Immune mediated haemolytic anaemia: in adverse event reports for animal drugs

Clinical sign, a VeDDRA term

In plain words: the immune system destroying red blood cells.

Read this first. FDA says this about the data:

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another. When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event. This dataset should not be the sole source of information for clinical decision-making or other assumptions about the safety or effectiveness of a product. The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine publishes these words. Source: Adverse Event Reports for Animal Drugs and Devices, read on 2 Oct 2026. The data have the reports that FDA received through 26 Jun 2026.

This page is not veterinary advice. For an animal that is ill, speak to a veterinarian.

Contacting a veterinarian How to report to FDA

From June 1987 to June 2026, FDA received 2,270 adverse event reports for animal drugs that list this sign. That is 0.2% of the 1,378,761 reports that FDA received from January 1987 to June 2026. In the 12 months to June 2026, FDA received 102 reports that list this sign.

Of the 2,270 reports, 93.2% are about dogs. A report can list more than one sign and more than one drug. A report is not proof that a drug caused a sign.

By number of reports in all years, this sign is number 252 of 1,149 clinical signs with a page. Reports that list this sign fell by 20.3% in the 12 months to June 2026, compared with the 12 months before. Reports for all animal drugs fell by 4.6% in the same periods. The newest months can get more reports in a later update. Reports about dogs are 93.2% of the reports that list this sign, and 72.6% of all reports.

Search engines list a sign page with 3,000 reports or more in all years. The page also needs 300 reports or more in the 12 months to June 2026. This page is under one of these numbers. The site keeps the page and keeps it out of search engines.

Drug pages with reports that list this sign

The table has every drug page with 20 or more reports that list this sign, in order of name. No count decides which drug is in the table. The table has 46 drug pages.

Show the 46 drug pages

Drug pages with 20 or more reports that list this sign, in order of name
Active ingredients	Reports that list the sign
Afoxolaner	78
Amoxicillin	48
Amoxicillin Trihydrate + Clavulanate Potassium	30
Azathioprine	20
Bedinvetmab	114
Buprenorphine	28
Butorphanol Tartrate	21
Carprofen	426
Cefovecin sodium	137
Cefpodoxime proxetil	36
Cyclosporine	78
Deracoxib	46
Dexamethasone	53
Dexamethasone Sodium Phosphate	33
Diphenhydramine	37
Doxycycline	80
Enrofloxacin	31
Famotidine	41
Firocoxib	32
Fluralaner	139
Gabapentin	62
Grapiprant	33
Ivermectin	27
Ivermectin + Pyrantel Pamoate	95
Lufenuron + Milbemycin Oxime	34
Maropitant	134
Meloxicam	40
Metronidazole	37
Milbemycin Oxime	53
Milbemycin Oxime + Praziquantel	44
Milbemycin Oxime + Spinosad	106
Moxidectin	367
Mycophenolate	30
Oclacitinib	65
Omeprazole	35
Polysulfated Glycosaminoglycan	22
Prednisolone	28
Prednisone	142
Propofol	22
Pyrantel Pamoate + Sarolaner	61
Sarolaner	31
Selamectin	57
Spinosad	64
Sucralfate	32
Tramadol	20
Trilostane	20

The openFDA records give the value "MSK" for the brand name and for the manufacturer name of each drug. FDA says that MSK means "masked". So the site cannot count a report for a brand. A report can name more than one drug.

An API dataset query result cannot be used to estimate the risk associated with the product or compare one drug or device product with another.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices

Ingredients, all combinations

The list has every active ingredient with 20 or more reports that list this sign, in order of name. It has 47 ingredients.

Show the 47 ingredients

Reports by species

Dog93.2%2,116
Cat6.5%148
Horse0.2%5
Otherunder 0.1%1

The share is of the 2,270 reports that list this sign. The sign is in 0.2% of all reports about the species dog. The sign is in 0.1% of all reports about the species cat.

Reports by month and by year

Reports for each month, Jul 2021 to Jun 2026. The month is the month in which FDA received the report.

FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.

Reports that list Immune mediated haemolytic anaemia, by the year in which FDA received them
Year	Reports
2026	44
2025	124
2024	138
2023	84
2022	60
2021	83
2020	114
2019	107
2018	91
2017	96
2016	84
2015	77
2014	88
2013	76
2012	86
2011	71
2010	57
2009	75
2008	57
2007	51
2006	54
2005	57
2004	95
2003	62
2002	57
2001	58
2000	55
1999	47
1998	64
1997	22
1996	9
1995	5
1994	6
1993	5
1992	3
1991	3
1990	2
1989	1
1988	1
1987	1

What these reports record

Outcome at the time of the report

Reports with this sign
All reports

Recovered/Normal4.1%92, All reports: 20.7%
Recovered with Sequela[recovered, with a lasting effect]1.1%26, All reports: 2.3%
Ongoing26.3%596, All reports: 17.4%
Died25.8%586, All reports: 4.9%
Euthanized14.6%331, All reports: 1.5%
Outcome Unknown6.4%145, All reports: 22.7%

An outcome in a report is not proof that the drug caused it. The person who sends the report gives the outcome. Each share is of the 2,270 reports that list this sign.

Age of the animal

Reports with this sign
All reports

Under 1 year3.6%81, All reports: 9.5%
1 to 3 years13.1%298, All reports: 23.9%
4 to 7 years31%704, All reports: 20.2%
8 to 11 years35%794, All reports: 15.4%
12 years and over13.1%297, All reports: 10.7%
Age not given4.2%96, All reports: 20.3%

The outcome is for the full report, not for this sign only.

Next in the A to Z list of signs

All clinical signs

Cite this page

Pet Drug Reports. Immune mediated haemolytic anaemia: adverse event reports for animal drugs. https://petdrugreports.com/reaction/immune-mediated-haemolytic-anaemia/ Source: FDA Center for Veterinary Medicine, openFDA Animal and Veterinary adverse event reports, export of 30 Oct 2026. Reports received through 26 Jun 2026.

Where the data come from

The counts come from the openFDA Animal and Veterinary adverse event files, export of 30 Oct 2026. The files have the reports that the FDA Center for Veterinary Medicine received through 26 Jun 2026. The files mask brand and manufacturer names. The site counts a drug by the active ingredients that each record gives, and gives no count to a brand, an application or a company. Ingredient names and the lists of approved products follow the FDA Green Book of 2 Nov 2026. The site counts the different spellings of one VeDDRA term together.

The site does not publish report text, lot numbers or details of a reporter. FDA's record is the authority. See how the site counts reports, the data sources and the corrections page.

Questions about this sign

What does this term mean in a report?: In plain words: the immune system destroying red blood cells. It is a term from VeDDRA, the list of terms that FDA and drug companies use to code a report. The person who coded the report selected the term.
How does the count of the latest 12 months compare with the 12 months before?: FDA received 102 reports in the 12 months to June 2026. It received 128 reports in the 12 months before. FDA says that a report can take 3 to 6 months to reach the public data. The newest months can get more reports in a later update.
How many of these reports have a serious flag?: Of the 1,316 reports that say if the event was serious, 96.7% have the serious flag. The person who sends a report sets the flag.
Does a drug in the table cause this sign?: The reports do not show that. A report can name more than one drug. FDA states this about the data.
When looking at the results, be aware that there is no certainty that the reported drug or device caused the adverse event.
The adverse event may have been related to an underlying disease, other drugs used at the same time or other non-drug related sources.
FDA Center for Veterinary Medicine. Source: Adverse Event Reports for Animal Drugs and Devices