Cardiac enlargement: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

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From March 1988 to June 2026, FDA received 1,508 adverse event reports for animal drugs that list this sign. That is 0.1% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 80 reports that list this sign.

Of the 1,508 reports, 79% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 354 of 1,149 clinical signs with a page. Reports that list this sign fell by 30.4% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 79% of the reports that list this sign, and 72.6% of all reports.

Search engines list a sign page with 3,000 reports or more in all years. The page also needs 300 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 34 drug pages.

Show the 34 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
Afoxolaner	39
Bedinvetmab	81
Buprenorphine	37
Butorphanol Tartrate	22
Carprofen	100
Cefovecin sodium	83
Cyclosporine	34
Deracoxib	26
Dexamethasone	29
Diphenhydramine	22
Doxycycline	37
Enalapril Maleate	22
Fluralaner	80
Furosemide	57
Gabapentin	55
Imidacloprid + Moxidectin	34
Ivermectin + Pyrantel Pamoate	90
Lufenuron + Milbemycin Oxime	34
Maropitant	84
Melarsomine Dihydrochloride	67
Meloxicam	33
Methylprednisolone Acetate	20
Metronidazole	20
Milbemycin Oxime	27
Milbemycin Oxime + Praziquantel	35
Milbemycin Oxime + Spinosad	153
Monensin	27
Moxidectin	96
Oclacitinib	56
Pimobendan	65
Prednisone	51
Selamectin	76
Spinosad	50
Trilostane	53

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 38 ingredients.

Show the 38 ingredients

Reports by species

Dog79%1,191
Cat17.4%263
Cattle2.3%35
Human exposure0.4%6
Horse0.2%3
Other Birds0.2%3

The share is of the 1,508 reports that list this sign. The sign is in 0.1% of all reports about the species dog. The sign is in 0.2% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Cardiac enlargement, by the year in which FDA received them
Year	Reports
2026	32
2025	103
2024	108
2023	58
2022	52
2021	46
2020	56
2019	52
2018	59
2017	86
2016	81
2015	99
2014	89
2013	78
2012	74
2011	50
2010	40
2009	44
2008	34
2007	35
2006	44
2005	35
2004	65
2003	22
2002	17
2001	9
2000	13
1999	12
1998	10
1997	2
1989	2
1988	1

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal2.3%35, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]5.2%79, All reports: 2.3%
Ongoing21.9%330, All reports: 17.4%
Died27.5%414, All reports: 4.9%
Euthanized12.9%194, All reports: 1.5%
Outcome Unknown15.3%230, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 1,508 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year3.6%54, All reports: 9.5%
1 to 3 years13.7%206, All reports: 23.9%
4 to 7 years19.8%299, All reports: 20.2%
8 to 11 years32%483, All reports: 15.4%
12 years and over27.5%414, All reports: 10.7%
Age not given3.4%52, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Calculi
Caps, Abnormal[a product quality report, not a sign in an animal]
Cardiac arrest
Cardiac disorder NOS[heart problem, type not specified]
Cardiomyopathy
Cardiorespiratory arrest
Cataract
Cellulitis

All clinical signs

Cite this page

Pet Drug Reports. Cardiac enlargement: adverse event reports for animal drugs. https://petdrugreports.com/reaction/cardiac-enlargement/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 80 reports in the 12 months to June 2026. It received 115 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 1,060 reports that say if the event was serious, 86.9% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices