Proteinuria: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: protein in the urine.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From February 1987 to June 2026, FDA received 5,276 adverse event reports for animal drugs that list this sign. That is 0.4% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 510 reports that list this sign.

Of the 5,276 reports, 84.8% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 127 of 1,149 clinical signs with a page. Reports that list this sign fell by 7.9% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 84.8% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 89 drug pages.

Show the 89 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
Afoxolaner	166
Afoxolaner + Moxidectin + Pyrantel Pamoate	26
Amoxicillin	93
Amoxicillin + Clavulanate Potassium	48
Amoxicillin Trihydrate + Clavulanate Potassium	78
Ampicillin Sodium	22
Atipamezole Hydrochloride	23
Bedinvetmab	415
Benazepril	20
Bexagliflozin	101
Buprenorphine	74
Butorphanol Tartrate	66
Capromorelin	48
Carprofen	956
Cefovecin sodium	173
Cefpodoxime proxetil	74
Cephalexin	30
Clindamycin	24
Cyclosporine	188
Deracoxib	275
Desoxycorticosterone Pivalate	25
Dexamethasone	45
Dexamethasone Sodium Phosphate	21
Dexmedetomidine	34
Dexmedetomidine hydrochloride	25
Diphenhydramine	53
Dirlotapide	20
Doxycycline	76
Enalapril Maleate	39
Enrofloxacin	82
Eprinomectin + Esafoxolaner + Praziquantel	26
Estriol	38
Famotidine	90
Firocoxib	101
Florfenicol + Mometasone furoate + Terbinafine	25
Fluoxetine hydrochloride	25
Fluralaner	234
Frunevetmab	50
Furosemide	28
Gabapentin	231
Grapiprant	120
Ilunocitinib	52
Imidacloprid + Moxidectin	23
Insulin	98
Isoflurane	38
Ivermectin	47
Ivermectin + Pyrantel Pamoate	149
Ketamine Hydrochloride	23
Ketoconazole	23
Levothyroxine sodium	51
Lotilaner	63
Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate	22
Lufenuron + Milbemycin Oxime	33
Marbofloxacin	31
Maropitant	307
Melarsomine Dihydrochloride	46
Meloxicam	193
Methylprednisolone Acetate	27
Metronidazole	76
Midazolam	31
Milbemycin Oxime	44
Milbemycin Oxime + Praziquantel	83
Milbemycin Oxime + Spinosad	179
Mirtazapine	41
Moxidectin	120
Oclacitinib	388
Omeprazole	21
Ondansetron	42
Pimobendan	46
Polysulfated Glycosaminoglycan	53
Prednisolone	28
Prednisolone + Trimeprazine Tartrate	27
Prednisone	130
Propofol	37
Pyrantel Pamoate + Sarolaner	87
Robenacoxib	58
Sarolaner	45
Selamectin	96
Selegiline Hydrochloride	22
Spinosad	100
Sucralfate	41
Telmisartan	27
Toceranib Phosphate	40
Tramadol	71
Trazodone	32
Trilostane	556
Ursodiol	35
Velagliflozin	133
Vitamin E	31

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 89 ingredients.

Show the 89 ingredients

Reports by species

Dog84.8%4,472
Cat14.9%788
Horse0.2%10
Cattleunder 0.1%2
Human exposureunder 0.1%2
Bobcatunder 0.1%1

The share is of the 5,276 reports that list this sign. The sign is in 0.4% of all reports about the species dog. The sign is in 0.5% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Proteinuria, by the year in which FDA received them
Year	Reports
2026	275
2025	525
2024	496
2023	228
2022	154
2021	130
2020	169
2019	187
2018	268
2017	244
2016	269
2015	264
2014	208
2013	172
2012	193
2011	157
2010	121
2009	149
2008	129
2007	170
2006	157
2005	133
2004	126
2003	79
2002	38
2001	44
2000	50
1999	66
1998	44
1997	9
1996	3
1994	2
1993	2
1992	1
1990	1
1989	3
1988	7
1987	3

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal4.6%241, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]2%103, All reports: 2.3%
Ongoing31.5%1,664, All reports: 17.4%
Died11%580, All reports: 4.9%
Euthanized8.8%462, All reports: 1.5%
Outcome Unknown21.2%1,116, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 5,276 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year2.6%139, All reports: 9.5%
1 to 3 years10.6%558, All reports: 23.9%
4 to 7 years24.9%1,312, All reports: 20.2%
8 to 11 years35.3%1,861, All reports: 15.4%
12 years and over25.6%1,349, All reports: 10.7%
Age not given1.1%57, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Prolonged one stage prothrombin time (OSPT)
Proprioception abnormality
Proprioception deficit[reduced awareness of limb position]
Proprioception loss
Pruritus[itching]
Pulmonary congestion
Pulmonary disorder NOS[NOS: not otherwise specified]
Pulmonary neoplasm

All clinical signs

Cite this page

Pet Drug Reports. Proteinuria: adverse event reports for animal drugs. https://petdrugreports.com/reaction/proteinuria/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: In plain words: protein in the urine. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 510 reports in the 12 months to June 2026. It received 554 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 3,705 reports that say if the event was serious, 62.9% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices