Unpalatable: in adverse event reports for animal drugs

Clinical sign, a term of older FDA reports

In plain words: the animal would not take it.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From March 1987 to June 2026, FDA received 28,524 adverse event reports for animal drugs that list this sign. That is 2.1% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 897 reports that list this sign.

Of the 28,524 reports, 19.8% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 17 of 1,149 clinical signs with a page. Reports that list this sign rose by 3.1% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 19.8% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 43 drug pages.

Show the 43 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
Afoxolaner	460
Afoxolaner + Moxidectin + Pyrantel Pamoate	174
Amoxicillin	26
Bexagliflozin	102
Capromorelin	207
Carprofen	100
Cyclosporine	528
Deracoxib	26
Diethylcarbamazine Citrate	23
Diphenhydramine	27
Febantel + Praziquantel + Pyrantel Pamoate	40
Fenbendazole	31
Fluoxetine hydrochloride	22
Fluralaner	4,071
Grapiprant	99
Imidacloprid	79
Ivermectin	110
Ivermectin + Praziquantel + Pyrantel Pamoate	30
Ivermectin + Pyrantel Pamoate	1,142
Lotilaner	721
Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate	353
Lufenuron + Milbemycin Oxime	35
Maropitant	21
Meloxicam	26
Milbemycin Oxime	162
Milbemycin Oxime + Praziquantel	1,754
Milbemycin Oxime + Spinosad	12,067
Monensin	79
Nitenpyram	287
Oclacitinib	45
Oxibendazole	120
Pimobendan	67
Pradofloxacin	29
Praziquantel	155
Prednisone	42
Pyrantel Pamoate	26
Pyrantel Pamoate + Sarolaner	318
Robenacoxib	52
Sarolaner	120
Spinosad	5,099
Tilmicosin Phosphate	30
Tylosin	37
Tylosin Tartrate	38

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 37 ingredients.

Show the 37 ingredients

Reports by species

Dog19.8%5,658
Cat3%868
Cattle0.3%72
Pig0.1%35
Horse0.1%26
Chickenunder 0.1%6

The share is of the 28,524 reports that list this sign. The sign is in 0.6% of all reports about the species dog. The sign is in 0.6% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update. New reports use VeDDRA terms, so a term of older reports has few reports in the latest years.

Reports that list Unpalatable, by the year in which FDA received them
Year	Reports
2026	460
2025	884
2024	889
2023	491
2022	483
2021	1,299
2020	1,973
2019	1,828
2018	2,258
2017	2,381
2016	2,397
2015	2,663
2014	2,617
2013	2,899
2012	2,247
2011	1,262
2010	619
2009	301
2008	103
2007	85
2006	40
2005	41
2004	48
2003	29
2002	21
2001	36
2000	76
1999	17
1998	19
1997	6
1996	6
1995	3
1993	8
1992	3
1991	2
1990	7
1989	8
1988	8
1987	7

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal9.9%2,829, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]0.7%196, All reports: 2.3%
Ongoing1.8%518, All reports: 17.4%
Died0.4%122, All reports: 4.9%
Euthanized0.2%54, All reports: 1.5%
Outcome Unknown6.9%1,956, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 28,524 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year1.3%384, All reports: 9.5%
1 to 3 years6.4%1,813, All reports: 23.9%
4 to 7 years5.6%1,587, All reports: 20.2%
8 to 11 years3%853, All reports: 15.4%
12 years and over1.9%556, All reports: 10.7%
Age not given81.8%23,331, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Underfilling, Package[a product quality report, not a sign in an animal]
Underfilling, Tubes[a product quality report, not a sign in an animal]
Underfilling, Vials[a product quality report, not a sign in an animal]
Unexplained death
Unrelated death
Unresponsive to stimuli
Unsteady gait
Unusual stool colour

All clinical signs

Cite this page

Pet Drug Reports. Unpalatable: adverse event reports for animal drugs. https://petdrugreports.com/reaction/unpalatable/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: In plain words: the animal would not take it. It is a term from older FDA reports, from before FDA used the VeDDRA list. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 897 reports in the 12 months to June 2026. It received 870 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 5,542 reports that say if the event was serious, 12.6% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices