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year8.5%749, All reports: 9.5%
1 to 3 years21.8%1,927, All reports: 23.9%
4 to 7 years23.7%2,099, All reports: 20.2%
8 to 11 years22.4%1,983, All reports: 15.4%
12 years and over17.4%1,537, All reports: 10.7%
Age not given6.2%551, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Otorrhoea
Overdose[more than the labelled amount was given]
Pacing
Paddling
Pale mucous membrane[pale gums]
Pallor
Palpable mass NOS[NOS: not otherwise specified]
Palpebral disorder NOS[NOS: not otherwise specified]

All clinical signs

Cite this page

Pet Drug Reports. Pain NOS: adverse event reports for animal drugs. https://petdrugreports.com/reaction/pain-nos/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: In plain words: NOS: not otherwise specified. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 608 reports in the 12 months to June 2026. It received 737 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 5,836 reports that say if the event was serious, 62.9% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices