Shaking: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From July 1987 to June 2026, FDA received 14,613 adverse event reports for animal drugs that list this sign. That is 1.1% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 831 reports that list this sign.

Of the 14,613 reports, 91.3% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 36 of 1,149 clinical signs with a page. Reports that list this sign fell by 9.3% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 91.3% of the reports that list this sign, and 72.6% of all reports.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 104 drug pages.

Show the 104 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
(S) - methoprene	162
Acepromazine Maleate	36
Afoxolaner	1,183
Afoxolaner + Moxidectin + Pyrantel Pamoate	141
Amoxicillin	61
Amoxicillin + Clavulanate Potassium	40
Amoxicillin Trihydrate + Clavulanate Potassium	47
Atipamezole Hydrochloride	46
Bedinvetmab	380
Buprenorphine	78
Butorphanol Tartrate	93
Capromorelin	33
Carprofen	494
Cefovecin sodium	140
Cefpodoxime proxetil	73
Cephalexin	48
Clomipramine Hydrochloride	23
Cyclosporine	231
Deracoxib	93
Desoxycorticosterone Pivalate	51
Dexamethasone	93
Dexamethasone Sodium Phosphate	27
Dexmedetomidine	26
Dexmedetomidine hydrochloride	40
Diphenhydramine	173
Doxycycline	73
Emodepside + Praziquantel	73
Enalapril Maleate	42
Enrofloxacin	85
Eprinomectin + Esafoxolaner + Praziquantel	42
Estriol	28
Famotidine	89
Febantel + Praziquantel + Pyrantel Pamoate	89
Fenbendazole	47
Firocoxib	71
Florfenicol + Mometasone furoate + Terbinafine	75
Flunixin Meglumine	25
Fluoxetine hydrochloride	107
Fluralaner	1,084
Fluralaner + Moxidectin	25
Frunevetmab	22
Furosemide	49
Gabapentin	229
Grapiprant	99
Hydroxyzine	28
Ilunocitinib	36
Imidacloprid	95
Imidacloprid + Moxidectin	335
Insulin	134
Isoflurane	49
Ivermectin	219
Ivermectin + Praziquantel + Pyrantel Pamoate	128
Ivermectin + Pyrantel Pamoate	971
Ketamine Hydrochloride	46
Ketoconazole	36
Levetiracetam	20
Levothyroxine sodium	67
Lotilaner	218
Lotilaner + Moxidectin + Praziquantel + Pyrantel Pamoate	56
Lufenuron + Milbemycin Oxime	185
Lufenuron + Milbemycin Oxime + Praziquantel	59
Lufenuron + Praziquantel	24
Maropitant	371
Melarsomine Dihydrochloride	236
Meloxicam	136
Methocarbamol	24
Metoclopramide	23
Metronidazole	102
Midazolam	42
Milbemycin Oxime	181
Milbemycin Oxime + Praziquantel	350
Milbemycin Oxime + Spinosad	2,701
Mirtazapine	28
Moxidectin	556
Moxidectin + Pyrantel Pamoate + Sarolaner	20
Nitenpyram	254
Oclacitinib	404
Omeprazole	26
Ondansetron	22
Phenobarbital	28
Pimobendan	121
Polysulfated Glycosaminoglycan	67
Praziquantel	26
Praziquantel + Pyrantel Pamoate	152
Prednisolone	58
Prednisolone + Trimeprazine Tartrate	31
Prednisone	215
Propofol	45
Pyrantel Pamoate	102
Pyrantel Pamoate + Sarolaner	793
Robenacoxib	20
Sarolaner	464
Sarolaner + Selamectin	57
Selamectin	411
Selegiline Hydrochloride	24
Spinosad	864
Sucralfate	31
Tigilanol tiglate	30
Tilmicosin Phosphate	35
Tramadol	92
Trazodone	39
Trilostane	435
Ursodiol	39
Vitamin E	23

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 105 ingredients.

Show the 105 ingredients

Reports by species

Dog91.3%13,338
Cat6.1%885
Horse0.9%135
Cattle0.7%108
Human exposure0.5%76
Pig0.2%36

The share is of the 14,613 reports that list this sign. The sign is in 1.3% of all reports about the species dog. The sign is in 0.6% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Shaking, by the year in which FDA received them
Year	Reports
2026	384
2025	907
2024	987
2023	789
2022	694
2021	784
2020	882
2019	771
2018	786
2017	865
2016	928
2015	898
2014	838
2013	1,045
2012	820
2011	421
2010	354
2009	257
2008	249
2007	134
2006	105
2005	83
2004	115
2003	80
2002	68
2001	78
2000	82
1999	42
1998	43
1997	26
1996	20
1995	22
1994	11
1993	8
1992	9
1991	6
1990	4
1989	7
1988	9
1987	2

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal34.3%5,008, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]2.6%385, All reports: 2.3%
Ongoing20.1%2,937, All reports: 17.4%
Died4.4%640, All reports: 4.9%
Euthanized2.9%430, All reports: 1.5%
Outcome Unknown23.4%3,418, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 14,613 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year13%1,902, All reports: 9.5%
1 to 3 years27%3,940, All reports: 23.9%
4 to 7 years23.4%3,423, All reports: 20.2%
8 to 11 years18.4%2,689, All reports: 15.4%
12 years and over13.8%2,014, All reports: 10.7%
Age not given4.4%645, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

Self mutilation
Self trauma
Sensory abnormality NOS[NOS: not otherwise specified]
Septicaemia
Shallow breathing
Shivering
Shock
Sickness

All clinical signs

Cite this page

Pet Drug Reports. Shaking: adverse event reports for animal drugs. https://petdrugreports.com/reaction/shaking/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 831 reports in the 12 months to June 2026. It received 916 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 12,396 reports that say if the event was serious, 45.9% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices